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Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.

Lindsey-Boltz LA, Kemp MG, Reardon JT, DeRocco V, Iyer RR, Modrich P, Sancar A.

J Biol Chem. 2014 Feb 21;289(8):5074-82. doi: 10.1074/jbc.M113.542787. Epub 2014 Jan 8.


Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo.

Hu J, Choi JH, Gaddameedhi S, Kemp MG, Reardon JT, Sancar A.

J Biol Chem. 2013 Jul 19;288(29):20918-26. doi: 10.1074/jbc.M113.482257. Epub 2013 Jun 8.


In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling.

Lindsey-Boltz LA, Reardon JT, Wold MS, Sancar A.

J Biol Chem. 2012 Oct 19;287(43):36123-31. doi: 10.1074/jbc.M112.407825. Epub 2012 Sep 4.


Effect of circadian clock mutations on DNA damage response in mammalian cells.

Gaddameedhi S, Reardon JT, Ye R, Ozturk N, Sancar A.

Cell Cycle. 2012 Sep 15;11(18):3481-91. doi: 10.4161/cc.21771. Epub 2012 Aug 23.


Mechanism of release and fate of excised oligonucleotides during nucleotide excision repair.

Kemp MG, Reardon JT, Lindsey-Boltz LA, Sancar A.

J Biol Chem. 2012 Jun 29;287(27):22889-99. doi: 10.1074/jbc.M112.374447. Epub 2012 May 9.


Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein.

Kang TH, Reardon JT, Sancar A.

Nucleic Acids Res. 2011 Apr;39(8):3176-87. doi: 10.1093/nar/gkq1318. Epub 2010 Dec 30.


Similar nucleotide excision repair capacity in melanocytes and melanoma cells.

Gaddameedhi S, Kemp MG, Reardon JT, Shields JM, Smith-Roe SL, Kaufmann WK, Sancar A.

Cancer Res. 2010 Jun 15;70(12):4922-30. doi: 10.1158/0008-5472.CAN-10-0095. Epub 2010 May 25.


Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.

Kang TH, Lindsey-Boltz LA, Reardon JT, Sancar A.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4890-5. doi: 10.1073/pnas.0915085107.


Circadian clock control of the cellular response to DNA damage.

Sancar A, Lindsey-Boltz LA, Kang TH, Reardon JT, Lee JH, Ozturk N.

FEBS Lett. 2010 Jun 18;584(12):2618-25. doi: 10.1016/j.febslet.2010.03.017. Epub 2010 Mar 15. Review.


An alternative form of replication protein a expressed in normal human tissues supports DNA repair.

Kemp MG, Mason AC, Carreira A, Reardon JT, Haring SJ, Borgstahl GE, Kowalczykowski SC, Sancar A, Wold MS.

J Biol Chem. 2010 Feb 12;285(7):4788-97. doi: 10.1074/jbc.M109.079418. Epub 2009 Dec 7.


The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines.

Li L, Perdigao J, Pegg AE, Lao Y, Hecht SS, Lindgren BR, Reardon JT, Sancar A, Wattenberg EV, Peterson LA.

Chem Res Toxicol. 2009 Aug;22(8):1464-72. doi: 10.1021/tx9001572.


Circadian oscillation of nucleotide excision repair in mammalian brain.

Kang TH, Reardon JT, Kemp M, Sancar A.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2864-7. doi: 10.1073/pnas.0812638106. Epub 2009 Jan 21.


cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.

Lovejoy KS, Todd RC, Zhang S, McCormick MS, D'Aquino JA, Reardon JT, Sancar A, Giacomini KM, Lippard SJ.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8902-7. doi: 10.1073/pnas.0803441105. Epub 2008 Jun 25.


A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading.

Kesseler KJ, Kaufmann WK, Reardon JT, Elston TC, Sancar A.

J Theor Biol. 2007 Nov 21;249(2):361-75. Epub 2007 Aug 8.


Repair of DNA-protein cross-links in mammalian cells.

Reardon JT, Cheng Y, Sancar A.

Cell Cycle. 2006 Jul;5(13):1366-70. Epub 2006 Jul 1.


Repair of DNA-polypeptide crosslinks by human excision nuclease.

Reardon JT, Sancar A.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4056-61. Epub 2006 Mar 6.


Nucleotide excision repair.

Reardon JT, Sancar A.

Prog Nucleic Acid Res Mol Biol. 2005;79:183-235. Review. No abstract available.


