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Items: 44

1.

An FTLD-associated SQSTM1 variant impacts Nrf2 and NF-κB signalling and is associated with reduced phosphorylation of p62.

Foster A, Scott D, Layfield R, Rea SL.

Mol Cell Neurosci. 2019 Jul;98:32-45. doi: 10.1016/j.mcn.2019.04.001. Epub 2019 Apr 4.

PMID:
30954537
2.

Targeted sequencing of DCSTAMP in familial Paget's disease of bone.

Sultana MA, Pavlos NJ, Ward L, Walsh JP, Rea SL.

Bone Rep. 2019 Feb 21;10:100198. doi: 10.1016/j.bonr.2019.100198. eCollection 2019 Jun.

3.

BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans.

Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N.

EMBO Rep. 2018 Dec;19(12). pii: e45856. doi: 10.15252/embr.201845856. Epub 2018 Oct 26.

4.

The Changing Presentation of Paget's Disease of Bone in Australia, A High Prevalence Region.

Britton C, Brown S, Ward L, Rea SL, Ratajczak T, Walsh JP.

Calcif Tissue Int. 2017 Dec;101(6):564-569. doi: 10.1007/s00223-017-0312-1. Epub 2017 Sep 7.

PMID:
28884211
5.

The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor.

Ward BK, Rea SL, Magno AL, Pedersen B, Brown SJ, Mullin S, Arulpragasam A, Ingley E, Conigrave AD, Ratajczak T.

J Cell Physiol. 2018 Jan;233(1):38-56. doi: 10.1002/jcp.25957. Epub 2017 Jun 5.

6.

CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System.

Kar A, Beam H, Borror MB, Luckow M, Gao X, Rea SL.

PLoS One. 2016 Sep 7;11(9):e0162165. doi: 10.1371/journal.pone.0162165. eCollection 2016.

7.

DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.

Munkácsy E, Khan MH, Lane RK, Borror MB, Park JH, Bokov AF, Fisher AL, Link CD, Rea SL.

PLoS Genet. 2016 Jul 15;12(7):e1006133. doi: 10.1371/journal.pgen.1006133. eCollection 2016 Jul.

8.

Bafilomycin A1 Attenuates Osteoclast Acidification and Formation, Accompanied by Increased Levels of SQSTM1/p62 Protein.

Zhu S, Rea SL, Cheng T, Feng HT, Walsh JP, Ratajczak T, Tickner J, Pavlos N, Xu HZ, Xu J.

J Cell Biochem. 2016 Jun;117(6):1464-70. doi: 10.1002/jcb.25442. Epub 2015 Nov 26.

PMID:
27043248
9.

Mitochondrial metabolites extend lifespan.

Mishur RJ, Khan M, Munkácsy E, Sharma L, Bokov A, Beam H, Radetskaya O, Borror M, Lane R, Bai Y, Rea SL.

Aging Cell. 2016 Apr;15(2):336-48. doi: 10.1111/acel.12439. Epub 2016 Jan 5.

10.

The role of mitochondrial dysfunction in age-related diseases.

Lane RK, Hilsabeck T, Rea SL.

Biochim Biophys Acta. 2015 Nov;1847(11):1387-400. doi: 10.1016/j.bbabio.2015.05.021. Epub 2015 Jun 4. Review.

11.

L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.

Shim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, Kho EY, Ghosh AP, Kirkman R, Velu S, Dutta S, Chenna B, Rea SL, Mishur RJ, Li Q, Johnson-Pais TL, Guo L, Bae S, Wei S, Block K, Sudarshan S.

Cancer Discov. 2014 Nov;4(11):1290-8. doi: 10.1158/2159-8290.CD-13-0696. Epub 2014 Sep 2.

12.

The paradox of mitochondrial dysfunction and extended longevity.

Munkácsy E, Rea SL.

Exp Gerontol. 2014 Aug;56:221-33. doi: 10.1016/j.exger.2014.03.016. Epub 2014 Apr 1. Review.

13.

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function.

Goode A, Long JE, Shaw B, Ralston SH, Visconti MR, Gianfrancesco F, Esposito T, Gennari L, Merlotti D, Rendina D, Rea SL, Sultana M, Searle MS, Layfield R.

Biochim Biophys Acta. 2014 Jul;1842(7):992-1000. doi: 10.1016/j.bbadis.2014.03.006. Epub 2014 Mar 16.

14.

SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

Rea SL, Majcher V, Searle MS, Layfield R.

