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Items: 1 to 50 of 84

1.

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.

Grimster NP, Anderson E, Alimzhanov M, Bebernitz G, Bell K, Chuaqui C, Deegan T, Ferguson AD, Gero T, Harsch A, Huszar D, Kawatkar A, Kettle JG, Lyne P, Read JA, Rivard Costa C, Ruston L, Schroeder P, Shi J, Su Q, Throner S, Toader D, Vasbinder M, Woessner R, Wang H, Wu A, Ye M, Zheng W, Zinda M.

J Med Chem. 2018 Jun 28;61(12):5235-5244. doi: 10.1021/acs.jmedchem.8b00076. Epub 2018 Jun 13.

PMID:
29856615
2.

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.

Yang B, Vasbinder MM, Hird AW, Su Q, Wang H, Yu Y, Toader D, Lyne PD, Read JA, Breed J, Ioannidis S, Deng C, Grondine M, DeGrace N, Whitston D, Brassil P, Janetka JW.

J Med Chem. 2018 Feb 8;61(3):1061-1073. doi: 10.1021/acs.jmedchem.7b01490. Epub 2018 Jan 19.

PMID:
29301085
3.

Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease.

Rueda FO, Bista M, Newton MD, Goeppert AU, Cuomo ME, Gordon E, Kröner F, Read JA, Wrigley JD, Rueda D, Taylor BJM.

Nat Commun. 2017 Nov 20;8(1):1610. doi: 10.1038/s41467-017-01732-9.

4.

X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.

Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA.

J Med Chem. 2017 Nov 22;60(22):9299-9319. doi: 10.1021/acs.jmedchem.7b01292. Epub 2017 Nov 8.

PMID:
29116812
5.

Additions of Organomagnesium Halides to α-Alkoxy Ketones: Revision of the Chelation-Control Model.

Read JA, Yang Y, Woerpel KA.

Org Lett. 2017 Jul 7;19(13):3346-3349. doi: 10.1021/acs.orglett.7b01161. Epub 2017 Jun 15.

PMID:
28617613
6.

Allylmagnesium Halides Do Not React Chemoselectively Because Reaction Rates Approach the Diffusion Limit.

Read JA, Woerpel KA.

J Org Chem. 2017 Feb 17;82(4):2300-2305. doi: 10.1021/acs.joc.7b00053. Epub 2017 Feb 8.

PMID:
28114754
7.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.

Soutter HH, Centrella P, Clark MA, Cuozzo JW, Dumelin CE, Guie MA, Habeshian S, Keefe AD, Kennedy KM, Sigel EA, Troast DM, Zhang Y, Ferguson AD, Davies G, Stead ER, Breed J, Madhavapeddi P, Read JA.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7880-E7889. Epub 2016 Nov 18.

8.

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

Marusiak AA, Stephenson NL, Baik H, Trotter EW, Li Y, Blyth K, Mason S, Chapman P, Puto LA, Read JA, Brassington C, Pollard HK, Phillips C, Green I, Overman R, Collier M, Testoni E, Miller CJ, Hunter T, Sansom OJ, Brognard J.

Cancer Res. 2016 Feb 1;76(3):724-35. doi: 10.1158/0008-5472.CAN-15-0701-T. Epub 2015 Dec 4.

9.

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.

Johannes JW, Almeida L, Daly K, Ferguson AD, Grosskurth SE, Guan H, Howard T, Ioannidis S, Kazmirski S, Lamb ML, Larsen NA, Lyne PD, Mikule K, Ogoe C, Peng B, Petteruti P, Read JA, Su N, Sylvester M, Throner S, Wang W, Wang X, Wu J, Ye Q, Yu Y, Zheng X, Scott DA.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7. doi: 10.1016/j.bmcl.2015.10.079. Epub 2015 Oct 27.

PMID:
26546219
10.

The relationship between nutritional status, inflammatory markers and survival in patients with advanced cancer: a prospective cohort study.

Tan CS, Read JA, Phan VH, Beale PJ, Peat JK, Clarke SJ.

Support Care Cancer. 2015 Feb;23(2):385-91. doi: 10.1007/s00520-014-2385-y. Epub 2014 Aug 13.

PMID:
25112562
11.

Evaluating cell-of-origin subtype methods for predicting diffuse large B-cell lymphoma survival: a meta-analysis of gene expression profiling and immunohistochemistry algorithms.

Read JA, Koff JL, Nastoupil LJ, Williams JN, Cohen JB, Flowers CR.

Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):460-467.e2. doi: 10.1016/j.clml.2014.05.002. Epub 2014 Jun 12.

12.

Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.

