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O-glycosylation on cerebrospinal fluid and plasma Apolipoprotein E differs in the lipid binding domain.

Flowers SA, Grant OC, Woods RJ, Rebeck GW.

Glycobiology. 2019 Oct 16. pii: cwz084. doi: 10.1093/glycob/cwz084. [Epub ahead of print]


Metabolic Disturbances of a High-Fat Diet Are Dependent on APOE Genotype and Sex.

Jones NS, Watson KQ, Rebeck GW.

eNeuro. 2019 Oct 16;6(5). pii: ENEURO.0267-19.2019. doi: 10.1523/ENEURO.0267-19.2019. Print 2019 Sep/Oct.


The Synergistic Effects of APOE Genotype and Obesity on Alzheimer's Disease Risk.

Jones NS, Rebeck GW.

Int J Mol Sci. 2018 Dec 24;20(1). pii: E63. doi: 10.3390/ijms20010063. Review.


Development of a Human APOE Knock-in Mouse Model for Study of Cognitive Function After Cancer Chemotherapy.

Speidell AP, Demby T, Lee Y, Rodriguez O, Albanese C, Mandelblatt J, Rebeck GW.

Neurotox Res. 2019 Feb;35(2):291-303. doi: 10.1007/s12640-018-9954-7. Epub 2018 Oct 4.


High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia.

Chernick D, Ortiz-Valle S, Jeong A, Swaminathan SK, Kandimalla KK, Rebeck GW, Li L.

J Neurochem. 2018 Dec;147(5):647-662. doi: 10.1111/jnc.14554. Epub 2018 Nov 26.


The role of APOE on lipid homeostasis and inflammation in normal brains.

Rebeck GW.

J Lipid Res. 2017 Aug;58(8):1493-1499. doi: 10.1194/jlr.R075408. Epub 2017 Mar 2. Review.


Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid.

Heinsinger NM, Gachechiladze MA, Rebeck GW.

J Neuropathol Exp Neurol. 2016 Oct;75(10):918-924. Epub 2016 Aug 11.


Identification and modification of amyloid-independent phenotypes of APOE4 mice.

DiBattista AM, Dumanis SB, Newman J, Rebeck GW.

Exp Neurol. 2016 Jun;280:97-105. doi: 10.1016/j.expneurol.2016.04.014. Epub 2016 Apr 14.


Reelin Proteolysis Affects Signaling Related to Normal Synapse Function and Neurodegeneration.

Lussier AL, Weeber EJ, Rebeck GW.

Front Cell Neurosci. 2016 Mar 29;10:75. doi: 10.3389/fncel.2016.00075. eCollection 2016. Review.


Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function.

Di Battista AM, Heinsinger NM, Rebeck GW.

Curr Alzheimer Res. 2016;13(11):1200-1207. Review.


Genetics ignite focus on microglial inflammation in Alzheimer's disease.

Malik M, Parikh I, Vasquez JB, Smith C, Tai L, Bu G, LaDu MJ, Fardo DW, Rebeck GW, Estus S.

Mol Neurodegener. 2015 Oct 5;10:52. doi: 10.1186/s13024-015-0048-1. Review.


APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice.

Zhou Y, Zhao W, Al-Muhtasib N, Rebeck GW.

J Alzheimers Dis. 2015;46(2):365-74. doi: 10.3233/JAD-142184.


Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.

DiBattista AM, Dumanis SB, Song JM, Bu G, Weeber E, Rebeck GW, Hoe HS.

Biochim Biophys Acta. 2015 May;1853(5):904-17. doi: 10.1016/j.bbamcr.2015.01.015. Epub 2015 Jan 31.


Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation.

Burrell TC, Divekar SD, Weeber EJ, Rebeck GW.

PLoS One. 2014 Oct 23;9(10):e110845. doi: 10.1371/journal.pone.0110845. eCollection 2014.


Two Alzheimer's disease risk genes increase entorhinal cortex volume in young adults.

DiBattista AM, Stevens BW, Rebeck GW, Green AE.

Front Hum Neurosci. 2014 Oct 6;8:779. doi: 10.3389/fnhum.2014.00779. eCollection 2014.


Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector.

Zhao W, Zhang J, Davis EG, Rebeck GW.

Front Aging Neurosci. 2014 Aug 15;6:210. doi: 10.3389/fnagi.2014.00210. eCollection 2014.


Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.

Rodriguez GA, Tai LM, LaDu MJ, Rebeck GW.

J Neuroinflammation. 2014 Jun 19;11:111. doi: 10.1186/1742-2094-11-111.


Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation.

