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Items: 31

1.

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study.

Vozella V, Basit A, Piras F, Realini N, Armirotti A, Bossù P, Assogna F, Sensi SL, Spalletta G, Piomelli D.

Aging (Albany NY). 2019 Jan 8;11(1):73-88. doi: 10.18632/aging.101719.

2.

Inhibition of serine palmitoyltransferase by a small organic molecule promotes neuronal survival after astrocyte amyloid beta 1-42 injury.

De Vita T, Albani C, Realini N, Migliore M, Basit A, Ottonello G, Cavalli A.

ACS Chem Neurosci. 2018 Nov 27. doi: 10.1021/acschemneuro.8b00556. [Epub ahead of print]

PMID:
30481470
3.

Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD).

Castellani B, Diamanti E, Pizzirani D, Tardia P, Maccesi M, Realini N, Magotti P, Garau G, Bakkum T, Rivara S, Mor M, Piomelli D.

Chem Commun (Camb). 2017 Nov 28;53(95):12814-12817. doi: 10.1039/c7cc07582k.

4.

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells.

Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazzanti CM, Piomelli D.

Sci Rep. 2017 Aug 7;7(1):7411. doi: 10.1038/s41598-017-07606-w.

5.

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F.

Mol Psychiatry. 2018 Apr;23(4):1040-1050. doi: 10.1038/mp.2017.126. Epub 2017 Jun 20.

PMID:
28630452
6.

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.

Migliore M Dr, Pontis S Dr, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, Garcia-Guzman M, Heim R, Scarpelli R, Piomelli D.

Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197. doi: 10.1002/anie.201603746. Epub 2016 Jul 12.

7.
8.

A simple and accurate protocol for absolute polar metabolite quantification in cell cultures using quantitative nuclear magnetic resonance.

Goldoni L, Beringhelli T, Rocchia W, Realini N, Piomelli D.

Anal Biochem. 2016 May 15;501:26-34. doi: 10.1016/j.ab.2016.02.009. Epub 2016 Feb 18.

PMID:
26898303
9.

An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis.

Bonezzi FT, Sasso O, Pontis S, Realini N, Romeo E, Ponzano S, Nuzzi A, Fiasella A, Bertozzi F, Piomelli D.

J Pharmacol Exp Ther. 2016 Mar;356(3):656-63. doi: 10.1124/jpet.115.230516. Epub 2016 Jan 14.

10.

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies.

Bach A, Pizzirani D, Realini N, Vozella V, Russo D, Penna I, Melzig L, Scarpelli R, Piomelli D.

J Med Chem. 2015 Dec 10;58(23):9258-72. doi: 10.1021/acs.jmedchem.5b01188. Epub 2015 Nov 23.

11.

Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION.

Realini N, Palese F, Pizzirani D, Pontis S, Basit A, Bach A, Ganesan A, Piomelli D.

J Biol Chem. 2016 Jan 29;291(5):2422-34. doi: 10.1074/jbc.M115.666909. Epub 2015 Nov 9.

12.

Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis.

Astarita G, Avanesian A, Grimaldi B, Realini N, Justinova Z, Panlilio LV, Basit A, Goldberg SR, Piomelli D.

PLoS One. 2015 Feb 11;10(2):e0116961. doi: 10.1371/journal.pone.0116961. eCollection 2015.

13.

Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase.

Pizzirani D, Bach A, Realini N, Armirotti A, Mengatto L, Bauer I, Girotto S, Pagliuca C, De Vivo M, Summa M, Ribeiro A, Piomelli D.

Angew Chem Int Ed Engl. 2015 Jan 7;54(2):485-9. doi: 10.1002/anie.201409042. Epub 2014 Nov 13.

14.

Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: application to human subjects with neurodegenerative dementia.

Armirotti A, Basit A, Realini N, Caltagirone C, Bossù P, Spalletta G, Piomelli D.

Anal Biochem. 2014 Jun 15;455:48-54. doi: 10.1016/j.ab.2014.03.019. Epub 2014 Apr 4.

15.

Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).

Pizzirani D, Pagliuca C, Realini N, Branduardi D, Bottegoni G, Mor M, Bertozzi F, Scarpelli R, Piomelli D, Bandiera T.

J Med Chem. 2013 May 9;56(9):3518-30. doi: 10.1021/jm301879g. Epub 2013 Apr 24.

16.

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity.

Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, Costi MP, Bandiera T, Piomelli D.

Sci Rep. 2013;3:1035. doi: 10.1038/srep01035. Epub 2013 Jan 8.

17.

Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models.

