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Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme).

Hashimoto H, Kafková L, Raczkowski A, Jordan KD, Read LK, Debler EW.

J Mol Biol. 2019 Nov 11. pii: S0022-2836(19)30658-8. doi: 10.1016/j.jmb.2019.11.002. [Epub ahead of print]


MRB10130 is a RESC assembly factor that promotes kinetoplastid RNA editing initiation and progression.

McAdams NM, Harrison GL, Tylec BL, Ammerman ML, Chen R, Sun Y, Read LK.

RNA. 2019 Sep;25(9):1177-1191. doi: 10.1261/rna.071902.119. Epub 2019 Jun 20.


Intrinsic and regulated properties of minimally edited trypanosome mRNAs.

Tylec BL, Simpson RM, Kirby LE, Chen R, Sun Y, Koslowsky DJ, Read LK.

Nucleic Acids Res. 2019 Apr 23;47(7):3640-3657. doi: 10.1093/nar/gkz012.


Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response.

Kafková L, Tu C, Pazzo KL, Smith KP, Debler EW, Paul KS, Qu J, Read LK.

MBio. 2018 Dec 18;9(6). pii: e02430-18. doi: 10.1128/mBio.02430-18.


High throughput sequencing revolution reveals conserved fundamentals of U-indel editing.

Zimmer SL, Simpson RM, Read LK.

Wiley Interdiscip Rev RNA. 2018 Jun 11:e1487. doi: 10.1002/wrna.1487. [Epub ahead of print] Review.


MRB7260 is essential for productive protein-RNA interactions within the RNA editing substrate binding complex during trypanosome RNA editing.

McAdams NM, Simpson RM, Chen R, Sun Y, Read LK.

RNA. 2018 Apr;24(4):540-556. doi: 10.1261/rna.065169.117. Epub 2018 Jan 12.


Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilization.

Simpson RM, Bruno AE, Chen R, Lott K, Tylec BL, Bard JE, Sun Y, Buck MJ, Read LK.

Nucleic Acids Res. 2017 Jul 27;45(13):7965-7983. doi: 10.1093/nar/gkx458.


The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.

Kafková L, Debler EW, Fisk JC, Jain K, Clarke SG, Read LK.

J Biol Chem. 2017 Feb 10;292(6):2089-2100. doi: 10.1074/jbc.M116.757112. Epub 2016 Dec 20.


Validating Resilience and Vulnerability Indices in the Context of Natural Disasters.

Bakkensen LA, Fox-Lent C, Read LK, Linkov I.

Risk Anal. 2017 May;37(5):982-1004. doi: 10.1111/risa.12677. Epub 2016 Aug 30.


High-throughput sequencing of partially edited trypanosome mRNAs reveals barriers to editing progression and evidence for alternative editing.

Simpson RM, Bruno AE, Bard JE, Buck MJ, Read LK.

RNA. 2016 May;22(5):677-95. doi: 10.1261/rna.055160.115. Epub 2016 Feb 23.


REH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and Small Guide RNA in Kinetoplastid Editosomes.

Kumar V, Madina BR, Gulati S, Vashisht AA, Kanyumbu C, Pieters B, Shakir A, Wohlschlegel JA, Read LK, Mooers BH, Cruz-Reyes J.

J Biol Chem. 2016 Mar 11;291(11):5753-64. doi: 10.1074/jbc.M115.708164. Epub 2016 Jan 14.


Trypanosome RNA editing: the complexity of getting U in and taking U out.

Read LK, Lukeš J, Hashimi H.

Wiley Interdiscip Rev RNA. 2016 Jan-Feb;7(1):33-51. doi: 10.1002/wrna.1313. Epub 2015 Nov 2. Review.


Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing.

Huang Z, Faktorová D, Křížová A, Kafková L, Read LK, Lukeš J, Hashimi H.

RNA. 2015 Dec;21(12):2088-102. doi: 10.1261/rna.052340.115. Epub 2015 Oct 7.


Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold.

Shaw PL, McAdams NM, Hast MA, Ammerman ML, Read LK, Schumacher MA.

Nucleic Acids Res. 2015 Aug 18;43(14):7096-109. doi: 10.1093/nar/gkv647. Epub 2015 Jun 27.


Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome.

Lott K, Mukhopadhyay S, Li J, Wang J, Yao J, Sun Y, Qu J, Read LK.

Nucleic Acids Res. 2015 Jun 23;43(11):5501-23. doi: 10.1093/nar/gkv428. Epub 2015 May 4.


An arginine-glycine-rich RNA binding protein impacts the abundance of specific mRNAs in the mitochondria of Trypanosoma brucei.

McAdams NM, Ammerman ML, Nanduri J, Lott K, Fisk JC, Read LK.

