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Items: 1 to 50 of 54

1.

Metformin abrogates age-associated ovarian fibrosis.

McCloskey CW, Cook DP, Kelly BS, Azzi F, Allen CH, Forsyth-Greig A, Upham J, Rayner KJ, Gray DA, Boyd RW, Murugkar S, Lo B, Trudel D, Senterman MK, Vanderhyden BC.

Clin Cancer Res. 2019 Oct 9. pii: clincanres.0603.2019. doi: 10.1158/1078-0432.CCR-19-0603. [Epub ahead of print]

PMID:
31597663
2.

Resolvin D1 promotes the targeting and clearance of necroptotic cells.

Gerlach BD, Marinello M, Heinz J, Rymut N, Sansbury BE, Riley CO, Sadhu S, Hosseini Z, Kojima Y, Tang DD, Leeper NJ, Spite M, Barroso M, Rayner KJ, Fredman G.

Cell Death Differ. 2019 Jun 20. doi: 10.1038/s41418-019-0370-1. [Epub ahead of print]

PMID:
31222041
3.

Delivery of MicroRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux in Vitro and in Vivo.

Nguyen MA, Wyatt H, Susser L, Geoffrion M, Rasheed A, Duchez AC, Cottee ML, Afolayan E, Farah E, Kahiel Z, Côté M, Gadde S, Rayner KJ.

ACS Nano. 2019 Jun 25;13(6):6491-6505. doi: 10.1021/acsnano.8b09679. Epub 2019 Jun 12.

PMID:
31125197
4.

Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions.

Crane ED, Al-Hashimi AA, Chen J, Lynn EG, Won KD, Lhoták Š, Naeim M, Platko K, Lebeau P, Byun JH, Shayegan B, Krepinsky JC, Rayner KJ, Marchiò S, Pasqualini R, Arap W, Austin RC.

JCI Insight. 2018 Dec 20;3(24). pii: 99363. doi: 10.1172/jci.insight.99363.

5.

Collagen biomaterial stimulates the production of extracellular vesicles containing microRNA-21 and enhances the proangiogenic function of CD34+ cells.

McNeill B, Ostojic A, Rayner KJ, Ruel M, Suuronen EJ.

FASEB J. 2019 Mar;33(3):4166-4177. doi: 10.1096/fj.201801332R. Epub 2018 Dec 7.

PMID:
30526047
6.

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions.

Raggi P, Genest J, Giles JT, Rayner KJ, Dwivedi G, Beanlands RS, Gupta M.

Atherosclerosis. 2018 Sep;276:98-108. doi: 10.1016/j.atherosclerosis.2018.07.014. Epub 2018 Jul 25. Review.

PMID:
30055326
7.

PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice.

Jones SM, Mann A, Conrad K, Saum K, Hall DE, McKinney LM, Robbins N, Thompson J, Peairs AD, Camerer E, Rayner KJ, Tranter M, Mackman N, Owens AP 3rd.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1271-1282. doi: 10.1161/ATVBAHA.117.310082. Epub 2018 Mar 29.

8.

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration.

Nguyen MA, Karunakaran D, Geoffrion M, Cheng HS, Tandoc K, Perisic Matic L, Hedin U, Maegdefessel L, Fish JE, Rayner KJ.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):49-63. doi: 10.1161/ATVBAHA.117.309795. Epub 2017 Sep 7.

9.

Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a.

Cheng HS, Besla R, Li A, Chen Z, Shikatani EA, Nazari-Jahantigh M, Hammoutène A, Nguyen MA, Geoffrion M, Cai L, Khyzha N, Li T, MacParland SA, Husain M, Cybulsky MI, Boulanger CM, Temel RE, Schober A, Rayner KJ, Robbins CS, Fish JE.

Circ Res. 2017 Aug 4;121(4):354-367. doi: 10.1161/CIRCRESAHA.116.310529. Epub 2017 Jun 21.

10.

Cell Death in the Vessel Wall: The Good, the Bad, the Ugly.