Sasso O, Moreno-Sanz G, Martucci C, Realini N, Dionisi M, Mengatto L, Duranti A, Tarozzo G, Tarzia G, Mor M, Bertorelli R, Reggiani A, Piomelli D.

Pain. 2013 Mar;154(3):350-60. doi: 10.1016/j.pain.2012.10.018. Epub 2012 Nov 2.

18.

Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages.

Zhu C, Solorzano C, Sahar S, Realini N, Fung E, Sassone-Corsi P, Piomelli D.

Mol Pharmacol. 2011 Apr;79(4):786-92. doi: 10.1124/mol.110.070201. Epub 2011 Jan 13.

19.

Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats.

Realini N, Vigano' D, Guidali C, Zamberletti E, Rubino T, Parolaro D.

Neuropharmacology. 2011 Feb-Mar;60(2-3):235-43. doi: 10.1016/j.neuropharm.2010.09.003. Epub 2010 Sep 17.

PMID:
20850463
20.

The endocannabinoid system and psychiatric disorders.

Parolaro D, Realini N, Vigano D, Guidali C, Rubino T.

Exp Neurol. 2010 Jul;224(1):3-14. doi: 10.1016/j.expneurol.2010.03.018. Epub 2010 Mar 29. Review.

PMID:
20353783
21.

Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine.

Guidali C, Viganò D, Petrosino S, Zamberletti E, Realini N, Binelli G, Rubino T, Di Marzo V, Parolaro D.

Int J Neuropsychopharmacol. 2011 Feb;14(1):17-28. doi: 10.1017/S1461145710000209. Epub 2010 Mar 3.

PMID:
20196921
22.

Cellular mechanisms underlying the interaction between cannabinoid and opioid system.

Parolaro D, Rubino T, Viganò D, Massi P, Guidali C, Realini N.

Curr Drug Targets. 2010 Apr;11(4):393-405. Review.

PMID:
20017730
23.

Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids.

Realini N, Rubino T, Parolaro D.

Pharmacol Res. 2009 Aug;60(2):132-8. doi: 10.1016/j.phrs.2009.03.006. Epub 2009 Mar 17. Review.

PMID:
19559364
24.

The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex.

Rubino T, Realini N, Braida D, Alberio T, Capurro V, Viganò D, Guidali C, Sala M, Fasano M, Parolaro D.

Neurotox Res. 2009 May;15(4):291-302. doi: 10.1007/s12640-009-9031-3. Epub 2009 Feb 28.

PMID:
19384563
25.

Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood.

Rubino T, Realini N, Braida D, Guidi S, Capurro V, Viganò D, Guidali C, Pinter M, Sala M, Bartesaghi R, Parolaro D.

Hippocampus. 2009 Aug;19(8):763-72. doi: 10.1002/hipo.20554.

PMID:
19156848
26.

Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia.

Vigano D, Guidali C, Petrosino S, Realini N, Rubino T, Di Marzo V, Parolaro D.

Int J Neuropsychopharmacol. 2009 Jun;12(5):599-614. doi: 10.1017/S1461145708009371. Epub 2008 Sep 15.

PMID:
18789179
27.

Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.

Rubino T, Vigano' D, Realini N, Guidali C, Braida D, Capurro V, Castiglioni C, Cherubino F, Romualdi P, Candeletti S, Sala M, Parolaro D.

Neuropsychopharmacology. 2008 Oct;33(11):2760-71. doi: 10.1038/sj.npp.1301664. Epub 2008 Jan 2.

28.

Role of endocannabinoids in regulating drug dependence.

Parolaro D, Vigano D, Realini N, Rubino T.

Neuropsychiatr Dis Treat. 2007 Dec;3(6):711-21.

29.

Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.

Rubino T, Realini N, Castiglioni C, Guidali C, Viganó D, Marras E, Petrosino S, Perletti G, Maccarrone M, Di Marzo V, Parolaro D.

Cereb Cortex. 2008 Jun;18(6):1292-301. Epub 2007 Oct 5.

PMID:
17921459
30.

CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour.

Rubino T, Guidali C, Vigano D, Realini N, Valenti M, Massi P, Parolaro D.

Neuropharmacology. 2008 Jan;54(1):151-60. Epub 2007 Jul 6. Erratum in: Neuropharmacology. 2008 Aug;55(2):247.

PMID:
17692344
31.

Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats.

Rubino T, Sala M, Viganò D, Braida D, Castiglioni C, Limonta V, Guidali C, Realini N, Parolaro D.

Neuropsychopharmacology. 2007 Sep;32(9):2036-45. Epub 2007 Feb 7.

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