Su Q, Ioannidis S, Chuaqui C, Almeida L, Alimzhanov M, Bebernitz G, Bell K, Block M, Howard T, Huang S, Huszar D, Read JA, Rivard Costa C, Shi J, Su M, Ye M, Zinda M.

J Med Chem. 2014 Jan 9;57(1):144-58. doi: 10.1021/jm401546n. Epub 2013 Dec 20.

PMID:
24359159
13.

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.

Hartkoorn RC, Pojer F, Read JA, Gingell H, Neres J, Horlacher OP, Altmann KH, Cole ST.

Nat Chem Biol. 2014 Feb;10(2):96-8. doi: 10.1038/nchembio.1405. Epub 2013 Dec 1.

PMID:
24292073
14.

Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis.

Shirude PS, Madhavapeddi P, Naik M, Murugan K, Shinde V, Nandishaiah R, Bhat J, Kumar A, Hameed S, Holdgate G, Davies G, McMiken H, Hegde N, Ambady A, Venkatraman J, Panda M, Bandodkar B, Sambandamurthy VK, Read JA.

J Med Chem. 2013 Nov 14;56(21):8533-42. doi: 10.1021/jm4012033. Epub 2013 Oct 25.

PMID:
24107081
15.

Stability and solubility engineering of the EphB4 tyrosine kinase catalytic domain using a rationally designed synthetic library.

Overman RC, Green I, Truman CM, Read JA, Embrey KJ, McAlister MS, Attwood TK.

Protein Eng Des Sel. 2013 Oct;26(10):695-704. doi: 10.1093/protein/gzt032. Epub 2013 Jul 8.

PMID:
23840071
16.

Physical effect of work on healthy individuals: implications for FCE testing.

Kyi MT, Fischer JA, Penner J, Read JA, Backman CL.

Work. 2012;42(2):233-9. doi: 10.3233/WOR-2012-1346.

PMID:
22699190
17.

Cell-cell membrane fusion induced by p15 fusion-associated small transmembrane (FAST) protein requires a novel fusion peptide motif containing a myristoylated polyproline type II helix.

Top D, Read JA, Dawe SJ, Syvitski RT, Duncan R.

J Biol Chem. 2012 Jan 27;287(5):3403-14. doi: 10.1074/jbc.M111.305268. Epub 2011 Dec 14.

18.

Biophysical and functional assays for viral membrane fusion peptides.

Read JA, Duncan R.

Methods. 2011 Oct;55(2):122-6. doi: 10.1016/j.ymeth.2011.09.010. Epub 2011 Sep 20.

PMID:
21958986
19.

Plaster cast burns: the reality.

Read JA, Ferguson N, Ricketts DM.

Emerg Med J. 2008 Dec;25(12):827-8. doi: 10.1136/emj.2007.053983.

PMID:
19033502
20.

Clavicular stress fracture in a cricket fast bowler: a case report.

Read JA, Bell P.

J Med Case Rep. 2008 Sep 19;2:306. doi: 10.1186/1752-1947-2-306.

21.

Massive haemorrhage following penetrating abdominal trauma.

Read JA, Ingram M.

J R Nav Med Serv. 2008;94(2):68-70. No abstract available.

PMID:
18711868
22.

Glycaemic control in critically ill patients with myotonic dystrophy.

Read JA, Bearfield P, Agarwal B.

Anaesthesia. 2008 Apr;63(4):444. doi: 10.1111/j.1365-2044.2008.05510.x. No abstract available.

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26.

Prospective comparison of sevoflurane and desflurane in formerly premature infants undergoing inguinal herniotomy.

Sale SM, Read JA, Stoddart PA, Wolf AR.

Br J Anaesth. 2006 Jun;96(6):774-8. Epub 2006 Apr 28.

27.

Emergence and recovery in children after desflurane and isoflurane anaesthesia: effect of anaesthetic duration.

Nordmann GR, Read JA, Sale SM, Stoddart PA, Wolf AR.

Br J Anaesth. 2006 Jun;96(6):779-85. Epub 2006 Apr 13.

28.

Nutritional assessment in cancer: comparing the Mini-Nutritional Assessment (MNA) with the scored Patient-Generated Subjective Global Assessment (PGSGA).

Read JA, Crockett N, Volker DH, MacLennan P, Choy ST, Beale P, Clarke SJ.

Nutr Cancer. 2005;53(1):51-6.

PMID:
16351506
30.

Dismutase activity of ADP-L-glycero-D-manno-heptose 6-epimerase: evidence for a direct oxidation/reduction mechanism.

Morrison JP, Read JA, Coleman WG Jr, Tanner ME.

