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Understanding the Pathophysiological Mechanisms of Cardiometabolic Complications in Obstructive Sleep Apnoea - Towards Personalised Treatment Approaches.

Ryan S, Cummins EP, Farre R, Gileles-Hillel A, Jun JC, Oster H, Pepin JL, Ray DW, Reutrakul S, Sanchez-de-la-Torre M, Tamisier R, Almendros I.

Eur Respir J. 2020 Apr 7. pii: 1902295. doi: 10.1183/13993003.02295-2019. [Epub ahead of print]


Regulatory T cells confer a circadian signature on inflammatory arthritis.

Hand LE, Gray KJ, Dickson SH, Simpkins DA, Ray DW, Konkel JE, Hepworth MR, Gibbs JE.

Nat Commun. 2020 Apr 3;11(1):1658. doi: 10.1038/s41467-020-15525-0.


The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.

Kitchen GB, Cunningham PS, Poolman TM, Iqbal M, Maidstone R, Baxter M, Bagnall J, Begley N, Saer B, Hussell T, Matthews LC, Dockrell DH, Durrington HJ, Gibbs JE, Blaikley JF, Loudon AS, Ray DW.

Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1543-1551. doi: 10.1073/pnas.1915932117. Epub 2020 Jan 3.


The circadian clock protein REVERBα inhibits pulmonary fibrosis development.

Cunningham PS, Meijer P, Nazgiewicz A, Anderson SG, Borthwick LA, Bagnall J, Kitchen GB, Lodyga M, Begley N, Venkateswaran RV, Shah R, Mercer PF, Durrington HJ, Henderson NC, Piper-Hanley K, Fisher AJ, Chambers RC, Bechtold DA, Gibbs JE, Loudon AS, Rutter MK, Hinz B, Ray DW, Blaikley JF.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1139-1147. doi: 10.1073/pnas.1912109117. Epub 2019 Dec 26.


Circadian rhythms in innate immunity and stress responses.

Baxter M, Ray DW.

Immunology. 2019 Dec 10. doi: 10.1111/imm.13166. [Epub ahead of print] Review.


Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits.

Hunter AL, Ray DW.

Biology (Basel). 2019 Oct 19;8(4). pii: E79. doi: 10.3390/biology8040079. Review.


Monthly variance in UK renal transplantation activity: a national retrospective cohort study.

Lowe M, Maidstone R, Poulton K, Worthington J, Durrington HJ, Ray DW, van Dellen D, Asderakis A, Blaikley J, Augustine T.

BMJ Open. 2019 Sep 17;9(9):e028786. doi: 10.1136/bmjopen-2018-028786.


Circadian rhythm of exhaled biomarkers in health and asthma.

Wilkinson M, Maidstone R, Loudon A, Blaikley J, White IR, Singh D, Ray DW, Goodacre R, Fowler SJ, Durrington HJ.

Eur Respir J. 2019 Oct 17;54(4). pii: 1901068. doi: 10.1183/13993003.01068-2019. Print 2019 Oct. No abstract available.


Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection.

Caratti G, Poolman T, Hurst RJ, Ince L, Knight A, Krakowiak K, Durrington HJ, Gibbs J, Else KJ, Matthews LC, Ray DW.

Sci Rep. 2019 Jun 12;9(1):8581. doi: 10.1038/s41598-019-44963-0.


An improved method for quantitative ChIP studies of nuclear receptor function.

Hunter AL, Narang N, Baxter M, Ray DW, Poolman TM.

J Mol Endocrinol. 2019 May 1;62(4):169-177. doi: 10.1530/JME-18-0243.


How Do Glucocorticoids Used in Rheumatic Disease Affect Body Weight? A Narrative Review of the Evidence.

Morgan C, Costello RE, Ray DW, Dixon WG.

Arthritis Care Res (Hoboken). 2020 Apr;72(4):489-497. doi: 10.1002/acr.23879. Review.


Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.

Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade BE, Garaulet M, Kyle SD, Little MA, Loudon AS, Luik AI, Scheer FAJL, Spiegelhalder K, Tyrrell J, Gottlieb DJ, Tiemeier H, Ray DW, Purcell SM, Frayling TM, Redline S, Lawlor DA, Rutter MK, Weedon MN, Saxena R.

