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Items: 1 to 50 of 126

1.

Three Faces of Mercaptopurine Cytotoxicity in vitro: Methylation, Nucleotide Homeostasis and Deoxythioguanosine in DNA.

Coulthard SA, McGarrity S, Sahota K, Berry P, Redfern CPF.

Drug Metab Dispos. 2018 Jun 8. pii: dmd.118.081844. doi: 10.1124/dmd.118.081844. [Epub ahead of print]

PMID:
29884651
2.

Differentiation-Induced Remodelling of Store-Operated Calcium Entry Is Independent of Neuronal or Glial Phenotype but Modulated by Cellular Context.

Whitworth CL, Redfern CPF, Cheek TR.

Mol Neurobiol. 2018 May 26. doi: 10.1007/s12035-018-1112-y. [Epub ahead of print]

PMID:
29802571
3.

Metabolites of endophytic fungi from Australian native plants as potential anticancer agents.

Zaferanloo B, Pepper SA, Coulthard SA, Redfern CPF, Palombo EA.

FEMS Microbiol Lett. 2018 May 1;365(9). doi: 10.1093/femsle/fny078.

PMID:
29590360
4.

Azathioprine with Allopurinol: Lower Deoxythioguanosine in DNA and Transcriptome Changes Indicate Mechanistic Differences to Azathioprine Alone.

Coulthard SA, Berry P, McGarrity S, McLaughlin S, Ansari A, Redfern CPF.

Inflamm Bowel Dis. 2017 Jun;23(6):946-955. doi: 10.1097/MIB.0000000000001131.

5.

Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients.

Coulthard SA, Berry P, McGarrity S, Ansari A, Redfern CPF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 15;1028:175-180. doi: 10.1016/j.jchromb.2016.06.017. Epub 2016 Jun 15.

6.

High-resolution micromechanical measurement in real time of forces exerted by living cells.

Swierczewski R, Hedley J, Redfern CP.

Cell Adh Migr. 2016 May 3;10(3):322-30. doi: 10.1080/19336918.2015.1120398. Epub 2015 Dec 8.

7.

Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition.

Nicholson L, Evans CA, Matheson E, Minto L, Keilty C, Sanichar M, Case M, Schwab C, Williamson D, Rainer J, Harrison CJ, Kofler R, Hall AG, Redfern CP, Whetton AD, Irving JA.

Br J Haematol. 2015 Nov;171(4):595-605. doi: 10.1111/bjh.13647. Epub 2015 Aug 27.

8.

Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death.

Armstrong JL, Hill DS, McKee CS, Hernandez-Tiedra S, Lorente M, Lopez-Valero I, Eleni Anagnostou M, Babatunde F, Corazzari M, Redfern CPF, Velasco G, Lovat PE.

J Invest Dermatol. 2015 Jun;135(6):1629-1637. doi: 10.1038/jid.2015.45. Epub 2015 Feb 10.

9.

Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells.

Martin S, Lovat PE, Redfern CP.

J Cell Biochem. 2015 Mar;116(3):438-49. doi: 10.1002/jcb.24996.

PMID:
25336069
10.

COX2 expression in neuroblastoma increases tumorigenicity but does not affect cell death in response to the COX2 inhibitor celecoxib.

Bell E, Ponthan F, Whitworth C, Tweddle DA, Lunec J, Redfern CP.

Clin Exp Metastasis. 2014 Aug;31(6):651-9. doi: 10.1007/s10585-014-9656-3. Epub 2014 May 25.

PMID:
24859418
11.

Identification of a neuronal transcription factor network involved in medulloblastoma development.

Lastowska M, Al-Afghani H, Al-Balool HH, Sheth H, Mercer E, Coxhead JM, Redfern CP, Peters H, Burt AD, Santibanez-Koref M, Bacon CM, Chesler L, Rust AG, Adams DJ, Williamson D, Clifford SC, Jackson MS.

Acta Neuropathol Commun. 2013 Jul 11;1:35. doi: 10.1186/2051-5960-1-35.

12.

Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic melanoma.

