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Items: 1 to 50 of 71

1.

A university - Led initiative to promote voluntary non-remunerated blood donation in a developing country.

Charles KS, Friday M, Lall D, Harrichan K, De Four M, Guy K, Earle A, Rawlins D, Chantry AD.

Transfus Apher Sci. 2019 Sep 5. pii: S1473-0502(19)30181-8. doi: 10.1016/j.transci.2019.07.008. [Epub ahead of print]

PMID:
31519526
2.

Biopharmaceutical Characterization and Oral Efficacy of a New Rapid Acting Antidepressant Ro 25-6981.

Yellepeddi VK, Zhudeva MY, Movahedi F, Vo A, Phan J, Kirsh RD, Rawlins DB, Talbot JN.

J Pharm Sci. 2018 Sep;107(9):2472-2478. doi: 10.1016/j.xphs.2018.05.005. Epub 2018 May 22.

PMID:
29800545
3.

LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice.

Powell DR, Smith MG, Doree DD, Harris AL, Greer J, DaCosta CM, Thompson A, Jeter-Jones S, Xiong W, Carson KG, Goodwin NC, Harrison BA, Rawlins DB, Strobel ED, Gopinathan S, Wilson A, Mseeh F, Zambrowicz B, Ding ZM.

J Pharmacol Exp Ther. 2017 Jul;362(1):85-97. doi: 10.1124/jpet.117.240820. Epub 2017 Apr 25.

PMID:
28442582
4.

Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes.

Goodwin NC, Ding ZM, Harrison BA, Strobel ED, Harris AL, Smith M, Thompson AY, Xiong W, Mseeh F, Bruce DJ, Diaz D, Gopinathan S, Li L, O'Neill E, Thiel M, Wilson AG, Carson KG, Powell DR, Rawlins DB.

J Med Chem. 2017 Jan 26;60(2):710-721. doi: 10.1021/acs.jmedchem.6b01541. Epub 2017 Jan 17.

PMID:
28045524
5.

Preparing to lead change: An innovative curriculum integrating theory, group skills and authentic presence.

Steckler NA, Rawlins DB, Williamson PR, Suchman AL.

Healthc (Amst). 2016 Dec;4(4):247-251. doi: 10.1016/j.hjdsi.2015.10.005. Epub 2015 Nov 18. No abstract available.

6.

HIDDEN IN PLAIN VIEW: BARRIERS TO QUALITY IMPROVEMENT.

Baker NJ, Suchman A, Rawlins D.

Physician Leadersh J. 2016 Mar-Apr;3(2):54-7. No abstract available.

PMID:
27101664
7.

Finite element simulation of articular contact mechanics with quadratic tetrahedral elements.

Maas SA, Ellis BJ, Rawlins DS, Weiss JA.

J Biomech. 2016 Mar 21;49(5):659-667. doi: 10.1016/j.jbiomech.2016.01.024. Epub 2016 Feb 6.

8.

Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.

Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.

J Med Chem. 2015 Sep 24;58(18):7609. doi: 10.1021/acs.jmedchem.5b01294. Epub 2015 Sep 2. No abstract available.

PMID:
26328598
9.

LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2.

Powell DR, Smith MG, Doree DD, Harris AL, Xiong WW, Mseeh F, Wilson A, Gopinathan S, Diaz D, Goodwin NC, Harrison B, Strobel E, Rawlins DB, Carson K, Zambrowicz B, Ding ZM.

Pharmacol Res Perspect. 2015 Mar;3(2):e00129. doi: 10.1002/prp2.129. Epub 2015 Mar 31.

10.

Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.

Harrison BA, Almstead ZY, Burgoon H, Gardyan M, Goodwin NC, Healy J, Liu Y, Mabon R, Marinelli B, Samala L, Zhang Y, Stouch TR, Whitlock NA, Gopinathan S, McKnight B, Wang S, Patel N, Wilson AG, Hamman BD, Rice DS, Rawlins DB.

ACS Med Chem Lett. 2014 Nov 24;6(1):84-8. doi: 10.1021/ml500367g. eCollection 2015 Jan 8.

11.

Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation.

Goodwin NC, Cianchetta G, Burgoon HA, Healy J, Mabon R, Strobel ED, Allen J, Wang S, Hamman BD, Rawlins DB.

ACS Med Chem Lett. 2014 Aug 7;6(1):53-7. doi: 10.1021/ml500242y. eCollection 2015 Jan 8.

12.

Reaction profiling by ultra high-pressure liquid chromatography/time-of-flight mass spectrometry in support of the synthesis of DNA-encoded libraries.

