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Items: 1 to 50 of 114

1.

Malaria Vaccines: Recent Advances and New Horizons.

Draper SJ, Sack BK, King CR, Nielsen CM, Rayner JC, Higgins MK, Long CA, Seder RA.

Cell Host Microbe. 2018 Jul 11;24(1):43-56. doi: 10.1016/j.chom.2018.06.008. Review.

2.

RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics.

Claessens A, Harris LM, Stanojcic S, Chappell L, Stanton A, Kuk N, Veneziano-Broccia P, Sterkers Y, Rayner JC, Merrick CJ.

PLoS Genet. 2018 Jul 2;14(7):e1007490. doi: 10.1371/journal.pgen.1007490. eCollection 2018 Jul.

3.

An in vitro erythrocyte preference assay reveals that Plasmodium falciparum parasites prefer Type O over Type A erythrocytes.

Theron M, Cross N, Cawkill P, Bustamante LY, Rayner JC.

Sci Rep. 2018 May 25;8(1):8133. doi: 10.1038/s41598-018-26559-2.

4.

Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis.

Zhang M, Wang C, Otto TD, Oberstaller J, Liao X, Adapa SR, Udenze K, Bronner IF, Casandra D, Mayho M, Brown J, Li S, Swanson J, Rayner JC, Jiang RHY, Adams JH.

Science. 2018 May 4;360(6388). pii: eaap7847. doi: 10.1126/science.aap7847.

PMID:
29724925
5.

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach.

Kumar K, Srinivasan P, Nold MJ, Moch JK, Reiter K, Sturdevant D, Otto TD, Squires RB, Herrera R, Nagarajan V, Rayner JC, Porcella SF, Geromanos SJ, Haynes JD, Narum DL.

Sci Rep. 2017 Dec 7;7(1):17146. doi: 10.1038/s41598-017-17505-9.

6.

Synergistic malaria vaccine combinations identified by systematic antigen screening.

Bustamante LY, Powell GT, Lin YC, Macklin MD, Cross N, Kemp A, Cawkill P, Sanderson T, Crosnier C, Muller-Sienerth N, Doumbo OK, Traore B, Crompton PD, Cicuta P, Tran TM, Wright GJ, Rayner JC.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12045-12050. doi: 10.1073/pnas.1702944114. Epub 2017 Oct 23.

7.

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.

França CT, White MT, He WQ, Hostetler JB, Brewster J, Frato G, Malhotra I, Gruszczyk J, Huon C, Lin E, Kiniboro B, Yadava A, Siba P, Galinski MR, Healer J, Chitnis C, Cowman AF, Takashima E, Tsuboi T, Tham WH, Fairhurst RM, Rayner JC, King CL, Mueller I.

Elife. 2017 Sep 26;6. pii: e28673. doi: 10.7554/eLife.28673.

8.

PhenoPlasm: a database of disruption phenotypes for malaria parasite genes.

Sanderson T, Rayner JC.

Wellcome Open Res. 2017 Jul 24;2:45. doi: 10.12688/wellcomeopenres.11896.2. eCollection 2017.

9.

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.

Charnaud SC, Dixon MWA, Nie CQ, Chappell L, Sanders PR, Nebl T, Hanssen E, Berriman M, Chan JA, Blanch AJ, Beeson JG, Rayner JC, Przyborski JM, Tilley L, Crabb BS, Gilson PR.

PLoS One. 2017 Jul 21;12(7):e0181656. doi: 10.1371/journal.pone.0181656. eCollection 2017.

10.

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.

Bushell E, Gomes AR, Sanderson T, Anar B, Girling G, Herd C, Metcalf T, Modrzynska K, Schwach F, Martin RE, Mather MW, McFadden GI, Parts L, Rutledge GG, Vaidya AB, Wengelnik K, Rayner JC, Billker O.

Cell. 2017 Jul 13;170(2):260-272.e8. doi: 10.1016/j.cell.2017.06.030.

11.

Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand.

Longley RJ, França CT, White MT, Kumpitak C, Sa-Angchai P, Gruszczyk J, Hostetler JB, Yadava A, King CL, Fairhurst RM, Rayner JC, Tham WH, Nguitragool W, Sattabongkot J, Mueller I.

Malar J. 2017 Apr 28;16(1):178. doi: 10.1186/s12936-017-1826-8.

12.

P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5.

Galaway F, Drought LG, Fala M, Cross N, Kemp AC, Rayner JC, Wright GJ.

Nat Commun. 2017 Feb 10;8:14333. doi: 10.1038/ncomms14333.

13.

A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle.

Modrzynska K, Pfander C, Chappell L, Yu L, Suarez C, Dundas K, Gomes AR, Goulding D, Rayner JC, Choudhary J, Billker O.

