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Items: 25

1.

Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction.

Wang W, Zhang L, Battiprolu PK, Fukushima A, Nguyen K, Milner K, Gupta A, Altamimi T, Byrne N, Mori J, Alrob OA, Wagg C, Fillmore N, Wang SH, Liu DM, Fu A, Lu JY, Chaves M, Motani A, Ussher JR, Reagan JD, Dyck JRB, Lopaschuk GD.

JACC Basic Transl Sci. 2019 Jun 24;4(3):385-400. doi: 10.1016/j.jacbts.2019.02.003. eCollection 2019 Jun.

2.

Discovery and pharmacological effects of a novel GPR142 antagonist.

Murakoshi M, Kuwabara H, Nagasaki M, Xiong YM, Reagan JD, Maeda H, Nara F.

J Recept Signal Transduct Res. 2017 Jun;37(3):290-296. doi: 10.1080/10799893.2016.1247861. Epub 2016 Nov 3.

PMID:
27807998
3.

Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.

Yu M, Lizarzaburu M, Motani A, Fu Z, Du X, Liu JJ, Jiao X, Lai S, Fan P, Fu A, Liu Q, Murakoshi M, Nara F, Oda K, Okuyama R, Reagan JD, Watanabe N, Yamazaki M, Xiong Y, Zhang Y, Zhuang R, Lin DC, Houze JB, Medina JC, Li L.

ACS Med Chem Lett. 2013 May 1;4(9):829-34. doi: 10.1021/ml4000854. eCollection 2013 Sep 12.

4.

Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.

Toda N, Hao X, Ogawa Y, Oda K, Yu M, Fu Z, Chen Y, Kim Y, Lizarzaburu M, Lively S, Lawlis S, Murakoshi M, Nara F, Watanabe N, Reagan JD, Tian H, Fu A, Motani A, Liu Q, Lin YJ, Zhuang R, Xiong Y, Fan P, Medina J, Li L, Izumi M, Okuyama R, Shibuya S.

ACS Med Chem Lett. 2013 Jun 17;4(8):790-4. doi: 10.1021/ml400186z. eCollection 2013 Aug 8.

5.

Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.

Wehn PM, Harrington PE, Carlson TJ, Davis J, Deprez P, Fotsch CH, Grillo MP, Lu JY, Morony S, Pattabiraman K, Poon SF, Reagan JD, St Jean DJ Jr, Temal T, Wang M, Yang Y, Henley C 3rd, Lively SE.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6625-8. doi: 10.1016/j.bmcl.2013.10.050. Epub 2013 Oct 31.

PMID:
24215889
6.

Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.

Du X, Kim YJ, Lai S, Chen X, Lizarzaburu M, Turcotte S, Fu Z, Liu Q, Zhang Y, Motani A, Oda K, Okuyama R, Nara F, Murakoshi M, Fu A, Reagan JD, Fan P, Xiong Y, Shen W, Li L, Houze J, Medina JC.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6218-23. doi: 10.1016/j.bmcl.2012.08.015. Epub 2012 Aug 10. Erratum in: Bioorg Med Chem Lett. 2012 Dec 15;22(24):7750.

PMID:
22926069
7.

GPR35 is a target of the loop diuretic drugs bumetanide and furosemide.

Yang Y, Fu A, Wu X, Reagan JD.

Pharmacology. 2012;89(1-2):13-7. doi: 10.1159/000335127. Epub 2012 Jan 10.

PMID:
22236570
8.

AMG 837: a potent, orally bioavailable GPR40 agonist.

Houze JB, Zhu L, Sun Y, Akerman M, Qiu W, Zhang AJ, Sharma R, Schmitt M, Wang Y, Liu J, Liu J, Medina JC, Reagan JD, Luo J, Tonn G, Zhang J, Lu JY, Chen M, Lopez E, Nguyen K, Yang L, Tang L, Tian H, Shuttleworth SJ, Lin DC.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70. doi: 10.1016/j.bmcl.2011.10.118. Epub 2011 Nov 6.

PMID:
22217876
9.

AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents.

