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Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-Specific Copy Number Alterations.

Giraldez S, Tamayo P, Wineinger N, Kim W, Reed SI.

iScience. 2019 Sep 27;19:850-859. doi: 10.1016/j.isci.2019.08.043. Epub 2019 Aug 27.


SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage.

Galindo-Moreno M, Giráldez S, Limón-Mortés MC, Belmonte-Fernández A, Reed SI, Sáez C, Japón MÁ, Tortolero M, Romero F.

FASEB J. 2019 Oct;33(10):11420-11430. doi: 10.1096/fj.201900885R. Epub 2019 Jul 23.


Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice.

Ekholm-Reed S, Baker R, Campos AR, Stouffer D, Henze M, Wolf DA, Loring JF, Thomas EA, Reed SI.

Commun Biol. 2019 Apr 4;2:125. doi: 10.1038/s42003-019-0366-x. eCollection 2019.


CKS protein overexpression renders tumors susceptible to a chemotherapeutic strategy that protects normal tissues.

Tat J, Loriot C, Henze M, Spruck C, Felding BH, Reed SI.

Oncotarget. 2017 Dec 4;8(70):114911-114923. doi: 10.18632/oncotarget.22931. eCollection 2017 Dec 29.


Cyclin E Deregulation and Genomic Instability.

Teixeira LK, Reed SI.

Adv Exp Med Biol. 2017;1042:527-547. doi: 10.1007/978-981-10-6955-0_22. Review.


CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin.

Mu R, Tat J, Zamudio R, Zhang Y, Yates JR 3rd, Kumagai A, Dunphy WG, Reed SI.

Mol Cell Biol. 2017 Sep 26;37(20). pii: e00344-17. doi: 10.1128/MCB.00344-17. Print 2017 Oct 15.


Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.

French ME, Klosowiak JL, Aslanian A, Reed SI, Yates JR 3rd, Hunter T.

J Biol Chem. 2017 Jun 23;292(25):10398-10413. doi: 10.1074/jbc.M117.789479. Epub 2017 May 1.


Cdc6: Skin in the carcinogenesis game.

Teixeira LK, Reed SI.

Cell Cycle. 2016;15(3):313. doi: 10.1080/15384101.2015.1131528. No abstract available.


Cyclin E deregulation promotes loss of specific genomic regions.

Teixeira LK, Wang X, Li Y, Ekholm-Reed S, Wu X, Wang P, Reed SI.

Curr Biol. 2015 May 18;25(10):1327-33. doi: 10.1016/j.cub.2015.03.022. Epub 2015 May 7.


Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints.

del Rincón SV, Widschwendter M, Sun D, Ekholm-Reed S, Tat J, Teixeira LK, Ellederova Z, Grolieres E, Reed SI, Spruck C.

Oncogene. 2015 Apr 9;34(15):1961-7. doi: 10.1038/onc.2014.137. Epub 2014 May 26.


Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1.

Ekholm-Reed S, Goldberg MS, Schlossmacher MG, Reed SI.

Mol Cell Biol. 2013 Sep;33(18):3627-43. doi: 10.1128/MCB.00535-13. Epub 2013 Jul 15.


Cks1 enhances transcription efficiency at the GAL1 locus by linking the Paf1 complex to the 19S proteasome.

Pan YR, Sun M, Wohlschlegel J, Reed SI.

Eukaryot Cell. 2013 Sep;12(9):1192-201. doi: 10.1128/EC.00151-13. Epub 2013 Jul 3.


Ubiquitin ligases and cell cycle control.

Teixeira LK, Reed SI.

Annu Rev Biochem. 2013;82:387-414. doi: 10.1146/annurev-biochem-060410-105307. Epub 2013 Mar 13. Review.


Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation.

Bhaskaran N, van Drogen F, Ng HF, Kumar R, Ekholm-Reed S, Peter M, Sangfelt O, Reed SI.

Mol Cell Biol. 2013 Jan;33(1):85-97. doi: 10.1128/MCB.00288-12. Epub 2012 Oct 29.


Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network.

Simmons Kovacs LA, Mayhew MB, Orlando DA, Jin Y, Li Q, Huang C, Reed SI, Mukherjee S, Haase SB.

Mol Cell. 2012 Mar 9;45(5):669-79. doi: 10.1016/j.molcel.2011.12.033. Epub 2012 Feb 2. Erratum in: Mol Cell. 2013 Mar 28;49(6):1177-9.


