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Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.

Spalinger MR, Schmidt TS, Schwarzfischer M, Hering L, Atrott K, Lang S, Gottier C, Geirnaert A, Lacroix C, Dai X, Rawlings DJ, Chan AC, von Mering C, Rogler G, Scharl M.

J Clin Invest. 2019 May 20;130:2527-2541. doi: 10.1172/JCI123263. eCollection 2019 May 20.


"I want to die in my sleep"-how people think about death, choice, and control: findings from a Massive Open Online Course.

Sanderson C, Miller-Lewis L, Rawlings D, Parker D, Tieman J.

Ann Palliat Med. 2019 Mar 28. pii: apm.2019.03.07. doi: 10.21037/apm.2019.03.07. [Epub ahead of print]


Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression.

Habib T, Long SA, Samuels PL, Brahmandam A, Tatum M, Funk A, Hocking AM, Cerosaletti K, Mason MT, Whalen E, Rawlings DJ, Greenbaum C, Buckner JH; Type 1 Diabetes TrialNet Study Group.

Diabetes. 2019 Jun;68(6):1240-1250. doi: 10.2337/db18-1081. Epub 2019 Mar 20.


The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.

Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ, Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M, Jackson SW, Cerosaletti K, Buckner JH, Rawlings DJ.

Front Immunol. 2019 Jan 25;10:44. doi: 10.3389/fimmu.2019.00044. eCollection 2019.


TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.

Lux CT, Pattabhi S, Berger M, Nourigat C, Flowers DA, Negre O, Humbert O, Yang JG, Lee C, Jacoby K, Bernstein I, Kiem HP, Scharenberg A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2018 Dec 31;12:175-183. doi: 10.1016/j.omtm.2018.12.008. eCollection 2019 Mar 15.


Correlates of perceived death competence: What role does meaning-in-life and quality-of-life play?

Miller-Lewis L, Tieman J, Rawlings D, Sanderson C, Parker D.

Palliat Support Care. 2019 Jan 22:1-11. doi: 10.1017/S1478951518000937. [Epub ahead of print]


Community Views on 'What I Want 'Before I Die'.

Rawlings D, Miller-Lewis L, Tieman J.

Behav Sci (Basel). 2018 Nov 30;8(12). pii: E111. doi: 10.3390/bs8120111.


The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy.

Hale M, Rawlings DJ, Jackson SW.

Curr Opin Immunol. 2018 Dec;55:81-88. doi: 10.1016/j.coi.2018.10.008. Epub 2018 Nov 1. Review.


Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells.

Du SW, Jacobs HM, Arkatkar T, Rawlings DJ, Jackson SW.

J Immunol. 2018 Dec 1;201(11):3258-3268. doi: 10.4049/jimmunol.1800393. Epub 2018 Oct 29.


Generation of functional murine CD11c+ age-associated B cells in the absence of B cell T-bet expression.

Du SW, Arkatkar T, Jacobs HM, Rawlings DJ, Jackson SW.

Eur J Immunol. 2019 Jan;49(1):170-178. doi: 10.1002/eji.201847641. Epub 2018 Nov 5.


What role do Death Doulas play in end-of-life care? A systematic review.

Rawlings D, Tieman J, Miller-Lewis L, Swetenham K.

Health Soc Care Community. 2019 May;27(3):e82-e94. doi: 10.1111/hsc.12660. Epub 2018 Sep 26. Review.


Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses.

Wray-Dutra MN, Al Qureshah F, Metzler G, Oukka M, James RG, Rawlings DJ.

J Exp Med. 2018 Oct 1;215(10):2485-2496. doi: 10.1084/jem.20180617. Epub 2018 Sep 7.


Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation.

Wray-Dutra MN, Chawla R, Thomas KR, Seymour BJ, Arkatkar T, Sommer KM, Khim S, Trapnell C, James RG, Rawlings DJ.

J Exp Med. 2018 Sep 3;215(9):2445-2461. doi: 10.1084/jem.20180230. Epub 2018 Aug 20.


Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.

Sanchez-Blanco C, Clarke F, Cornish GH, Depoil D, Thompson SJ, Dai X, Rawlings DJ, Dustin ML, Zamoyska R, Cope AP, Purvis HA.

J Autoimmun. 2018 Nov;94:45-55. doi: 10.1016/j.jaut.2018.07.008. Epub 2018 Jul 24.


Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase.

Paul B, Ibarra GSR, Hubbard N, Einhaus T, Astrakhan A, Rawlings DJ, Kiem HP, Peterson CW.