Lin DC, Zhang J, Zhuang R, Li F, Nguyen K, Chen M, Tran T, Lopez E, Lu JY, Li XN, Tang L, Tonn GR, Swaminath G, Reagan JD, Chen JL, Tian H, Lin YJ, Houze JB, Luo J.

PLoS One. 2011;6(11):e27270. doi: 10.1371/journal.pone.0027270. Epub 2011 Nov 8.

10.

Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion.

Henley C 3rd, Yang Y, Davis J, Lu JY, Morony S, Fan W, Florio M, Sun B, Shatzen E, Pretorius JK, Richards WG, St Jean DJ Jr, Fotsch C, Reagan JD.

J Pharmacol Exp Ther. 2011 Jun;337(3):681-91. doi: 10.1124/jpet.110.178681. Epub 2011 Mar 21.

PMID:
21422163
11.

The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.

Harrington PE, St Jean DJ Jr, Clarine J, Coulter TS, Croghan M, Davenport A, Davis J, Ghiron C, Hutchinson J, Kelly MG, Lott F, Lu JY, Martin D, Morony S, Poon SF, Portero-Larragueta E, Reagan JD, Regal KA, Tasker A, Wang M, Yang Y, Yao G, Zeng Q, Henley C 3rd, Fotsch C.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5544-7. doi: 10.1016/j.bmcl.2010.07.060. Epub 2010 Aug 12.

PMID:
20708930
12.

G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium.

Yang Y, Lu JY, Wu X, Summer S, Whoriskey J, Saris C, Reagan JD.

Pharmacology. 2010;86(1):1-5. doi: 10.1159/000314164. Epub 2010 Jun 19.

PMID:
20559017
13.

Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics.

Poon SF, St Jean DJ Jr, Harrington PE, Henley C 3rd, Davis J, Morony S, Lott FD, Reagan JD, Lu JY, Yang Y, Fotsch C.

J Med Chem. 2009 Nov 12;52(21):6535-8. doi: 10.1021/jm9012278.

PMID:
19835382
14.

Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor.

Lu JY, Yang Y, Gnacadja G, Christopoulos A, Reagan JD.

J Pharmacol Exp Ther. 2009 Dec;331(3):775-86. doi: 10.1124/jpet.109.159228. Epub 2009 Sep 16.

PMID:
19759318
15.

Application of an allosteric model to describe the interactions among retinol binding protein 4, transthyretin, and small molecule retinol binding protein 4 ligands.

Coward P, Conn M, Tang J, Xiong F, Menjares A, Reagan JD.

Anal Biochem. 2009 Jan 15;384(2):312-20. doi: 10.1016/j.ab.2008.09.051. Epub 2008 Oct 12.

PMID:
18952041
16.

The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist.

Tang H, Lu JY, Zheng X, Yang Y, Reagan JD.

Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. doi: 10.1016/j.bbrc.2008.08.041. Epub 2008 Aug 21.

PMID:
18722346
17.

High throughput screening for orphan and liganded GPCRs.

Xiao SH, Reagan JD, Lee PH, Fu A, Schwandner R, Zhao X, Knop J, Beckmann H, Young SW.

Comb Chem High Throughput Screen. 2008 Mar;11(3):195-215. Review.

PMID:
18336213
18.

Elucidation of signaling and functional activities of an orphan GPCR, GPR81.

Ge H, Weiszmann J, Reagan JD, Gupte J, Baribault H, Gyuris T, Chen JL, Tian H, Li Y.

J Lipid Res. 2008 Apr;49(4):797-803. doi: 10.1194/jlr.M700513-JLR200. Epub 2008 Jan 3.

19.

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication.

Chen QM, Bartholomew JC, Campisi J, Acosta M, Reagan JD, Ames BN.

Biochem J. 1998 May 15;332 ( Pt 1):43-50.

20.

The N-1-Naphthylphthalamic Acid-Binding Protein Is an Integral Membrane Protein.

Bernasconi P, Patel BC, Reagan JD, Subramanian MV.

Plant Physiol. 1996 Jun;111(2):427-432.

21.
23.

Oxidative DNA damage and senescence of human diploid fibroblast cells.

Chen Q, Fischer A, Reagan JD, Yan LJ, Ames BN.

Proc Natl Acad Sci U S A. 1995 May 9;92(10):4337-41.

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