Trotter JH, Lussier AL, Psilos KE, Mahoney HL, Sponaugle AE, Hoe HS, Rebeck GW, Weeber EJ.

Neuroscience. 2014 Aug 22;274:299-307. doi: 10.1016/j.neuroscience.2014.05.046. Epub 2014 Jun 2.


Ligand-induced homotypic and heterotypic clustering of apolipoprotein E receptor 2.

Divekar SD, Burrell TC, Lee JE, Weeber EJ, Rebeck GW.

J Biol Chem. 2014 Jun 6;289(23):15894-903. doi: 10.1074/jbc.M113.537548. Epub 2014 Apr 22.


Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease.

Tamboli IY, Heo D, Rebeck GW.

PLoS One. 2014 Mar 27;9(3):e93120. doi: 10.1371/journal.pone.0093120. eCollection 2014.


Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk.

Tai LM, Mehra S, Shete V, Estus S, Rebeck GW, Bu G, LaDu MJ.

Mol Neurodegener. 2014 Jan 4;9:2. doi: 10.1186/1750-1326-9-2. Review.


ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro.

Nwabuisi-Heath E, Rebeck GW, Ladu MJ, Yu C.

ASN Neuro. 2014 Jan 13;6(1):e00134. doi: 10.1042/AN20130043.


APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature.

Nelson PT, Pious NM, Jicha GA, Wilcock DM, Fardo DW, Estus S, Rebeck GW.

J Neuropathol Exp Neurol. 2013 Jul;72(7):708-15. doi: 10.1097/NEN.0b013e31829a25b9.


Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex.

Rodriguez GA, Burns MP, Weeber EJ, Rebeck GW.

Learn Mem. 2013 Apr 16;20(5):256-66. doi: 10.1101/lm.030031.112.


Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse.

Rogers JT, Zhao L, Trotter JH, Rusiana I, Peters MM, Li Q, Donaldson E, Banko JL, Keenoy KE, Rebeck GW, Hoe HS, D'Arcangelo G, Weeber EJ.

J Psychopharmacol. 2013 Apr;27(4):386-95. doi: 10.1177/0269881112463468. Epub 2012 Oct 26.


APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ.

J Biol Chem. 2012 Dec 7;287(50):41774-86. doi: 10.1074/jbc.M112.407957. Epub 2012 Oct 11.


APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals.

Dumanis SB, DiBattista AM, Miessau M, Moussa CE, Rebeck GW.

J Neurochem. 2013 Jan;124(1):4-14. doi: 10.1111/j.1471-4159.2012.07908.x. Epub 2012 Sep 28.


FE65 as a link between VLDLR and APP to regulate their trafficking and processing.

Dumanis SB, Chamberlain KA, Jin Sohn Y, Jin Lee Y, Guénette SY, Suzuki T, Mathews PM, Pak DTs, Rebeck GW, Suh YH, Park HS, Hoe HS.

Mol Neurodegener. 2012 Mar 19;7:9. doi: 10.1186/1750-1326-7-9.


Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models.

Herman AM, Khandelwal PJ, Rebeck GW, Moussa CE.

Exp Neurol. 2012 May;235(1):297-305. doi: 10.1016/j.expneurol.2012.02.011. Epub 2012 Feb 28.


APOE genotype alters glial activation and loss of synaptic markers in mice.

Zhu Y, Nwabuisi-Heath E, Dumanis SB, Tai LM, Yu C, Rebeck GW, LaDu MJ.

Glia. 2012 Apr;60(4):559-69. doi: 10.1002/glia.22289. Epub 2012 Jan 6.


Age-related loss of noradrenergic neurons in the brains of triple transgenic mice.

Manaye KF, Mouton PR, Xu G, Drew A, Lei DL, Sharma Y, Rebeck GW, Turner S.

Age (Dordr). 2013 Feb;35(1):139-47. doi: 10.1007/s11357-011-9343-0. Epub 2011 Nov 30.


Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.

Khandelwal PJ, Dumanis SB, Herman AM, Rebeck GW, Moussa CE.

Mol Cell Neurosci. 2012 Jan;49(1):44-53. doi: 10.1016/j.mcn.2011.09.002. Epub 2011 Sep 14.


Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice.

Babus LW, Little EM, Keenoy KE, Minami SS, Chen E, Song JM, Caviness J, Koo SY, Pak DT, Rebeck GW, Turner RS, Hoe HS.

Brain Res. 2011 Sep 30;1415:96-102. doi: 10.1016/j.brainres.2011.07.059. Epub 2011 Aug 5.


Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density.

Rogers JT, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak DT, Babus LW, Peters M, Banko JL, Chavis P, Rebeck GW, Hoe HS, Weeber EJ.

