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Items: 1 to 50 of 73

1.

Inflammation and reactive oxygen species as disease modifiers in epilepsy.

Terrone G, Balosso S, Pauletti A, Ravizza T, Vezzani A.

Neuropharmacology. 2019 Aug 14:107742. doi: 10.1016/j.neuropharm.2019.107742. [Epub ahead of print] Review.

PMID:
31421074
2.

TLR3 preconditioning induces anti-inflammatory and anti-ictogenic effects in mice mediated by the IRF3/IFN-β axis.

Kostoula C, Shaker T, Cerovic M, Craparotta I, Marchini S, Butti E, Pascente R, Iori V, Garlanda C, Aronica E, Martino G, Ravizza T, Carmant L, Vezzani A.

Brain Behav Immun. 2019 Oct;81:598-607. doi: 10.1016/j.bbi.2019.07.021. Epub 2019 Jul 20.

PMID:
31336144
3.

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy.

Vezzani A, Balosso S, Ravizza T.

Nat Rev Neurol. 2019 Aug;15(8):459-472. doi: 10.1038/s41582-019-0217-x. Epub 2019 Jul 1. Review.

PMID:
31263255
4.

Inflammation and reactive oxygen species in status epilepticus: Biomarkers and implications for therapy.

Terrone G, Frigerio F, Balosso S, Ravizza T, Vezzani A.

Epilepsy Behav. 2019 Jun 3. pii: S1525-5050(19)30301-4. doi: 10.1016/j.yebeh.2019.04.028. [Epub ahead of print] Review.

PMID:
31171434
5.

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

Pauletti A, Terrone G, Shekh-Ahmad T, Salamone A, Ravizza T, Rizzi M, Pastore A, Pascente R, Liang LP, Villa BR, Balosso S, Abramov AY, van Vliet EA, Del Giudice E, Aronica E, Patel M, Walker MC, Vezzani A.

Brain. 2019 Jul 1;142(7):e39. doi: 10.1093/brain/awz130.

PMID:
31145451
6.

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Walker LE, Frigerio F, Ravizza T, Ricci E, Tse K, Jenkins RE, Sills GJ, Jorgensen A, Porcu L, Thippeswamy T, Alapirtti T, Peltola J, Brodie MJ, Park BK, Marson AG, Antoine DJ, Vezzani A, Pirmohamed M.

J Clin Invest. 2019 Apr 8;129(5):2166. doi: 10.1172/JCI129285. eCollection 2019 Apr 8. No abstract available.

7.

Pharmacological targeting of brain inflammation in epilepsy: Therapeutic perspectives from experimental and clinical studies.

Ravizza T, Vezzani A.

Epilepsia Open. 2018 Jul 16;3(Suppl Suppl 2):133-142. doi: 10.1002/epi4.12242. eCollection 2018 Dec.

8.

A companion to the preclinical common data elements for pharmacologic studies in animal models of seizures and epilepsy. A Report of the TASK3 Pharmacology Working Group of the ILAE/AES Joint Translational Task Force.

Barker-Haliski M, Harte-Hargrove LC, Ravizza T, Smolders I, Xiao B, Brandt C, Löscher W.

Epilepsia Open. 2018 Sep 15;3(Suppl Suppl 1):53-68. doi: 10.1002/epi4.12254. eCollection 2018 Nov.

9.

Viral Triggers and Inflammatory Mechanisms in Pediatric Epilepsy.

Bartolini L, Libbey JE, Ravizza T, Fujinami RS, Jacobson S, Gaillard WD.

Mol Neurobiol. 2019 Mar;56(3):1897-1907. doi: 10.1007/s12035-018-1215-5. Epub 2018 Jul 5. Review.

PMID:
29978423
10.

Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells.

Frigerio F, Flynn C, Han Y, Lyman K, Lugo JN, Ravizza T, Ghestem A, Pitsch J, Becker A, Anderson AE, Vezzani A, Chetkovich D, Bernard C.

Mol Neurobiol. 2018 Sep;55(9):7500-7511. doi: 10.1007/s12035-018-0915-1. Epub 2018 Feb 9.

11.

High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy.

Ravizza T, Terrone G, Salamone A, Frigerio F, Balosso S, Antoine DJ, Vezzani A.

Brain Behav Immun. 2018 Aug;72:14-21. doi: 10.1016/j.bbi.2017.10.008. Epub 2017 Oct 13. Review.

PMID:
29031614
12.

Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies.

van Vliet EA, Aronica E, Vezzani A, Ravizza T.

Neuropathol Appl Neurobiol. 2018 Feb;44(1):91-111. doi: 10.1111/nan.12444. Review.

PMID:
28977690
13.

Neuroinflammation imaging markers for epileptogenesis.

Koepp MJ, Årstad E, Bankstahl JP, Dedeurwaerdere S, Friedman A, Potschka H, Ravizza T, Theodore WH, Baram TZ.

Epilepsia. 2017 Jul;58 Suppl 3:11-19. doi: 10.1111/epi.13778.

14.

Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis.

Kostoula C, Pascente R, Ravizza T, McCown T, Schoch S, Vezzani A, Becker AJ, van Loo KMJ.

Mol Neurobiol. 2018 May;55(5):4463-4472. doi: 10.1007/s12035-017-0660-x. Epub 2017 Jul 1.

PMID:
28669125
15.