Rayner KJ.

Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):e75-e81. doi: 10.1161/ATVBAHA.117.309229. Review. No abstract available.

11.

microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis.

Ouimet M, Ediriweera H, Afonso MS, Ramkhelawon B, Singaravelu R, Liao X, Bandler RC, Rahman K, Fisher EA, Rayner KJ, Pezacki JP, Tabas I, Moore KJ.

Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1058-1067. doi: 10.1161/ATVBAHA.116.308916. Epub 2017 Apr 20.

12.

MicroRNAs in the Pathobiology and Therapy of Atherosclerosis.

Laffont B, Rayner KJ.

Can J Cardiol. 2017 Mar;33(3):313-324. doi: 10.1016/j.cjca.2017.01.001. Epub 2017 Jan 5. Review.

13.

The walking dead: macrophage inflammation and death in atherosclerosis.

Kavurma MM, Rayner KJ, Karunakaran D.

Curr Opin Lipidol. 2017 Apr;28(2):91-98. doi: 10.1097/MOL.0000000000000394. Review.

14.

A big shot of small RNAs repairs a broken heart.

Rayner KJ.

Sci Transl Med. 2017 Jan 25;9(374). pii: eaal4999. doi: 10.1126/scitranslmed.aal4999.

PMID:
28123072
15.

LDL cholesterol hitches a ride.

Rayner KJ.

Sci Transl Med. 2016 Dec 7;8(368):368ec196. No abstract available.

PMID:
27928022
16.

Nanomedicine Meets microRNA: Current Advances in RNA-Based Nanotherapies for Atherosclerosis.

Gadde S, Rayner KJ.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):e73-9. doi: 10.1161/ATVBAHA.116.307481. Review.

17.

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis.

Karunakaran D, Geoffrion M, Wei L, Gan W, Richards L, Shangari P, DeKemp EM, Beanlands RA, Perisic L, Maegdefessel L, Hedin U, Sad S, Guo L, Kolodgie FD, Virmani R, Ruddy T, Rayner KJ.

Sci Adv. 2016 Jul 22;2(7):e1600224. doi: 10.1126/sciadv.1600224. eCollection 2016 Jul.

18.

How Biomaterials Can Influence Various Cell Types in the Repair and Regeneration of the Heart after Myocardial Infarction.

Lister Z, Rayner KJ, Suuronen EJ.

Front Bioeng Biotechnol. 2016 Jul 18;4:62. doi: 10.3389/fbioe.2016.00062. eCollection 2016. Review.

19.

Long Noncoding RNAs in the Heart: The Regulatory Roadmap of Cardiovascular Development and Disease.

Rayner KJ, Liu PP.

Circ Cardiovasc Genet. 2016 Apr;9(2):101-3. doi: 10.1161/CIRCGENETICS.116.001413. No abstract available.

PMID:
27094196
20.

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism.

Ouimet M, Koster S, Sakowski E, Ramkhelawon B, van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA, Moore KJ.

Nat Immunol. 2016 Jun;17(6):677-86. doi: 10.1038/ni.3434. Epub 2016 Apr 18.

21.

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux.

Ouimet M, Hennessy EJ, van Solingen C, Koelwyn GJ, Hussein MA, Ramkhelawon B, Rayner KJ, Temel RE, Perisic L, Hedin U, Maegdefessel L, Garabedian MJ, Holdt LM, Teupser D, Moore KJ.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):942-951. doi: 10.1161/ATVBAHA.116.307282. Epub 2016 Mar 3.

22.

Macrophage miRNAs in atherosclerosis.

Karunakaran D, Rayner KJ.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2087-2093. doi: 10.1016/j.bbalip.2016.02.006. Epub 2016 Feb 18. Review.

PMID:
26899196
23.

MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.

Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ.

J Clin Invest. 2015 Oct 26;125(12):4334-48. doi: 10.1172/JCI81676.

24.

MicroRNAs regulate the immunometabolic response to viral infection in the liver.

