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Items: 1 to 50 of 150

1.

Mixed Malignant Pancreatic Tumour in a Rhesus Macaque (Macaca mullata).

Olstad KJ, Kasantikul T, Kiupel M, Reader JR.

J Comp Pathol. 2019 Feb;167:46-49. doi: 10.1016/j.jcpa.2018.12.003. Epub 2019 Jan 21.

PMID:
30898297
2.

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.

Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates C, Wittlin S, Prudêncio M, Chibale K.

J Med Chem. 2019 Jan 24;62(2):1022-1035. doi: 10.1021/acs.jmedchem.8b01769. Epub 2018 Dec 24.

PMID:
30562027
3.

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.

Kumar M, Okombo J, Mambwe D, Taylor D, Lawrence N, Reader J, van der Watt M, Fontinha D, Sanches-Vaz M, Bezuidenhout BC, Lauterbach SB, Liebenberg D, Birkholtz LM, Coetzer TL, Prudêncio M, Egan TJ, Wittlin S, Chibale K.

ACS Infect Dis. 2019 Feb 8;5(2):303-315. doi: 10.1021/acsinfecdis.8b00272. Epub 2019 Jan 7.

PMID:
30525439
4.

Review of Immune Therapies Targeting Ovarian Cancer.

Fan CA, Reader J, Roque DM.

Curr Treat Options Oncol. 2018 Nov 14;19(12):74. doi: 10.1007/s11864-018-0584-3. Review.

PMID:
30430276
5.

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites.

van Biljon R, Niemand J, van Wyk R, Clark K, Verlinden B, Abrie C, von Grüning H, Smidt W, Smit A, Reader J, Painter H, Llinás M, Doerig C, Birkholtz LM.

Sci Rep. 2018 Nov 8;8(1):16581. doi: 10.1038/s41598-018-34964-w.

6.

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01941-18. doi: 10.1128/AAC.01941-18. Print 2018 Nov. No abstract available.

7.

Primary Myxoid Liposarcoma of the Greater Omentum in a Rhesus Macaque (Macaca mulatta).

Lemoy MM, Salyards GW, Keesler RI, Reader JR.

Comp Med. 2018 Aug 1;68(4):308-313. doi: 10.30802/AALAS-CM-18-000013. Epub 2018 Aug 2.

8.

Is Sexual Abuse a Unique Predictor of Sexual Risk Behaviors, Pregnancy, and Motherhood in Adolescence?

Noll JG, Guastaferro K, Beal SJ, Schreier HMC, Barnes J, Reader JM, Font SA.

J Res Adolesc. 2018 Jul 18. doi: 10.1111/jora.12436. [Epub ahead of print]

PMID:
30019514
9.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. doi: 10.1128/AAC.00012-18. Print 2018 Sep. Erratum in: Antimicrob Agents Chemother. 2018 Oct 24;62(11):.

10.

Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease.

Coffey LL, Keesler RI, Pesavento PA, Woolard K, Singapuri A, Watanabe J, Cruzen C, Christe KL, Usachenko J, Yee J, Heng VA, Bliss-Moreau E, Reader JR, von Morgenland W, Gibbons AM, Jackson K, Ardeshir A, Heimsath H, Permar S, Senthamaraikannan P, Presicce P, Kallapur SG, Linnen JM, Gao K, Orr R, MacGill T, McClure M, McFarland R, Morrison JH, Van Rompay KKA.

Nat Commun. 2018 Jun 20;9(1):2414. doi: 10.1038/s41467-018-04777-6.

11.

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.

Coertzen D, Reader J, van der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, du Preez JL, Wu RWK, Birkholtz LM, Haynes RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02214-17. doi: 10.1128/AAC.02214-17. Print 2018 Aug.

12.

Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.

van der Watt ME, Reader J, Churchyard A, Nondaba SH, Lauterbach SB, Niemand J, Abayomi S, van Biljon RA, Connacher JI, van Wyk RDJ, Le Manach C, Paquet T, González Cabrera D, Brunschwig C, Theron A, Lozano-Arias S, Rodrigues JFI, Herreros E, Leroy D, Duffy J, Street LJ, Chibale K, Mancama D, Coetzer TL, Birkholtz LM.

J Antimicrob Chemother. 2018 May 1;73(5):1279-1290. doi: 10.1093/jac/dky008.

