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Items: 32

1.

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).

Johnson CN, Ahn JS, Buck IM, Chiarparin E, Day JEH, Hopkins A, Howard S, Lewis EJ, Martins V, Millemaggi A, Munck JM, Page LW, Peakman T, Reader M, Rich SJ, Saxty G, Smyth T, Thompson NT, Ward GA, Williams PA, Wilsher NE, Chessari G.

J Med Chem. 2018 Aug 23;61(16):7314-7329. doi: 10.1021/acs.jmedchem.8b00900. Epub 2018 Aug 9.

PMID:
30091600
2.

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.

Heightman TD, Berdini V, Braithwaite H, Buck IM, Cassidy M, Castro J, Courtin A, Day JEH, East C, Fazal L, Graham B, Griffiths-Jones CM, Lyons JF, Martins V, Muench S, Munck JM, Norton D, O'Reilly M, Palmer N, Pathuri P, Reader M, Rees DC, Rich SJ, Richardson C, Saini H, Thompson NT, Wallis NG, Walton H, Wilsher NE, Woolford AJ, Cooke M, Cousin D, Onions S, Shannon J, Watts J, Murray CW.

J Med Chem. 2018 Jun 14;61(11):4978-4992. doi: 10.1021/acs.jmedchem.8b00421. Epub 2018 May 31.

PMID:
29775310
3.

Diagnosis and operative management of a perforated de Garengeot hernia.

Bloom A, Baio FE, Kim K, Fernandez-Moure JS, Reader M.

Int J Surg Case Rep. 2017;41:114-116. doi: 10.1016/j.ijscr.2017.10.009. Epub 2017 Oct 10.

4.

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

Tamanini E, Buck IM, Chessari G, Chiarparin E, Day JEH, Frederickson M, Griffiths-Jones CM, Hearn K, Heightman TD, Iqbal A, Johnson CN, Lewis EJ, Martins V, Peakman T, Reader M, Rich SJ, Ward GA, Williams PA, Wilsher NE.

J Med Chem. 2017 Jun 8;60(11):4611-4625. doi: 10.1021/acs.jmedchem.6b01877. Epub 2017 May 24.

PMID:
28492317
5.

An unusual presentation of congenital intestinal malrotation in a nonagenarian.

Fernandez-Moure JS, Moses ML, Garcia A, Reader MM.

Int J Surg Case Rep. 2016;25:229-33. doi: 10.1016/j.ijscr.2016.06.053. Epub 2016 Jul 1.

6.

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.

Chessari G, Buck IM, Day JE, Day PJ, Iqbal A, Johnson CN, Lewis EJ, Martins V, Miller D, Reader M, Rees DC, Rich SJ, Tamanini E, Vitorino M, Ward GA, Williams PA, Williams G, Wilsher NE, Woolford AJ.

J Med Chem. 2015 Aug 27;58(16):6574-88. doi: 10.1021/acs.jmedchem.5b00706. Epub 2015 Aug 7.

PMID:
26218264
7.

Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.

Squires M, Ward G, Saxty G, Berdini V, Cleasby A, King P, Angibaud P, Perera T, Fazal L, Ross D, Jones CG, Madin A, Benning RK, Vickerstaffe E, O'Brien A, Frederickson M, Reader M, Hamlett C, Batey MA, Rich S, Carr M, Miller D, Feltell R, Thiru A, Bethell S, Devine LA, Graham BL, Pike A, Cosme J, Lewis EJ, Freyne E, Lyons J, Irving J, Murray C, Newell DR, Thompson NT.

Mol Cancer Ther. 2011 Sep;10(9):1542-52. doi: 10.1158/1535-7163.MCT-11-0426. Epub 2011 Jul 15.

8.

Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.

Russell MG, Carling RW, Street LJ, Hallett DJ, Goodacre S, Mezzogori E, Reader M, Cook SM, Bromidge FA, Newman R, Smith AJ, Wafford KA, Marshall GR, Reynolds DS, Dias R, Ferris P, Stanley J, Lincoln R, Tye SJ, Sheppard WF, Sohal B, Pike A, Dominguez M, Atack JR, Castro JL.

J Med Chem. 2006 Feb 23;49(4):1235-8.

PMID:
16480260
9.

Massage therapy improves the management of alcohol withdrawal syndrome.

Reader M, Young R, Connor JP.

J Altern Complement Med. 2005 Apr;11(2):311-3.

PMID:
15865498
10.

Brief exposure to testosterone is sufficient to induce sex differences in the rabbit masseter muscle.

Reader M, Schwartz G, English AW.

Cells Tissues Organs. 2001;169(3):210-7.

PMID:
11455116
11.

Structural analysis of apolipoprotein A-I: limited proteolysis of methionine-reduced and -oxidized lipid-free and lipid-bound human apo A-I.

Roberts LM, Ray MJ, Shih TW, Hayden E, Reader MM, Brouillette CG.

Biochemistry. 1997 Jun 17;36(24):7615-24.

PMID:
9200714
12.

Bupropion hydrochloride in attention deficit disorder with hyperactivity.