Eukaryot Cell. 2015 Feb;14(2):149-57. doi: 10.1128/EC.00232-14. Epub 2014 Dec 5.


Functional interplay between protein arginine methyltransferases in Trypanosoma brucei.

Lott K, Zhu L, Fisk JC, Tomasello DL, Read LK.

Microbiologyopen. 2014 Oct;3(5):595-609. doi: 10.1002/mbo3.191. Epub 2014 Jul 7.


A core MRB1 complex component is indispensable for RNA editing in insect and human infective stages of Trypanosoma brucei.

Ammerman ML, Tomasello DL, Faktorová D, Kafková L, Hashimi H, Lukeš J, Read LK.

PLoS One. 2013 Oct 18;8(10):e78015. doi: 10.1371/journal.pone.0078015. eCollection 2013.


Ribosome biogenesis requires a highly diverged XRN family 5'->3' exoribonuclease for rRNA processing in Trypanosoma brucei.

Sakyiama J, Zimmer SL, Ciganda M, Williams N, Read LK.

RNA. 2013 Oct;19(10):1419-31. doi: 10.1261/rna.038547.113. Epub 2013 Aug 23.


Global proteomic analysis in trypanosomes reveals unique proteins and conserved cellular processes impacted by arginine methylation.

Lott K, Li J, Fisk JC, Wang H, Aletta JM, Qu J, Read LK.

J Proteomics. 2013 Oct 8;91:210-25. doi: 10.1016/j.jprot.2013.07.010. Epub 2013 Jul 19.


Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex.

Hashimi H, Zimmer SL, Ammerman ML, Read LK, Lukeš J.

Trends Parasitol. 2013 Feb;29(2):91-9. doi: 10.1016/ Epub 2013 Jan 8. Review.


Proteomic analysis reveals diverse classes of arginine methylproteins in mitochondria of trypanosomes.

Fisk JC, Li J, Wang H, Aletta JM, Qu J, Read LK.

Mol Cell Proteomics. 2013 Feb;12(2):302-11. doi: 10.1074/mcp.M112.022533. Epub 2012 Nov 14.


Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei.

Kafková L, Ammerman ML, Faktorová D, Fisk JC, Zimmer SL, Sobotka R, Read LK, Lukes J, Hashimi H.

RNA. 2012 Oct;18(10):1846-61. doi: 10.1261/rna.033852.112. Epub 2012 Aug 16. Erratum in: RNA. 2012 Dec;18(12):2345.


Multifunctional G-rich and RRM-containing domains of TbRGG2 perform separate yet essential functions in trypanosome RNA editing.

Foda BM, Downey KM, Fisk JC, Read LK.

Eukaryot Cell. 2012 Sep;11(9):1119-31. doi: 10.1128/EC.00175-12. Epub 2012 Jul 13.


Additive and transcript-specific effects of KPAP1 and TbRND activities on 3' non-encoded tail characteristics and mRNA stability in Trypanosoma brucei.

Zimmer SL, McEvoy SM, Menon S, Read LK.

PLoS One. 2012;7(5):e37639. doi: 10.1371/journal.pone.0037639. Epub 2012 May 21.


Architecture of the trypanosome RNA editing accessory complex, MRB1.

Ammerman ML, Downey KM, Hashimi H, Fisk JC, Tomasello DL, Faktorová D, Kafková L, King T, Lukes J, Read LK.

Nucleic Acids Res. 2012 Jul;40(12):5637-50. doi: 10.1093/nar/gks211. Epub 2012 Mar 6.


Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.

Madina BR, Kuppan G, Vashisht AA, Liang YH, Downey KM, Wohlschlegel JA, Ji X, Sze SH, Sacchettini JC, Read LK, Cruz-Reyes J.

RNA. 2011 Oct;17(10):1821-30. doi: 10.1261/rna.2815911. Epub 2011 Aug 2.


Protein arginine methylation in parasitic protozoa.

Fisk JC, Read LK.

Eukaryot Cell. 2011 Aug;10(8):1013-22. doi: 10.1128/EC.05103-11. Epub 2011 Jun 17. Review.


Marked for translation: long A/U tails as an interface between completion of RNA editing and ribosome recruitment.

Read LK, Zimmer SL, Ammerman ML.

Mol Cell. 2011 Apr 8;42(1):6-8. doi: 10.1016/j.molcel.2011.03.013.


MRB3010 is a core component of the MRB1 complex that facilitates an early step of the kinetoplastid RNA editing process.

Ammerman ML, Hashimi H, Novotná L, Cicová Z, McEvoy SM, Lukes J, Read LK.

RNA. 2011 May;17(5):865-77. doi: 10.1261/rna.2446311. Epub 2011 Mar 30.