PMID:
29420756
13.

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites.

Harmse R, Coertzen D, Wong HN, Smit FJ, van der Watt ME, Reader J, Nondaba SH, Birkholtz LM, Haynes RK, N'Da DD.

ChemMedChem. 2017 Dec 19;12(24):2086-2093. doi: 10.1002/cmdc.201700599. Epub 2017 Dec 8.

PMID:
29219249
14.

Clinicians' attitudes to pain and the use of analgesia in cattle.

Reader J.

Vet Rec. 2017 Oct 14;181(15):397-399. doi: 10.1136/vr.j4724. No abstract available.

PMID:
29030513
15.
16.

Pneumatosis intestinalis in an SIV-infected rhesus macaque (Macaca mulatta).

Johnson AL, Van Rompay K, Reader JR.

J Med Primatol. 2017 Dec;46(6):368-371. doi: 10.1111/jmp.12305. Epub 2017 Aug 15.

17.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ, Bantscheff M, Ruecker A, Blagborough AM, Zakutansky SE, Zeeman AM, White KL, Shackleford DM, Mannila J, Morizzi J, Scheurer C, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Reader J, Botha M, Dechering KJ, Sauerwein RW, Tungtaeng A, Vanachayangkul P, Lim CS, Burrows J, Witty MJ, Marsh KC, Bodenreider C, Rochford R, Solapure SM, Jiménez-Díaz MB, Wittlin S, Charman SA, Donini C, Campo B, Birkholtz LM, Hanson KK, Drewes G, Kocken CHM, Delves MJ, Leroy D, Fidock DA, Waterson D, Street LJ, Chibale K.

Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735. doi: 10.1126/scitranslmed.aad9735.

18.

Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques.

Coffey LL, Pesavento PA, Keesler RI, Singapuri A, Watanabe J, Watanabe R, Yee J, Bliss-Moreau E, Cruzen C, Christe KL, Reader JR, von Morgenland W, Gibbons AM, Allen AM, Linnen J, Gao K, Delwart E, Simmons G, Stone M, Lanteri M, Bakkour S, Busch M, Morrison J, Van Rompay KK.

PLoS One. 2017 Jan 31;12(1):e0171148. doi: 10.1371/journal.pone.0171148. eCollection 2017.

19.

Haemodynamics Regulate Fibronectin Assembly via PECAM.

Chen Z, Givens C, Reader JS, Tzima E.

Sci Rep. 2017 Jan 25;7:41223. doi: 10.1038/srep41223.

20.

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz LM, Lauterbach S, Churchyard A, Coetzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K.

J Med Chem. 2017 Feb 23;60(4):1432-1448. doi: 10.1021/acs.jmedchem.6b01641. Epub 2017 Feb 7.

PMID:
28094524
21.

Cognitions about infant sleep: Interparental differences, trajectories across the first year, and coparenting quality.

Reader JM, Teti DM, Cleveland MJ.

J Fam Psychol. 2017 Jun;31(4):453-463. doi: 10.1037/fam0000283. Epub 2017 Jan 5.

22.

Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.

Kochel TJ, Reader JC, Ma X, Kundu N, Fulton AM.

Oncotarget. 2017 Jan 24;8(4):6540-6554. doi: 10.18632/oncotarget.14145.

23.

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.

Le Manach C, Nchinda AT, Paquet T, Gonzàlez Cabrera D, Younis Y, Han Z, Bashyam S, Zabiulla M, Taylor D, Lawrence N, White KL, Charman SA, Waterson D, Witty MJ, Wittlin S, Botha ME, Nondaba SH, Reader J, Birkholtz LM, Jiménez-Díaz MB, Martínez MS, Ferrer S, Angulo-Barturen I, Meister S, Antonova-Koch Y, Winzeler EA, Street LJ, Chibale K.

J Med Chem. 2016 Nov 10;59(21):9890-9905. Epub 2016 Oct 26.

PMID:
27748596
24.

Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Chopra S, Palencia A, Virus C, Schulwitz S, Temple BR, Cusack S, Reader J.

Nat Commun. 2016 Oct 7;7:12928. doi: 10.1038/ncomms12928.

25.

Antemortem Screening for Left Ventricular Hypertrophy in Rhesus Macaques (Macaca mulatta).

