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Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL.

JCI Insight. 2016 Sep 22;1(15):e88843. doi: 10.1172/jci.insight.88843.


S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.

Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL.

PLoS Pathog. 2016 Jun 29;12(6):e1005705. doi: 10.1371/journal.ppat.1005705. eCollection 2016 Jun.


IL-27 Suppresses Antimicrobial Activity in Human Leprosy.

Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL.

J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.


Recognizing and managing the immunologic reactions in leprosy.

Kamath S, Vaccaro SA, Rea TH, Ochoa MT.

J Am Acad Dermatol. 2014 Oct;71(4):795-803. doi: 10.1016/j.jaad.2014.03.034. Epub 2014 Apr 24. Review.


A comparison of stigma among patients with leprosy in rural Tanzania and urban United States: a role for public health in dermatology.

Roosta N, Black DS, Rea TH.

Int J Dermatol. 2013 Apr;52(4):432-40. doi: 10.1111/j.1365-4632.2011.05226.x. Epub 2013 Mar 3.


Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.

Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL.

Science. 2013 Mar 22;339(6126):1448-53. doi: 10.1126/science.1233665. Epub 2013 Feb 28.


Galectin-3 regulates the innate immune response of human monocytes.

Chung AW, Sieling PA, Schenk M, Teles RM, Krutzik SR, Hsu DK, Liu FT, Sarno EN, Rea TH, Stenger S, Modlin RL, Lee DJ.

J Infect Dis. 2013 Mar 15;207(6):947-56. doi: 10.1093/infdis/jis920. Epub 2012 Dec 18.


NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.

Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL.

Nat Med. 2012 Mar 25;18(4):555-63. doi: 10.1038/nm.2650.


MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy.

Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Mehta MD, Vazirnia A, Rea TH, Sarno EN, Graeber TG, Modlin RL.

Nat Med. 2012 Jan 29;18(2):267-73. doi: 10.1038/nm.2584.


A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy.

Ochoa MT, Teles R, Haas BE, Zaghi D, Li H, Sarno EN, Rea TH, Modlin RL, Lee DJ.

Immunology. 2010 Nov;131(3):405-14. doi: 10.1111/j.1365-2567.2010.03314.x.


Latapi's lepromatosis (Lucio's leprosy) without Lucio's phenomenon in a pubertal boy.

Rea TH.

Lepr Rev. 2009 Dec;80(4):445-7. No abstract available.


Integrated pathways for neutrophil recruitment and inflammation in leprosy.

Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL.

J Infect Dis. 2010 Feb 15;201(4):558-69. doi: 10.1086/650318.


Comparative genomic and phylogeographic analysis of Mycobacterium leprae.

Monot M, Honoré N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD, Bouwman A, Mays S, Watson C, Lockwood D, Khamesipour A, Dowlati Y, Jianping S, Rea TH, Vera-Cabrera L, Stefani MM, Banu S, Macdonald M, Sapkota BR, Spencer JS, Thomas J, Harshman K, Singh P, Busso P, Gattiker A, Rougemont J, Brennan PJ, Cole ST.

Nat Genet. 2009 Dec;41(12):1282-9. doi: 10.1038/ng.477. Epub 2009 Nov 1. Erratum in: Nat Genet. 2010 Apr;42(4):361. Khamispour, Ali [corrected to Khamesipour, Ali].


Divergence of macrophage phagocytic and antimicrobial programs in leprosy.

Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL.

Cell Host Microbe. 2009 Oct 22;6(4):343-53. doi: 10.1016/j.chom.2009.09.002.


Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses.

Tanaka M, Krutzik SR, Sieling PA, Lee DJ, Rea TH, Modlin RL.

J Immunol. 2009 Aug 15;183(4):2349-55. doi: 10.4049/jimmunol.0801683. Epub 2009 Jul 27.


Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy.

Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL.

J Clin Invest. 2008 Aug;118(8):2917-28. doi: 10.1172/JCI34189.


Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation.

Sieling PA, Hill PJ, Dobos KM, Brookman K, Kuhlman AM, Fabri M, Krutzik SR, Rea TH, Heaslip DG, Belisle JT, Modlin RL.

J Immunol. 2008 May 1;180(9):5833-42.


Leprosy as immune reconstitution inflammatory syndrome in HIV-positive persons.

Martiniuk F, Rao SD, Rea TH, Glickman MS, Giovinazzo J, Rom WN, Cabrera A, Levis WR.

Emerg Infect Dis. 2007 Sep;13(9):1438-40. doi: 10.3201/eid1309.070301. No abstract available.


Angiogenesis in cutaneous lesions of leprosy: implications for treatment.

Bhandarkar SS, Cohen C, Kuruvila M, Rea TH, Mackelfresh JB, Lee DJ, Modlin RL, Arbiser JL.

Arch Dermatol. 2007 Dec;143(12):1527-9.


LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells.

Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL.

J Immunol. 2007 Dec 15;179(12):8128-36.


Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences.

Niazi KR, Ochoa MT, Sieling PA, Rooke NE, Peter AK, Mollahan P, Dickey M, Rabizadeh S, Rea TH, Modlin RL.

Immunology. 2007 Dec;122(4):522-31. Epub 2007 Jul 16.


Regulation of human T-cell homing receptor expression in cutaneous bacterial infection.

Sieling PA, Legaspi A, Ochoa MT, Rea TH, Modlin RL.

Immunology. 2007 Apr;120(4):518-25.


Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion.