Hargiss LO, Zipp GG, Jessop TC, Sun X, Keyes P, Rawlins DB, Liang Z, Park KJ, Gu H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:120-5. doi: 10.1016/j.jchromb.2014.09.001. Epub 2014 Sep 23.

PMID:
25282130
13.

Investigating the role of cardiovascular biomarkers in children with pre-dialysis chronic kidney disease: a substitute to echocardiography to detect increased left ventricular mass?

Clothier JC, Simpson JM, Turner C, Dalton RN, Rasmussen P, Rawlins D, Booth CJ, Peacock JL, Sinha MD.

Nephron Clin Pract. 2013;124(3-4):191-201. doi: 10.1159/000356385. Epub 2014 Jan 4.

PMID:
24401719
14.

Assessment of right ventricular volumes in hypoplastic left heart syndrome by real-time three-dimensional echocardiography: comparison with cardiac magnetic resonance imaging.

Bell A, Rawlins D, Bellsham-Revell H, Miller O, Razavi R, Simpson J.

Eur Heart J Cardiovasc Imaging. 2014 Mar;15(3):257-66. doi: 10.1093/ehjci/jet145. Epub 2013 Aug 14.

PMID:
23946284
15.

Systolic and diastolic ventricular function assessed by tissue Doppler imaging in children with chronic kidney disease.

Simpson JM, Rawlins D, Mathur S, Chubb H, Sinha MD.

Echocardiography. 2013 Mar;30(3):331-7. doi: 10.1111/echo.12015. Epub 2012 Nov 20.

PMID:
23167909
16.

LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial.

Zambrowicz B, Freiman J, Brown PM, Frazier KS, Turnage A, Bronner J, Ruff D, Shadoan M, Banks P, Mseeh F, Rawlins DB, Goodwin NC, Mabon R, Harrison BA, Wilson A, Sands A, Powell DR.

Clin Pharmacol Ther. 2012 Aug;92(2):158-69. doi: 10.1038/clpt.2012.58. Epub 2012 Jul 4.

17.

Three-dimensional echocardiography in the management of parachute mitral valve.

Valverde I, Rawlins D, Austin C, Simpson JM.

Eur Heart J Cardiovasc Imaging. 2012 May;13(5):446. doi: 10.1093/ejechocard/jer299. Epub 2011 Dec 29. No abstract available.

PMID:
22207340
18.

Clinical application of a micro multiplane transoesophageal probe in congenital cardiac disease.

Pushparajah K, Miller OI, Rawlins D, Barlow A, Nugent K, Simpson JM.

Cardiol Young. 2012 Apr;22(2):170-7. doi: 10.1017/S1047951111000977. Epub 2011 Aug 19.

PMID:
21851758
19.

Blood pressure control and left ventricular mass in children with chronic kidney disease.

Sinha MD, Tibby SM, Rasmussen P, Rawlins D, Turner C, Dalton RN, Reid CJ, Rigden SP, Booth CJ, Simpson JM.

Clin J Am Soc Nephrol. 2011 Mar;6(3):543-51. doi: 10.2215/CJN.04690510. Epub 2010 Nov 29.

20.

Electrocardiography is a poor screening test to detect left ventricular hypertrophy in children.

Killian L, Simpson JM, Savis A, Rawlins D, Sinha MD.

Arch Dis Child. 2010 Oct;95(10):832-6. doi: 10.1136/adc.2009.168377. Epub 2010 Jul 23.

PMID:
20656727
21.

Incidence of left ventricular hypertrophy in children with kidney disease: impact of method of indexation of left ventricular mass.

Simpson JM, Savis A, Rawlins D, Qureshi S, Sinha MD.

Eur J Echocardiogr. 2010 Apr;11(3):271-7. doi: 10.1093/ejechocard/jep211. Epub 2009 Dec 15. Erratum in: Eur J Echocardiogr. 2010 Apr;11(3):306.

PMID:
20015849
22.

Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma.

Harrison BA, Whitlock NA, Voronkov MV, Almstead ZY, Gu KJ, Mabon R, Gardyan M, Hamman BD, Allen J, Gopinathan S, McKnight B, Crist M, Zhang Y, Liu Y, Courtney LF, Key B, Zhou J, Patel N, Yates PW, Liu Q, Wilson AG, Kimball SD, Crosson CE, Rice DS, Rawlins DB.

J Med Chem. 2009 Nov 12;52(21):6515-8. doi: 10.1021/jm901226j.

PMID:
19831390
23.

Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Goodwin NC, Mabon R, Harrison BA, Shadoan MK, Almstead ZY, Xie Y, Healy J, Buhring LM, DaCosta CM, Bardenhagen J, Mseeh F, Liu Q, Nouraldeen A, Wilson AG, Kimball SD, Powell DR, Rawlins DB.