Stacking the deck: putting your Ases where you want them.

Reed SI.

Cell Cycle. 2011 Aug 15;10(16):2625-6. Epub 2011 Aug 15. No abstract available.


Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins.

Liberal V, Martinsson-Ahlzén HS, Liberal J, Spruck CH, Widschwendter M, McGowan CH, Reed SI.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2754-9. doi: 10.1073/pnas.1102434108. Epub 2011 Jun 22.


Reduced spermatogonial proliferation and decreased fertility in mice overexpressing cyclin E in spermatogonia.

Liberal V, De Miguel MP, Henze M, Nistal M, Reed SI.

Cell Cycle. 2010 Oct 15;9(20):4222-7. Epub 2010 Oct 4.


Cks1, Cdk1, and the 19S proteasome collaborate to regulate gene induction-dependent nucleosome eviction in yeast.

Chaves S, Baskerville C, Yu V, Reed SI.

Mol Cell Biol. 2010 Nov;30(22):5284-94. doi: 10.1128/MCB.00952-10. Epub 2010 Sep 20.


Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry.

Chuang LC, Teixeira LK, Wohlschlegel JA, Henze M, Yates JR, Méndez J, Reed SI.

Mol Cell. 2009 Jul 31;35(2):206-16. doi: 10.1016/j.molcel.2009.06.014.


Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.

Martinsson-Ahlzén HS, Liberal V, Grünenfelder B, Chaves SR, Spruck CH, Reed SI.

Mol Cell Biol. 2008 Sep;28(18):5698-709. doi: 10.1128/MCB.01833-07. Epub 2008 Jul 14.


The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin.

Baskerville C, Segal M, Reed SI.

Genetics. 2008 Apr;178(4):2361-72. doi: 10.1534/genetics.107.085308.


Both SCF(Cdc4alpha) and SCF(Cdc4gamma) are required for cyclin E turnover in cell lines that do not overexpress cyclin E.

Sangfelt O, Cepeda D, Malyukova A, van Drogen F, Reed SI.

Cell Cycle. 2008 Apr 15;7(8):1075-82. Epub 2008 Jan 17.


First-episode psychosis: a literature review.

Reed SI.

Int J Ment Health Nurs. 2008 Apr;17(2):85-91. doi: 10.1111/j.1447-0349.2008.00515.x. Review.


Deathproof: new insights on the role of skp2 in tumorigenesis.

Reed SI.

Cancer Cell. 2008 Feb;13(2):88-9. doi: 10.1016/j.ccr.2008.01.023.


SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.

Olson BL, Hock MB, Ekholm-Reed S, Wohlschlegel JA, Dev KK, Kralli A, Reed SI.

Genes Dev. 2008 Jan 15;22(2):252-64. doi: 10.1101/gad.1624208.


FBXW7/hCDC4 is a general tumor suppressor in human cancer.

Akhoondi S, Sun D, von der Lehr N, Apostolidou S, Klotz K, Maljukova A, Cepeda D, Fiegl H, Dafou D, Marth C, Mueller-Holzner E, Corcoran M, Dagnell M, Nejad SZ, Nayer BN, Zali MR, Hansson J, Egyhazi S, Petersson F, Sangfelt P, Nordgren H, Grander D, Reed SI, Widschwendter M, Sangfelt O, Spruck C.

Cancer Res. 2007 Oct 1;67(19):9006-12. Erratum in: Cancer Res. 2008 Feb 15;68(4):1245. Dofou, Dimitra [corrected to Dafou, Dimitra].


Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1).

Keck JM, Summers MK, Tedesco D, Ekholm-Reed S, Chuang LC, Jackson PK, Reed SI.

J Cell Biol. 2007 Jul 30;178(3):371-85.


Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.

Keller UB, Old JB, Dorsey FC, Nilsson JA, Nilsson L, MacLean KH, Chung L, Yang C, Spruck C, Boyd K, Reed SI, Cleveland JL.

EMBO J. 2007 May 16;26(10):2562-74. Epub 2007 Apr 26.


The ubiquitin-proteasome pathway in cell cycle control.

Reed SI.

Results Probl Cell Differ. 2006;42:147-81. Review.


Detection of low molecular weight derivatives of cyclin E1 is a function of cyclin E1 protein levels in breast cancer.