Sabet S, Ochoa MT, Sieling PA, Rea TH, Modlin RL.

Immunology. 2007 Mar;120(3):354-61. Epub 2006 Nov 28.


TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.

Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL.

Nat Med. 2005 Jun;11(6):653-60. Epub 2005 May 8.


The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens.

Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Porcelli SA, Modlin RL.

J Immunol. 2005 Mar 1;174(5):2637-44.


Reversal reaction occurring 16 years after beginning antibacterial treatment.

Rea TH.

Lepr Rev. 2004 Mar;75(1):86-90. No abstract available.


Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.

Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL.

J Clin Invest. 2004 Mar;113(5):701-8.


Use of genetic profiling in leprosy to discriminate clinical forms of the disease.

Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL.

Science. 2003 Sep 12;301(5639):1527-30.


Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.

Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL.

Nat Med. 2003 May;9(5):525-32. Epub 2003 Apr 14.


Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy.

Oliveira RB, Ochoa MT, Sieling PA, Rea TH, Rambukkana A, Sarno EN, Modlin RL.

Infect Immun. 2003 Mar;71(3):1427-33.


Elevated platelet counts and thrombocytosis in erythema nodosum leprosum.

Rea TH.

Int J Lepr Other Mycobact Dis. 2002 Sep;70(3):167-73.


A role for IL-12 receptor expression and signal transduction in host defense in leprosy.

Kim J, Uyemura K, Van Dyke MK, Legaspi AJ, Rea TH, Shuai K, Modlin RL.

J Immunol. 2001 Jul 15;167(2):779-86.


Frequency and extent of thickening of the nucleated epidermis in leprosy lesions.

Rea TH.

Int J Lepr Other Mycobact Dis. 2000 Dec;68(4):410-6.


Role of granulysin in immunity to leprosy.

Ochoa MT, Thoma-Uszynski S, Sieling PA, Sabet S, Cho S, Krensky AM, Burdick A, Rea TH, Modlin RL.

Lepr Rev. 2000 Dec;71 Suppl:S115; discussion S115-6. No abstract available.


T-cell release of granulysin contributes to host defense in leprosy.

Ochoa MT, Stenger S, Sieling PA, Thoma-Uszynski S, Sabet S, Cho S, Krensky AM, Rollinghoff M, Nunes Sarno E, Burdick AE, Rea TH, Modlin RL.

Nat Med. 2001 Feb;7(2):174-9.


A role for CD40-CD40 ligand interactions in the generation of type 1 cytokine responses in human leprosy.

Yamauchi PS, Bleharski JR, Uyemura K, Kim J, Sieling PA, Miller A, Brightbill H, Schlienger K, Rea TH, Modlin RL.

J Immunol. 2000 Aug 1;165(3):1506-12.


Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions.

Sieling PA, Ochoa MT, Jullien D, Leslie DS, Sabet S, Rosat JP, Burdick AE, Rea TH, Brenner MB, Porcelli SA, Modlin RL.

J Immunol. 2000 May 1;164(9):4790-6.


IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection.

García VE, Uyemura K, Sieling PA, Ochoa MT, Morita CT, Okamura H, Kurimoto M, Rea TH, Modlin RL.

J Immunol. 1999 May 15;162(10):6114-21.


CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity.

Sieling PA, Jullien D, Dahlem M, Tedder TF, Rea TH, Modlin RL, Porcelli SA.

J Immunol. 1999 Feb 1;162(3):1851-8.


Delayed-type hypersensitivity reactions followed by erythema nodosum leprosum.

Rea TH, Sieling PA.

Int J Lepr Other Mycobact Dis. 1998 Sep;66(3):316-27.


B7-1, but not CD28, is crucial for the maintenance of the CD4+ T cell responses in human leprosy.

Schlienger K, Uyemura K, Jullien D, Sieling PA, Rea TH, Linsley PS, Modlin RL.

J Immunol. 1998 Sep 1;161(5):2407-13.


Silicone oil prevention of insensitive pressure ulcers.

Balkin SW, Rea TH, Kaplan L.

Int J Lepr Other Mycobact Dis. 1997 Sep;65(3):372-4. No abstract available. Erratum in: Int J Lepr Other Mycobact Dis 1998 Dec;66(4):following 609.


Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue.

Kim J, Sette A, Rodda S, Southwood S, Sieling PA, Mehra V, Ohmen JD, Oliveros J, Appella E, Higashimoto Y, Rea TH, Bloom BR, Modlin RL.

J Immunol. 1997 Jul 1;159(1):335-43.


Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy.

Libraty DH, Airan LE, Uyemura K, Jullien D, Spellberg B, Rea TH, Modlin RL.

J Clin Invest. 1997 Jan 15;99(2):336-41.


IL-15, an immunomodulator of T cell responses in intracellular infection.

Jullien D, Sieling PA, Uyemura K, Mar ND, Rea TH, Modlin RL.

J Immunol. 1997 Jan 15;158(2):800-6.


IL-7 in the cell-mediated immune response to a human pathogen.

Sieling PA, Sakimura L, Uyemura K, Yamamura M, Oliveros J, Nickoloff BJ, Rea TH, Modlin RL.

J Immunol. 1995 Mar 15;154(6):2775-83.


St. John Dermatological Society Oration, 1994. Immune responses in leprosy, cytokines and new archetypes for dermatology.

Rea TH.

Clin Exp Dermatol. 1995 Mar;20(2):89-97. Review. No abstract available.


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