A novel member of the RNase D exoribonuclease family functions in mitochondrial guide RNA metabolism in Trypanosoma brucei.

Zimmer SL, McEvoy SM, Li J, Qu J, Read LK.

J Biol Chem. 2011 Mar 25;286(12):10329-40. doi: 10.1074/jbc.M110.152439. Epub 2011 Jan 20.


TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sites.

Ammerman ML, Presnyak V, Fisk JC, Foda BM, Read LK.

RNA. 2010 Nov;16(11):2239-51. doi: 10.1261/rna.2285510. Epub 2010 Sep 20.


TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei.

Fisk JC, Zurita-Lopez C, Sayegh J, Tomasello DL, Clarke SG, Read LK.

Eukaryot Cell. 2010 Jun;9(6):866-77. doi: 10.1128/EC.00018-10. Epub 2010 Apr 23.


Structure of the Trypanosoma brucei p22 protein, a cytochrome oxidase subunit II-specific RNA-editing accessory factor.

Sprehe M, Fisk JC, McEvoy SM, Read LK, Schumacher MA.

J Biol Chem. 2010 Jun 11;285(24):18899-908. doi: 10.1074/jbc.M109.066597. Epub 2010 Apr 14.


Distinct and overlapping functions of MRP1/2 and RBP16 in mitochondrial RNA metabolism.

Fisk JC, Presnyak V, Ammerman ML, Read LK.

Mol Cell Biol. 2009 Oct;29(19):5214-25. doi: 10.1128/MCB.00520-09. Epub 2009 Jul 20.


Evidence for a degradosome-like complex in the mitochondria of Trypanosoma brucei.

Mattiacio JL, Read LK.

FEBS Lett. 2009 Jul 21;583(14):2333-8. doi: 10.1016/j.febslet.2009.06.024. Epub 2009 Jun 18.


A type III protein arginine methyltransferase from the protozoan parasite Trypanosoma brucei.

Fisk JC, Sayegh J, Zurita-Lopez C, Menon S, Presnyak V, Clarke SG, Read LK.

J Biol Chem. 2009 Apr 24;284(17):11590-600. doi: 10.1074/jbc.M807279200. Epub 2009 Mar 2.


TbRGG2, an essential RNA editing accessory factor in two Trypanosoma brucei life cycle stages.

Fisk JC, Ammerman ML, Presnyak V, Read LK.

J Biol Chem. 2008 Aug 22;283(34):23016-25. doi: 10.1074/jbc.M801021200. Epub 2008 Jun 26.


gRNA/pre-mRNA annealing and RNA chaperone activities of RBP16.

Ammerman ML, Fisk JC, Read LK.

RNA. 2008 Jun;14(6):1069-80. doi: 10.1261/rna.982908. Epub 2008 Apr 25.


Roles for TbDSS-1 in RNA surveillance and decay of maturation by-products from the 12S rRNA locus.

Mattiacio JL, Read LK.

Nucleic Acids Res. 2008 Jan;36(1):319-29. Epub 2007 Nov 21.


Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatment.

Cree MG, Newcomer BR, Read LK, Sheffield-Moore M, Paddon-Jones D, Chinkes D, Aarsland A, Wolfe RR.

Mech Ageing Dev. 2007 Oct;128(10):558-65. Epub 2007 Aug 15.


Isolation of RNA binding proteins involved in insertion/deletion editing.

Pelletier M, Read LK, Aphasizhev R.

Methods Enzymol. 2007;424:75-105.


Pentatricopeptide repeat proteins in Trypanosoma brucei function in mitochondrial ribosomes.

Pusnik M, Small I, Read LK, Fabbro T, Schneider A.

Mol Cell Biol. 2007 Oct;27(19):6876-88. Epub 2007 Jul 23.


Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei.

Pasternack DA, Sayegh J, Clarke S, Read LK.

Eukaryot Cell. 2007 Sep;6(9):1665-81. Epub 2007 Jun 29.


Generation of polyclonal antiserum for the detection of methylarginine proteins.

Duan P, Xu Y, Birkaya B, Myers J, Pelletier M, Read LK, Guarnaccia C, Pongor S, Denman RB, Aletta JM.

J Immunol Methods. 2007 Mar 30;320(1-2):132-42. Epub 2007 Feb 6.


RBP16 stimulates trypanosome RNA editing in vitro at an early step in the editing reaction.

Miller MM, Halbig K, Cruz-Reyes J, Read LK.

RNA. 2006 Jul;12(7):1292-303. Epub 2006 May 11.


Biphasic decay of guide RNAs in Trypanosoma brucei.

Ryan CM, Kao CY, Sleve DA, Read LK.

Mol Biochem Parasitol. 2006 Mar;146(1):68-77. Epub 2005 Nov 10.


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