Mol Ther Methods Clin Dev. 2018 Apr 5;9:347-357. doi: 10.1016/j.omtm.2018.04.002. eCollection 2018 Jun 15.


αv Integrins regulate germinal center B cell responses through noncanonical autophagy.

Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, Stuart LM, Orr MT, Rawlings DJ, Jackson SW, Lacy-Hulbert A, Acharya M.

J Clin Invest. 2018 Aug 31;128(9):4163-4178. doi: 10.1172/JCI99597. Epub 2018 Aug 20.


TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression.

Arkatkar T, Jacobs HM, Du SW, Li QZ, Hudkins KL, Alpers CE, Rawlings DJ, Jackson SW.

Kidney Int. 2018 Oct;94(4):728-740. doi: 10.1016/j.kint.2018.03.012. Epub 2018 Jun 12.


Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.

Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP.

Blood Adv. 2018 May 8;2(9):987-999. doi: 10.1182/bloodadvances.2018016451.


Can Exposure to Online Conversations About Death and Dying Influence Death Competence? An Exploratory Study Within an Australian Massive Open Online Course.

Miller-Lewis L, Tieman J, Rawlings D, Parker D, Sanderson C.

Omega (Westport). 2018 Jan 1:30222818765813. doi: 10.1177/0030222818765813. [Epub ahead of print]


The contribution of a MOOC to community discussions around death and dying.

Tieman J, Miller-Lewis L, Rawlings D, Parker D, Sanderson C.

BMC Palliat Care. 2018 Feb 20;17(1):31. doi: 10.1186/s12904-018-0287-3.


Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells.

Hung KL, Meitlis I, Hale M, Chen CY, Singh S, Jackson SW, Miao CH, Khan IF, Rawlings DJ, James RG.

Mol Ther. 2018 Feb 7;26(2):456-467. doi: 10.1016/j.ymthe.2017.11.012. Epub 2017 Nov 22.


Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

Clarke F, Jordan CK, Gutiérrez-Martinez E, Bibby JA, Sanchez-Blanco C, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Guermonprez P, Cope AP, Purvis HA.

PLoS One. 2017 Oct 17;12(10):e0186625. doi: 10.1371/journal.pone.0186625. eCollection 2017.


Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.

Purvis HA, Clarke F, Jordan CK, Blanco CS, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Cope AP.

Eur J Immunol. 2018 Feb;48(2):306-315. doi: 10.1002/eji.201747092. Epub 2017 Oct 20.


B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity.

Arkatkar T, Du SW, Jacobs HM, Dam EM, Hou B, Buckner JH, Rawlings DJ, Jackson SW.

J Exp Med. 2017 Nov 6;214(11):3207-3217. doi: 10.1084/jem.20170580. Epub 2017 Sep 12.


A23 Identification of HIV drug resistance mutation patterns using illumina MiSeq next generation sequencing in patients failing second-line boosted protease inhibitor therapy in Nigeria.

James OE, Johanna L, Rawlings D, Babajehson M, Ashrad I, Anne D, Abimiku A, Dakum P, Gillian H, Ndembi N.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.022. doi: 10.1093/ve/vew036.022. eCollection 2017 Mar. No abstract available.


The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.

Metzler G, Dai X, Thouvenel CD, Khim S, Habib T, Buckner JH, Rawlings DJ.

J Immunol. 2017 Oct 1;199(7):2249-2260. doi: 10.4049/jimmunol.1700601. Epub 2017 Aug 11.


PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.

Spalinger MR, Lang S, Gottier C, Dai X, Rawlings DJ, Chan AC, Rogler G, Scharl M.

Autophagy. 2017 Sep 2;13(9):1590-1601. doi: 10.1080/15548627.2017.1341453. Epub 2017 Aug 8.


Never say die: death euphemisms, misunderstandings and their implications for practice.

Rawlings D, Tieman JJ, Sanderson C, Parker D, Miller-Lewis L.

Int J Palliat Nurs. 2017 Jul 2;23(7):324-330. doi: 10.12968/ijpn.2017.23.7.324.


The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29.


Altered B cell signalling in autoimmunity.

Rawlings DJ, Metzler G, Wray-Dutra M, Jackson SW.

Nat Rev Immunol. 2017 Jul;17(7):421-436. doi: 10.1038/nri.2017.24. Epub 2017 Apr 10. Review.


Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells.

