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Molecular Design, Optimization, and Genomic Integration of Chimeric B Cell Receptors in Murine B Cells.

Pesch T, Bonati L, Kelton W, Parola C, Ehling RA, Csepregi L, Kitamura D, Reddy ST.

Front Immunol. 2019 Nov 14;10:2630. doi: 10.3389/fimmu.2019.02630. eCollection 2019.


A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration.

Su F, Spee C, Araujo E, Barron E, Wang M, Ghione C, Hinton DR, Nusinowitz S, Kannan R, Reddy ST, Farias-Eisner R.

Int J Mol Sci. 2019 Sep 27;20(19). pii: E4807. doi: 10.3390/ijms20194807.


LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.

Guirgis FW, Black LP, Rosenthal MD, Henson M, Ferreira J, Leeuwenburgh C, Kalynych C, Moldawer LL, Miller T, Jones L, Crandall M, Reddy ST, Wu SS, Moore FA.

BMJ Open. 2019 Sep 18;9(9):e029348. doi: 10.1136/bmjopen-2019-029348.


Antibody discovery and engineering by enhanced CRISPR-Cas9 integration of variable gene cassette libraries in mammalian cells.

Parola C, Neumeier D, Friedensohn S, Csepregi L, Di Tacchio M, Mason DM, Reddy ST.

MAbs. 2019 Nov-Dec;11(8):1367-1380. doi: 10.1080/19420862.2019.1662691. Epub 2019 Sep 16.


Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis.

Ruffenach G, Umar S, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Cunningham CM, Ardehali A, Reddy ST, Saggar R, Fishbein G, Eghbali M.

EMBO Mol Med. 2019 Sep;11(9):e10061. doi: 10.15252/emmm.201810061. Epub 2019 Aug 29.


Synthetic and Systems Immunology Conference in Ascona, Switzerland.

Csepregi L, Neumeier D, Reddy ST.

Eur J Immunol. 2019 Jul;49(7):980-981. doi: 10.1002/eji.201970075. No abstract available.


HDL and LDL: Potential New Players in Breast Cancer Development.

Cedó L, Reddy ST, Mato E, Blanco-Vaca F, Escolà-Gil JC.

J Clin Med. 2019 Jun 14;8(6). pii: E853. doi: 10.3390/jcm8060853. Review.


Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.

Meriwether D, Sulaiman D, Volpe C, Dorfman A, Grijalva V, Dorreh N, Solorzano-Vargas RS, Wang J, O'Connor E, Papesh J, Larauche M, Trost H, Palgunachari MN, Anantharamaiah GM, Herschman HR, Martin MG, Fogelman AM, Reddy ST.

J Clin Invest. 2019 Jun 11;130:3670-3685. doi: 10.1172/JCI123700.


Exploring structural aspects of the human Golgi matrix protein GRASP55 in solution.

Reddy ST, Mendes LFS, Fontana NA, Costa-Filho AJ.

Int J Biol Macromol. 2019 Aug 15;135:481-489. doi: 10.1016/j.ijbiomac.2019.05.089. Epub 2019 May 15.


Large-scale network analysis reveals the sequence space architecture of antibody repertoires.

Miho E, Roškar R, Greiff V, Reddy ST.

Nat Commun. 2019 Mar 21;10(1):1321. doi: 10.1038/s41467-019-09278-8.


Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.

Sulaiman D, Li J, Devarajan A, Cunningham CM, Li M, Fishbein GA, Fogelman AM, Eghbali M, Reddy ST.

J Mol Cell Cardiol. 2019 Apr;129:154-164. doi: 10.1016/j.yjmcc.2019.02.008. Epub 2019 Feb 23.


Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen.

Sesterhenn F, Galloux M, Vollers SS, Csepregi L, Yang C, Descamps D, Bonet J, Friedensohn S, Gainza P, Corthésy P, Chen M, Rosset S, Rameix-Welti MA, Éléouët JF, Reddy ST, Graham BS, Riffault S, Correia BE.

PLoS Biol. 2019 Feb 21;17(2):e3000164. doi: 10.1371/journal.pbio.3000164. eCollection 2019 Feb.


PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity.

