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Items: 1 to 50 of 239

1.

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import.

Rodriguez-Bravo V, Pippa R, Song WM, Carceles-Cordon M, Dominguez-Andres A, Fujiwara N, Woo J, Koh AP, Ertel A, Lokareddy RK, Cuesta-Dominguez A, Kim RS, Rodriguez-Fernandez I, Li P, Gordon R, Hirschfield H, Prats JM, Reddy EP, Fatatis A, Petrylak DP, Gomella L, Kelly WK, Lowe SW, Knudsen KE, Galsky MD, Cingolani G, Lujambio A, Hoshida Y, Domingo-Domenech J.

Cell. 2018 Aug 3. pii: S0092-8674(18)30909-7. doi: 10.1016/j.cell.2018.07.015. [Epub ahead of print]

PMID:
30100187
2.

Effect of feeding higher concentrations of limiting amino acids on performance, slaughter variables and nitrogen retention in broiler chicken fed graded levels of toasted guar (Cyamopsis tetragonoloba) meal.

Rao SVR, Raju MVLN, Prakash B, Rajkumar U, Srilatha T, Reddy EPK.

Br Poult Sci. 2018 Jun 1. doi: 10.1080/00071668.2018.1483574. [Epub ahead of print]

PMID:
29855192
3.

Effect of supplementing germinated sprouts of pulses on performance, carcass variables, immune and oxidative stress indicators in broiler chickens reared during tropical summer season.

Rama Rao SV, Prakash B, Rajkumar U, Raju MVLN, Srilatha T, Reddy EPK.

Trop Anim Health Prod. 2018 Jun;50(5):1147-1154. doi: 10.1007/s11250-018-1543-5. Epub 2018 Feb 22.

PMID:
29470740
4.

JNK-signaling: A multiplexing hub in programmed cell death.

Dhanasekaran DN, Reddy EP.

Genes Cancer. 2017 Sep;8(9-10):682-694. doi: 10.18632/genesandcancer.155. Review.

5.

Drugging the 'undruggable' cancer targets.

Dang CV, Reddy EP, Shokat KM, Soucek L.

Nat Rev Cancer. 2017 Aug;17(8):502-508. doi: 10.1038/nrc.2017.36. Epub 2017 Jun 23. Review.

6.

Effect of Supplemental Trace Minerals on Hsp-70 mRNA Expression in Commercial Broiler Chicken.

Rajkumar U, Vinoth A, Reddy EPK, Shanmugam M, Rao SVR.

Anim Biotechnol. 2018 Jan 2;29(1):20-25. doi: 10.1080/10495398.2017.1287712. Epub 2017 Mar 28.

PMID:
28350488
7.

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Kotini AG, Chang CJ, Chow A, Yuan H, Ho TC, Wang T, Vora S, Solovyov A, Husser C, Olszewska M, Teruya-Feldstein J, Perumal D, Klimek VM, Spyridonidis A, Rampal RK, Silverman L, Reddy EP, Papaemmanuil E, Parekh S, Greenbaum BD, Leslie CS, Kharas MG, Papapetrou EP.

Cell Stem Cell. 2017 Mar 2;20(3):315-328.e7. doi: 10.1016/j.stem.2017.01.009. Epub 2017 Feb 16.

8.

Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer.

Ha JH, Yan M, Gomathinayagam R, Jayaraman M, Husain S, Liu J, Mukherjee P, Reddy EP, Song YS, Dhanasekaran DN.

Oncotarget. 2016 Nov 8;7(45):72845-72859. doi: 10.18632/oncotarget.12069.

9.

The Effect of Position on PaCO2 and PETCO2 in Patients Undergoing Cervical Spine Surgery in Supine and Prone Position.

Yadav M, Reddy EP, Sharma A, Kulkarni DK, Gopinath R.

J Neurosurg Anesthesiol. 2017 Jul;29(3):298-303. doi: 10.1097/ANA.0000000000000322.

PMID:
27271232
10.

Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations.

Troilo A, Benson EK, Esposito D, Garibsingh RA, Reddy EP, Mungamuri SK, Aaronson SA.

Oncotarget. 2016 May 17;7(20):28765-82. doi: 10.18632/oncotarget.9117.

11.

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.

Athuluri-Divakar SK, Vasquez-Del Carpio R, Dutta K, Baker SJ, Cosenza SC, Basu I, Gupta YK, Reddy MV, Ueno L, Hart JR, Vogt PK, Mulholland D, Guha C, Aggarwal AK, Reddy EP.