Cell Host Microbe. 2017 Jan 11;21(1):11-22. doi: 10.1016/j.chom.2016.12.003.

14.

Extreme mutation bias and high AT content in Plasmodium falciparum.

Hamilton WL, Claessens A, Otto TD, Kekre M, Fairhurst RM, Rayner JC, Kwiatkowski D.

Nucleic Acids Res. 2017 Feb 28;45(4):1889-1901. doi: 10.1093/nar/gkw1259.

15.

Plasmodium vivax vaccine research - we've only just begun.

Tham WH, Beeson JG, Rayner JC.

Int J Parasitol. 2017 Feb;47(2-3):111-118. doi: 10.1016/j.ijpara.2016.09.006. Epub 2016 Nov 27. Review.

16.

Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications.

Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, Rayner JC.

PLoS Negl Trop Dis. 2016 Oct 31;10(10):e0005091. doi: 10.1371/journal.pntd.0005091. eCollection 2016 Oct.

17.

Palmitoyl transferases have critical roles in the development of mosquito and liver stages of Plasmodium.

Hopp CS, Balaban AE, Bushell ES, Billker O, Rayner JC, Sinnis P.

Cell Microbiol. 2016 Nov;18(11):1625-1641. doi: 10.1111/cmi.12601. Epub 2016 Jun 1.

18.

Study of Plasmodium falciparum DHHC palmitoyl transferases identifies a role for PfDHHC9 in gametocytogenesis.

Tay CL, Jones ML, Hodson N, Theron M, Choudhary JS, Rayner JC.

Cell Microbiol. 2016 Nov;18(11):1596-1610. doi: 10.1111/cmi.12599. Epub 2016 May 3.

19.

A Stem Cell Strategy Identifies Glycophorin C as a Major Erythrocyte Receptor for the Rodent Malaria Parasite Plasmodium berghei.

Yiangou L, Montandon R, Modrzynska K, Rosen B, Bushell W, Hale C, Billker O, Rayner JC, Pance A.

PLoS One. 2016 Jun 30;11(6):e0158238. doi: 10.1371/journal.pone.0158238. eCollection 2016.

20.

Genomic analysis of local variation and recent evolution in Plasmodium vivax.

Pearson RD, Amato R, Auburn S, Miotto O, Almagro-Garcia J, Amaratunga C, Suon S, Mao S, Noviyanti R, Trimarsanto H, Marfurt J, Anstey NM, William T, Boni MF, Dolecek C, Hien TT, White NJ, Michon P, Siba P, Tavul L, Harrison G, Barry A, Mueller I, Ferreira MU, Karunaweera N, Randrianarivelojosia M, Gao Q, Hubbart C, Hart L, Jeffery B, Drury E, Mead D, Kekre M, Campino S, Manske M, Cornelius VJ, MacInnis B, Rockett KA, Miles A, Rayner JC, Fairhurst RM, Nosten F, Price RN, Kwiatkowski DP.

Nat Genet. 2016 Aug;48(8):959-964. doi: 10.1038/ng.3599. Epub 2016 Jun 27.

21.

Multigenomic Delineation of Plasmodium Species of the Laverania Subgenus Infecting Wild-Living Chimpanzees and Gorillas.

Liu W, Sundararaman SA, Loy DE, Learn GH, Li Y, Plenderleith LJ, Ndjango JB, Speede S, Atencia R, Cox D, Shaw GM, Ayouba A, Peeters M, Rayner JC, Hahn BH, Sharp PM.

Genome Biol Evol. 2016 Jul 2;8(6):1929-39. doi: 10.1093/gbe/evw128.

22.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Martínez MS, Bolscher JM, Woodland A, Luksch T, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Jiménez-Díaz MB, Sanz LM, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW, Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Gamo FJ, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler EA, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD, Gilbert IH.

Nature. 2016 Sep 1;537(7618):122. doi: 10.1038/nature18280. Epub 2016 May 25. No abstract available.

23.

Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants.

Crosnier C, Iqbal Z, Knuepfer E, Maciuca S, Perrin AJ, Kamuyu G, Goulding D, Bustamante LY, Miles A, Moore SC, Dougan G, Holder AA, Kwiatkowski DP, Rayner JC, Pleass RJ, Wright GJ.

J Biol Chem. 2016 Jul 1;291(27):14285-99. doi: 10.1074/jbc.M116.722074. Epub 2016 May 12.

24.

Quantitative insertion-site sequencing (QIseq) for high throughput phenotyping of transposon mutants.

Bronner IF, Otto TD, Zhang M, Udenze K, Wang C, Quail MA, Jiang RH, Adams JH, Rayner JC.

Genome Res. 2016 Jul;26(7):980-9. doi: 10.1101/gr.200279.115. Epub 2016 May 10.

25.

