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Items: 1 to 50 of 186

1.

The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy.

Hale M, Rawlings DJ, Jackson SW.

Curr Opin Immunol. 2018 Dec;55:81-88. doi: 10.1016/j.coi.2018.10.008. Epub 2018 Nov 1. Review.

PMID:
30390507
2.

Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells.

Du SW, Jacobs HM, Arkatkar T, Rawlings DJ, Jackson SW.

J Immunol. 2018 Dec 1;201(11):3258-3268. doi: 10.4049/jimmunol.1800393. Epub 2018 Oct 29.

PMID:
30373855
3.

Generation of functional murine CD11c+ age-associated B cells in the absence of B cell T-bet expression.

Du SW, Arkatkar T, Jacobs HM, Rawlings DJ, Jackson SW.

Eur J Immunol. 2019 Jan;49(1):170-178. doi: 10.1002/eji.201847641. Epub 2018 Nov 5.

PMID:
30353919
4.

Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses.

Wray-Dutra MN, Al Qureshah F, Metzler G, Oukka M, James RG, Rawlings DJ.

J Exp Med. 2018 Oct 1;215(10):2485-2496. doi: 10.1084/jem.20180617. Epub 2018 Sep 7.

PMID:
30194267
5.

Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation.

Wray-Dutra MN, Chawla R, Thomas KR, Seymour BJ, Arkatkar T, Sommer KM, Khim S, Trapnell C, James RG, Rawlings DJ.

J Exp Med. 2018 Sep 3;215(9):2445-2461. doi: 10.1084/jem.20180230. Epub 2018 Aug 20.

PMID:
30127060
6.

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.

Sanchez-Blanco C, Clarke F, Cornish GH, Depoil D, Thompson SJ, Dai X, Rawlings DJ, Dustin ML, Zamoyska R, Cope AP, Purvis HA.

J Autoimmun. 2018 Nov;94:45-55. doi: 10.1016/j.jaut.2018.07.008. Epub 2018 Jul 24.

7.

Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase.

Paul B, Ibarra GSR, Hubbard N, Einhaus T, Astrakhan A, Rawlings DJ, Kiem HP, Peterson CW.

Mol Ther Methods Clin Dev. 2018 Apr 5;9:347-357. doi: 10.1016/j.omtm.2018.04.002. eCollection 2018 Jun 15.

8.

αv Integrins regulate germinal center B cell responses through noncanonical autophagy.

Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, Stuart LM, Orr MT, Rawlings DJ, Jackson SW, Lacy-Hulbert A, Acharya M.

J Clin Invest. 2018 Aug 31;128(9):4163-4178. doi: 10.1172/JCI99597. Epub 2018 Aug 20.

9.

TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression.

Arkatkar T, Jacobs HM, Du SW, Li QZ, Hudkins KL, Alpers CE, Rawlings DJ, Jackson SW.

Kidney Int. 2018 Oct;94(4):728-740. doi: 10.1016/j.kint.2018.03.012. Epub 2018 Jun 12.

PMID:
29907458
10.

Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.

Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP.

Blood Adv. 2018 May 8;2(9):987-999. doi: 10.1182/bloodadvances.2018016451.

11.

Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells.

Hung KL, Meitlis I, Hale M, Chen CY, Singh S, Jackson SW, Miao CH, Khan IF, Rawlings DJ, James RG.

Mol Ther. 2018 Feb 7;26(2):456-467. doi: 10.1016/j.ymthe.2017.11.012. Epub 2017 Nov 22.

12.

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

Clarke F, Jordan CK, Gutiérrez-Martinez E, Bibby JA, Sanchez-Blanco C, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Guermonprez P, Cope AP, Purvis HA.

PLoS One. 2017 Oct 17;12(10):e0186625. doi: 10.1371/journal.pone.0186625. eCollection 2017.

13.

Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.

Purvis HA, Clarke F, Jordan CK, Blanco CS, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Cope AP.

Eur J Immunol. 2018 Feb;48(2):306-315. doi: 10.1002/eji.201747092. Epub 2017 Oct 20.

14.

B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity.

Arkatkar T, Du SW, Jacobs HM, Dam EM, Hou B, Buckner JH, Rawlings DJ, Jackson SW.

J Exp Med. 2017 Nov 6;214(11):3207-3217. doi: 10.1084/jem.20170580. Epub 2017 Sep 12.

15.

The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.

Metzler G, Dai X, Thouvenel CD, Khim S, Habib T, Buckner JH, Rawlings DJ.

J Immunol. 2017 Oct 1;199(7):2249-2260. doi: 10.4049/jimmunol.1700601. Epub 2017 Aug 11.

16.

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.

Spalinger MR, Lang S, Gottier C, Dai X, Rawlings DJ, Chan AC, Rogler G, Scharl M.

Autophagy. 2017 Sep 2;13(9):1590-1601. doi: 10.1080/15548627.2017.1341453. Epub 2017 Aug 8.