Cell. 2016 Apr 21;165(3):643-55. doi: 10.1016/j.cell.2016.03.045.

12.

Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma.

Perumal D, Kuo PY, Leshchenko VV, Jiang Z, Divakar SK, Cho HJ, Chari A, Brody J, Reddy MV, Zhang W, Reddy EP, Jagannath S, Parekh S.

Cancer Res. 2016 Mar 1;76(5):1225-36. doi: 10.1158/0008-5472.CAN-15-2934. Epub 2016 Feb 12.

13.

Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).

Reddy MV, Akula B, Jatiani S, Vasquez-Del Carpio R, Billa VK, Mallireddigari MR, Cosenza SC, Venkata Subbaiah DR, Bharathi EV, Pallela VR, Ramkumar P, Jain R, Aggarwal AK, Reddy EP.

Bioorg Med Chem. 2016 Feb 15;24(4):521-44. doi: 10.1016/j.bmc.2015.11.045. Epub 2015 Dec 1.

14.

Effect of Supplementing Organic Forms of Zinc, Selenium and Chromium on Performance, Anti-Oxidant and Immune Responses in Broiler Chicken Reared in Tropical Summer.

Rao SV, Prakash B, Raju MV, Panda AK, Kumari RK, Reddy EP.

Biol Trace Elem Res. 2016 Aug;172(2):511-20. doi: 10.1007/s12011-015-0587-x. Epub 2016 Jan 8.

PMID:
26743864
15.

Effect of dietary inclusion of toasted guar (Cyamopsis tetragonoloba) meal as a source of protein on performance of White Leghorn layers.

Rao SV, Raju MV, Prakash B, Reddy EP, Panda AK.

Br Poult Sci. 2015;56(6):733-9. doi: 10.1080/00071668.2015.1113498.

PMID:
26674393
16.

JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.

Ramkumar P, Lee CM, Moradian A, Sweredoski MJ, Hess S, Sharrocks AD, Haines DS, Reddy EP.

J Biol Chem. 2015 Dec 4;290(49):29617-28. doi: 10.1074/jbc.M115.664649. Epub 2015 Oct 14.

17.

Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.

Divakar SK, Ramana Reddy MV, Cosenza SC, Baker SJ, Perumal D, Antonelli AC, Brody J, Akula B, Parekh S, Reddy EP.

Leukemia. 2016 Jan;30(1):86-93. doi: 10.1038/leu.2015.185. Epub 2015 Jul 15.

18.

Identification and characterization of a cell division-regulating kinase AKB1 (associated kinase of Trypanosoma brucei 14-3-3) through proteomics study of the Tb14-3-3 binding proteins.

Inoue M, Okamoto K, Uemura H, Yasuda K, Motohara Y, Morita K, Hiromura M, Reddy EP, Fukuma T, Horikoshi N.

J Biochem. 2015 Jul;158(1):49-60. doi: 10.1093/jb/mvv018. Epub 2015 Feb 13.

PMID:
25681612
19.

Myb permits multilineage airway epithelial cell differentiation.

Pan JH, Adair-Kirk TL, Patel AC, Huang T, Yozamp NS, Xu J, Reddy EP, Byers DE, Pierce RA, Holtzman MJ, Brody SL.

Stem Cells. 2014 Dec;32(12):3245-56. doi: 10.1002/stem.1814.

20.

Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140.

Eachkoti R, Reddy MV, Lieu YK, Cosenza SC, Reddy EP.

Eur J Cancer. 2014 Jul;50(11):1982-92. doi: 10.1016/j.ejca.2014.04.017. Epub 2014 May 15.

21.

Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor models.

Zhang X, Lv H, Zhou Q, Elkholi R, Chipuk JE, Reddy MV, Reddy EP, Gallo JM.

Mol Cancer Ther. 2014 May;13(5):1105-16. doi: 10.1158/1535-7163.MCT-13-0847. Epub 2014 Feb 25.

22.

Rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma, in vitro and in vivo.

Agoni L, Basu I, Gupta S, Alfieri A, Gambino A, Goldberg GL, Reddy EP, Guha C.

Int J Radiat Oncol Biol Phys. 2014 Apr 1;88(5):1180-7. doi: 10.1016/j.ijrobp.2013.12.051. Epub 2014 Feb 11.

23.

B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.