Biochemistry. 2005 Apr 19;44(15):5907-15.

PMID:
15823050
31.

The mechanism of the reaction catalyzed by ADP-beta-L-glycero-D-manno-heptose 6-epimerase.

Read JA, Ahmed RA, Morrison JP, Coleman WG Jr, Tanner ME.

J Am Chem Soc. 2004 Jul 28;126(29):8878-9.

PMID:
15264802
32.

Baseline nutritional assessment in advanced cancer patients receiving palliative chemotherapy.

Slaviero KA, Read JA, Clarke SJ, Rivory LP.

Nutr Cancer. 2003;46(2):148-57.

PMID:
14690790
33.

Organisation of truck-driver training for the transportation of dangerous goods in Europe and North America.

Kuncyté R, Laberge-Nadeau C, Crainic TG, Read JA.

Accid Anal Prev. 2003 Mar;35(2):191-200.

PMID:
12504140
34.

Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.

Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL.

Proteins. 2001 May 1;43(2):175-85.

PMID:
11276087
35.

Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.

Tranter R, Read JA, Jones R, Brady RL.

Structure. 2000 Nov 15;8(11):1179-88.

36.

Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD).

Powell AJ, Read JA, Banfield MJ, Gunn-Moore F, Yan SD, Lustbader J, Stern AR, Stern DM, Brady RL.

J Mol Biol. 2000 Oct 20;303(2):311-27.

PMID:
11023795
37.

Purification, co-crystallization and preliminary X--ray analysis of the natural aspartic proteinase inhibitor IA3 complexed with saccharopepsin from Saccharomyces cerevisiae.

Badasso MO, Read JA, Dhanaraj V, Cooper JB, Wood SP, Blundell TL, Dreyer T, Winther J.

Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):915-7.

PMID:
10930843
38.

Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.

Read JA, Wilkinson KW, Tranter R, Sessions RB, Brady RL.

J Biol Chem. 1999 Apr 9;274(15):10213-8.

39.

Prenatal maternal blood pressure response to stress predicts birth weight and gestational age: a preliminary study.

McCubbin JA, Lawson EJ, Cox S, Sherman JJ, Norton JA, Read JA.

Am J Obstet Gynecol. 1996 Sep;175(3 Pt 1):706-12.

PMID:
8828438
40.

Risk factors for preterm delivery in a healthy cohort.

Adams MM, Sarno AP, Harlass FE, Rawlings JS, Read JA.

Epidemiology. 1995 Sep;6(5):525-32.

PMID:
8562630
41.
42.

Antenatal hospitalization among enlisted servicewomen, 1987-1990.

Adams MM, Harlass FE, Sarno AP, Read JA, Rawlings JS.

Obstet Gynecol. 1994 Jul;84(1):35-9.

PMID:
8008319
43.

Preterm delivery among black and white enlisted women in the United States Army.

Adams MM, Read JA, Rawlings JS, Harlass FB, Sarno AP, Rhodes PH.

Obstet Gynecol. 1993 Jan;81(1):65-71.

PMID:
8416464
44.

Risk of chromosomal abnormalities in patients with idiopathic polyhydramnios.

Brady K, Polzin WJ, Kopelman JN, Read JA.

Obstet Gynecol. 1992 Feb;79(2):234-8.

PMID:
1731291
45.

The association of antiphospholipid antibodies with pregnancies complicated by fetal growth restriction.

Polzin WJ, Kopelman JN, Robinson RD, Read JA, Brady K.

Obstet Gynecol. 1991 Dec;78(6):1108-11.

PMID:
1945217
46.

A simple method of separation of Pneumocystis carinii from rat lung.

Read JA, Burns SM.

Int J Exp Pathol. 1991 Dec;72(6):673-7.

47.

Screening for illicit drug use in a military obstetric population.

Polzin WJ, Kopelman JN, Brady K, Read JA.

Obstet Gynecol. 1991 Oct;78(4):600-1.

PMID:
1923161
48.

Sonographic evidence of fetal hydrothorax after in-utero death of monozygotic twin.

Yancey MK, Brady K, Read JA.

J Clin Ultrasound. 1991 Mar-Apr;19(3):162-6. No abstract available.

PMID:
1849923
49.

Use of a standard preparatory diet for the oral glucose tolerance test. Is it necessary?

Harlass FE, McClure GB, Read JA, Brady K.

J Reprod Med. 1991 Feb;36(2):147-50.

PMID:
2010899
50.

Reproducibility of the oral glucose tolerance test in pregnancy.

Harlass FE, Brady K, Read JA.

Am J Obstet Gynecol. 1991 Feb;164(2):564-8.

PMID:
1992702

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