McKee CS, Hill DS, Redfern CP, Armstrong JL, Lovat PE.

Exp Dermatol. 2013 Nov;22(11):767-9. doi: 10.1111/exd.12254.

PMID:
24118207
13.

Cell survival signalling through PPARδ and arachidonic acid metabolites in neuroblastoma.

Bell E, Ponthan F, Whitworth C, Westermann F, Thomas H, Redfern CP.

PLoS One. 2013 Jul 9;8(7):e68859. doi: 10.1371/journal.pone.0068859. Print 2013.

14.

Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.

Martin S, Lamb HK, Brady C, Lefkove B, Bonner MY, Thompson P, Lovat PE, Arbiser JL, Hawkins AR, Redfern CP.

Br J Cancer. 2013 Jul 23;109(2):433-43. doi: 10.1038/bjc.2013.325. Epub 2013 Jun 27.

15.

Store-operated Ca(2+) entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells.

Bell N, Hann V, Redfern CP, Cheek TR.

Biochim Biophys Acta. 2013 Mar;1833(3):643-51. doi: 10.1016/j.bbamcr.2012.11.025. Epub 2012 Dec 6.

16.

Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates.

Gomaa MS, Lim AS, Lau SC, Watts AM, Illingworth NA, Bridgens CE, Veal GJ, Redfern CP, Brancale A, Armstrong JL, Simons C.

Bioorg Med Chem. 2012 Oct 15;20(20):6080-8. doi: 10.1016/j.bmc.2012.08.044. Epub 2012 Aug 30.

PMID:
22989911
17.

Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold.

Gomaa MS, Bridgens CE, Illingworth NA, Veal GJ, Redfern CP, Brancale A, Armstrong JL, Simons C.

Bioorg Med Chem. 2012 Jul 15;20(14):4201-7. doi: 10.1016/j.bmc.2012.05.076. Epub 2012 Jun 7.

PMID:
22727372
18.

Outcome of the p53-mediated DNA damage response in neuroblastoma is determined by morphological subtype and MYCN expression.

Carr-Wilkinson J, Griffiths R, Elston R, Gamble LD, Goranov B, Redfern CP, Lunec J, Tweddle DA.

Cell Cycle. 2011 Nov 1;10(21):3778-87. doi: 10.4161/cc.10.21.17973. Epub 2011 Nov 1.

PMID:
22052359
19.

The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide.

Armstrong JL, Martin S, Illingworth NA, Jamieson D, Neilson A, Lovat PE, Redfern CP, Veal GJ.

Oncol Rep. 2012 Jan;27(1):293-8. doi: 10.3892/or.2011.1479. Epub 2011 Sep 29.

PMID:
21964808
20.

Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).

Gomaa MS, Bridgens CE, Veal GJ, Redfern CP, Brancale A, Armstrong JL, Simons C.

J Med Chem. 2011 Oct 13;54(19):6803-11. doi: 10.1021/jm200695m. Epub 2011 Sep 8.

PMID:
21838328
21.

Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates.

Gomaa MS, Bridgens CE, Aboraia AS, Veal GJ, Redfern CP, Brancale A, Armstrong JL, Simons C.

J Med Chem. 2011 Apr 28;54(8):2778-91. doi: 10.1021/jm101583w. Epub 2011 Mar 23.

PMID:
21428449
22.

Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers.

Coulthard SA, Redfern CP, Vikingsson S, Lindqvist-Appell M, Skoglund K, Jakobsen-Falk I, Hall AG, Taylor GA, Hogarth LA.

Mol Cancer Ther. 2011 Mar;10(3):495-504. doi: 10.1158/1535-7163.MCT-10-0798. Epub 2011 Jan 31.

23.

Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.

Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, Hill DS, Ellis N, Al Sabah S, Redfern CP, Fimia GM, Piacentini M, Lovat PE.

Clin Cancer Res. 2011 Apr 15;17(8):2216-26. doi: 10.1158/1078-0432.CCR-10-3003. Epub 2011 Jan 26.

24.

Targeting GRP78 to enhance melanoma cell death.