Shih DM, Meng Y, Sallam T, Vergnes L, Shu ML, Reue K, Tontonoz P, Fogelman AM, Lusis AJ, Reddy ST.

Antioxidants (Basel). 2019 Jan 11;8(1). pii: E19. doi: 10.3390/antiox8010019.


Geriatrics Curriculum Needs Assessment for Dermatology Residency Programs.

Endo J, Awe A, Reddy ST, Hirshfield LE, Kamin C, Lineberry M.

J Grad Med Educ. 2018 Dec;10(6):657-664. doi: 10.4300/JGME-D-18-00183.1.


Endovascular Thrombectomy for Mild Strokes: How Low Should We Go?

Sarraj A, Hassan A, Savitz SI, Grotta JC, Cai C, Parsha KN, Farrell CM, Imam B, Sitton CW, Reddy ST, Kamal H, Goyal N, Elijovich L, Reishus K, Krishnan R, Sangha N, Wu A, Costa R, Malik R, Mir O, Hasan R, Snodgrass LM, Requena M, Graybeal D, Abraham M, Chen M, McCullough LD, Ribo M.

Stroke. 2018 Oct;49(10):2398-2405. doi: 10.1161/STROKEAHA.118.022114.


Tracing Antibody Repertoire Evolution by Systems Phylogeny.

Yermanos AD, Dounas AK, Stadler T, Oxenius A, Reddy ST.

Front Immunol. 2018 Oct 2;9:2149. doi: 10.3389/fimmu.2018.02149. eCollection 2018. Review.


Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression.

Parola C, Mason DM, Zingg A, Neumeier D, Reddy ST.

Methods Mol Biol. 2018;1850:79-111. doi: 10.1007/978-1-4939-8730-6_7.


HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock.

Guirgis FW, Dodani S, Leeuwenburgh C, Moldawer L, Bowman J, Kalynych C, Grijalva V, Reddy ST, Jones AE, Moore FA.

PLoS One. 2018 Sep 14;13(9):e0203813. doi: 10.1371/journal.pone.0203813. eCollection 2018.


Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice.

Mukherjee P, Hough G, Chattopadhyay A, Grijalva V, O'Connor EI, Meriwether D, Wagner A, Ntambi JM, Navab M, Reddy ST, Fogelman AM.

J Lipid Res. 2018 Oct;59(10):1818-1840. doi: 10.1194/jlr.M083527. Epub 2018 Aug 23.


Synthetic Standards Combined With Error and Bias Correction Improve the Accuracy and Quantitative Resolution of Antibody Repertoire Sequencing in Human Naïve and Memory B Cells.

Friedensohn S, Lindner JM, Cornacchione V, Iazeolla M, Miho E, Zingg A, Meng S, Traggiai E, Reddy ST.

Front Immunol. 2018 Jun 20;9:1401. doi: 10.3389/fimmu.2018.01401. eCollection 2018.


Preliminary Validity Evidence for a Milestones-Based Rating Scale for Chart-Stimulated Recall.

Reddy ST, Tekian A, Durning SJ, Gupta S, Endo J, Affinati B, Park YS.

J Grad Med Educ. 2018 Jun;10(3):269-275. doi: 10.4300/JGME-D-17-00435.1.


High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis.

Mason DM, Weber CR, Parola C, Meng SM, Greiff V, Kelton WJ, Reddy ST.

Nucleic Acids Res. 2018 Aug 21;46(14):7436-7449. doi: 10.1093/nar/gky550.


Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer.

Chattopadhyay A, Yang X, Mukherjee P, Sulaiman D, Fogelman HR, Grijalva V, Dubinett S, Wasler TC, Paul MK, Salehi-Rad R, Mack JJ, Iruela-Arispe ML, Navab M, Fogelman AM, Reddy ST.

Sci Rep. 2018 Jun 13;8(1):9032. doi: 10.1038/s41598-018-26755-0.


Remodeling of the HDL proteome with treatment response to abatacept or adalimumab in the AMPLE trial of patients with rheumatoid arthritis.

Charles-Schoeman C, Gugiu GB, Ge H, Shahbazian A, Lee YY, Wang X, Furst DE, Ranganath VK, Maldonado M, Lee T, Reddy ST.