Spruck C, Sun D, Fiegl H, Marth C, Mueller-Holzner E, Goebel G, Widschwendter M, Reed SI.

Cancer Res. 2006 Jul 15;66(14):7355-60.


Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms.

van Drogen F, Sangfelt O, Malyukova A, Matskova L, Yeh E, Means AR, Reed SI.

Mol Cell. 2006 Jul 7;23(1):37-48.


Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland.

Smith AP, Henze M, Lee JA, Osborn KG, Keck JM, Tedesco D, Bortner DM, Rosenberg MP, Reed SI.

Oncogene. 2006 Nov 23;25(55):7245-59. Epub 2006 Jun 5.


Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies.

Wohlschlegel JA, Johnson ES, Reed SI, Yates JR 3rd.

J Proteome Res. 2006 Apr;5(4):761-70.


Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.

Jackson LP, Reed SI, Haase SB.

Mol Cell Biol. 2006 Mar;26(6):2456-66.


Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes.

Wittenberg C, Reed SI.

Oncogene. 2005 Apr 18;24(17):2746-55. Review.


A kinase-independent function of Cks1 and Cdk1 in regulation of transcription.

Yu VP, Baskerville C, Grünenfelder B, Reed SI.

Mol Cell. 2005 Jan 7;17(1):145-51.


Differential contribution of Bud6p and Kar9p to microtubule capture and spindle orientation in S. cerevisiae.

Huisman SM, Bales OA, Bertrand M, Smeets MF, Reed SI, Segal M.

J Cell Biol. 2004 Oct 25;167(2):231-44. Epub 2004 Oct 18.


Cks1 is dispensable for survival in Saccharomyces cerevisiae.

Yu VP, Reed SI.

Cell Cycle. 2004 Nov;3(11):1402-4. Epub 2004 Nov 6.


Global analysis of protein sumoylation in Saccharomyces cerevisiae.

Wohlschlegel JA, Johnson ES, Reed SI, Yates JR 3rd.

J Biol Chem. 2004 Oct 29;279(44):45662-8. Epub 2004 Aug 23.


Deregulation of cyclin E in human cells interferes with prereplication complex assembly.

Ekholm-Reed S, Méndez J, Tedesco D, Zetterberg A, Stillman B, Reed SI.

J Cell Biol. 2004 Jun 21;165(6):789-800. Epub 2004 Jun 14.


Cyclin E dysregulation and chromosomal instability in endometrial cancer.

Hubalek MM, Widschwendter A, Erdel M, Gschwendtner A, Fiegl HM, Müller HM, Goebel G, Mueller-Holzner E, Marth C, Spruck CH, Reed SI, Widschwendter M.

Oncogene. 2004 May 20;23(23):4187-92.


Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.

Ekholm-Reed S, Spruck CH, Sangfelt O, van Drogen F, Mueller-Holzner E, Widschwendter M, Zetterberg A, Reed SI.

Cancer Res. 2004 Feb 1;64(3):795-800. Erratum in: Cancer Res. 2004 Apr 15;64(8):2939. Reed, Susanna Ekholm [corrected to Reed-Ekholm, Susanna].


Cdc20 in S-phase: the Banquo at replication's banquet.

Andrews CA, Segal M, Reed SI, Clarke DJ.

Cell Cycle. 2004 Mar;3(3):276-9. Epub 2004 Mar 1.


Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover.

Reed SI.

Nat Rev Mol Cell Biol. 2003 Nov;4(11):855-64. Review. No abstract available.


S-phase checkpoint controls mitosis via an APC-independent Cdc20p function.

Clarke DJ, Segal M, Andrews CA, Rudyak SG, Jensen S, Smith K, Reed SI.

Nat Cell Biol. 2003 Oct;5(10):928-35. Epub 2003 Sep 21.


Germline exclusion of Cks1 in the mouse reveals a metaphase I role for Cks proteins in male and female meiosis.

Donovan PJ, Reed SI.

Cell Cycle. 2003 Jul-Aug;2(4):275-6. Review. No abstract available.


Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast.

Morris MC, Kaiser P, Rudyak S, Baskerville C, Watson MH, Reed SI.

Nature. 2003 Jun 26;423(6943):1009-13.


Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.

Spruck CH, de Miguel MP, Smith AP, Ryan A, Stein P, Schultz RM, Lincoln AJ, Donovan PJ, Reed SI.

Science. 2003 Apr 25;300(5619):647-50.

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