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Items: 1 to 50 of 138

1.

Properties of Intermediates in the Catalytic Cycle of Oxalate Oxidoreductase and Its Suicide Inactivation by Pyruvate.

Pierce E, Mansoorabadi SO, Can M, Reed GH, Ragsdale SW.

Biochemistry. 2017 Jun 6;56(22):2824-2835. doi: 10.1021/acs.biochem.7b00222. Epub 2017 May 23.

2.

Fourier Deconvolution Methods for Resolution Enhancement in Continuous-Wave EPR Spectroscopy.

Reed GH, Poyner RR.

Methods Enzymol. 2015;563:23-36. doi: 10.1016/bs.mie.2015.06.009. Epub 2015 Jul 2.

PMID:
26478480
3.

The ubiquity of iron.

Frey PA, Reed GH.

ACS Chem Biol. 2012 Sep 21;7(9):1477-81. Epub 2012 Aug 27.

PMID:
22845493
4.

Radical reactions of thiamin pyrophosphate in 2-oxoacid oxidoreductases.

Reed GH, Ragsdale SW, Mansoorabadi SO.

Biochim Biophys Acta. 2012 Nov;1824(11):1291-8. doi: 10.1016/j.bbapap.2011.11.010. Epub 2011 Dec 8. Review.

5.

Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases.

Frey PA, Reed GH.

Biochim Biophys Acta. 2011 Nov;1814(11):1548-57. doi: 10.1016/j.bbapap.2011.03.005. Epub 2011 Mar 22. Review.

PMID:
21435400
6.

Rapid genetic analysis of x-linked chronic granulomatous disease by high-resolution melting.

Hill HR, Augustine NH, Pryor RJ, Reed GH, Bagnato JD, Tebo AE, Bender JM, Pasi BM, Chinen J, Hanson IC, de Boer M, Roos D, Wittwer CT.

J Mol Diagn. 2010 May;12(3):368-76. doi: 10.2353/jmoldx.2010.090147. Epub 2010 Mar 12.

7.

Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase.

Tang KH, Mansoorabadi SO, Reed GH, Frey PA.

Biochemistry. 2009 Sep 1;48(34):8151-60. doi: 10.1021/bi900828f.

8.

Reaction of AdoMet with ThiC generates a backbone free radical.

Martinez-Gomez NC, Poyner RR, Mansoorabadi SO, Reed GH, Downs DM.

Biochemistry. 2009 Jan 20;48(2):217-9. doi: 10.1021/bi802154j.

9.

Identification of the substrate radical intermediate derived from ethanolamine during catalysis by ethanolamine ammonia-lyase.

Bender G, Poyner RR, Reed GH.

Biochemistry. 2008 Oct 28;47(43):11360-6. doi: 10.1021/bi801316v. Epub 2008 Oct 1.

10.

High-resolution DNA melting analysis for simple and efficient molecular diagnostics.

Reed GH, Kent JO, Wittwer CT.

Pharmacogenomics. 2007 Jun;8(6):597-608. Review.

PMID:
17559349
12.

The catalytic Mn2+ sites in the enolase-inhibitor complex: crystallography, single-crystal EPR, and DFT calculations.

Carmieli R, Larsen TM, Reed GH, Zein S, Neese F, Goldfarb D.

J Am Chem Soc. 2007 Apr 11;129(14):4240-52. Epub 2007 Mar 17.

13.

Analysis of the Cob(II)alamin-5'-deoxy-3',4'-anhydroadenosyl radical triplet spin system in the active site of diol dehydrase.

Mansoorabadi SO, Magnusson OT, Poyner RR, Frey PA, Reed GH.

Biochemistry. 2006 Dec 5;45(48):14362-70.

14.

Enantiomeric free radicals and enzymatic control of stereochemistry in a radical mechanism: the case of lysine 2,3-aminomutases.

Behshad E, Ruzicka FJ, Mansoorabadi SO, Chen D, Reed GH, Frey PA.

Biochemistry. 2006 Oct 24;45(42):12639-46.

15.

Reaction of adenosylcobalamin-dependent glutamate mutase with 2-thiolglutarate.

Yoon M, Patwardhan A, Qiao C, Mansoorabadi SO, Menefee AL, Reed GH, Marsh EN.

Biochemistry. 2006 Sep 26;45(38):11650-7.

16.

Free radical mechanisms in enzymology.

Frey PA, Hegeman AD, Reed GH.

Chem Rev. 2006 Aug;106(8):3302-16. Review. No abstract available.

PMID:
16895329
17.

EPR spectroscopic and computational characterization of the hydroxyethylidene-thiamine pyrophosphate radical intermediate of pyruvate:ferredoxin oxidoreductase.

Mansoorabadi SO, Seravalli J, Furdui C, Krymov V, Gerfen GJ, Begley TP, Melnick J, Ragsdale SW, Reed GH.

Biochemistry. 2006 Jun 13;45(23):7122-31.

18.

Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase.

Poyner RR, Anderson MA, Bandarian V, Cleland WW, Reed GH.

J Am Chem Soc. 2006 Jun 7;128(22):7120-1.

19.

Pulsed electron paramagnetic resonance experiments identify the paramagnetic intermediates in the pyruvate ferredoxin oxidoreductase catalytic cycle.

