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Human-Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges.

De Los Angeles A, Hyun I, Latham SR, Elsworth JD, Redmond DE Jr.

Methods Mol Biol. 2019;2005:221-231. doi: 10.1007/978-1-4939-9524-0_15.


ERK-independent African Green monkey pluripotent stem cells in a putative chimera-competent state.

De Los Angeles A, Elsworth JD, Redmond DE Jr.

Biochem Biophys Res Commun. 2019 Feb 26;510(1):78-84. doi: 10.1016/j.bbrc.2019.01.037. Epub 2019 Jan 16.


Generating Human Organs via Interspecies Chimera Formation: Advances and Barriers.

De Los Angeles A, Pho N, Redmond DE Jr.

Yale J Biol Med. 2018 Sep 21;91(3):333-342. eCollection 2018 Sep. Review.


Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias.

Kordower JH, Vinuela A, Chu Y, Isacson O, Redmond DE Jr.

J Comp Neurol. 2017 Feb 15;525(3):498-512. doi: 10.1002/cne.24081. Epub 2016 Aug 29.


Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease.

Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, Attwood J, Noskov A, Christiansen-Weber T, Khater M, Mora-Castilla S, To C, Crain A, Sherman G, Semechkin A, Laurent LC, Elsworth JD, Sladek J, Snyder EY, Redmond DE Jr, Kern RA.

Cell Transplant. 2016 Nov;25(11):1945-1966. doi: 10.3727/096368916X691682.


Impaired Arm Function and Finger Dexterity in a Nonhuman Primate Model of Stroke: Motor and Cognitive Assessments.

McEntire CR, Choudhury GR, Torres A, Steinberg GK, Redmond DE Jr, Daadi MM.

Stroke. 2016 Apr;47(4):1109-16. doi: 10.1161/STROKEAHA.115.012506. Epub 2016 Mar 8.


Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates.

Collier TJ, Redmond DE Jr, Steece-Collier K, Lipton JW, Manfredsson FP.

Front Neurosci. 2016 Jan 29;10:12. doi: 10.3389/fnins.2016.00012. eCollection 2016.


Proof of concept studies exploring the safety and functional activity of human parthenogenetic-derived neural stem cells for the treatment of Parkinson's disease.

Gonzalez R, Garitaonandia I, Crain A, Poustovoitov M, Abramihina T, Noskov A, Jiang C, Morey R, Laurent LC, Elsworth JD, Snyder EY, Redmond DE Jr, Semechkin R.

Cell Transplant. 2015;24(4):681-90. doi: 10.3727/096368915X687769. Epub 2015 Mar 24.


A potential compensatory role for endogenous striatal tyrosine hydroxylase-positive neurons in a nonhuman primate model of Parkinson's disease.

Bubak AN, Redmond DE Jr, Elsworth JD, Roth RH, Collier TJ, Bjugstad KB, Blanchard BC, Sladek JR Jr.

Cell Transplant. 2015;24(4):673-80. doi: 10.3727/096368915X687741. Epub 2015 Mar 24.


Primate phencyclidine model of schizophrenia: sex-specific effects on cognition, brain derived neurotrophic factor, spine synapses, and dopamine turnover in prefrontal cortex.

Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE Jr, Kim JD, Diano S, Roth RH.

Int J Neuropsychopharmacol. 2014 Oct 31;18(6). pii: pyu048. doi: 10.1093/ijnp/pyu048.


Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate target.

Wakeman DR, Redmond DE Jr, Dodiya HB, Sladek JR Jr, Leranth C, Teng YD, Samulski RJ, Snyder EY.

Stem Cells Transl Med. 2014 Jun;3(6):692-701. doi: 10.5966/sctm.2013-0208. Epub 2014 Apr 17.


Primate adult brain cell autotransplantation produces behavioral and biological recovery in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian St. Kitts monkeys.

Bloch J, Brunet JF, McEntire CR, Redmond DE.

J Comp Neurol. 2014 Aug 15;522(12):2729-40. doi: 10.1002/cne.23579. Epub 2014 Apr 4.


Intracerebroventricular injection of adeno-associated virus 6 and 9 vectors for cell type-specific transgene expression in the spinal cord.

Dirren E, Towne CL, Setola V, Redmond DE Jr, Schneider BL, Aebischer P.

Hum Gene Ther. 2014 Feb;25(2):109-20. doi: 10.1089/hum.2013.021. Epub 2014 Jan 15.


Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model.

Redmond DE Jr, McEntire CR, Kingsbery JP, Leranth C, Elsworth JD, Bjugstad KB, Roth RH, Samulski RJ, Sladek JR Jr.

Mol Ther. 2013 Dec;21(12):2160-8. doi: 10.1038/mt.2013.180. Epub 2013 Aug 5.


Survival and integration of neurons derived from human embryonic stem cells in MPTP-lesioned primates.

Wakeman DR, Weiss S, Sladek JR, Elsworth JD, Bauereis B, Leranth C, Hurley PJ, Roth RH, Redmond DE.