Singaravelu R, O'Hara S, Jones DM, Chen R, Taylor NG, Srinivasan P, Quan C, Roy DG, Steenbergen RH, Kumar A, Lyn RK, Özcelik D, Rouleau Y, Nguyen MA, Rayner KJ, Hobman TC, Tyrrell DL, Russell RS, Pezacki JP.

Nat Chem Biol. 2015 Dec;11(12):988-93. doi: 10.1038/nchembio.1940. Epub 2015 Oct 19.

PMID:
26479438
25.

Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced Obesity.

Karunakaran D, Richards L, Geoffrion M, Barrette D, Gotfrit RJ, Harper ME, Rayner KJ.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2536-43. doi: 10.1161/ATVBAHA.115.306404. Epub 2015 Oct 1.

26.

Local Anti-miR Delivery: The Latest in the Arsenal of Drug-Eluting Stents.

Moore KJ, Rayner KJ.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1905-6. doi: 10.1161/ATVBAHA.115.306187. No abstract available.

27.

IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.

Chen HH, Keyhanian K, Zhou X, Vilmundarson RO, Almontashiri NA, Cruz SA, Pandey NR, Lerma Yap N, Ho T, Stewart CA, Huang H, Hari A, Geoffrion M, McPherson R, Rayner KJ, Stewart AF.

Circ Res. 2015 Sep 25;117(8):671-83. doi: 10.1161/CIRCRESAHA.114.305777. Epub 2015 Jul 20.

PMID:
26195219
28.

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis.

Karunakaran D, Thrush AB, Nguyen MA, Richards L, Geoffrion M, Singaravelu R, Ramphos E, Shangari P, Ouimet M, Pezacki JP, Moore KJ, Perisic L, Maegdefessel L, Hedin U, Harper ME, Rayner KJ.

Circ Res. 2015 Jul 17;117(3):266-78. doi: 10.1161/CIRCRESAHA.117.305624. Epub 2015 May 22.

29.

MicroRNA-155 in the Heart: The Right Time at the Right Place in the Right Cell.

Rayner KJ.

Circulation. 2015 May 5;131(18):1533-5. doi: 10.1161/CIRCULATIONAHA.115.016327. Epub 2015 Apr 7. No abstract available.

PMID:
25850723
30.

MicroRNA regulation of vascular smooth muscle function and phenotype: early career committee contribution.

Maegdefessel L, Rayner KJ, Leeper NJ.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):2-6. doi: 10.1161/ATVBAHA.114.304877. Review. No abstract available.

PMID:
25520518
31.

Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction.

Blackburn NJ, Sofrenovic T, Kuraitis D, Ahmadi A, McNeill B, Deng C, Rayner KJ, Zhong Z, Ruel M, Suuronen EJ.

Biomaterials. 2015 Jan;39:182-92. doi: 10.1016/j.biomaterials.2014.11.004. Epub 2014 Nov 22.

PMID:
25468370
32.

Unlocking the door to new therapies in cardiovascular disease: microRNAs hold the key.

Nguyen MA, Karunakaran D, Rayner KJ.

Curr Cardiol Rep. 2014 Nov;16(11):539. doi: 10.1007/s11886-014-0539-7. Review.

PMID:
25303893
33.

Spatio-temporal expression patterns of microRNAs in remodelling and repair of the infarcted heart.

Chiarella-Redfern HH, Rayner KJ, Suuronen EJ.

Histol Histopathol. 2015 Feb;30(2):141-9. doi: 10.14670/HH-30.141. Epub 2014 Sep 3. Review.

PMID:
25184277
34.

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.

Ramkhelawon B, Hennessy EJ, Ménager M, Ray TD, Sheedy FJ, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner KJ, Moore KJ.

Nat Med. 2014 Apr;20(4):377-84. doi: 10.1038/nm.3467. Epub 2014 Mar 2.

35.

MicroRNA control of high-density lipoprotein metabolism and function.

Rayner KJ, Moore KJ.