Martin S, Hill DS, Paton JC, Paton AW, Birch-Machin MA, Lovat PE, Redfern CP.

Pigment Cell Melanoma Res. 2010 Oct;23(5):675-82. doi: 10.1111/j.1755-148X.2010.00731.x. Epub 2010 Jul 12.

25.

Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy.

Hiscutt EL, Hill DS, Martin S, Kerr R, Harbottle A, Birch-Machin M, Redfern CP, Fulda S, Armstrong JL, Lovat PE.

J Invest Dermatol. 2010 Sep;130(9):2250-8. doi: 10.1038/jid.2010.146. Epub 2010 Jun 3.

26.

Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

Rowbotham SE, Boddy AV, Redfern CP, Veal GJ, Daly AK.

Drug Metab Dispos. 2010 Aug;38(8):1261-6. doi: 10.1124/dmd.109.030866. Epub 2010 Apr 26.

27.

NFkappaB modulators in a model of glucocorticoid resistant, childhood acute lymphoblastic leukemia.

Nicholson L, Hall AG, Redfern CP, Irving J.

Leuk Res. 2010 Oct;34(10):1366-73. doi: 10.1016/j.leukres.2009.12.014. Epub 2010 Jan 27.

PMID:
20106524
28.

Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells.

Armstrong JL, Flockhart R, Veal GJ, Lovat PE, Redfern CP.

J Biol Chem. 2010 Feb 26;285(9):6091-100. doi: 10.1074/jbc.M109.014092. Epub 2009 Dec 18.

29.

Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma.

Hill DS, Martin S, Armstrong JL, Flockhart R, Tonison JJ, Simpson DG, Birch-Machin MA, Redfern CP, Lovat PE.

Clin Cancer Res. 2009 Feb 15;15(4):1192-8. doi: 10.1158/1078-0432.CCR-08-2150.

30.

Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation.

Christie VB, Barnard JH, Batsanov AS, Bridgens CE, Cartmell EB, Collings JC, Maltman DJ, Redfern CP, Marder TB, Przyborski S, Whiting A.

Org Biomol Chem. 2008 Oct 7;6(19):3497-507. doi: 10.1039/b808574a. Epub 2008 Aug 8.

PMID:
19082150
31.

Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells.

Gomaa MS, Armstrong JL, Bobillon B, Veal GJ, Brancale A, Redfern CP, Simons C.

Bioorg Med Chem. 2008 Sep 1;16(17):8301-13. doi: 10.1016/j.bmc.2007.06.048. Epub 2007 Jun 29.

PMID:
18722776
32.

In vivo and in vitro glucocorticoid sensitivity in obese people with cushingoid appearance.

Syed AA, Redfern CP, Weaver JU.

Obesity (Silver Spring). 2008 Oct;16(10):2374-8. doi: 10.1038/oby.2008.346. Epub 2008 Jul 24.

33.

The effect of thiopurine drugs on DNA methylation in relation to TPMT expression.

Hogarth LA, Redfern CP, Teodoridis JM, Hall AG, Anderson H, Case MC, Coulthard SA.

Biochem Pharmacol. 2008 Oct 15;76(8):1024-35. doi: 10.1016/j.bcp.2008.07.026. Epub 2008 Jul 30.

PMID:
18708030
34.

Histological profile of tumours from MYCN transgenic mice.

Moore HC, Wood KM, Jackson MS, Lastowska MA, Hall D, Imrie H, Redfern CP, Lovat PE, Ponthan F, O'Toole K, Lunec J, Tweddle DA.

J Clin Pathol. 2008 Oct;61(10):1098-103. doi: 10.1136/jcp.2007.054627. Epub 2008 Aug 4.

PMID:
18682419
35.

Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress.

Lovat PE, Corazzari M, Armstrong JL, Martin S, Pagliarini V, Hill D, Brown AM, Piacentini M, Birch-Machin MA, Redfern CP.

Cancer Res. 2008 Jul 1;68(13):5363-9. doi: 10.1158/0008-5472.CAN-08-0035.