Cell Transplant. 2014;23(8):981-94. doi: 10.3727/096368913X664865. Epub 2013 Apr 2.


Coordinated expression of dopamine transporter and vesicular monoamine transporter in the primate striatum during development.

Elsworth JD, Redmond DE Jr, Roth RH.

Synapse. 2013 Sep;67(9):580-5. doi: 10.1002/syn.21662. Epub 2013 Apr 18.


Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates.

Elsworth JD, Jentsch JD, Vandevoort CA, Roth RH, Redmond DE Jr, Leranth C.

Neurotoxicology. 2013 Mar;35:113-20. doi: 10.1016/j.neuro.2013.01.001. Epub 2013 Jan 18.


Using monkeys to understand and cure Parkinson disease.

Redmond DE Jr.

Hastings Cent Rep. 2012 Nov-Dec;Suppl:S7-S11. doi: 10.1002/hast.100. No abstract available.


Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis.

Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B, Lachyankar MB, Marconi M, Li J, Yu D, Han I, Maragakis NJ, Lládo J, Erkmen K, Redmond DE Jr, Sidman RL, Przedborski S, Rothstein JD, Brown RH Jr, Snyder EY.

Sci Transl Med. 2012 Dec 19;4(165):165ra164. doi: 10.1126/scitranslmed.3004579.


Loss of asymmetric spine synapses in prefrontal cortex of motor-asymptomatic, dopamine-depleted, cognitively impaired MPTP-treated monkeys.

Elsworth JD, Leranth C, Redmond DE Jr, Roth RH.

Int J Neuropsychopharmacol. 2013 May;16(4):905-12. doi: 10.1017/S1461145712000892. Epub 2012 Sep 4.


Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease.

Daadi MM, Grueter BA, Malenka RC, Redmond DE Jr, Steinberg GK.

PLoS One. 2012;7(7):e41120. doi: 10.1371/journal.pone.0041120. Epub 2012 Jul 17.


Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research.

Teng YD, Yu D, Ropper AE, Li J, Kabatas S, Wakeman DR, Wang J, Sullivan MP, Redmond DE Jr, Langer R, Snyder EY, Sidman RL.

Curr Neuropharmacol. 2011 Dec;9(4):574-85. doi: 10.2174/157015911798376299.


Susceptibility to a parkinsonian toxin varies during primate development.

Morrow BA, Roth RH, Redmond DE Jr, Diano S, Elsworth JD.

Exp Neurol. 2012 May;235(1):273-81. doi: 10.1016/j.expneurol.2012.02.005. Epub 2012 Feb 14.


Determination of fetal age by ultrasonography in St. Kitts green monkeys.

Redmond DE Jr, Evans L.

Am J Primatol. 2012 May;74(5):433-41. doi: 10.1002/ajp.22000. Epub 2012 Feb 6.


Comparison of fresh to fixed weights of the vervet monkey (Chlorocebus sabaeus) placenta and its relation to gestational age.

DeMartelly V, Hurley P, Lawrence M, Redmond DE Jr, Rutherford J.

J Med Primatol. 2012 Jun;41(3):158-62. doi: 10.1111/j.1600-0684.2011.00534.x. Epub 2012 Feb 1.


Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease.

Morrow BA, Roth RH, Redmond DE, Elsworth JD.

Neuroscience. 2011 Aug 25;189:277-85. doi: 10.1016/j.neuroscience.2011.05.046. Epub 2011 Jun 1.


Aged monkeys as a partial model for Parkinson's disease.

Hurley PJ, Elsworth JD, Whittaker MC, Roth RH, Redmond DE Jr.

Pharmacol Biochem Behav. 2011 Sep;99(3):324-32. doi: 10.1016/j.pbb.2011.05.007. Epub 2011 May 18.


Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development.

Bloch J, Kaeser M, Sadeghi Y, Rouiller EM, Redmond DE Jr, Brunet JF.

J Comp Neurol. 2011 Mar 1;519(4):775-89. doi: 10.1002/cne.22547.


Cellular repair in the parkinsonian nonhuman primate brain.

Redmond DE Jr, Weiss S, Elsworth JD, Roth RH, Wakeman DR, Bjugstad KB, Collier TJ, Blanchard BC, Teng YD, Synder EY, Sladek JR Jr.

Rejuvenation Res. 2010 Apr-Jun;13(2-3):188-94. doi: 10.1089/rej.2009.0960. Review.


Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain.

Markakis EA, Vives KP, Bober J, Leichtle S, Leranth C, Beecham J, Elsworth JD, Roth RH, Samulski RJ, Redmond DE Jr.

Mol Ther. 2010 Mar;18(3):588-93. doi: 10.1038/mt.2009.286. Epub 2009 Dec 15.


Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6.

Towne C, Schneider BL, Kieran D, Redmond DE Jr, Aebischer P.

Gene Ther. 2010 Jan;17(1):141-6. doi: 10.1038/gt.2009.119. Epub 2009 Sep 3.


Primate adult brain cell autotransplantation, a pilot study in asymptomatic MPTP-treated monkeys.

Brunet JF, Redmond DE Jr, Bloch J.