Learn Mem. 2011 Aug 18;18(9):558-64. doi: 10.1101/lm.2153511. Print 2011 Sep.


Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.

Minami SS, Clifford TG, Hoe HS, Matsuoka Y, Rebeck GW.

Neurobiol Aging. 2012 Apr;33(4):825.e15-24. doi: 10.1016/j.neurobiolaging.2011.05.014. Epub 2011 Jul 7.


Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent-resistant membranes.

Minami SS, Hoe HS, Rebeck GW.

J Neurochem. 2011 Sep;118(5):879-90. doi: 10.1111/j.1471-4159.2011.07296.x. Epub 2011 May 25.


Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models.

Khandelwal PJ, Herman AM, Hoe HS, Rebeck GW, Moussa CE.

Hum Mol Genet. 2011 Jun 1;20(11):2091-102. doi: 10.1093/hmg/ddr091. Epub 2011 Mar 4.


β-amyloid triggers ALS-associated TDP-43 pathology in AD models.

Herman AM, Khandelwal PJ, Stanczyk BB, Rebeck GW, Moussa CE.

Brain Res. 2011 Apr 22;1386:191-9. doi: 10.1016/j.brainres.2011.02.052. Epub 2011 Mar 2.


ApoE receptor 2 regulates synapse and dendritic spine formation.

Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS.

PLoS One. 2011 Feb 15;6(2):e17203. doi: 10.1371/journal.pone.0017203.


Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury.

Loane DJ, Washington PM, Vardanian L, Pocivavsek A, Hoe HS, Duff KE, Cernak I, Rebeck GW, Faden AI, Burns MP.

J Neurotrauma. 2011 Feb;28(2):225-36. doi: 10.1089/neu.2010.1595.


Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model.

Khandelwal PJ, Dumanis SB, Feng LR, Maguire-Zeiss K, Rebeck G, Lashuel HA, Moussa CE.

Mol Neurodegener. 2010 Nov 4;5:47. doi: 10.1186/1750-1326-5-47.


Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.

Minami SS, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, Rebeck GW, Prendergast JS, Dealwis C, Wetzel R, Bosetti F, Matsuoka Y, Hoe HS, Turner RS.

J Neuroinflammation. 2010 Sep 28;7:57. doi: 10.1186/1742-2094-7-57.


ApoE mimetic peptide decreases Abeta production in vitro and in vivo.

Minami SS, Cordova A, Cirrito JR, Tesoriero JA, Babus LW, Davis GC, Dakshanamurthy S, Turner RS, Pak DTs, Rebeck GW, Paige M, Hoe HS.

Mol Neurodegener. 2010 Apr 20;5:16. doi: 10.1186/1750-1326-5-16.


Intracellular cholesterol homeostasis and amyloid precursor protein processing.

Burns MP, Rebeck GW.

Biochim Biophys Acta. 2010 Aug;1801(8):853-9. doi: 10.1016/j.bbalip.2010.03.004. Epub 2010 Mar 19. Review.


Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits.

Tomidokoro Y, Rostagno A, Neubert TA, Lu Y, Rebeck GW, Frangione B, Greenberg SM, Ghiso J.

Am J Pathol. 2010 Apr;176(4):1841-54. doi: 10.2353/ajpath.2010.090636. Epub 2010 Mar 12.


Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss.

Rebeck GW, Hoe HS, Moussa CE.

J Biol Chem. 2010 Mar 5;285(10):7440-6. doi: 10.1074/jbc.M109.083915. Epub 2010 Jan 13.


24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury.

Cartagena CM, Burns MP, Rebeck GW.

Brain Res. 2010 Mar 10;1319:1-12. doi: 10.1016/j.brainres.2009.12.080. Epub 2010 Jan 4.


ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, Weeber EJ, Turner RS, Xu B, Rebeck GW, Hoe HS.

J Neurosci. 2009 Dec 2;29(48):15317-22. doi: 10.1523/JNEUROSCI.4026-09.2009.


The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement.

Minami SS, Sung YM, Dumanis SB, Chi SH, Burns MP, Ann EJ, Suzuki T, Turner RS, Park HS, Pak DT, Rebeck GW, Hoe HS.

FASEB J. 2010 Jan;24(1):58-69. doi: 10.1096/fj.09-138123. Epub 2009 Aug 31.


Inhibition of c-Jun N-terminal kinase increases apoE expression in vitro and in vivo.

Pocivavsek A, Rebeck GW.

Biochem Biophys Res Commun. 2009 Sep 25;387(3):516-20. doi: 10.1016/j.bbrc.2009.07.048. Epub 2009 Jul 15.

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