Nat Commun. 2019 Mar 7;10(1):1100. doi: 10.1038/s41467-019-08917-4.


Biological and clinical insights from genetics of insomnia symptoms.

Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J; HUNT All In Sleep, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R.

Nat Genet. 2019 Mar;51(3):387-393. doi: 10.1038/s41588-019-0361-7. Epub 2019 Feb 25.


Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.

Zhang Z, Hunter L, Wu G, Maidstone R, Mizoro Y, Vonslow R, Fife M, Hopwood T, Begley N, Saer B, Wang P, Cunningham P, Baxter M, Durrington H, Blaikley JF, Hussell T, Rattray M, Hogenesch JB, Gibbs J, Ray DW, Loudon ASI.

FASEB J. 2019 May;33(5):6226-6238. doi: 10.1096/fj.201801682R. Epub 2019 Feb 22.


Rheumatoid arthritis reprograms circadian output pathways.

Poolman TM, Gibbs J, Walker AL, Dickson S, Farrell L, Hensman J, Kendall AC, Maidstone R, Warwood S, Loudon A, Rattray M, Bruce IN, Nicolaou A, Ray DW.

Arthritis Res Ther. 2019 Feb 6;21(1):47. doi: 10.1186/s13075-019-1825-y.


Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.

Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H, Sharp SA, Jie Y, Thompson WD, Harrison JW, Dawes A, Byrne EM, Tiemeier H, Allebrandt KV, Bowden J, Ray DW, Freathy RM, Murray A, Mazzotti DR, Gehrman PR, Lawlor DA, Frayling TM, Rutter MK, Hinds DA, Saxena R, Weedon MN.

Nat Commun. 2019 Jan 29;10(1):343. doi: 10.1038/s41467-018-08259-7.


Cardiomyocyte transcription is controlled by combined MR and circadian clock signalling.

Fletcher EK, Kanki M, Morgan J, Ray DW, Delbridge L, Fuller PJ, Clyne CD, Young MJ.

J Endocrinol. 2019 Jan 1. pii: JOE-18-0584.R3. doi: 10.1530/JOE-18-0584. [Epub ahead of print]


The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis.

Hand LE, Dickson SH, Freemont AJ, Ray DW, Gibbs JE.

Arthritis Res Ther. 2019 Jan 6;21(1):5. doi: 10.1186/s13075-018-1770-1.


Reply to Moitra et al.: Individual Chronotype May Confound Asthma Symptoms and Therapy.

Durrington HJ, Loudon ASI, Ray DW.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):392-394. doi: 10.1164/rccm.201809-1712LE. No abstract available.


Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records.

Joseph RM, Ray DW, Keevil B, van Staa TP, Dixon WG.

RMD Open. 2018 Oct 1;4(2):e000700. doi: 10.1136/rmdopen-2018-000700. eCollection 2018.


Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation.

Cunningham PS, Maidstone R, Durrington HJ, Venkateswaran RV, Cypel M, Keshavjee S, Gibbs JE, Loudon AS, Chow CW, Ray DW, Blaikley JF.

Thorax. 2019 Apr;74(4):413-416. doi: 10.1136/thoraxjnl-2018-212021. Epub 2018 Oct 9.


REVERBa couples the circadian clock to hepatic glucocorticoid action.

Caratti G, Iqbal M, Hunter L, Kim D, Wang P, Vonslow RM, Begley N, Tetley AJ, Woodburn JL, Pariollaud M, Maidstone R, Donaldson IJ, Zhang Z, Ince LM, Kitchen G, Baxter M, Poolman TM, Daniels DA, Stirling DR, Brocker C, Gonzalez F, Loudon AS, Bechtold DA, Rattray M, Matthews LC, Ray DW.

J Clin Invest. 2018 Oct 1;128(10):4454-4471. doi: 10.1172/JCI96138. Epub 2018 Sep 4.


Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment.

