Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 131

1.

Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases.

Ervin SM, Hanley RP, Lim L, Walton WG, Pearce KH, Bhatt AP, James LI, Redinbo MR.

ACS Chem Biol. 2019 Nov 12. doi: 10.1021/acschembio.9b00663. [Epub ahead of print]

PMID:
31663730
2.

Gut microbiome-derived β-glucuronidases are components of the estrobolome that reactivate estrogens.

Ervin SM, Li H, Lim L, Roberts LR, Liang X, Mani S, Redinbo MR.

J Biol Chem. 2019 Oct 21. pii: jbc.RA119.010950. doi: 10.1074/jbc.RA119.010950. [Epub ahead of print]

3.

A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease.

Mashbat B, Bellos E, Hodeib S, Bidmos F, Thwaites RS, Lu Y, Wright VJ, Herberg JA, Klobassa DS, Zenz W, Hansel TT, Nadel S, Langford PR, Schlapbach LJ, Li MS, Redinbo MR, Di YP, Levin M, Sancho-Shimizu V; European Union Childhood Life-Threatening Infectious Disease Study (EUCLIDS) Consortium.

Clin Infect Dis. 2019 Jul 1. pii: ciz600. doi: 10.1093/cid/ciz600. [Epub ahead of print]

PMID:
31504285
4.

Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure.

Creekmore BC, Gray JH, Walton WG, Biernat KA, Little MS, Xu Y, Liu J, Gharaibeh RZ, Redinbo MR.

mSystems. 2019 Aug 27;4(4). pii: e00452-19. doi: 10.1128/mSystems.00452-19.

5.

Epithelial delamination is protective during pharmaceutical-induced enteropathy.

Espenschied ST, Cronan MR, Matty MA, Mueller O, Redinbo MR, Tobin DM, Rawls JF.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16961-16970. doi: 10.1073/pnas.1902596116. Epub 2019 Aug 7.

PMID:
31391308
6.

Enterococcus faecalis Gluconate Phosphotransferase System Accelerates Experimental Colitis and Bacterial Killing by Macrophages.

Fan TJ, Goeser L, Naziripour A, Redinbo MR, Hansen JJ.

Infect Immun. 2019 Jun 20;87(7). pii: e00080-19. doi: 10.1128/IAI.00080-19. Print 2019 Jul.

PMID:
31036600
7.

Selecting a Single Stereocenter: The Molecular Nuances That Differentiate β-Hexuronidases in the Human Gut Microbiome.

Pellock SJ, Walton WG, Redinbo MR.

Biochemistry. 2019 Mar 5;58(9):1311-1317. doi: 10.1021/acs.biochem.8b01285. Epub 2019 Feb 18.

PMID:
30729778
8.

Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases.

Biernat KA, Pellock SJ, Bhatt AP, Bivins MM, Walton WG, Tran BNT, Wei L, Snider MC, Cesmat AP, Tripathy A, Erie DA, Redinbo MR.

Sci Rep. 2019 Jan 29;9(1):825. doi: 10.1038/s41598-018-36069-w.

9.

Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome.

Pellock SJ, Walton WG, Ervin SM, Torres-Rivera D, Creekmore BC, Bergan G, Dunn ZD, Li B, Tripathy A, Redinbo MR.

J Mol Biol. 2019 Mar 1;431(5):970-980. doi: 10.1016/j.jmb.2019.01.013. Epub 2019 Jan 15.

PMID:
30658055
10.

In Fimo: A Term Proposed for Excrement Examined Experimentally.

Bhatt AP, Grillo L, Redinbo MR.

Gastroenterology. 2019 Apr;156(5):1232. doi: 10.1053/j.gastro.2018.11.070. Epub 2018 Dec 13. No abstract available.

PMID:
30553913
11.

Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK).

Shapiro JA, Varga JJ, Parsonage D, Walton W, Redinbo MR, Ross LJ, White EL, Bostwick R, Wuest WM, Claiborne A, Goldberg JB.

ChemMedChem. 2019 Jan 8;14(1):78-82. doi: 10.1002/cmdc.201800652. Epub 2018 Dec 3.

PMID:
30376607
12.

Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis.

Pellock SJ, Walton WG, Biernat KA, Torres-Rivera D, Creekmore BC, Xu Y, Liu J, Tripathy A, Stewart LJ, Redinbo MR.

J Biol Chem. 2018 Nov 30;293(48):18559-18573. doi: 10.1074/jbc.RA118.005414. Epub 2018 Oct 9.

PMID:
30301767
13.

Active site flexibility revealed in crystal structures of Parabacteroides merdae β-glucuronidase from the human gut microbiome.

Little MS, Ervin SM, Walton WG, Tripathy A, Xu Y, Liu J, Redinbo MR.

Protein Sci. 2018 Dec;27(12):2010-2022. doi: 10.1002/pro.3507. Epub 2018 Oct 27.

PMID:
30230652
14.

Enhanced biofilm prevention activity of a SPLUNC1-derived antimicrobial peptide against Staphylococcus aureus.

Yu Z, Deslouches B, Walton WG, Redinbo MR, Di YP.

