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Items: 12

1.

Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.

Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, Leonard HL, Grenn FP, Ruskey JA, Sabir M, Ahmed S, Makarious MB, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola-Rautio J, Tienari PJ, Team TAR, Pantelyat A, Hillis AE, Dawson TM, Rosenthal LS, Albert MS, Resnick SM, Ferrucci L, Morris CM, Pletnikova O, Troncoso J, Grosset D, Lesage S, Corvol JC, Brice A, Noyce AJ, Masliah E, Wood N, Hardy J, Shulman LM, Jankovic J, Shulman JM, Heutink P, Gasser T, Cannon P, Scholz SW, Morris H, Cookson MR, Nalls MA, Gan-Or Z, Singleton AB.

Brain. 2019 Nov 22. pii: awz350. doi: 10.1093/brain/awz350. [Epub ahead of print]

PMID:
31755958
2.

Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics.

Wu CX, Liao J, Park Y, Reed X, Engel VA, Hoang NC, Takagi Y, Johnson SM, Wang M, Federici M, Nichols RJ, Sanishvili R, Cookson MR, Hoang QQ.

J Biol Chem. 2019 Apr 12;294(15):5907-5913. doi: 10.1074/jbc.RA119.007631. Epub 2019 Feb 22.

PMID:
30796162
3.

Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.

McClymont SA, Hook PW, Soto AI, Reed X, Law WD, Kerans SJ, Waite EL, Briceno NJ, Thole JF, Heckman MG, Diehl NN, Wszolek ZK, Moore CD, Zhu H, Akiyama JA, Dickel DE, Visel A, Pennacchio LA, Ross OA, Beer MA, McCallion AS.

Am J Hum Genet. 2018 Dec 6;103(6):874-892. doi: 10.1016/j.ajhg.2018.10.018. Epub 2018 Nov 29.

4.

The role of monogenic genes in idiopathic Parkinson's disease.

Reed X, Bandrés-Ciga S, Blauwendraat C, Cookson MR.

Neurobiol Dis. 2019 Apr;124:230-239. doi: 10.1016/j.nbd.2018.11.012. Epub 2018 Nov 15. Review.

PMID:
30448284
5.

Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease.

Blauwendraat C, Reed X, Kia DA, Gan-Or Z, Lesage S, Pihlstrøm L, Guerreiro R, Gibbs JR, Sabir M, Ahmed S, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Hernandez DG, Chung SJ, Goldwurm S, Toft M, Schulte C, Bras J, Wood NW, Brice A, Morris HR, Scholz SW, Nalls MA, Singleton AB, Cookson MR; COURAGE-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease) Consortium, the French Parkinson’s Disease Consortium, and the International Parkinson’s Disease Genomics Consortium (IPDGC).

JAMA Neurol. 2018 Nov 1;75(11):1416-1422. doi: 10.1001/jamaneurol.2018.1885.

6.

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.

Hernandez DG, Reed X, Singleton AB.

J Neurochem. 2016 Oct;139 Suppl 1:59-74. doi: 10.1111/jnc.13593. Epub 2016 Apr 18. Review.

7.

Integration of genomic and functional approaches reveals enhancers at LMX1A and LMX1B.

Burzynski GM, Reed X, Maragh S, Matsui T, McCallion AS.

Mol Genet Genomics. 2013 Nov;288(11):579-89. doi: 10.1007/s00438-013-0771-7. Epub 2013 Aug 13.

8.

Integration of ChIP-seq and machine learning reveals enhancers and a predictive regulatory sequence vocabulary in melanocytes.

Gorkin DU, Lee D, Reed X, Fletez-Brant C, Bessling SL, Loftus SK, Beer MA, Pavan WJ, McCallion AS.

Genome Res. 2012 Nov;22(11):2290-301. doi: 10.1101/gr.139360.112. Epub 2012 Sep 27.

9.

Systematic elucidation and in vivo validation of sequences enriched in hindbrain transcriptional control.

Burzynski GM, Reed X, Taher L, Stine ZE, Matsui T, Ovcharenko I, McCallion AS.

Genome Res. 2012 Nov;22(11):2278-89. doi: 10.1101/gr.139717.112. Epub 2012 Jul 3.

10.

SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer.

Prasad MK, Reed X, Gorkin DU, Cronin JC, McAdow AR, Chain K, Hodonsky CJ, Jones EA, Svaren J, Antonellis A, Johnson SL, Loftus SK, Pavan WJ, McCallion AS.

BMC Dev Biol. 2011 Jun 14;11:40. doi: 10.1186/1471-213X-11-40.

11.

Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1.

Chen SC, Frett E, Marx J, Bosnakovski D, Reed X, Kyba M, Kennedy BK.

PLoS One. 2011;6(5):e19780. doi: 10.1371/journal.pone.0019780. Epub 2011 May 16.

12.

Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis.

Knox SM, Lombaert IM, Reed X, Vitale-Cross L, Gutkind JS, Hoffman MP.

Science. 2010 Sep 24;329(5999):1645-7. doi: 10.1126/science.1192046.

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