Haertel AJ, Stern JA, Reader JR, Spinner A, Roberts JA, Christe KL.

Comp Med. 2016;66(4):333-42.

26.

Spectrum and Energy Levels of Five-Times Ionized Zirconium (Zr VI).

Reader J, Lindsay MD.

Phys Scr. 2016 Feb;91(2). pii: 025401. Epub 2016 Jan 5.

27.

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).

Osborne JD, Matthews TP, McHardy T, Proisy N, Cheung KM, Lainchbury M, Brown N, Walton MI, Eve PD, Boxall KJ, Hayes A, Henley AT, Valenti MR, De Haven Brandon AK, Box G, Jamin Y, Robinson SP, Westwood IM, van Montfort RL, Leonard PM, Lamers MB, Reader JC, Aherne GW, Raynaud FI, Eccles SA, Garrett MD, Collins I.

J Med Chem. 2016 Jun 9;59(11):5221-37. doi: 10.1021/acs.jmedchem.5b01938. Epub 2016 May 23.

28.

Left Ventricular Hypertrophy in Rhesus Macaques (Macaca mulatta) at the California National Primate Research Center (1992-2014).

Reader JR, Canfield DR, Lane JF, Kanthaswamy S, Ardeshir A, Allen AM, Tarara RP.

Comp Med. 2016 Apr;66(2):162-9.

29.

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.

Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, Meister S, Winzeler EA, Waterson D, Witty MJ, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Street LJ, Chibale K.

J Med Chem. 2015 Nov 12;58(21):8713-22. doi: 10.1021/acs.jmedchem.5b01605. Epub 2015 Nov 2.

PMID:
26502160
30.

Claw trimming of dairy cattle.

Burnell M, Reader J, Alcock P.

Vet Rec. 2015 Oct 24;177(16):423. doi: 10.1136/vr.h5620. No abstract available.

PMID:
26494896
31.

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.

Walton MI, Eve PD, Hayes A, Henley AT, Valenti MR, De Haven Brandon AK, Box G, Boxall KJ, Tall M, Swales K, Matthews TP, McHardy T, Lainchbury M, Osborne J, Hunter JE, Perkins ND, Aherne GW, Reader JC, Raynaud FI, Eccles SA, Collins I, Garrett MD.

Oncotarget. 2016 Jan 19;7(3):2329-42. doi: 10.18632/oncotarget.4919.

32.

A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens.

El Sahili A, Li SZ, Lang J, Virus C, Planamente S, Ahmar M, Guimaraes BG, Aumont-Nicaise M, Vigouroux A, Soulère L, Reader J, Queneau Y, Faure D, Moréra S.

PLoS Pathog. 2015 Aug 5;11(8):e1005071. doi: 10.1371/journal.ppat.1005071. eCollection 2015 Aug.

33.

Spontaneous lactogenesis and galactopoeisis in a virgin dairy heifer with evidence of a granulosa theca cell tumour.

Gunn AJ, Reader J.

N Z Vet J. 2015 Nov;63(6):345-6. doi: 10.1080/00480169.2015.1047912. Epub 2015 Jul 10. No abstract available.

PMID:
26108227
34.

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

Reader J, Botha M, Theron A, Lauterbach SB, Rossouw C, Engelbrecht D, Wepener M, Smit A, Leroy D, Mancama D, Coetzer TL, Birkholtz LM.

Malar J. 2015 May 22;14:213. doi: 10.1186/s12936-015-0718-z.

35.

Radicinin from Cochliobolus sp. inhibits Xylella fastidiosa, the causal agent of Pierce's Disease of grapevine.

Aldrich TJ, Rolshausen PE, Roper MC, Reader JM, Steinhaus MJ, Rapicavoli J, Vosburg DA, Maloney KN.

Phytochemistry. 2015 Aug;116:130-137. doi: 10.1016/j.phytochem.2015.03.015. Epub 2015 Apr 16.

PMID:
25892412
36.

Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.

Verlinden BK, de Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, van Biljon R, Guy K, Egan T, Woster PM, Birkholtz LM.

Bioorg Med Chem. 2015 Aug 15;23(16):5131-43. doi: 10.1016/j.bmc.2015.01.036. Epub 2015 Jan 28.

37.

tRNAs as antibiotic targets.

Chopra S, Reader J.