Durrington HJ, Gioan-Tavernier GO, Maidstone RJ, Krakowiak K, Loudon ASI, Blaikley JF, Fowler SJ, Singh D, Simpson A, Ray DW.

Am J Respir Crit Care Med. 2018 Aug 29. doi: 10.1164/rccm.201807-1289LE. [Epub ahead of print] No abstract available.


Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

Bougarne N, Weyers B, Desmet SJ, Deckers J, Ray DW, Staels B, De Bosscher K.

Endocr Rev. 2018 Oct 1;39(5):760-802. doi: 10.1210/er.2018-00064. Review.


Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells.

Ince LM, Zhang Z, Beesley S, Vonslow RM, Saer BR, Matthews LC, Begley N, Gibbs JE, Ray DW, Loudon ASI.

FASEB J. 2019 Jan;33(1):126-139. doi: 10.1096/fj.201800026RR. Epub 2018 Jul 2.


The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts.

Taylor KM, Wheeler R, Singh N, Vosloo D, Ray DW, Sommer P.

Sci Rep. 2018 Mar 20;8(1):4903. doi: 10.1038/s41598-018-23309-2.


Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.

Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW.

J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30.


The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock.

Hopwood TW, Hall S, Begley N, Forman R, Brown S, Vonslow R, Saer B, Little MC, Murphy EA, Hurst RJ, Ray DW, MacDonald AS, Brass A, Bechtold DA, Gibbs JE, Loudon AS, Else KJ.

Sci Rep. 2018 Feb 28;8(1):3782. doi: 10.1038/s41598-018-22021-5.


Misalignment with the external light environment drives metabolic and cardiac dysfunction.

West AC, Smith L, Ray DW, Loudon ASI, Brown TM, Bechtold DA.

Nat Commun. 2017 Sep 12;8(1):417. doi: 10.1038/s41467-017-00462-2.


Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1.

McCaffrey JC, Webb NJ, Poolman TM, Fresquet M, Moxey C, Zeef LAH, Donaldson IJ, Ray DW, Lennon R.

Sci Rep. 2017 Jul 27;7(1):6725. doi: 10.1038/s41598-017-06810-y.


'In a dark place, we find ourselves': light intensity in critical care units.

Durrington HJ, Clark R, Greer R, Martial FP, Blaikley J, Dark P, Lucas RJ, Ray DW.

Intensive Care Med Exp. 2017 Dec;5(1):9. doi: 10.1186/s40635-017-0122-9. Epub 2017 Feb 7.


Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.

Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R.

Nat Genet. 2017 Feb;49(2):274-281. doi: 10.1038/ng.3749. Epub 2016 Dec 19.


The circadian clock regulates inflammatory arthritis.

Hand LE, Hopwood TW, Dickson SH, Walker AL, Loudon AS, Ray DW, Bechtold DA, Gibbs JE.

FASEB J. 2016 Nov;30(11):3759-3770. Epub 2016 Aug 3.


Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production.

Morgan DJ, Poolman TM, Williamson AJ, Wang Z, Clark NR, Ma'ayan A, Whetton AD, Brass A, Matthews LC, Ray DW.

Sci Rep. 2016 May 26;6:26419. doi: 10.1038/srep26419.


Systemic glucocorticoid therapy and adrenal insufficiency in adults: A systematic review.

Joseph RM, Hunter AL, Ray DW, Dixon WG.

Semin Arthritis Rheum. 2016 Aug;46(1):133-41. doi: 10.1016/j.semarthrit.2016.03.001. Epub 2016 Mar 9.


Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.

Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R.

Nat Commun. 2016 Mar 9;7:10889. doi: 10.1038/ncomms10889.


Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an EULAR task force.

Strehl C, Bijlsma JW, de Wit M, Boers M, Caeyers N, Cutolo M, Dasgupta B, Dixon WG, Geenen R, Huizinga TW, Kent A, de Thurah AL, Listing J, Mariette X, Ray DW, Scherer HU, Seror R, Spies CM, Tarp S, Wiek D, Winthrop KL, Buttgereit F.

Ann Rheum Dis. 2016 Jun;75(6):952-7. doi: 10.1136/annrheumdis-2015-208916. Epub 2016 Mar 1. Review.


Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus.

Reynolds JA, Haque S, Williamson K, Ray DW, Alexander MY, Bruce IN.

Sci Rep. 2016 Mar 1;6:22341. doi: 10.1038/srep22341.


A matter of time: study of circadian clocks and their role in inflammation.

Carter SJ, Durrington HJ, Gibbs JE, Blaikley J, Loudon AS, Ray DW, Sabroe I.

J Leukoc Biol. 2016 Apr;99(4):549-60. doi: 10.1189/jlb.3RU1015-451R. Epub 2016 Feb 8. Review.


Glucocorticoid receptors in lung cancer: new perspectives.

Taylor KM, Ray DW, Sommer P.

J Endocrinol. 2016 Apr;229(1):R17-28. doi: 10.1530/JOE-15-0496. Epub 2016 Jan 21. Review.


Risk of Incident Diabetes Mellitus Associated With the Dosage and Duration of Oral Glucocorticoid Therapy in Patients With Rheumatoid Arthritis.

Movahedi M, Beauchamp ME, Abrahamowicz M, Ray DW, Michaud K, Pedro S, Dixon WG.

Arthritis Rheumatol. 2016 May;68(5):1089-98. doi: 10.1002/art.39537.


Management of adrenocortical insufficiency with continuous subcutaneous hydrocortisone infusion: long-term experience in three patients.

Khanna A, Khurana R, Kyriacou A, Davies R, Ray DW.

Endocrinol Diabetes Metab Case Rep. 2015;2015:150005. doi: 10.1530/EDM-15-0005. Epub 2015 May 1.


Characterization of the molecular genetic pathology in patients with 11β-hydroxylase deficiency.

Mooij CF, Parajes S, Rose IT, Taylor AE, Bayraktaroglu T, Wass JA, Connell JM, Ray DW, Arlt W, Krone N.

Clin Endocrinol (Oxf). 2015 Nov;83(5):629-35. doi: 10.1111/cen.12834. Epub 2015 Jul 14.


Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, White MR, Ray DW.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5479-84. doi: 10.1073/pnas.1411356112. Epub 2015 Apr 6.


Circadian biology: rhythms leave their imprint.

Ray DW.

Curr Biol. 2015 Mar 2;25(5):R201-3. doi: 10.1016/j.cub.2014.12.045.


An abnormality in glucocorticoid receptor expression differentiates steroid responders from nonresponders in keloid disease.

Rutkowski D, Syed F, Matthews LC, Ray DW, McGrouther DA, Watson RE, Bayat A.

Br J Dermatol. 2015 Sep;173(3):690-700. doi: 10.1111/bjd.13752. Epub 2015 Jul 28.


Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit.

Hand LE, Usan P, Cooper GJ, Xu LY, Ammori B, Cunningham PS, Aghamohammadzadeh R, Soran H, Greenstein A, Loudon AS, Bechtold DA, Ray DW.

Diabetes. 2015 Jan;64(1):128-36. doi: 10.2337/db13-1835. Epub 2014 Sep 4.


Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK.

Yang N, Caratti G, Ince LM, Poolman TM, Trebble PJ, Holt CM, Ray DW, Matthews LC.

J Endocrinol. 2014 Nov;223(2):155-66. doi: 10.1530/JOE-14-0456. Epub 2014 Aug 26.


The N-terminal transactivation domain of the glucocorticoid receptor mediates apoptosis of human small cell lung cancer cells.

Singh N, Taylor K, Mjoli PB, Poolman T, Ray DW, Sommer P.

Genes Chromosomes Cancer. 2014 Dec;53(12):999-1007. doi: 10.1002/gcc.22209. Epub 2014 Aug 13.


Buccal microRNA dysregulation in lung field carcinogenesis: gender-specific implications.

Wali RK, Hensing TA, Ray DW, Dela Cruz M, Tiwari AK, Radosevich A, Jepeal L, Fernando HC, Litle VR, Charlot M, Momi N, Backman V, Roy HK.

Int J Oncol. 2014 Sep;45(3):1209-15. doi: 10.3892/ijo.2014.2495. Epub 2014 Jun 11.

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