Hale M, Lee B, Honaker Y, Leung WH, Grier AE, Jacobs HM, Sommer K, Sahni J, Jackson SW, Scharenberg AM, Astrakhan A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2017 Jan 10;4:192-203. doi: 10.1016/j.omtm.2016.12.008. eCollection 2017 Mar 17.


Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector.

Singh S, Khan I, Khim S, Seymour B, Sommer K, Wielgosz M, Norgaard Z, Kiem HP, Adair J, Liggitt D, Nienhuis A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2016 Dec 18;4:1-16. doi: 10.1016/j.omtm.2016.11.001. eCollection 2017 Mar 17.


Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity.

Allenspach EJ, Finn LS, Rendi MH, Eken A, Singh AK, Oukka M, Taylor SD, Altman MC, Fligner CL, Ochs HD, Rawlings DJ, Torgerson TR.

J Allergy Clin Immunol. 2017 Aug;140(2):616-619.e7. doi: 10.1016/j.jaci.2017.02.017. Epub 2017 Mar 16. No abstract available.


Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells.

Hale M, Mesojednik T, Romano Ibarra GS, Sahni J, Bernard A, Sommer K, Scharenberg AM, Rawlings DJ, Wagner TA.

Mol Ther. 2017 Mar 1;25(3):570-579. doi: 10.1016/j.ymthe.2016.12.023. Epub 2017 Jan 28.


Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.

Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ.

J Immunol. 2016 Dec 15;197(12):4529-4534. Epub 2016 Nov 11.


NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 Nov 1;126(11):4388. doi: 10.1172/JCI90897. Epub 2016 Nov 1. No abstract available.


Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ.

Mol Ther Nucleic Acids. 2016 Aug 23;5(8):e352. doi: 10.1038/mtna.2016.56.


Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge.

Krishnamurty AT, Thouvenel CD, Portugal S, Keitany GJ, Kim KS, Holder A, Crompton PD, Rawlings DJ, Pepper M.

Immunity. 2016 Aug 16;45(2):402-14. doi: 10.1016/j.immuni.2016.06.014. Epub 2016 Jul 26.


High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins.

Gwiazda KS, Grier AE, Sahni J, Burleigh SM, Martin U, Yang JG, Popp NA, Krutein MC, Khan IF, Jacoby K, Jensen MC, Rawlings DJ, Scharenberg AM.

Mol Ther. 2016 Sep 29;24(9):1570-80. doi: 10.1038/mt.2016.105. Epub 2016 May 16.


pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.

Grier AE, Burleigh S, Sahni J, Clough CA, Cardot V, Choe DC, Krutein MC, Rawlings DJ, Jensen MC, Scharenberg AM, Jacoby K.

Mol Ther Nucleic Acids. 2016 Apr 19;5:e306. doi: 10.1038/mtna.2016.21.


B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.

Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ.

J Exp Med. 2016 May 2;213(5):733-50. doi: 10.1084/jem.20151724. Epub 2016 Apr 11.


X-Linked Severe Combined Immunodeficiency.

Allenspach E, Rawlings DJ, Scharenberg AM.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2003 Aug 26 [updated 2016 Apr 14].


NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 May 2;126(5):1783-800. doi: 10.1172/JCI83669. Epub 2016 Apr 4. Erratum in: J Clin Invest. 2016 Nov 1;126(11):4388.


Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.

Jacobs HM, Thouvenel CD, Leach S, Arkatkar T, Metzler G, Scharping NE, Kolhatkar NS, Rawlings DJ, Jackson SW.

J Immunol. 2016 May 1;196(9):3525-31. doi: 10.4049/jimmunol.1600017. Epub 2016 Mar 28.


You Don't See What I See: Individual Differences in the Perception of Meaning from Visual Stimuli.

Partos TR, Cropper SJ, Rawlings D.

PLoS One. 2016 Mar 8;11(3):e0150615. doi: 10.1371/journal.pone.0150615. eCollection 2016.


Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome.

Hubbard N, Hagin D, Sommer K, Song Y, Khan I, Clough C, Ochs HD, Rawlings DJ, Scharenberg AM, Torgerson TR.

Blood. 2016 May 26;127(21):2513-22. doi: 10.1182/blood-2015-11-683235. Epub 2016 Feb 22.


Patient and carer information: Can they read and understand it? An example from palliative care.

Rawlings D, Tieman J.

Aust Nurs Midwifery J. 2015 Nov;23(5):26-9. No abstract available.


BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.

Metzler G, Kolhatkar NS, Rawlings DJ.

Curr Opin Immunol. 2015 Dec;37:46-53. doi: 10.1016/j.coi.2015.10.001. Review.

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