Baker SJ, Ma'ayan A, Lieu YK, John P, Reddy MV, Chen EY, Duan Q, Snoeck HW, Reddy EP.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3122-7. doi: 10.1073/pnas.1315464111. Epub 2014 Feb 10.

24.

A study on knowledge, attitude and practice regarding voluntary blood donation among medical students in Puducherry, India.

Kowsalya V, Vijayakumar R, Chidambaram R, Srikumar R, Reddy EP, Latha S, Fathima IG, Kumar CK.

Pak J Biol Sci. 2013 May 1;16(9):439-42.

PMID:
24498809
25.

Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).

Reddy MV, Akula B, Cosenza SC, Athuluridivakar S, Mallireddigari MR, Pallela VR, Billa VK, Subbaiah DR, Bharathi EV, Vasquez-Del Carpio R, Padgaonkar A, Baker SJ, Reddy EP.

J Med Chem. 2014 Feb 13;57(3):578-99. doi: 10.1021/jm401073p. Epub 2014 Jan 24.

26.

Understanding the temporal sequence of genetic events that lead to prostate cancer progression and metastasis.

Baker SJ, Reddy EP.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14819-20. doi: 10.1073/pnas.1313997110. Epub 2013 Aug 30. No abstract available.

27.

Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.

Reddy MV, Mallireddigari MR, Pallela VR, Cosenza SC, Billa VK, Akula B, Subbaiah DR, Bharathi EV, Padgaonkar A, Lv H, Gallo JM, Reddy EP.

J Med Chem. 2013 Jul 11;56(13):5562-86. doi: 10.1021/jm400575x. Epub 2013 Jun 25.

28.

CDK4: A Key Player in the Cell Cycle, Development, and Cancer.

Baker SJ, Reddy EP.

Genes Cancer. 2012 Nov;3(11-12):658-69. doi: 10.1177/1947601913478972.

29.

ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway.

Kang AD, Cosenza SC, Bonagura M, Manair M, Reddy MV, Reddy EP.

PLoS One. 2013;8(3):e58355. doi: 10.1371/journal.pone.0058355. Epub 2013 Mar 7.

30.

Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent.

Pallela VR, Mallireddigari MR, Cosenza SC, Akula B, Subbaiah DR, Reddy EP, Reddy MV.

Org Biomol Chem. 2013 Mar 28;11(12):1964-77. doi: 10.1039/c3ob27220f. Epub 2013 Feb 6.

31.

Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS.

Cho SY, Cosenza SC, Pallela V, Panda G, Reddy MV, Reddy EP, Roboz J.

J Pharm Biomed Anal. 2013 Mar 5;75:138-44. doi: 10.1016/j.jpba.2012.11.022. Epub 2012 Nov 23.

32.

The ins and outs of bcr-abl inhibition.

Reddy EP, Aggarwal AK.

Genes Cancer. 2012 May;3(5-6):447-54. doi: 10.1177/1947601912462126.

33.

A novel role of the scaffolding protein JLP in tuning CD40-induced activation of dendritic cells.

Wang H, Zhao C, Zhang M, Lee CM, Reddy EP, Kung SK.

Immunobiology. 2013 Jun;218(6):835-43. doi: 10.1016/j.imbio.2012.10.002. Epub 2012 Oct 13.

PMID:
23182713
34.

Integrated pharmacokinetic-driven approach to screen candidate anticancer drugs for brain tumor chemotherapy.

Lv H, Zhang X, Sharma J, Reddy MV, Reddy EP, Gallo JM.

AAPS J. 2013 Jan;15(1):250-7. doi: 10.1208/s12248-012-9428-4. Epub 2012 Nov 22.

35.

Combined administration of rituximab and on 013105 induces apoptosis in mantle cell lymphoma cells and reduces tumor burden in a mouse model of mantle cell lymphoma.

Prasad A, Shrivastava A, Papadopoulos E, Kuzontkoski PM, Reddy MV, Gillum AM, Kumar R, Reddy EP, Groopman JE.

Clin Cancer Res. 2013 Jan 1;19(1):85-95. doi: 10.1158/1078-0432.CCR-12-1425. Epub 2012 Nov 1.

36.

Effect of reuse of polysulfone membrane on oxidative stress during hemodialysis.

Ramakrishna P, Reddy EP, Suchitra MM, Bitla AR, Rao PV, Sivakumar V.

Indian J Nephrol. 2012 May;22(3):200-5. doi: 10.4103/0971-4065.98758.

37.

An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response.