36.

A common intron 2 polymorphism of the glucocorticoid receptor gene is associated with insulin resistance in men.

Syed AA, Halpin CG, Irving JA, Unwin NC, White M, Bhopal RS, Redfern CP, Weaver JU.

Clin Endocrinol (Oxf). 2008 Jun;68(6):879-84. doi: 10.1111/j.1365-2265.2008.03175.x. Epub 2008 Jan 10.

PMID:
18194492
37.

Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.

Armstrong JL, Taylor GA, Thomas HD, Boddy AV, Redfern CP, Veal GJ.

Br J Cancer. 2007 Jun 4;96(11):1675-83. Epub 2007 May 8.

38.

Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.

Corazzari M, Lovat PE, Armstrong JL, Fimia GM, Hill DS, Birch-Machin M, Redfern CP, Piacentini M.

Br J Cancer. 2007 Apr 10;96(7):1062-71. Epub 2007 Mar 13.

39.

Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.

Ponthan F, Wickström M, Gleissman H, Fuskevåg OM, Segerström L, Sveinbjörnsson B, Redfern CP, Eksborg S, Kogner P, Johnsen JI.

Clin Cancer Res. 2007 Feb 1;13(3):1036-44.

40.

Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours.

Armstrong JL, Veal GJ, Redfern CP, Lovat PE.

Apoptosis. 2007 Mar;12(3):613-22.

PMID:
17216584
41.

Changes in functional properties of the caffeine-sensitive Ca2+ store during differentiation of human SH-SY5Y neuroblastoma cells.

Riddoch FC, Brown AM, Rowbotham SE, Redfern CP, Cheek TR.

Cell Calcium. 2007 Mar;41(3):195-206. Epub 2006 Aug 17.

PMID:
16914200
42.

Association of glucocorticoid receptor polymorphism A3669G in exon 9beta with reduced central adiposity in women.

Syed AA, Irving JA, Redfern CP, Hall AG, Unwin NC, White M, Bhopal RS, Weaver JU.

Obesity (Silver Spring). 2006 May;14(5):759-64.

43.

Overexpression of RARgamma increases death of SH-SY5Y neuroblastoma cells in response to retinoic acid but not fenretinide.

Goranov BB, Campbell Hewson QD, Pearson AD, Redfern CP.

Cell Death Differ. 2006 Apr;13(4):676-9. No abstract available.

44.

Release and sequestration of Ca2+ by a caffeine- and ryanodine-sensitive store in a sub-population of human SH-SY5Y neuroblastoma cells.

Riddoch FC, Rowbotham SE, Brown AM, Redfern CP, Cheek TR.

Cell Calcium. 2005 Aug;38(2):111-20.

PMID:
16095688
45.

The NF-kappaB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells.

Hewson QD, Lovat PE, Corazzari M, Catterall JB, Redfern CP.

Apoptosis. 2005 May;10(3):493-8.

PMID:
15909111
46.

The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma.

Lovat PE, Corazzari M, Di Sano F, Piacentini M, Redfern CP.

Cancer Lett. 2005 Oct 18;228(1-2):105-10. Review.

PMID:
15907365
47.

Fenretinide: a p53-independent way to kill cancer cells.

Corazzari M, Lovat PE, Oliverio S, Di Sano F, Donnorso RP, Redfern CP, Piacentini M.

Biochem Biophys Res Commun. 2005 Jun 10;331(3):810-5. Review.

PMID:
15865936
48.

p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death.

Myatt SS, Redfern CP, Burchill SA.

Clin Cancer Res. 2005 Apr 15;11(8):3136-48.

49.

13-cis retinoic acid and isomerisation in paediatric oncology--is changing shape the key to success?

Armstrong JL, Redfern CP, Veal GJ.

Biochem Pharmacol. 2005 May 1;69(9):1299-306. Review.

PMID:
15826600
50.

Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells.

Armstrong JL, Ruiz M, Boddy AV, Redfern CP, Pearson AD, Veal GJ.

Br J Cancer. 2005 Feb 28;92(4):696-704.

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