Cell Transplant. 2009;18(7):787-99. doi: 10.3727/096368909X470847. Epub 2009 Apr 6.


Long-term multilayer adherent network (MAN) expansion, maintenance, and characterization, chemical and genetic manipulation, and transplantation of human fetal forebrain neural stem cells.

Wakeman DR, Hofmann MR, Redmond DE Jr, Teng YD, Snyder EY.

Curr Protoc Stem Cell Biol. 2009 May;Chapter 2:Unit2D.3. doi: 10.1002/9780470151808.sc02d03s9.


Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF.

Redmond DE Jr, Elsworth JD, Roth RH, Leranth C, Collier TJ, Blanchard B, Bjugstad KB, Samulski RJ, Aebischer P, Sladek JR Jr.

J Comp Neurol. 2009 Jul 1;515(1):31-40. doi: 10.1002/cne.22028.


Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate.

Sladek JR Jr, Bjugstad KB, Collier TJ, Bundock EA, Blanchard BC, Elsworth JD, Roth RH, Redmond DE Jr.

Cell Transplant. 2008;17(4):427-44.


Biocompatibility of PEG-based hydrogels in primate brain.

Bjugstad KB, Redmond DE Jr, Lampe KJ, Kern DS, Sladek JR Jr, Mahoney MJ.

Cell Transplant. 2008;17(4):409-15.


Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles.

Li W, Asokan A, Wu Z, Van Dyke T, DiPrimio N, Johnson JS, Govindaswamy L, Agbandje-McKenna M, Leichtle S, Redmond DE Jr, McCown TJ, Petermann KB, Sharpless NE, Samulski RJ.

Mol Ther. 2008 Jul;16(7):1252-60. doi: 10.1038/mt.2008.100. Epub 2008 May 20.


Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease.

Bjugstad KB, Teng YD, Redmond DE Jr, Elsworth JD, Roth RH, Cornelius SK, Snyder EY, Sladek JR Jr.

Exp Neurol. 2008 Jun;211(2):362-9. doi: 10.1016/j.expneurol.2008.01.025. Epub 2008 Feb 14.


AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons.

Elsworth JD, Redmond DE Jr, Leranth C, Bjugstad KB, Sladek JR Jr, Collier TJ, Foti SB, Samulski RJ, Vives KP, Roth RH.

Exp Neurol. 2008 May;211(1):252-8. doi: 10.1016/j.expneurol.2008.01.026. Epub 2008 Feb 15.


Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells.

Redmond DE Jr, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR Jr, Sidman RL, Snyder EY.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12175-80. Epub 2007 Jun 22.


Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine.

Elsworth JD, Jentsch JD, Morrow BA, Redmond DE Jr, Roth RH.

Neuropsychopharmacology. 2008 Feb;33(3):491-6. Epub 2007 May 16.


Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation.

Morrow BA, Roth RH, Redmond DE Jr, Sladek JR Jr, Elsworth JD.

Exp Neurol. 2007 Apr;204(2):802-7. Epub 2007 Jan 19.


Safety of direct administration of AAV2(CU)hCLN2, a candidate treatment for the central nervous system manifestations of late infantile neuronal ceroid lipofuscinosis, to the brain of rats and nonhuman primates.

Hackett NR, Redmond DE, Sondhi D, Giannaris EL, Vassallo E, Stratton J, Qiu J, Kaminsky SM, Lesser ML, Fisch GS, Rouselle SD, Crystal RG.

Hum Gene Ther. 2005 Dec;16(12):1484-503.


Know thyself: autologous cell transplantation strategies for brain repair.

Markakis EA, Redmond DE Jr.

Exp Neurol. 2005 Nov;196(1):6-8. Epub 2005 Sep 12. Review. No abstract available.


AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL.

Sondhi D, Peterson DA, Giannaris EL, Sanders CT, Mendez BS, De B, Rostkowski AB, Blanchard B, Bjugstad K, Sladek JR Jr, Redmond DE Jr, Leopold PL, Kaminsky SM, Hackett NR, Crystal RG.

Gene Ther. 2005 Nov;12(22):1618-32.


Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures.

Bjugstad KB, Redmond DE Jr, Teng YD, Elsworth JD, Roth RH, Blanchard BC, Snyder EY, Sladek JR Jr.

Cell Transplant. 2005;14(4):183-92.


Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkey.

Morrow BA, Redmond DE Jr, Roth RH, Elsworth JD.

J Comp Neurol. 2005 Jul 25;488(2):215-23.


Spatiotemporal patterns of gene expression during fetal monkey brain development.

Redmond DE Jr, Zhao JL, Randall JD, Eklund AC, Eusebi LO, Roth RH, Gullans SR, Jensen RV.

Brain Res Dev Brain Res. 2003 Dec 19;146(1-2):99-106.


Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease.

Horvath TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, Elsworth JD, Sotonyi P, Roth RH, Dietrich EH, Matthews RT, Barnstable CJ, Redmond DE Jr.

Endocrinology. 2003 Jul;144(7):2757-60.


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