Conners CK, Casat CD, Gualtieri CT, Weller E, Reader M, Reiss A, Weller RA, Khayrallah M, Ascher J.

J Am Acad Child Adolesc Psychiatry. 1996 Oct;35(10):1314-21.

PMID:
8885585
13.

Basal ganglia volumes in children with attention-deficit hyperactivity disorder.

Aylward EH, Reiss AL, Reader MJ, Singer HS, Brown JE, Denckla MB.

J Child Neurol. 1996 Mar;11(2):112-5.

PMID:
8881987
14.

Executive function in children with Tourette syndrome and/or attention deficit hyperactivity disorder.

Harris EL, Schuerholz LJ, Singer HS, Reader MJ, Brown JE, Cox C, Mohr J, Chase GA, Denckla MB.

J Int Neuropsychol Soc. 1995 Nov;1(6):511-6.

PMID:
9375237
15.

Expression and distribution of fetuin in the developing sheep fetus.

Saunders NR, Sheardown SA, Deal A, Møllgård K, Reader M, Dziegielewska KM.

Histochemistry. 1994 Dec;102(6):457-75.

PMID:
7535298
16.

Extracting Lambda MS-bar from experiment.

Barclay DT, Maxwell CJ, Reader MT.

Phys Rev D Part Fields. 1994 Apr 1;49(7):3480-3498. No abstract available.

PMID:
10017345
17.

The effects of X monosomy on brain development: monozygotic twins discordant for Turner's syndrome.

Reiss AL, Freund L, Plotnick L, Baumgardner T, Green K, Sozer AC, Reader M, Boehm C, Denckla MB.

Ann Neurol. 1993 Jul;34(1):95-107.

PMID:
8517687
18.

Volumetric MRI changes in basal ganglia of children with Tourette's syndrome.

Singer HS, Reiss AL, Brown JE, Aylward EH, Shih B, Chee E, Harris EL, Reader MJ, Chase GA, Bryan RN, et al.

Neurology. 1993 May;43(5):950-6.

PMID:
8492951
19.

Synthesis of the foetal protein fetuin by early developing neurons in the immature neocortex.

Dziegielewska KM, Reader M, Matthews N, Brown WM, Møllgård K, Saunders NR.

J Neurocytol. 1993 Apr;22(4):266-72.

PMID:
7683041
20.

Frontal sinusitis with chronic epidural abscess: a case presentation.

Reader ME, Eliachar I, McIntire LD, Hahn J.

Ear Nose Throat J. 1992 Nov;71(11):599-603. Review.

PMID:
1493762
21.

Hormonal evidence for induced ovulation in Monodelphis domestica.

Hinds LA, Reader M, Wernberg-Moller S, Saunders NR.

J Reprod Fertil. 1992 May;95(1):303-12.

PMID:
1625246
22.

Proteins in cerebrospinal fluid and plasma of postnatal Monodelphis domestica (grey short-tailed opossum).

Dziegielewska KM, Habgood M, Jones SE, Reader M, Saunders NR.

Comp Biochem Physiol B. 1989;92(3):569-76.

PMID:
2706945
23.

Monodelphis domestica (grey short-tailed opossum): an accessible model for studies of early neocortical development.

Saunders NR, Adam E, Reader M, Møllgård K.

Anat Embryol (Berl). 1989;180(3):227-36.

PMID:
2596703
24.

Responses of neonates to parents' and others' voices.

Ockleford EM, Vince MA, Layton C, Reader MR.

Early Hum Dev. 1988 Nov;18(1):27-36.

PMID:
3234282
25.

The effects of piracetam upon visual event-related potentials in dyslexic children.

Conners CK, Reader M, Reiss A, Caldwell J, Caldwell L, Adesman A, Mayer L, Berg M, Clymer R, Erwin R.

Psychophysiology. 1987 Sep;24(5):513-21. No abstract available.

PMID:
3685231
26.
27.

The synchronisation of hatching in quail embryos: aspects of development affected by a retarding stimulus.

Vince MA, Ockleford E, Reader M.

J Exp Zool. 1984 Feb;229(2):273-82.

PMID:
6736887
28.
29.

Psychological-Mindedness, Psychological-Construing, and the Judgment of Deception.

Dollinger SJ, Reader MJ, Marnett JP, Tylenda B.

J Gen Psychol. 1983 Apr;108(2):183-191. doi: 10.1080/00221309.1983.9711492.

PMID:
28150552
30.

Validity of the Missouri Children's Picture Series as a predictor of childhood sleep disturbances.

Dollinger SJ, Schum RL, Reader MJ, Nichols B.

J Pers Assess. 1981 Oct;45(5):526-32.

PMID:
7288545
31.

Heart rate response to egg rotation in the domestic fowl embryo.

Vince MA, Clarke JV, Reader MR.

Br Poult Sci. 1979 May;20(3):247-54.

PMID:
497869
32.

Effects of stimulation on embryonic activity in the chick.

Vince M, Reader M, Tolhurst B.

J Comp Physiol Psychol. 1976 Mar;90(3):221-30.

PMID:
932241

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