An Antibody Screen of a Plasmodium vivax Antigen Library Identifies Novel Merozoite Proteins Associated with Clinical Protection.

França CT, Hostetler JB, Sharma S, White MT, Lin E, Kiniboro B, Waltmann A, Darcy AW, Li Wai Suen CS, Siba P, King CL, Rayner JC, Fairhurst RM, Mueller I.

PLoS Negl Trop Dis. 2016 May 16;10(5):e0004639. doi: 10.1371/journal.pntd.0004639. eCollection 2016 May.

26.

Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria.

Sundararaman SA, Plenderleith LJ, Liu W, Loy DE, Learn GH, Li Y, Shaw KS, Ayouba A, Peeters M, Speede S, Shaw GM, Bushman FD, Brisson D, Rayner JC, Sharp PM, Hahn BH.

Nat Commun. 2016 Mar 22;7:11078. doi: 10.1038/ncomms11078.

27.

Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN).

WAMIN consortium authors include (in alphabetical order):, Ahouidi AD, Amambua-Ngwa A, Awandare GA, Bei AK, Conway DJ, Diakite M, Duraisingh MT, Rayner JC, Zenonos ZA.

Trends Parasitol. 2016 Apr;32(4):274-283. doi: 10.1016/j.pt.2015.11.009. Epub 2015 Dec 23. Review.

PMID:
26725306
28.

A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions.

Hostetler JB, Sharma S, Bartholdson SJ, Wright GJ, Fairhurst RM, Rayner JC.

PLoS Negl Trop Dis. 2015 Dec 23;9(12):e0004264. doi: 10.1371/journal.pntd.0004264. eCollection 2015 Dec.

29.

Plasmodium malariae Malaria: From Monkey to Man?

Rayner JC.

EBioMedicine. 2015 Sep 7;2(9):1023-4. doi: 10.1016/j.ebiom.2015.08.035. eCollection 2015 Sep. No abstract available.

30.

Ape parasite origins of human malaria virulence genes.

Larremore DB, Sundararaman SA, Liu W, Proto WR, Clauset A, Loy DE, Speede S, Plenderleith LJ, Sharp PM, Hahn BH, Rayner JC, Buckee CO.

Nat Commun. 2015 Oct 12;6:8368. doi: 10.1038/ncomms9368.

31.

Basigin is a druggable target for host-oriented antimalarial interventions.

Zenonos ZA, Dummler SK, Müller-Sienerth N, Chen J, Preiser PR, Rayner JC, Wright GJ.

J Exp Med. 2015 Jul 27;212(8):1145-51. doi: 10.1084/jem.20150032. Epub 2015 Jul 20.

32.

Calcium Builds Strong Host-Parasite Interactions.

Billker O, Rayner JC.

Cell Host Microbe. 2015 Jul 8;18(1):9-10. doi: 10.1016/j.chom.2015.06.012.

33.

A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Luksch T, Martínez MS, Luksch T, Bolscher JM, Woodland A, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Jiménez-Díaz MB, Sanz LM, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW, Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Gamo FJ, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler EA, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD, Gilbert IH.

Nature. 2015 Jun 18;522(7556):315-20. doi: 10.1038/nature14451. Erratum in: Nature. 2016 Sep 1;537(7618):122.

34.

Palmitoylation and palmitoyl-transferases in Plasmodium parasites.

Hodson N, Invergo B, Rayner JC, Choudhary JS.

Biochem Soc Trans. 2015 Apr;43(2):240-5. doi: 10.1042/BST20140289. Review.

PMID:
25849924
35.

Plasmodium knowlesi genome sequences from clinical isolates reveal extensive genomic dimorphism.

Pinheiro MM, Ahmed MA, Millar SB, Sanderson T, Otto TD, Lu WC, Krishna S, Rayner JC, Cox-Singh J.

PLoS One. 2015 Apr 1;10(4):e0121303. doi: 10.1371/journal.pone.0121303. eCollection 2015.

36.

A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite.

Gomes AR, Bushell E, Schwach F, Girling G, Anar B, Quail MA, Herd C, Pfander C, Modrzynska K, Rayner JC, Billker O.

Cell Host Microbe. 2015 Mar 11;17(3):404-413. doi: 10.1016/j.chom.2015.01.014. Epub 2015 Feb 26.

37.

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes.

Weiss GE, Gilson PR, Taechalertpaisarn T, Tham WH, de Jong NW, Harvey KL, Fowkes FJ, Barlow PN, Rayner JC, Wright GJ, Cowman AF, Crabb BS.

PLoS Pathog. 2015 Feb 27;11(2):e1004670. doi: 10.1371/journal.ppat.1004670. eCollection 2015 Feb.

38.

Post-translational protein modifications in malaria parasites.