Circ Res. 2014 Jan 3;114(1):183-92. doi: 10.1161/CIRCRESAHA.114.300645. Review.

36.

MicroRNAs in cardiovascular health: from order to disorder.

Karunakaran D, Rayner KJ.

Endocrinology. 2013 Nov;154(11):4000-9. doi: 10.1210/en.2013-1299. Epub 2013 Sep 5. Review.

PMID:
24008347
37.

Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.

Rafatian N, Karunakaran D, Rayner KJ, Leenen FH, Milne RW, Whitman SC.

Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1141-8. doi: 10.1152/ajpheart.00618.2012. Epub 2013 Aug 9.

38.

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.

Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ.

Nat Immunol. 2013 Aug;14(8):812-20. doi: 10.1038/ni.2639. Epub 2013 Jun 30.

39.

Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival.

Ramkhelawon B, Yang Y, van Gils JM, Hewing B, Rayner KJ, Parathath S, Guo L, Oldebeken S, Feig JL, Fisher EA, Moore KJ.

Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1180-8. doi: 10.1161/ATVBAHA.112.301008. Epub 2013 Apr 18.

40.

Extracellular communication via microRNA: lipid particles have a new message.

Rayner KJ, Hennessy EJ.

J Lipid Res. 2013 May;54(5):1174-81. doi: 10.1194/jlr.R034991. Epub 2013 Mar 15. Review.

41.

Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention.

Wanschel A, Seibert T, Hewing B, Ramkhelawon B, Ray TD, van Gils JM, Rayner KJ, Feig JE, O'Brien ER, Fisher EA, Moore KJ.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):886-93. doi: 10.1161/ATVBAHA.112.300941. Epub 2013 Feb 21.

42.

The plaque "micro" environment: microRNAs control the risk and the development of atherosclerosis.

Rayner KJ, Moore KJ.

Curr Atheroscler Rep. 2012 Oct;14(5):413-21. doi: 10.1007/s11883-012-0272-x. Review.

43.

MicroRNAs regulating lipid metabolism in atherogenesis.

Rayner KJ, Fernandez-Hernando C, Moore KJ.

Thromb Haemost. 2012 Apr;107(4):642-7. doi: 10.1160/TH11-10-0694. Epub 2012 Jan 25. Review.

44.

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.

van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O'Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ.

Nat Immunol. 2012 Jan 8;13(2):136-43. doi: 10.1038/ni.2205.

45.

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.

Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Goedeke L, Liu X, Khatsenko OG, Kaimal V, Lees CJ, Fernandez-Hernando C, Fisher EA, Temel RE, Moore KJ.

Nature. 2011 Oct 19;478(7369):404-7. doi: 10.1038/nature10486.

46.

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis.

Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, Fernandez-Hernando C, Fisher EA, Moore KJ.

J Clin Invest. 2011 Jul;121(7):2921-31. doi: 10.1172/JCI57275. Epub 2011 Jun 6.

47.

The role of microRNAs in cholesterol efflux and hepatic lipid metabolism.

Moore KJ, Rayner KJ, Suárez Y, Fernández-Hernando C.

Annu Rev Nutr. 2011 Aug 21;31:49-63. doi: 10.1146/annurev-nutr-081810-160756. Review.

48.

MicroRNAs in lipid metabolism.

Fernández-Hernando C, Suárez Y, Rayner KJ, Moore KJ.

Curr Opin Lipidol. 2011 Apr;22(2):86-92. doi: 10.1097/MOL.0b013e3283428d9d. Review.

49.

microRNAs and cholesterol metabolism.

Moore KJ, Rayner KJ, Suárez Y, Fernández-Hernando C.

Trends Endocrinol Metab. 2010 Dec;21(12):699-706. doi: 10.1016/j.tem.2010.08.008. Epub 2010 Sep 27. Review.

50.

MiR-33 contributes to the regulation of cholesterol homeostasis.

Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernández-Hernando C.

Science. 2010 Jun 18;328(5985):1570-3. doi: 10.1126/science.1189862. Epub 2010 May 13.

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