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Items: 31

1.

Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism.

Thompson JM, Alvarez A, Singha MK, Pavesic MW, Nguyen QH, Nelson LJ, Fruman DA, Razorenova OV.

Mol Cancer Ther. 2018 Aug;17(8):1781-1792. doi: 10.1158/1535-7163.MCT-17-1076. Epub 2018 May 2.

2.

CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation.

Wright HJ, Hou J, Xu B, Cortez M, Potma EO, Tromberg BJ, Razorenova OV.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6556-E6565. doi: 10.1073/pnas.1703791114. Epub 2017 Jul 24.

3.

Targeting the RhoGTPase/ROCK pathway for the treatment of VHL/HIF pathway-driven cancers.

Thompson JM, Landman J, Razorenova OV.

Small GTPases. 2017 Jun 20:1-7. doi: 10.1080/21541248.2017.1336193. [Epub ahead of print]

PMID:
28632992
4.

KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage.

Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ.

Nucleic Acids Res. 2017 Apr 20;45(7):3674-3692. doi: 10.1093/nar/gkw1281.

5.

Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma.

Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV.

Oncogene. 2017 Feb 23;36(8):1080-1089. doi: 10.1038/onc.2016.272. Epub 2016 Nov 14.

6.

Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering.

Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA.

Acta Biomater. 2016 Oct 1;43:122-138. doi: 10.1016/j.actbio.2016.07.043. Epub 2016 Jul 27.

7.

Targeting CDCP1 dimerization in triple-negative breast cancer.

Wright HJ, Police AM, Razorenova OV.

Cell Cycle. 2016 Sep 16;15(18):2385-6. doi: 10.1080/15384101.2016.1204849. Epub 2016 Jun 30. No abstract available.

8.

Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption.

Hou J, Wright HJ, Chan N, Tran R, Razorenova OV, Potma EO, Tromberg BJ.

J Biomed Opt. 2016 Jun 1;21(6):60503. doi: 10.1117/1.JBO.21.6.060503.

9.

CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer.

Wright HJ, Arulmoli J, Motazedi M, Nelson LJ, Heinemann FS, Flanagan LA, Razorenova OV.

Oncogene. 2016 Sep 8;35(36):4762-72. doi: 10.1038/onc.2016.7. Epub 2016 Feb 15.

10.

Approaches to identifying synthetic lethal interactions in cancer.

Thompson JM, Nguyen QH, Singh M, Razorenova OV.

Yale J Biol Med. 2015 Jun 1;88(2):145-55. eCollection 2015 Jun. Review.

11.

The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells.

Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ.

Mol Cell Biol. 2014 Feb;34(4):739-51. doi: 10.1128/MCB.00644-12. Epub 2013 Dec 16.

12.

Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.

Chernikova SB, Razorenova OV, Higgins JP, Sishc BJ, Nicolau M, Dorth JA, Chernikova DA, Kwok S, Brooks JD, Bailey SM, Game JC, Brown JM.

Cancer Res. 2012 Apr 15;72(8):2111-9. doi: 10.1158/0008-5472.CAN-11-2209. Epub 2012 Feb 21.

13.

Brain and muscle ARNT-like protein BMAL1 regulates ROS homeostasis and senescence: a possible link to hypoxia-inducible factor-mediated pathway.

Razorenova OV.

Cell Cycle. 2012 Jan 15;11(2):213-4. doi: 10.4161/cc.11.2.18786. Epub 2012 Jan 15. No abstract available.

PMID:
22223094
14.

VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.

Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1931-6. doi: 10.1073/pnas.1011777108. Epub 2011 Jan 13.

15.

Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.

Chernikova SB, Dorth JA, Razorenova OV, Game JC, Brown JM.

Radiat Res. 2010 Nov;174(5):558-65. doi: 10.1667/RR2184.1. Epub 2010 Aug 25.

16.

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271.

Boiko AD, Razorenova OV, van de Rijn M, Swetter SM, Johnson DL, Ly DP, Butler PD, Yang GP, Joshua B, Kaplan MJ, Longaker MT, Weissman IL.