Exp Cell Res. 2014 Jul 1;325(1):27-37. doi: 10.1016/j.yexcr.2014.01.020. Epub 2014 Jan 30. Review.

PMID:
24486447
15.

TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.

Khan MH, Ligon M, Hussey LR, Hufnal B, Farber R 2nd, Munkácsy E, Rodriguez A, Dillow A, Kahlig E, Rea SL.

Aging (Albany NY). 2013 Oct;5(10):741-58.

16.

Exometabolomic mapping of Caenorhabditis elegans: a tool to noninvasively investigate aging.

Mishur RJ, Butler JA, Rea SL.

Methods Mol Biol. 2013;1048:195-213. doi: 10.1007/978-1-62703-556-9_15.

PMID:
23929107
17.

The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones.

Cluning C, Ward BK, Rea SL, Arulpragasam A, Fuller PJ, Ratajczak T.

Mol Endocrinol. 2013 Jul;27(7):1020-35. doi: 10.1210/me.2012-1023. Epub 2013 May 17.

18.

Common susceptibility alleles and SQSTM1 mutations predict disease extent and severity in a multinational study of patients with Paget's disease.

Albagha OM, Visconti MR, Alonso N, Wani S, Goodman K, Fraser WD, Gennari L, Merlotti D, Gianfrancesco F, Esposito T, Rendina D, di Stefano M, Isaia G, Brandi ML, Giusti F, Del Pino-Montes J, Corral-Gudino L, Gonzalez-Sarmiento R, Ward L, Rea SL, Ratajczak T, Walsh JP, Ralston SH.

J Bone Miner Res. 2013 Nov;28(11):2338-46. doi: 10.1002/jbmr.1975.

19.

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.

Rea SL, Walsh JP, Layfield R, Ratajczak T, Xu J.

Endocr Rev. 2013 Aug;34(4):501-24. doi: 10.1210/er.2012-1034. Epub 2013 Apr 23. Review.

PMID:
23612225
20.

Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans.

Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condò I, Bei R, Rea SL, Braeckman BP, Tavernarakis N, Testi R, Ventura N.

Exp Gerontol. 2013 Feb;48(2):191-201. doi: 10.1016/j.exger.2012.12.002. Epub 2012 Dec 13. Erratum in: Exp Gerontol. 2013 Sep;48(9):1001.

21.

A metabolic signature for long life in the Caenorhabditis elegans Mit mutants.

Butler JA, Mishur RJ, Bhaskaran S, Rea SL.

Aging Cell. 2013 Feb;12(1):130-8. doi: 10.1111/acel.12029.

22.

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

Wright T, Rea SL, Goode A, Bennett AJ, Ratajczak T, Long JE, Searle MS, Goldring CE, Park BK, Copple IM, Layfield R.

Bone. 2013 Feb;52(2):699-706. doi: 10.1016/j.bone.2012.10.023. Epub 2012 Oct 29.

PMID:
23117207
23.

Profiling the anaerobic response of C. elegans using GC-MS.

Butler JA, Mishur RJ, Bokov AF, Hakala KW, Weintraub ST, Rea SL.

PLoS One. 2012;7(9):e46140. doi: 10.1371/journal.pone.0046140. Epub 2012 Sep 27.

24.

Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol.

Davis VL, Newbold RR, Couse JF, Rea SL, Gallagher KM, Hamilton KJ, Goulding EH, Jefferson W, Eddy EM, Bullock BC, Korach KS.

Reprod Toxicol. 2012 Dec;34(4):512-21. doi: 10.1016/j.reprotox.2012.08.005. Epub 2012 Aug 31.

25.

Inhibition of Neu-induced mammary carcinogenesis in transgenic mice expressing ERΔ3, a dominant negative estrogen receptor α variant.

Davis VL, Shaikh F, Gallagher KM, Villegas M, Rea SL, Cline JM, Hughes CL.

Horm Cancer. 2012 Dec;3(5-6):227-39. doi: 10.1007/s12672-012-0122-x. Epub 2012 Sep 12.

PMID:
22968785
26.

The role of MAP4K3 in lifespan regulation of Caenorhabditis elegans.

Khan MH, Hart MJ, Rea SL.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):413-8. doi: 10.1016/j.bbrc.2012.07.113. Epub 2012 Jul 27.

PMID:
22846570
27.

Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.