17.

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29.

18.

Altered B cell signalling in autoimmunity.

Rawlings DJ, Metzler G, Wray-Dutra M, Jackson SW.

Nat Rev Immunol. 2017 Jul;17(7):421-436. doi: 10.1038/nri.2017.24. Epub 2017 Apr 10. Review.

19.

Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells.

Hale M, Lee B, Honaker Y, Leung WH, Grier AE, Jacobs HM, Sommer K, Sahni J, Jackson SW, Scharenberg AM, Astrakhan A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2017 Jan 10;4:192-203. doi: 10.1016/j.omtm.2016.12.008. eCollection 2017 Mar 17.

20.

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector.

Singh S, Khan I, Khim S, Seymour B, Sommer K, Wielgosz M, Norgaard Z, Kiem HP, Adair J, Liggitt D, Nienhuis A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2016 Dec 18;4:1-16. doi: 10.1016/j.omtm.2016.11.001. eCollection 2017 Mar 17.

21.

Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity.

Allenspach EJ, Finn LS, Rendi MH, Eken A, Singh AK, Oukka M, Taylor SD, Altman MC, Fligner CL, Ochs HD, Rawlings DJ, Torgerson TR.

J Allergy Clin Immunol. 2017 Aug;140(2):616-619.e7. doi: 10.1016/j.jaci.2017.02.017. Epub 2017 Mar 16. No abstract available.

PMID:
28322850
22.

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells.

Hale M, Mesojednik T, Romano Ibarra GS, Sahni J, Bernard A, Sommer K, Scharenberg AM, Rawlings DJ, Wagner TA.

Mol Ther. 2017 Mar 1;25(3):570-579. doi: 10.1016/j.ymthe.2016.12.023. Epub 2017 Jan 28.

23.

Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.

Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ.

J Immunol. 2016 Dec 15;197(12):4529-4534. Epub 2016 Nov 11.

24.

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 Nov 1;126(11):4388. doi: 10.1172/JCI90897. Epub 2016 Nov 1. No abstract available.

25.

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ.

Mol Ther Nucleic Acids. 2016 Aug 23;5(8):e352. doi: 10.1038/mtna.2016.56.

26.

Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge.

Krishnamurty AT, Thouvenel CD, Portugal S, Keitany GJ, Kim KS, Holder A, Crompton PD, Rawlings DJ, Pepper M.

Immunity. 2016 Aug 16;45(2):402-14. doi: 10.1016/j.immuni.2016.06.014. Epub 2016 Jul 26.

27.

High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins.

Gwiazda KS, Grier AE, Sahni J, Burleigh SM, Martin U, Yang JG, Popp NA, Krutein MC, Khan IF, Jacoby K, Jensen MC, Rawlings DJ, Scharenberg AM.

Mol Ther. 2016 Sep 29;24(9):1570-80. doi: 10.1038/mt.2016.105. Epub 2016 May 16.

28.

pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.

Grier AE, Burleigh S, Sahni J, Clough CA, Cardot V, Choe DC, Krutein MC, Rawlings DJ, Jensen MC, Scharenberg AM, Jacoby K.

Mol Ther Nucleic Acids. 2016 Apr 19;5:e306. doi: 10.1038/mtna.2016.21.

29.

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.

Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ.

J Exp Med. 2016 May 2;213(5):733-50. doi: 10.1084/jem.20151724. Epub 2016 Apr 11.

30.

X-Linked Severe Combined Immunodeficiency.

Allenspach E, Rawlings DJ, Scharenberg AM.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2003 Aug 26 [updated 2016 Apr 14].

31.

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 May 2;126(5):1783-800. doi: 10.1172/JCI83669. Epub 2016 Apr 4. Erratum in: J Clin Invest. 2016 Nov 1;126(11):4388.

32.

Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.

Jacobs HM, Thouvenel CD, Leach S, Arkatkar T, Metzler G, Scharping NE, Kolhatkar NS, Rawlings DJ, Jackson SW.

J Immunol. 2016 May 1;196(9):3525-31. doi: 10.4049/jimmunol.1600017. Epub 2016 Mar 28.

33.

Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome.

Hubbard N, Hagin D, Sommer K, Song Y, Khan I, Clough C, Ochs HD, Rawlings DJ, Scharenberg AM, Torgerson TR.

Blood. 2016 May 26;127(21):2513-22. doi: 10.1182/blood-2015-11-683235. Epub 2016 Feb 22.

34.

BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.

Metzler G, Kolhatkar NS, Rawlings DJ.

Curr Opin Immunol. 2015 Dec;37:46-53. doi: 10.1016/j.coi.2015.10.001. Review.

35.

Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.

Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J, Jarjour J, Astrakhan A, Wagner TA, Scharenberg AM, Rawlings DJ.