J Med Chem. 2009 Oct 22;52(20):6201-4. doi: 10.1021/jm900951n.

PMID:
19785435
24.
25.

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.

J Med Chem. 2004 Mar 25;47(7):1719-28. Erratum in: J Med Chem. 2015 Sep 24;58(18):7609.

PMID:
15027863
26.

1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues.

Misra RN, Xiao Hy, Rawlins DB, Shan W, Kellar KA, Mulheron JG, Sack JS, Tokarski JS, Kimball SD, Webster KR.

Bioorg Med Chem Lett. 2003 Jul 21;13(14):2405-8.

PMID:
12824044
27.

1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.

Misra RN, Rawlins DB, Xiao HY, Shan W, Bursuker I, Kellar KA, Mulheron JG, Sack JS, Tokarski JS, Kimball SD, Webster KR.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1133-6.

PMID:
12643928
28.

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.

Kim KS, Kimball SD, Misra RN, Rawlins DB, Hunt JT, Xiao HY, Lu S, Qian L, Han WC, Shan W, Mitt T, Cai ZW, Poss MA, Zhu H, Sack JS, Tokarski JS, Chang CY, Pavletich N, Kamath A, Humphreys WG, Marathe P, Bursuker I, Kellar KA, Roongta U, Batorsky R, Mulheron JG, Bol D, Fairchild CR, Lee FY, Webster KR.

J Med Chem. 2002 Aug 29;45(18):3905-27.

PMID:
12190313
29.

Variation in plasma leptin levels in response to fasting in Antarctic fur seals (Arctocephalus gazella).

Arnould JP, Morris MJ, Rawlins DR, Boyd IL.

J Comp Physiol B. 2002 Jan;172(1):27-34.

PMID:
11824401
30.

Ancient chronology. Astronomical orientation of the pyramids.

Rawlins D, Pickering K.

Nature. 2001 Aug 16;412(6848):699-700.

PMID:
11507629
31.

Fasting metabolism in Antarctic fur seal (Arctocephalus gazella) pups.

Arnould JP, Green JA, Rawlins DR.

Comp Biochem Physiol A Mol Integr Physiol. 2001 Jul;129(4):829-41.

PMID:
11440869
32.

The effect of nasal patency on the clearance of radiolabeled saline in healthy volunteers.

Washington N, McGlashan JA, Jackson SJ, Bush D, Pitt KG, Rawlins DA, Gill DA.

Pharm Res. 2000 Jun;17(6):733-6.

PMID:
10955849
33.

Determination of baseline human nasal pH and the effect of intranasally administered buffers.

Washington N, Steele RJ, Jackson SJ, Bush D, Mason J, Gill DA, Pitt K, Rawlins DA.

Int J Pharm. 2000 Apr 5;198(2):139-46.

PMID:
10767563
34.

The Pinene Path to Taxanes. 4. Approaches to Taxol and Taxol Analogs through Elaboration of Aromatic C-Ring Precursors.

Wender PA, Glass TE, Krauss NE, Mühlebach M, Peschke B, Rawlins DB.

J Org Chem. 1996 Nov 1;61(22):7662-7663. No abstract available.

PMID:
11667717
35.
37.
38.

The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein.

Ling PD, Rawlins DR, Hayward SD.

Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9237-41.

39.

The unsuspected allergy.

Rawlins D, Smith S, Tyndall J.

Can Oper Room Nurs J. 1992 Nov-Dec;10(4):6-9. No abstract available.

PMID:
1493603
40.

Microtubules rich in post-translationally modified alpha-tubulin form distinct arrays in frog lens epithelial cells.

Prescott AR, Webb SF, Rawlins D, Shaw PJ, Warn RM.

Exp Eye Res. 1991 Jun;52(6):743-53.

PMID:
1855548
41.

Three-dimensional fluorescence microscopy.

Shaw PJ, Rawlins DJ.

Prog Biophys Mol Biol. 1991;56(3):187-213. Review. No abstract available.

PMID:
1771232
42.
46.
47.
48.
49.

Effect of ibuprofen on blood pressure control by propranolol and bendrofluazide.

Davies JG, Rawlins DC, Busson M.

J Int Med Res. 1988 May-Jun;16(3):173-81.

PMID:
3044869
50.

An actin network is present in the cytoplasm throughout the cell cycle of carrot cells and associates with the dividing nucleus.

Traas JA, Doonan JH, Rawlins DJ, Shaw PJ, Watts J, Lloyd CW.

J Cell Biol. 1987 Jul;105(1):387-95.

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