Common garden and natural selection experiments support ecotypic differentiation in the Dominican anole (Anolis oculatus).

Thorpe RS, Reardon JT, Malhotra A.

Am Nat. 2005 Apr;165(4):495-504. Epub 2005 Feb 11.


Nucleotide excision repair in E. coli and man.

Sancar A, Reardon JT.

Adv Protein Chem. 2004;69:43-71. Review. No abstract available.


Thermodynamic cooperativity and kinetic proofreading in DNA damage recognition and repair.

Reardon JT, Sancar A.

Cell Cycle. 2004 Feb;3(2):141-4. Review.


Molecular anatomy of the human excision nuclease assembled at sites of DNA damage.

Reardon JT, Sancar A.

Mol Cell Biol. 2002 Aug;22(16):5938-45.


Restoration of nucleotide excision repair in a helicase-deficient XPD mutant from intragenic suppression by a trichothiodystrophy mutation.

George JW, Salazar EP, Vreeswijk MP, Lamerdin JE, Reardon JT, Zdzienicka MZ, Sancar A, Kadkhodayan S, Tebbs RS, Mullenders LH, Thompson LH.

Mol Cell Biol. 2001 Nov;21(21):7355-65.


DNA repair excision nuclease attacks undamaged DNA. A potential source of spontaneous mutations.

Branum ME, Reardon JT, Sancar A.

J Biol Chem. 2001 Jul 6;276(27):25421-6. Epub 2001 May 15.


Excision of tamoxifen-DNA adducts by the human nucleotide excision repair system.

Shibutani S, Reardon JT, Suzuki N, Sancar A.

Cancer Res. 2000 May 15;60(10):2607-10.


Nucleotide excision repair of melphalan monoadducts.

Grant DF, Bessho T, Reardon JT.

Cancer Res. 1998 Nov 15;58(22):5196-200.


Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia.

Khan SG, Levy HL, Legerski R, Quackenbush E, Reardon JT, Emmert S, Sancar A, Li L, Schneider TD, Cleaver JE, Kraemer KH.

J Invest Dermatol. 1998 Nov;111(5):791-6. Erratum in: J Invest Dermatol 1999 Mar;112(3):402.


The non-catalytic function of XPG protein during dual incision in human nucleotide excision repair.

Wakasugi M, Reardon JT, Sancar A.

J Biol Chem. 1997 Jun 20;272(25):16030-4.


ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs.

Brookman KW, Lamerdin JE, Thelen MP, Hwang M, Reardon JT, Sancar A, Zhou ZQ, Walter CA, Parris CN, Thompson LH.

Mol Cell Biol. 1996 Nov;16(11):6553-62.


Repair of cisplatin--DNA adducts by the mammalian excision nuclease.

Zamble DB, Mu D, Reardon JT, Sancar A, Lippard SJ.

Biochemistry. 1996 Aug 6;35(31):10004-13.


Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.

Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ.

Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6482-7. Erratum in: Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10538.


Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

Duckett DR, Drummond JT, Murchie AI, Reardon JT, Sancar A, Lilley DM, Modrich P.

Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6443-7.


The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA.

Ozer Z, Reardon JT, Hsu DS, Malhotra K, Sancar A.

Biochemistry. 1995 Dec 12;34(49):15886-9.


Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21.

Pan ZQ, Reardon JT, Li L, Flores-Rozas H, Legerski R, Sancar A, Hurwitz J.

J Biol Chem. 1995 Sep 15;270(37):22008-16.


Reconstitution of human DNA repair excision nuclease in a highly defined system.

Mu D, Park CH, Matsunaga T, Hsu DS, Reardon JT, Sancar A.

J Biol Chem. 1995 Feb 10;270(6):2415-8.


HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.

Huang JC, Zamble DB, Reardon JT, Lippard SJ, Sancar A.

Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10394-8.


Molecular cloning of the human nucleotide-excision-repair gene ERCC4.

Thompson LH, Brookman KW, Weber CA, Salazar EP, Reardon JT, Sancar A, Deng Z, Siciliano MJ.

Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6855-9.


Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II.

Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D.

Nature. 1994 Apr 21;368(6473):769-72.


Excision repair in man and the molecular basis of xeroderma pigmentosum syndrome.

Reardon JT, Thompson LH, Sancar A.

Cold Spring Harb Symp Quant Biol. 1993;58:605-17. No abstract available.


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