Sci Transl Med. 2015 Sep 30;7(307):307ra156. doi: 10.1126/scitranslmed.aac5530.

36.

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.

Kolhatkar NS, Brahmandam A, Thouvenel CD, Becker-Herman S, Jacobs HM, Schwartz MA, Allenspach EJ, Khim S, Panigrahi AK, Luning Prak ET, Thrasher AJ, Notarangelo LD, Candotti F, Torgerson TR, Sanz I, Rawlings DJ.

J Exp Med. 2015 Sep 21;212(10):1663-77. doi: 10.1084/jem.20150585. Epub 2015 Sep 14.

37.

B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.

Kolhatkar NS, Scharping NE, Sullivan JM, Jacobs HM, Schwartz MA, Khim S, Notarangelo LD, Thrasher AJ, Rawlings DJ, Jackson SW.

Eur J Immunol. 2015 Oct;45(10):2773-9. doi: 10.1002/eji.201545644. Epub 2015 Aug 31. Erratum in: Eur J Immunol. 2016 Mar;46(3):782.

38.

VISA--Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing.

Hocum JD, Battrell LR, Maynard R, Adair JE, Beard BC, Rawlings DJ, Kiem HP, Miller DG, Trobridge GD.

BMC Bioinformatics. 2015 Jul 7;16:212. doi: 10.1186/s12859-015-0653-6.

39.

The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.

Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG.

J Immunol. 2015 Jul 1;195(1):246-56. doi: 10.4049/jimmunol.1403238. Epub 2015 May 29.

40.

The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.

Rawlings DJ, Dai X, Buckner JH.

J Immunol. 2015 Apr 1;194(7):2977-84. doi: 10.4049/jimmunol.1403034. Review.

41.

Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection.

Olszko ME, Adair JE, Linde I, Rae DT, Trobridge P, Hocum JD, Rawlings DJ, Kiem HP, Trobridge GD.

Gene Ther. 2015 Jul;22(7):591-5. doi: 10.1038/gt.2015.20. Epub 2015 Mar 19.

42.

B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production.

Jackson SW, Kolhatkar NS, Rawlings DJ.

Curr Opin Immunol. 2015 Apr;33:70-7. doi: 10.1016/j.coi.2015.01.018. Epub 2015 Feb 11. Review.

43.

Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets corrects murine hemophilia A.

Wang X, Shin SC, Chiang AF, Khan I, Pan D, Rawlings DJ, Miao CH.

Mol Ther. 2015 Apr;23(4):617-26. doi: 10.1038/mt.2015.20. Epub 2015 Feb 6.

44.

Treosulfan-based conditioning and hematopoietic cell transplantation for nonmalignant diseases: a prospective multicenter trial.

Burroughs LM, Nemecek ER, Torgerson TR, Storer BE, Talano JA, Domm J, Giller RH, Shimamura A, Delaney C, Skoda-Smith S, Thakar MS, Baker KS, Rawlings DJ, Englund JA, Flowers ME, Deeg HJ, Storb R, Woolfrey AE.

Biol Blood Marrow Transplant. 2014 Dec;20(12):1996-2003. doi: 10.1016/j.bbmt.2014.08.020. Epub 2014 Sep 6.

45.

CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.

Schwartz MA, Kolhatkar NS, Thouvenel C, Khim S, Rawlings DJ.

J Immunol. 2014 Oct 1;193(7):3492-502. doi: 10.4049/jimmunol.1400798. Epub 2014 Aug 29.

46.

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.

Wang CX, Sather BD, Wang X, Adair J, Khan I, Singh S, Lang S, Adams A, Curinga G, Kiem HP, Miao CH, Rawlings DJ, Torbett BE.

Blood. 2014 Aug 7;124(6):913-23. doi: 10.1182/blood-2013-12-546218. Epub 2014 Jun 9.

47.

Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.

Jackson SW, Scharping NE, Kolhatkar NS, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ.

J Immunol. 2014 May 15;192(10):4525-32. doi: 10.4049/jimmunol.1400098. Epub 2014 Apr 7.

48.

Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus.

Wang Y, Khan IF, Boissel S, Jarjour J, Pangallo J, Thyme S, Baker D, Scharenberg AM, Rawlings DJ.

Nucleic Acids Res. 2014 Jun;42(10):6463-75. doi: 10.1093/nar/gku224. Epub 2014 Mar 25.

49.

Intravenous injection of a foamy virus vector to correct canine SCID-X1.

Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ, Kiem HP.

Blood. 2014 Jun 5;123(23):3578-84. doi: 10.1182/blood-2013-11-538926. Epub 2014 Mar 18.

50.

In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease.

Aubert M, Boyle NM, Stone D, Stensland L, Huang ML, Magaret AS, Galetto R, Rawlings DJ, Scharenberg AM, Jerome KR.

Mol Ther Nucleic Acids. 2014 Feb 4;3:e146. doi: 10.1038/mtna.2013.75.

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