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Items: 24


Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.

Padgaonkar A, Rechkoblit O, Vasquez-Del Carpio R, Pallela V, Venkata Subbaiah D, Cosenza SC, Baker SJ, Ramana Reddy MV, Aggarwal A, Reddy EP.

Oncotarget. 2018 Dec 28;9(102):37753-37765. doi: 10.18632/oncotarget.26514. eCollection 2018 Dec 28.


Structural basis for polymerase η-promoted resistance to the anticancer nucleoside analog cytarabine.

Rechkoblit O, Choudhury JR, Buku A, Prakash L, Prakash S, Aggarwal AK.

Sci Rep. 2018 Aug 23;8(1):12702. doi: 10.1038/s41598-018-30796-w.


Eukaryotic DNA polymerases.

Jain R, Aggarwal AK, Rechkoblit O.

Curr Opin Struct Biol. 2018 Dec;53:77-87. doi: 10.1016/ Epub 2018 Jul 10. Review.


Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.

Rechkoblit O, Kolbanovskiy A, Landes H, Geacintov NE, Aggarwal AK.

Nat Commun. 2017 Oct 17;8(1):965. doi: 10.1038/s41467-017-01013-5.


Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.

Rechkoblit O, Gupta YK, Malik R, Rajashankar KR, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Sci Adv. 2016 Oct 21;2(10):e1601317. eCollection 2016 Oct.


Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy.

Ummat A, Rechkoblit O, Jain R, Roy Choudhury J, Johnson RE, Silverstein TD, Buku A, Lone S, Prakash L, Prakash S, Aggarwal AK.

Nat Struct Mol Biol. 2012 May 6;19(6):628-32. doi: 10.1038/nsmb.2295.


Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions.

Rechkoblit O, Delaney JC, Essigmann JM, Patel DJ.

Structure. 2011 Jun 8;19(6):821-32. doi: 10.1016/j.str.2011.03.020.


Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.

Song J, Rechkoblit O, Bestor TH, Patel DJ.

Science. 2011 Feb 25;331(6020):1036-40. doi: 10.1126/science.1195380. Epub 2010 Dec 16.


Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4.

Rechkoblit O, Kolbanovskiy A, Malinina L, Geacintov NE, Broyde S, Patel DJ.

Nat Struct Mol Biol. 2010 Mar;17(3):379-88. doi: 10.1038/nsmb.1771. Epub 2010 Feb 14.


Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases.

Rechkoblit O, Malinina L, Cheng Y, Geacintov NE, Broyde S, Patel DJ.

Structure. 2009 May 13;17(5):725-36. doi: 10.1016/j.str.2009.03.011.


Lesion processing: high-fidelity versus lesion-bypass DNA polymerases.

Broyde S, Wang L, Rechkoblit O, Geacintov NE, Patel DJ.

Trends Biochem Sci. 2008 May;33(5):209-19. doi: 10.1016/j.tibs.2008.02.004. Epub 2008 Apr 11. Review.


[Probing of contacts between EcoRII DNA methyltransferase and DNA using substrate analogs and molecular modeling].

Kudan EV, Brevnov MG, Subach OM, Rechkoblit OA, Buĭnitskiĭ IaM, Gromova ES.

Mol Biol (Mosk). 2007 Sep-Oct;41(5):885-99. Russian.


DNA adduct structure-function relationships: comparing solution with polymerase structures.

Broyde S, Wang L, Zhang L, Rechkoblit O, Geacintov NE, Patel DJ.

Chem Res Toxicol. 2008 Jan;21(1):45-52. Epub 2007 Dec 4. Review.


Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion.

Rechkoblit O, Malinina L, Cheng Y, Kuryavyi V, Broyde S, Geacintov NE, Patel DJ.

PLoS Biol. 2006 Jan;4(1):e11.


Two-step error-prone bypass of the (+)- and (-)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa.

Zhang Y, Wu X, Guo D, Rechkoblit O, Geacintov NE, Wang Z.

Mutat Res. 2002 Dec 29;510(1-2):23-35.


Lesion bypass activities of human DNA polymerase mu.

Zhang Y, Wu X, Guo D, Rechkoblit O, Taylor JS, Geacintov NE, Wang Z.

J Biol Chem. 2002 Nov 15;277(46):44582-7. Epub 2002 Sep 12.


trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases.

Rechkoblit O, Zhang Y, Guo D, Wang Z, Amin S, Krzeminsky J, Louneva N, Geacintov NE.

J Biol Chem. 2002 Aug 23;277(34):30488-94. Epub 2002 Jun 12.


Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion.

Zhang Y, Wu X, Rechkoblit O, Geacintov NE, Taylor JS, Wang Z.

Nucleic Acids Res. 2002 Apr 1;30(7):1630-8.


Influence of bulky polynuclear carcinogen lesions in a TATA promoter sequence on TATA binding protein-DNA complex formation.

Rechkoblit O, Krzeminsky J, Amin S, Jernström B, Louneva N, Geacintov NE.

Biochemistry. 2001 May 15;40(19):5622-32.


Error-prone lesion bypass by human DNA polymerase eta.

Zhang Y, Yuan F, Wu X, Rechkoblit O, Taylor JS, Geacintov NE, Wang Z.

Nucleic Acids Res. 2000 Dec 1;28(23):4717-24.


Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro.

Zhang Y, Yuan F, Wu X, Wang M, Rechkoblit O, Taylor JS, Geacintov NE, Wang Z.

Nucleic Acids Res. 2000 Nov 1;28(21):4138-46.


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