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Items: 10


CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition.

Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, Redwood AB, Piwnica-Worms H, Schlacher K, Frederick MJ, Myers JN.

Cancer Res. 2018 Feb 1;78(3):781-797. doi: 10.1158/0008-5472.CAN-17-2802. Epub 2017 Dec 11.


CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib.

Sen T, Tong P, Stewart CA, Cristea S, Valliani A, Shames DS, Redwood AB, Fan YH, Li L, Glisson BS, Minna JD, Sage J, Gibbons DL, Piwnica-Worms H, Heymach JV, Wang J, Byers LA.

Cancer Res. 2017 Jul 15;77(14):3870-3884. doi: 10.1158/0008-5472.CAN-16-3409. Epub 2017 May 10.


Loss of lamin A function increases chromatin dynamics in the nuclear interior.

Bronshtein I, Kepten E, Kanter I, Berezin S, Lindner M, Redwood AB, Mai S, Gonzalo S, Foisner R, Shav-Tal Y, Garini Y.

Nat Commun. 2015 Aug 24;6:8044. doi: 10.1038/ncomms9044.


Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability.

Das A, Grotsky DA, Neumann MA, Kreienkamp R, Gonzalez-Suarez I, Redwood AB, Kennedy BK, Stewart CL, Gonzalo S.

Nucleus. 2013 Sep-Oct;4(5):410-9. doi: 10.4161/nucl.26873. Epub 2013 Oct 23.


BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells.

Grotsky DA, Gonzalez-Suarez I, Novell A, Neumann MA, Yaddanapudi SC, Croke M, Martinez-Alonso M, Redwood AB, Ortega-Martinez S, Feng Z, Lerma E, Ramon y Cajal T, Zhang J, Matias-Guiu X, Dusso A, Gonzalo S.

J Cell Biol. 2013 Jan 21;200(2):187-202. doi: 10.1083/jcb.201204053.


Regulating the levels of key factors in cell cycle and DNA repair: new pathways revealed by lamins.

Redwood AB, Gonzalez-Suarez I, Gonzalo S.

Cell Cycle. 2011 Nov 1;10(21):3652-7. doi: 10.4161/cc.10.21.18201. Epub 2011 Nov 1. Review.


A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.

Gonzalez-Suarez I, Redwood AB, Grotsky DA, Neumann MA, Cheng EH, Stewart CL, Dusso A, Gonzalo S.

EMBO J. 2011 Jul 12;30(16):3383-96. doi: 10.1038/emboj.2011.225.


A dual role for A-type lamins in DNA double-strand break repair.

Redwood AB, Perkins SM, Vanderwaal RP, Feng Z, Biehl KJ, Gonzalez-Suarez I, Morgado-Palacin L, Shi W, Sage J, Roti-Roti JL, Stewart CL, Zhang J, Gonzalo S.

Cell Cycle. 2011 Aug 1;10(15):2549-60. Epub 2011 Aug 1.


Loss of A-type lamins and genomic instability.

Gonzalez-Suarez I, Redwood AB, Gonzalo S.

Cell Cycle. 2009 Dec;8(23):3860-5. Epub 2009 Dec 15. Review.


Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

Gonzalez-Suarez I, Redwood AB, Perkins SM, Vermolen B, Lichtensztejin D, Grotsky DA, Morgado-Palacin L, Gapud EJ, Sleckman BP, Sullivan T, Sage J, Stewart CL, Mai S, Gonzalo S.

EMBO J. 2009 Aug 19;28(16):2414-27. doi: 10.1038/emboj.2009.196. Epub 2009 Jul 23.

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