Doerig C, Rayner JC, Scherf A, Tobin AB.

Nat Rev Microbiol. 2015 Mar;13(3):160-72. doi: 10.1038/nrmicro3402. Epub 2015 Feb 9. Review.

PMID:
25659318
39.

PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites.

Schwach F, Bushell E, Gomes AR, Anar B, Girling G, Herd C, Rayner JC, Billker O.

Nucleic Acids Res. 2015 Jan;43(Database issue):D1176-82. doi: 10.1093/nar/gku1143.

40.

Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis.

Claessens A, Hamilton WL, Kekre M, Otto TD, Faizullabhoy A, Rayner JC, Kwiatkowski D.

PLoS Genet. 2014 Dec 18;10(12):e1004812. doi: 10.1371/journal.pgen.1004812. eCollection 2014 Dec.

41.

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts.

Otto TD, Rayner JC, Böhme U, Pain A, Spottiswoode N, Sanders M, Quail M, Ollomo B, Renaud F, Thomas AW, Prugnolle F, Conway DJ, Newbold C, Berriman M.

Nat Commun. 2014 Sep 9;5:4754. doi: 10.1038/ncomms5754.

42.

Quantitation of malaria parasite-erythrocyte cell-cell interactions using optical tweezers.

Crick AJ, Theron M, Tiffert T, Lew VL, Cicuta P, Rayner JC.

Biophys J. 2014 Aug 19;107(4):846-53. doi: 10.1016/j.bpj.2014.07.010.

43.

New antigens for a multicomponent blood-stage malaria vaccine.

Osier FH, Mackinnon MJ, Crosnier C, Fegan G, Kamuyu G, Wanaguru M, Ogada E, McDade B, Rayner JC, Wright GJ, Marsh K.

Sci Transl Med. 2014 Jul 30;6(247):247ra102. doi: 10.1126/scitranslmed.3008705.

44.

The origins of malaria: there are more things in heaven and earth ….

Keeling PJ, Rayner JC.

Parasitology. 2015 Feb;142 Suppl 1:S16-25. doi: 10.1017/S0031182014000766. Epub 2014 Jun 25. Review.

45.

Confident and sensitive phosphoproteomics using combinations of collision induced dissociation and electron transfer dissociation.

Collins MO, Wright JC, Jones M, Rayner JC, Choudhary JS.

J Proteomics. 2014 May 30;103:1-14. doi: 10.1016/j.jprot.2014.03.010. Epub 2014 Mar 21.

46.

Plasmodium falciparum erythrocyte invasion: combining function with immune evasion.

Wright GJ, Rayner JC.

PLoS Pathog. 2014 Mar 20;10(3):e1003943. doi: 10.1371/journal.ppat.1003943. eCollection 2014 Mar. Review.

47.

Towards a comprehensive Plasmodium falciparum merozoite cell surface and secreted recombinant protein library.

Zenonos ZA, Rayner JC, Wright GJ.

Malar J. 2014 Mar 12;13:93. doi: 10.1186/1475-2875-13-93.

48.

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites.

Brochet M, Collins MO, Smith TK, Thompson E, Sebastian S, Volkmann K, Schwach F, Chappell L, Gomes AR, Berriman M, Rayner JC, Baker DA, Choudhary J, Billker O.

PLoS Biol. 2014 Mar 4;12(3):e1001806. doi: 10.1371/journal.pbio.1001806. eCollection 2014 Mar.

49.

African origin of the malaria parasite Plasmodium vivax.

Liu W, Li Y, Shaw KS, Learn GH, Plenderleith LJ, Malenke JA, Sundararaman SA, Ramirez MA, Crystal PA, Smith AG, Bibollet-Ruche F, Ayouba A, Locatelli S, Esteban A, Mouacha F, Guichet E, Butel C, Ahuka-Mundeke S, Inogwabini BI, Ndjango JB, Speede S, Sanz CM, Morgan DB, Gonder MK, Kranzusch PJ, Walsh PD, Georgiev AV, Muller MN, Piel AK, Stewart FA, Wilson ML, Pusey AE, Cui L, Wang Z, Färnert A, Sutherland CJ, Nolder D, Hart JA, Hart TB, Bertolani P, Gillis A, LeBreton M, Tafon B, Kiyang J, Djoko CF, Schneider BS, Wolfe ND, Mpoudi-Ngole E, Delaporte E, Carter R, Culleton RL, Shaw GM, Rayner JC, Peeters M, Hahn BH, Sharp PM.

Nat Commun. 2014;5:3346. doi: 10.1038/ncomms4346.

50.

RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum.

Wanaguru M, Liu W, Hahn BH, Rayner JC, Wright GJ.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20735-40. doi: 10.1073/pnas.1320771110. Epub 2013 Dec 2.

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