Int J Mol Sci. 2014 Dec 25;16(1):321-49. doi: 10.3390/ijms16010321. Review.

38.

Divergent roles of CXCR3 isoforms in promoting cancer stem-like cell survival and metastasis.

Li Y, Reader JC, Ma X, Kundu N, Kochel T, Fulton AM.

Breast Cancer Res Treat. 2015 Jan;149(2):403-15. doi: 10.1007/s10549-014-3229-7. Epub 2014 Dec 24.

PMID:
25537642
39.

Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction.

McCormick ME, Rojas M, Moser-Katz T, Tzima E, Reader JS.

PLoS One. 2014 Oct 8;9(10):e109325. doi: 10.1371/journal.pone.0109325. eCollection 2014.

40.

Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis.

Works MG, Yin F, Yin CC, Yiu Y, Shew K, Tran TT, Dunlap N, Lam J, Mitchell T, Reader J, Stein PL, D'Andrea A.

J Immunol. 2014 Oct 1;193(7):3278-87. doi: 10.4049/jimmunol.1400205. Epub 2014 Aug 25.

41.

Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells.

Collins C, Osborne LD, Guilluy C, Chen Z, O'Brien ET 3rd, Reader JS, Burridge K, Superfine R, Tzima E.

Nat Commun. 2014 Jun 11;5:3984. doi: 10.1038/ncomms4984.

42.

Methods for siting emergency stomas in the absence of a stoma therapist.

Pengelly S, Reader J, Jones A, Roper K, Douie WJ, Lambert AW.

Ann R Coll Surg Engl. 2014 Apr;96(3):216-8. doi: 10.1308/003588414X13814021679717.

43.

Enhanced viral replication and modulated innate immune responses in infant airway epithelium following H1N1 infection.

Clay CC, Reader JR, Gerriets JE, Wang TT, Harrod KS, Miller LA.

J Virol. 2014 Jul;88(13):7412-25. doi: 10.1128/JVI.00188-14. Epub 2014 Apr 16.

44.

Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.

Saïdani N, Botté CY, Deligny M, Bonneau AL, Reader J, Lasselin R, Merer G, Niepceron A, Brossier F, Cintrat JC, Rousseau B, Birkholtz LM, Cesbron-Delauw MF, Dubremetz JF, Mercier C, Vial H, Lopez R, Maréchal E.

Antimicrob Agents Chemother. 2014 May;58(5):2586-97. doi: 10.1128/AAC.01445-13. Epub 2014 Feb 18.

45.

Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties.

Kundu N, Ma X, Kochel T, Goloubeva O, Staats P, Thompson K, Martin S, Reader J, Take Y, Collin P, Fulton A.

Breast Cancer Res Treat. 2014 Jan;143(1):19-31. doi: 10.1007/s10549-013-2779-4. Epub 2013 Nov 27.

46.

Meeting report: Emerging respiratory viral infections and nonhuman primate case reports.

Sasseville VG, Mankowski JL, Baldessari A, Harbison C, Laing S, Kaliyaperumal S, Mätz-Rensing K, Miller AD, Schmidt LD, Kaplan-Kees J, Dick EJ Jr, Reader JR, Liu D, Crawford LK, Lane JH, Corner SM, Pardo ID, Evans MG, Murnane R, Terio KA.

Vet Pathol. 2013 Nov;50(6):1145-53. doi: 10.1177/0300985813495898. Epub 2013 Jul 9.

PMID:
23839235
47.

Role of aminoacyl-tRNA synthetases in infectious diseases and targets for therapeutic development.

Dewan V, Reader J, Forsyth KM.

Top Curr Chem. 2014;344:293-329. doi: 10.1007/128_2013_425. Review.

PMID:
23666077
48.

Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.

Niemand J, Burger P, Verlinden BK, Reader J, Joubert AM, Kaiser A, Louw AI, Kirk K, Phanstiel O 4th, Birkholtz LM.

Antimicrob Agents Chemother. 2013 Jun;57(6):2874-7. doi: 10.1128/AAC.00106-13. Epub 2013 Apr 1.

49.
50.

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase.

Chopra S, Palencia A, Virus C, Tripathy A, Temple BR, Velazquez-Campoy A, Cusack S, Reader JS.

Nat Commun. 2013;4:1417. doi: 10.1038/ncomms2421.

PMID:
23361008

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