PLoS One. 2018 Sep 14;13(9):e0203621. doi: 10.1371/journal.pone.0203621. eCollection 2018.

15.

Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception.

Pellock SJ, Creekmore BC, Walton WG, Mehta N, Biernat KA, Cesmat AP, Ariyarathna Y, Dunn ZD, Li B, Jin J, James LI, Redinbo MR.

ACS Cent Sci. 2018 Jul 25;4(7):868-879. doi: 10.1021/acscentsci.8b00239. Epub 2018 Jul 12.

16.

Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1.

Little MS, Redinbo MR.

Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):268-276. doi: 10.1107/S2053230X18004600. Epub 2018 Apr 16.

17.

Microbial Glucuronidase Inhibition Reduces Severity of Diclofenac-Induced Anastomotic Leak in Rats.

Yauw STK, Arron M, Lomme RMLM, van den Broek P, Greupink R, Bhatt AP, Redinbo MR, van Goor H.

Surg Infect (Larchmt). 2018 May/Jun;19(4):417-423. doi: 10.1089/sur.2017.245. Epub 2018 Apr 6.

18.

Microbial Unmasking of Plant Glycosides.

Biernat KA, Li B, Redinbo MR.

MBio. 2018 Jan 30;9(1). pii: e02433-17. doi: 10.1128/mBio.02433-17.

19.

SPLUNC1 is an allosteric modulator of the epithelial sodium channel.

Kim CS, Ahmad S, Wu T, Walton WG, Redinbo MR, Tarran R.

FASEB J. 2018 May;32(5):2478-2491. doi: 10.1096/fj.201701126R. Epub 2018 Jan 8.

20.

Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae.

Little MS, Pellock SJ, Walton WG, Tripathy A, Redinbo MR.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E152-E161. doi: 10.1073/pnas.1716241115. Epub 2017 Dec 21.

21.

Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells.

Bhatt AP, Gunasekara DB, Speer J, Reed MI, Peña AN, Midkiff BR, Magness ST, Bultman SJ, Allbritton NL, Redinbo MR.

ACS Infect Dis. 2018 Jan 12;4(1):46-52. doi: 10.1021/acsinfecdis.7b00139. Epub 2017 Nov 10.

22.

An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.

Pollet RM, D'Agostino EH, Walton WG, Xu Y, Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC, Isenberg HN, Bahethi RR, Bhatt AP, Liu J, Gharaibeh RZ, Redinbo MR.

Structure. 2017 Jul 5;25(7):967-977.e5. doi: 10.1016/j.str.2017.05.003. Epub 2017 Jun 1.

23.

The role of the microbiome in cancer development and therapy.

Bhatt AP, Redinbo MR, Bultman SJ.

CA Cancer J Clin. 2017 Jul 8;67(4):326-344. doi: 10.3322/caac.21398. Epub 2017 May 8. Review.

24.

Glucuronides in the gut: Sugar-driven symbioses between microbe and host.

Pellock SJ, Redinbo MR.

J Biol Chem. 2017 May 26;292(21):8569-8576. doi: 10.1074/jbc.R116.767434. Epub 2017 Apr 7. Review.

25.

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB.

Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.

26.

Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.

Bellendir SP, Rognstad DJ, Morris LP, Zapotoczny G, Walton WG, Redinbo MR, Ramsden DA, Sekelsky J, Erie DA.

Nucleic Acids Res. 2017 May 19;45(9):5333-5348. doi: 10.1093/nar/gkx214.

27.

Microbial Molecules from the Multitudes within Us.

Redinbo MR.

Cell Metab. 2017 Feb 7;25(2):230-232. doi: 10.1016/j.cmet.2017.01.013.

28.

Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor.

Wu T, Huang J, Moore PJ, Little MS, Walton WG, Fellner RC, Alexis NE, Peter Di Y, Redinbo MR, Tilley SL, Tarran R.

Nat Commun. 2017 Feb 6;8:14118. doi: 10.1038/ncomms14118.

29.

Short Palate, Lung, and Nasal Epithelial Clone 1 Has Antimicrobial and Antibiofilm Activities against the Burkholderia cepacia Complex.

Ahmad S, Tyrrell J, Walton WG, Tripathy A, Redinbo MR, Tarran R.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6003-12. doi: 10.1128/AAC.00975-16. Print 2016 Oct.

30.

Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.

Walton WG, Ahmad S, Little MS, Kim CS, Tyrrell J, Lin Q, Di YP, Tarran R, Redinbo MR.

Biochemistry. 2016 May 31;55(21):2979-91. doi: 10.1021/acs.biochem.6b00271. Epub 2016 May 17.

31.

Post-translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A.

Ghodge SV, Biernat KA, Bassett SJ, Redinbo MR, Bowers AA.

J Am Chem Soc. 2016 May 4;138(17):5487-90. doi: 10.1021/jacs.5b13529. Epub 2016 Apr 22.

32.

Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.

Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski MD, Biswas A, Walton WG, Redinbo MR, Dvorak Z, Mani S.