Albagha OM, Wani SE, Visconti MR, Alonso N, Goodman K, Brandi ML, Cundy T, Chung PY, Dargie R, Devogelaer JP, Falchetti A, Fraser WD, Gennari L, Gianfrancesco F, Hooper MJ, Van Hul W, Isaia G, Nicholson GC, Nuti R, Papapoulos S, Montes Jdel P, Ratajczak T, Rea SL, Rendina D, Gonzalez-Sarmiento R, Di Stefano M, Ward LC, Walsh JP, Ralston SH; Genetic Determinants of Paget's Disease (GDPD) Consortium.

Nat Genet. 2011 May 29;43(7):685-9. doi: 10.1038/ng.845.

28.

Applications of mass spectrometry to metabolomics and metabonomics: detection of biomarkers of aging and of age-related diseases.

Mishur RJ, Rea SL.

Mass Spectrom Rev. 2012 Jan-Feb;31(1):70-95. doi: 10.1002/mas.20338. Epub 2011 Apr 28. Review.

PMID:
21538458
29.

Breaking Caenorhabditis elegans the easy way using the Balch homogenizer: an old tool for a new application.

Bhaskaran S, Butler JA, Becerra S, Fassio V, Girotti M, Rea SL.

Anal Biochem. 2011 Jun 15;413(2):123-32. doi: 10.1016/j.ab.2011.02.029. Epub 2011 Feb 24.

30.

Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases.

Rea SL, Graham BH, Nakamaru-Ogiso E, Kar A, Falk MJ.

Dev Disabil Res Rev. 2010;16(2):200-18. doi: 10.1002/ddrr.114. Review.

31.

Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism.

Butler JA, Ventura N, Johnson TE, Rea SL.

FASEB J. 2010 Dec;24(12):4977-88. doi: 10.1096/fj.10-162941. Epub 2010 Aug 23.

32.

Mortality shifts in Caenorhabditis elegans: remembrance of conditions past.

Wu D, Rea SL, Cypser JR, Johnson TE.

Aging Cell. 2009 Dec;8(6):666-75. doi: 10.1111/j.1474-9726.2009.00523.x. Epub 2009 Oct 11.

33.

p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.

Ventura N, Rea SL, Schiavi A, Torgovnick A, Testi R, Johnson TE.

Aging Cell. 2009 Aug;8(4):380-93. doi: 10.1111/j.1474-9726.2009.00482.x. Epub 2009 Apr 22.

34.

Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades.

Ang E, Pavlos NJ, Rea SL, Qi M, Chai T, Walsh JP, Ratajczak T, Zheng MH, Xu J.

J Cell Physiol. 2009 Aug;220(2):450-9. doi: 10.1002/jcp.21787.

PMID:
19365810
35.

Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.

Rea SL, Walsh JP, Ward L, Magno AL, Ward BK, Shaw B, Layfield R, Kent GN, Xu J, Ratajczak T.

J Bone Miner Res. 2009 Jul;24(7):1216-23. doi: 10.1359/jbmr.090214.

36.

Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.

Rea SL, Ventura N, Johnson TE.

PLoS Biol. 2007 Oct 2;5(10):e259. Erratum in: PLoS Biol. 2008 Jan;6(1):e23. PLoS Biol. 2008 Mar;6(3):e78. PLoS Biol. 2008 May;6(5):e136.

37.
39.

Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases.

Ventura N, Rea SL, Testi R.

Exp Gerontol. 2006 Oct;41(10):974-91. Epub 2006 Sep 1. Review.

PMID:
16945497
40.

A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signaling and Paget's disease of bone with a severe phenotype.

Rea SL, Walsh JP, Ward L, Yip K, Ward BK, Kent GN, Steer JH, Xu J, Ratajczak T.

J Bone Miner Res. 2006 Jul;21(7):1136-45.

41.

C. elegans as a model for Friedreich Ataxia.

Ventura N, Rea SL, Handerson ST, Condò I, Testi R, Johnson TE.

FASEB J. 2006 May;20(7):1029-30. No abstract available.

PMID:
16675853
42.

Visualizing hidden heterogeneity in isogenic populations of C. elegans.

Wu D, Rea SL, Yashin AI, Johnson TE.

Exp Gerontol. 2006 Mar;41(3):261-70. Epub 2006 Feb 9.

PMID:
16480844
43.

Metabolism in the Caenorhabditis elegans Mit mutants.

Rea SL.

Exp Gerontol. 2005 Nov;40(11):841-9. Epub 2005 Aug 30. Review. Erratum in: Exp Gerontol. 2006 Mar;41(3):338.

PMID:
16137850
44.

A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.

Rea SL, Wu D, Cypser JR, Vaupel JW, Johnson TE.

Nat Genet. 2005 Aug;37(8):894-8. Epub 2005 Jul 24.

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