Atherosclerosis. 2018 Aug;275:107-114. doi: 10.1016/j.atherosclerosis.2018.04.003. Epub 2018 Apr 17.


Magnesium Balance and Measurement.

Reddy ST, Soman SS, Yee J.

Adv Chronic Kidney Dis. 2018 May;25(3):224-229. doi: 10.1053/j.ackd.2018.03.002. Review.


Paraoxonase 2 prevents the development of heart failure.

Li W, Kennedy D, Shao Z, Wang X, Kamdar AK, Weber M, Mislick K, Kiefer K, Morales R, Agatisa-Boyle B, Shih DM, Reddy ST, Moravec CS, Tang WHW.

Free Radic Biol Med. 2018 Jun;121:117-126. doi: 10.1016/j.freeradbiomed.2018.04.583. Epub 2018 May 2.


Leptomeningeal disease in uveal melanoma: a case series.

Glitza IC, Reddy ST, Patel SP.

J Neurooncol. 2018 Sep;139(2):503-505. doi: 10.1007/s11060-018-2878-5. Epub 2018 Apr 27. No abstract available.


A short-term increase in dietary cholesterol and fat intake affects high-density lipoprotein composition in healthy subjects.

Morgantini C, Trifirò S, Tricò D, Meriwether D, Baldi S, Mengozzi A, Reddy ST, Natali A.

Nutr Metab Cardiovasc Dis. 2018 Jun;28(6):575-581. doi: 10.1016/j.numecd.2018.03.005. Epub 2018 Mar 19.


Awareness of Bullying in Residency: Results of a National Survey of Internal Medicine Program Directors.

Ayyala MS, Chaudhry S, Windish D, Dupras D, Reddy ST, Wright SM.

J Grad Med Educ. 2018 Apr;10(2):209-213. doi: 10.4300/JGME-D-17-00386.1.


Role Models' Influence on Specialty Choice for Residency Training: A National Longitudinal Study.

Yoon JD, Ham SA, Reddy ST, Curlin FA.

J Grad Med Educ. 2018 Apr;10(2):149-154. doi: 10.4300/JGME-D-17-00063.1.


Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.

Singh R, Pervin S, Lee SJ, Kuo A, Grijalva V, David J, Vergnes L, Reddy ST.

Diabetes Metab Syndr Obes. 2018 Mar 26;11:65-84. doi: 10.2147/DMSO.S159315. eCollection 2018.


Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer.

Devarajan A, Su F, Grijalva V, Yalamanchi M, Yalamanchi A, Gao F, Trost H, Nwokedi J, Farias-Eisner G, Farias-Eisner R, Fogelman AM, Reddy ST.

Cell Death Dis. 2018 Mar 12;9(3):392. doi: 10.1038/s41419-018-0395-2.


Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires.

Miho E, Yermanos A, Weber CR, Berger CT, Reddy ST, Greiff V.

Front Immunol. 2018 Feb 21;9:224. doi: 10.3389/fimmu.2018.00224. eCollection 2018. Review.


Cardio-hepatic risk assessment by CMR imaging in liver transplant candidates.

Reddy ST, Thai NL, Oliva J, Tom KB, Dishart MK, Doyle M, Yamrozik JA, Williams RB, Shah M, Wani A, Singh A, Maheswary R, Biederman RWW.

Clin Transplant. 2018 May;32(5):e13229. doi: 10.1111/ctr.13229. Epub 2018 Apr 11.


Atypical Cause of "Typical" Hypertensive Intracranial Bleeding.

Reddy ST, Rosenbaum D, Sheth SA.

JAMA Neurol. 2018 Mar 1;75(3):373. doi: 10.1001/jamaneurol.2017.4099. No abstract available.


Local anesthetics induce interdigitation and thermotropic changes in dipalmitoylphosphatidylcholine bilayers.

Reddy ST, Shrivastava S, Chattopadhyay A.

Chem Phys Lipids. 2018 Jan;210:22-27. doi: 10.1016/j.chemphyslip.2017.12.003. Epub 2017 Dec 21.