Biochim Biophys Acta. 2016 Sep;1859(9):1155-1169. doi: 10.1016/j.bbagrm.2016.01.006. Epub 2016 Feb 23.

33.

Processing of Nonconjugative Resistance Plasmids by Conjugation Nicking Enzyme of Staphylococci.

Pollet RM, Ingle JD, Hymes JP, Eakes TC, Eto KY, Kwong SM, Ramsay JP, Firth N, Redinbo MR.

J Bacteriol. 2016 Jan 4;198(6):888-97. doi: 10.1128/JB.00832-15.

34.

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.

Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, Frye SV, Zamboni WC, Pepe-Ranney C, Mani S, Kelly L, Redinbo MR.

Chem Biol. 2015 Sep 17;22(9):1238-49. doi: 10.1016/j.chembiol.2015.08.005. Epub 2015 Sep 10.

35.

The microbiota, chemical symbiosis, and human disease.

Redinbo MR.

J Mol Biol. 2014 Nov 25;426(23):3877-91. doi: 10.1016/j.jmb.2014.09.011. Epub 2014 Oct 8. Review.

36.

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.

Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S.

Immunity. 2014 Aug 21;41(2):296-310. doi: 10.1016/j.immuni.2014.06.014. Epub 2014 Jul 24.

37.

Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1.

McLaughlin KJ, Nash RP, Redinbo MR.

J Bacteriol. 2014 Sep;196(17):3082-90. doi: 10.1128/JB.01496-14. Epub 2014 Jun 16.

38.

Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration.

Tarran R, Redinbo MR.

Int J Biochem Cell Biol. 2014 Jul;52:130-5. doi: 10.1016/j.biocel.2014.03.002. Epub 2014 Mar 13. Review.

39.

Understanding and modulating mammalian-microbial communication for improved human health.

Mani S, Boelsterli UA, Redinbo MR.

Annu Rev Pharmacol Toxicol. 2014;54:559-80. doi: 10.1146/annurev-pharmtox-011613-140007. Epub 2013 Oct 23. Review.

40.

Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.

Hobbs CA, Blanchard MG, Alijevic O, Tan CD, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Henderson AG, Redinbo MR, Stutts MJ, Tarran R.

Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L990-L1001. doi: 10.1152/ajplung.00103.2013. Epub 2013 Oct 11. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L708.

41.

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.

Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15973-8. doi: 10.1073/pnas.1311999110. Epub 2013 Sep 16.

42.

Mutation of the conserved calcium-binding motif in Neisseria gonorrhoeae PilC1 impacts adhesion but not piliation.

Cheng Y, Johnson MD, Burillo-Kirch C, Mocny JC, Anderson JE, Garrett CK, Redinbo MR, Thomas CE.

Infect Immun. 2013 Nov;81(11):4280-9. doi: 10.1128/IAI.00493-13. Epub 2013 Sep 3.

43.

An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa.

Marden JN, Diaz MR, Walton WG, Gode CJ, Betts L, Urbanowski ML, Redinbo MR, Yahr TL, Wolfgang MC.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15055-60. doi: 10.1073/pnas.1307217110. Epub 2013 Aug 26.

44.

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics.

Saitta KS, Zhang C, Lee KK, Fujimoto K, Redinbo MR, Boelsterli UA.

Xenobiotica. 2014 Jan;44(1):28-35. doi: 10.3109/00498254.2013.811314. Epub 2013 Jul 5.

45.

Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity.

Roberts AB, Wallace BD, Venkatesh MK, Mani S, Redinbo MR.

Mol Pharmacol. 2013 Aug;84(2):208-17. doi: 10.1124/mol.113.085852. Epub 2013 May 20.

46.

The human microbiome is a source of therapeutic drug targets.

Wallace BD, Redinbo MR.

Curr Opin Chem Biol. 2013 Jun;17(3):379-84. doi: 10.1016/j.cbpa.2013.04.011. Epub 2013 May 13. Review.

47.

Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα.

Wallace BD, Betts L, Talmage G, Pollet RM, Holman NS, Redinbo MR.

J Mol Biol. 2013 Jul 24;425(14):2561-77. doi: 10.1016/j.jmb.2013.04.012. Epub 2013 Apr 16.

48.

Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR.

Li H, Redinbo MR, Venkatesh M, Ekins S, Chaudhry A, Bloch N, Negassa A, Mukherjee P, Kalpana G, Mani S.

J Biol Chem. 2013 May 10;288(19):13655-68. doi: 10.1074/jbc.M113.455485. Epub 2013 Mar 22.

49.

Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.

Edwards JS, Betts L, Frazier ML, Pollet RM, Kwong SM, Walton WG, Ballentine WK 3rd, Huang JJ, Habibi S, Del Campo M, Meier JL, Dervan PB, Firth N, Redinbo MR.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2804-9. doi: 10.1073/pnas.1219701110. Epub 2013 Jan 28.

50.

PXR antagonists and implication in drug metabolism.

Mani S, Dou W, Redinbo MR.

Drug Metab Rev. 2013 Feb;45(1):60-72. doi: 10.3109/03602532.2012.746363. Review.

Supplemental Content

Loading ...
Support Center