Adams BD, Guo S, Bai H, Guo Y, Megyola CM, Cheng J, Heydari K, Xiao C, Reddy EP, Lu J.

Cell Rep. 2012 Oct 25;2(4):1048-60. doi: 10.1016/j.celrep.2012.09.014. Epub 2012 Oct 19.

38.

Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout mice.

Lieu YK, Reddy EP.

Cell Cycle. 2012 Sep 15;11(18):3504-12. doi: 10.4161/cc.21802. Epub 2012 Aug 23.

39.

Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapy.

Nuthalapati S, Zhou Q, Guo P, Lv H, Cosenza S, Reddy MV, Reddy EP, Gallo JM.

Pharm Res. 2012 Sep;29(9):2499-511. doi: 10.1007/s11095-012-0780-y. Epub 2012 Jun 8.

PMID:
22678771
40.

A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.

Bongers G, Muniz LR, Pacer ME, Iuga AC, Thirunarayanan N, Slinger E, Smit MJ, Reddy EP, Mayer L, Furtado GC, Harpaz N, Lira SA.

Gastroenterology. 2012 Sep;143(3):730-740. doi: 10.1053/j.gastro.2012.05.034. Epub 2012 May 26.

41.

(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.

Reddy MV, Akula B, Cosenza SC, Lee CM, Mallireddigari MR, Pallela VR, Subbaiah DR, Udofa A, Reddy EP.

J Med Chem. 2012 Jun 14;55(11):5174-87. doi: 10.1021/jm300176j. Epub 2012 May 25.

42.

Screening candidate anticancer drugs for brain tumor chemotherapy: pharmacokinetic-driven approach for a series of (E)-N-(substituted aryl)-3-(substituted phenyl)propenamide analogues.

Lv H, Wang F, Reddy MV, Zhou Q, Zhang X, Reddy EP, Gallo JM.

Invest New Drugs. 2012 Dec;30(6):2263-73. doi: 10.1007/s10637-012-9806-x. Epub 2012 Mar 1.

43.

Nutritional evaluation and utilisation of quality protein maize, Nityashree hybrid maize, and normal maize in broiler chickens.

Panda AK, Raju MV, Rao SV, Lavanya G, Reddy EP, Sunder GS.

Br Poult Sci. 2011 Oct;52(5):632-8. doi: 10.1080/00071668.2011.626758.

PMID:
22029791
44.

Application of a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to the pharmacokinetics of ON01910 in brain tumor-bearing mice.

Nuthalapati S, Guo P, Zhou Q, Reddy MV, Reddy EP, Gallo JM.

J Pharm Biomed Anal. 2011 Dec 15;56(5):1117-20. doi: 10.1016/j.jpba.2011.08.003. Epub 2011 Aug 9.

45.

Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity.

Reddy MV, Venkatapuram P, Mallireddigari MR, Pallela VR, Cosenza SC, Robell KA, Akula B, Hoffman BS, Reddy EP.

J Med Chem. 2011 Sep 22;54(18):6254-76. doi: 10.1021/jm200570p. Epub 2011 Aug 17.

46.

Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation.

Oussenko IA, Holland JF, Reddy EP, Ohnuma T.

Cancer Res. 2011 Jul 15;71(14):4968-76. doi: 10.1158/0008-5472.CAN-10-1603. Epub 2011 Jun 6. Erratum in: Cancer Res. 2011 Sep 15;71(18):6086.

47.

Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer.

Baek HJ, Pishvaian MJ, Tang Y, Kim TH, Yang S, Zouhairi ME, Mendelson J, Shetty K, Kallakury B, Berry DL, Shin KH, Mishra B, Reddy EP, Kim SS, Mishra L.

Hepatology. 2011 May;53(5):1676-84. doi: 10.1002/hep.24128.

48.

Neoplastic transformation induced by the gep oncogenes involves the scaffold protein JNK-interacting leucine zipper protein.

Kashef K, Radhakrishnan R, Lee CM, Reddy EP, Dhanasekaran DN.

Neoplasia. 2011 Apr;13(4):358-64.

49.

Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies.

Jatiani SS, Baker SJ, Silverman LR, Reddy EP.

Genes Cancer. 2010 Oct;1(10):979-93. doi: 10.1177/1947601910397187.

50.

Targeted inhibition of kinases in cancer therapy.

Baker SJ, Reddy EP.

Mt Sinai J Med. 2010 Nov-Dec;77(6):573-86. doi: 10.1002/msj.20220. Review.

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