Astashkin AV, Seravalli J, Mansoorabadi SO, Reed GH, Ragsdale SW.

J Am Chem Soc. 2006 Mar 29;128(12):3888-9.

20.

Structure and catalytic properties of an engineered heterodimer of enolase composed of one active and one inactive subunit.

Sims PA, Menefee AL, Larsen TM, Mansoorabadi SO, Reed GH.

J Mol Biol. 2006 Jan 20;355(3):422-31. Epub 2005 Nov 8.

21.
22.

Radical mechanisms in adenosylcobalamin-dependent enzymes.

Reed GH.

Curr Opin Chem Biol. 2004 Oct;8(5):477-83. Review.

PMID:
15450489
23.
24.

The positions of radical intermediates in the active sites of adenosylcobalamin-dependent enzymes.

Reed GH, Mansoorabadi SO.

Curr Opin Struct Biol. 2003 Dec;13(6):716-21. Review.

25.

Reverse protonation is the key to general acid-base catalysis in enolase.

Sims PA, Larsen TM, Poyner RR, Cleland WW, Reed GH.

Biochemistry. 2003 Jul 15;42(27):8298-306.

PMID:
12846578
26.

High-resolution genotyping by amplicon melting analysis using LCGreen.

Wittwer CT, Reed GH, Gundry CN, Vandersteen JG, Pryor RJ.

Clin Chem. 2003 Jun;49(6 Pt 1):853-60.

27.

Amplicon melting analysis with labeled primers: a closed-tube method for differentiating homozygotes and heterozygotes.

Gundry CN, Vandersteen JG, Reed GH, Pryor RJ, Chen J, Wittwer CT.

Clin Chem. 2003 Mar;49(3):396-406.

28.

Kinetic characterization of transient free radical intermediates in reaction of lysine 2,3-aminomutase by EPR lineshape analysis.

Frey PA, Chang CH, Ballinger MD, Reed GH.

Methods Enzymol. 2002;354:426-35. No abstract available.

PMID:
12418244
30.

Functional and structural changes due to a serine to alanine mutation in the active-site flap of enolase.

Poyner RR, Larsen TM, Wong SW, Reed GH.

Arch Biochem Biophys. 2002 May 15;401(2):155-63.

PMID:
12054465
31.

Role of metal ions in catalysis by enolase: an ordered kinetic mechanism for a single substrate enzyme.

Poyner RR, Cleland WW, Reed GH.

Biochemistry. 2001 Jul 10;40(27):8009-17.

PMID:
11434770
32.
33.
34.
35.

Radical mechanisms in adenosylmethionine- and adenosylcobalamin-dependent enzymatic reactions.

Frey PA, Reed GH.

Arch Biochem Biophys. 2000 Oct 1;382(1):6-14. Review.

PMID:
11051091
37.

Lysine 2,3-aminomutase and trans-4,5-dehydrolysine: characterization of an allylic analogue of a substrate-based radical in the catalytic mechanism.

Wu W, Booker S, Lieder KW, Bandarian V, Reed GH, Frey PA.

Biochemistry. 2000 Aug 8;39(31):9561-70.

PMID:
10924153
39.

Mn2+ as a probe of divalent metal ion binding and function in enzymes and other proteins.

Reed GH, Poyner RR.

Met Ions Biol Syst. 2000;37:183-207. Review. No abstract available.

PMID:
10693135
40.

Rapid F508del and F508C assay using fluorescent hybridization probes.

Gundry CN, Bernard PS, Herrmann MG, Reed GH, Wittwer CT.

Genet Test. 1999;3(4):365-70.

PMID:
10627945
41.

Ethanolamine ammonia-lyase has a "base-on" binding mode for coenzyme B(12).

Abend A, Bandarian V, Nitsche R, Stupperich E, R├ętey J, Reed GH.

Arch Biochem Biophys. 1999 Oct 1;370(1):138-41.

PMID:
10496987
42.
43.
44.

S-adenosylmethionine: a 'poor man's coenzyme B12' in the reaction of lysine 2,3-aminomutase.

Frey PA, Ballinger MD, Reed GH.

Biochem Soc Trans. 1998 Aug;26(3):304-10. Review. No abstract available.

PMID:
9765869
45.
46.
47.
48.

Ligand-induced domain movement in pyruvate kinase: structure of the enzyme from rabbit muscle with Mg2+, K+, and L-phospholactate at 2.7 A resolution.

Larsen TM, Benning MM, Wesenberg GE, Rayment I, Reed GH.

Arch Biochem Biophys. 1997 Sep 15;345(2):199-206.

PMID:
9308890
49.

The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids.

Babbitt PC, Hasson MS, Wedekind JE, Palmer DR, Barrett WC, Reed GH, Rayment I, Ringe D, Kenyon GL, Gerlt JA.

Biochemistry. 1996 Dec 24;35(51):16489-501.

PMID:
8987982
50.

Kinetic characterization of an organic radical in the ascarylose biosynthetic pathway.

Johnson DA, Gassner GT, Bandarian V, Ruzicka FJ, Ballou DP, Reed GH, Liu HW.

Biochemistry. 1996 Dec 10;35(49):15846-56.

PMID:
8961949

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