High levels of oxidized fatty acids in HDL are associated with impaired HDL function in patients with active rheumatoid arthritis.

Charles-Schoeman C, Meriwether D, Lee YY, Shahbazian A, Reddy ST.

Clin Rheumatol. 2018 Mar;37(3):615-622. doi: 10.1007/s10067-017-3896-y. Epub 2017 Nov 11.


Unmatched U.S. Seniors and Residency Placement Fever.

Jenkins TM, Reddy ST.

Acad Med. 2017 Nov;92(11):1510. doi: 10.1097/ACM.0000000000001942. No abstract available.


Coronary artery disease in high risk South Asian immigrants: Role of dysfunctional HDL in risk prediction.

Dodani S, Kaeley GS, Arora S, Reddy ST.

Indian Heart J. 2017 Sep - Oct;69(5):658-659. doi: 10.1016/j.ihj.2017.07.014. Epub 2017 Jul 29. No abstract available.


HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study.

Guirgis FW, Leeuwenburgh C, Grijalva V, Bowman J, Kalynych C, Moldawer L, Moore FA, Reddy ST.

Shock. 2018 Jul;50(1):66-70. doi: 10.1097/SHK.0000000000001030.


Making sense of a seemingly odd connection.

Fogelman AM, Reddy ST.

Eur Heart J. 2017 Dec 21;38(48):3588-3589. doi: 10.1093/eurheartj/ehx506. No abstract available.


Surface micropattern reduces colonization and medical device-associated infections.

Xu B, Wei Q, Mettetal MR, Han J, Rau L, Tie J, May RM, Pathe ET, Reddy ST, Sullivan L, Parker AE, Maul DH, Brennan AB, Mann EE.

J Med Microbiol. 2017 Nov;66(11):1692-1698. doi: 10.1099/jmm.0.000600. Epub 2017 Oct 6.


Comparison of methods for phylogenetic B-cell lineage inference using time-resolved antibody repertoire simulations (AbSim).

Yermanos A, Greiff V, Krautler NJ, Menzel U, Dounas A, Miho E, Oxenius A, Stadler T, Reddy ST.

Bioinformatics. 2017 Dec 15;33(24):3938-3946. doi: 10.1093/bioinformatics/btx533.


Learning the High-Dimensional Immunogenomic Features That Predict Public and Private Antibody Repertoires.

Greiff V, Weber CR, Palme J, Bodenhofer U, Miho E, Menzel U, Reddy ST.

J Immunol. 2017 Oct 15;199(8):2985-2997. doi: 10.4049/jimmunol.1700594. Epub 2017 Sep 18.


Integrating high-throughput screening and sequencing for monoclonal antibody discovery and engineering.

Parola C, Neumeier D, Reddy ST.

Immunology. 2018 Jan;153(1):31-41. doi: 10.1111/imm.12838. Epub 2017 Oct 30. Review.


Molecular structure, supramolecular organization and thermotropic phase behavior of N-acylglycine alkyl esters with matched acyl and alkyl chains.

Reddy ST, Swamy MJ.

Chem Phys Lipids. 2017 Nov;208:43-51. doi: 10.1016/j.chemphyslip.2017.09.002. Epub 2017 Sep 8.


Non-Vitamin K Oral Anticoagulants (NOACs) and Their Reversal.

Reddy ST, Cossey TC, Savitz SI, Grotta JC.

Curr Neurol Neurosci Rep. 2017 Sep;17(9):67. doi: 10.1007/s11910-017-0774-6. Review.


Immunology: The patterns of T-cell target recognition.

Reddy ST.

Nature. 2017 Jul 6;547(7661):36-38. doi: 10.1038/nature23091. Epub 2017 Jun 21. No abstract available.


Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum.

Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM.

J Lipid Res. 2017 Aug;58(8):1636-1647. doi: 10.1194/jlr.M076554. Epub 2017 Jun 7.


Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development.

Greiff V, Menzel U, Miho E, Weber C, Riedel R, Cook S, Valai A, Lopes T, Radbruch A, Winkler TH, Reddy ST.

Cell Rep. 2017 May 16;19(7):1467-1478. doi: 10.1016/j.celrep.2017.04.054.

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