Nature. 2010 Jul 1;466(7302):133-7. doi: 10.1038/nature09161. Erratum in: Nature. 2011 Feb 17;470(7334):424.

17.

Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.

Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ.

Mol Cell Biol. 2010 Jan;30(1):344-53. doi: 10.1128/MCB.00444-09.

18.

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans.

Malinin NL, Zhang L, Choi J, Ciocea A, Razorenova O, Ma YQ, Podrez EA, Tosi M, Lennon DP, Caplan AI, Shurin SB, Plow EF, Byzova TV.

Nat Med. 2009 Mar;15(3):313-8. doi: 10.1038/nm.1917. Epub 2009 Feb 22.

19.

Integrin affinity modulation in angiogenesis.

Mahabeleshwar GH, Chen J, Feng W, Somanath PR, Razorenova OV, Byzova TV.

Cell Cycle. 2008 Feb 1;7(3):335-47. Epub 2007 Nov 1.

20.

Akt1 in endothelial cell and angiogenesis.

Somanath PR, Razorenova OV, Chen J, Byzova TV.

Cell Cycle. 2006 Mar;5(5):512-8. Epub 2006 Mar 1. Review.

21.

A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.

Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV.

Genes Dev. 2006 Jan 15;20(2):236-52.

22.

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.

Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV.

Nat Med. 2005 Nov;11(11):1188-96. Epub 2005 Oct 16.

23.

VEGF-integrin interplay controls tumor growth and vascularization.

De S, Razorenova O, McCabe NP, O'Toole T, Qin J, Byzova TV.

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7589-94. Epub 2005 May 16.

24.

[Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors].

Razorenova OV, Agapova LS, Budanov AV, Ivanov AV, Strunina SM, Chumakov PM.

Mol Biol (Mosk). 2005 Mar-Apr;39(2):286-93. Russian.

25.

Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium.

Narizhneva NV, Razorenova OV, Podrez EA, Chen J, Chandrasekharan UM, DiCorleto PE, Plow EF, Topol EJ, Byzova TV.

FASEB J. 2005 Jul;19(9):1158-60. Epub 2005 Apr 15.

26.

Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1.

Razorenova OV, Ivanov AV, Budanov AV, Chumakov PM.

Gene. 2005 Apr 25;350(1):89-98.

27.

p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.

Gurova KV, Hill JE, Razorenova OV, Chumakov PM, Gudkov AV.

Cancer Res. 2004 Mar 15;64(6):1951-8.

28.

[Mobile genetic element MDG4 (gypsy) in Drosophila melanogaster. Features of structure and regulation of transposition].

Kusulidu LK, Karpova NN, Razorenova OV, Glukhov IA, Kim AI, Liubomirskaia NV, Il'in IuV.

Genetika. 2001 Dec;37(12):1589-97. Russian.

PMID:
11785284
29.

Two variants of the Drosophila melanogaster retrotransposon gypsy (mdg4): structural and functional differences, and distribution in fly stocks.

Lyubomirskaya NV, Smirnova JB, Razorenova OV, Karpova NN, Surkov SA, Avedisov SN, Kim AI, Ilyin YV.

Mol Genet Genomics. 2001 Apr;265(2):367-74.

PMID:
11361349
30.

[Interlineage distribution and characteristics of the structure of two subfamilies of Drosophila melanogaster MDG4 (gypsy) retrotransposon].

Razorenova OV, Karpova NN, Smirnova IuB, Kusulidu LK, Reneva NK, Subocheva EA, Kim AI, Liubomirskaia NV, Il'in IuV.

Genetika. 2001 Feb;37(2):175-82. Russian.

PMID:
11253423
31.

[Genomic factors regulating the transposition of drosophila mobile elements].

Kim AI, Pasiukova EG, Karpova NN, Razorenova OV.

Genetika. 1999 Nov;35(11):1511-21. Review. Russian.

PMID:
10624574

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