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

Pauletti A, Terrone G, Shekh-Ahmad T, Salamone A, Ravizza T, Rizzi M, Pastore A, Pascente R, Liang LP, Villa BR, Balosso S, Abramov AY, van Vliet EA, Del Giudice E, Aronica E, Antoine DJ, Patel M, Walker MC, Vezzani A.

Brain. 2017 Jul 1;140(7):1885-1899. doi: 10.1093/brain/awx117. Retraction in: Brain. 2019 Jul 1;142(7):e38.

16.

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Walker LE, Frigerio F, Ravizza T, Ricci E, Tse K, Jenkins RE, Sills GJ, Jorgensen A, Porcu L, Thippeswamy T, Alapirtti T, Peltola J, Brodie MJ, Park BK, Marson AG, Antoine DJ, Vezzani A, Pirmohamed M.

J Clin Invest. 2017 Jun 1;127(6):2118-2132. doi: 10.1172/JCI92001. Epub 2017 May 15. Retraction in: J Clin Invest. 2019 Apr 8;129(5):2166.

17.

Biomarkers of Epileptogenesis: The Focus on Glia and Cognitive Dysfunctions.

Vezzani A, Pascente R, Ravizza T.

Neurochem Res. 2017 Jul;42(7):2089-2098. doi: 10.1007/s11064-017-2271-3. Epub 2017 Apr 22. Review.

PMID:
28434163
18.

Common data elements and data management: Remedy to cure underpowered preclinical studies.

Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A.

Epilepsy Res. 2017 Jan;129:87-90. doi: 10.1016/j.eplepsyres.2016.11.010. Epub 2016 Nov 22.

PMID:
28038337
19.

WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities.

Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A.

Epilepsia. 2017 Mar;58(3):331-342. doi: 10.1111/epi.13652. Epub 2016 Dec 30. Review.

20.

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.

Iori V, Iyer AM, Ravizza T, Beltrame L, Paracchini L, Marchini S, Cerovic M, Hill C, Ferrari M, Zucchetti M, Molteni M, Rossetti C, Brambilla R, Steve White H, D'Incalci M, Aronica E, Vezzani A.

Neurobiol Dis. 2017 Mar;99:12-23. doi: 10.1016/j.nbd.2016.12.007. Epub 2016 Dec 9.

PMID:
27939857
21.

Advances in the development of biomarkers for epilepsy.

Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H.

Lancet Neurol. 2016 Jul;15(8):843-856. doi: 10.1016/S1474-4422(16)00112-5. Review.

PMID:
27302363
22.

Cognitive deficits and brain myo-Inositol are early biomarkers of epileptogenesis in a rat model of epilepsy.

Pascente R, Frigerio F, Rizzi M, Porcu L, Boido M, Davids J, Zaben M, Tolomeo D, Filibian M, Gray WP, Vezzani A, Ravizza T.

Neurobiol Dis. 2016 Sep;93:146-55. doi: 10.1016/j.nbd.2016.05.001. Epub 2016 May 10.

PMID:
27173096
23.

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy.

Mishto M, Raza ML, de Biase D, Ravizza T, Vasuri F, Martucci M, Keller C, Bellavista E, Buchholz TJ, Kloetzel PM, Pession A, Vezzani A, Heinemann U.

Brain Behav Immun. 2015 Oct;49:188-96. doi: 10.1016/j.bbi.2015.05.007. Epub 2015 Jun 1.

PMID:
26044087
24.

Immunity activation in brain cells in epilepsy: mechanistic insights and pathological consequences.

Ravizza T, Kostoula C, Vezzani A.

Neuropediatrics. 2013 Dec;44(6):330-5. doi: 10.1055/s-0033-1358601. Epub 2013 Oct 28. Review.

PMID:
24166145
25.

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.

Noe FM, Polascheck N, Frigerio F, Bankstahl M, Ravizza T, Marchini S, Beltrame L, Banderó CR, Löscher W, Vezzani A.

Neurobiol Dis. 2013 Nov;59:183-93. doi: 10.1016/j.nbd.2013.07.015. Epub 2013 Aug 9.

PMID:
23938763
26.

The dual role of TNF-α and its receptors in seizures.

Balosso S, Ravizza T, Aronica E, Vezzani A.

Exp Neurol. 2013 Sep;247:267-71. doi: 10.1016/j.expneurol.2013.05.010. Epub 2013 May 23. No abstract available.

PMID:
23707217
27.

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures.

Iori V, Maroso M, Rizzi M, Iyer AM, Vertemara R, Carli M, Agresti A, Antonelli A, Bianchi ME, Aronica E, Ravizza T, Vezzani A.

Neurobiol Dis. 2013 Oct;58:102-14. doi: 10.1016/j.nbd.2013.03.006. Epub 2013 Mar 21.

PMID:
23523633
28.

In vivo imaging of glia activation using 1H-magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity.

Filibian M, Frasca A, Maggioni D, Micotti E, Vezzani A, Ravizza T.

Epilepsia. 2012 Nov;53(11):1907-16. doi: 10.1111/j.1528-1167.2012.03685.x. Epub 2012 Oct 2.

29.

Inflammation and epilepsy.

Vezzani A, Balosso S, Ravizza T.

Handb Clin Neurol. 2012;107:163-75. doi: 10.1016/B978-0-444-52898-8.00010-0. Review. No abstract available.

PMID:
22938970
30.

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage.

Librizzi L, Noè F, Vezzani A, de Curtis M, Ravizza T.

Ann Neurol. 2012 Jul;72(1):82-90. doi: 10.1002/ana.23567.

PMID:
22829270
31.

Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators.

Vezzani A, Auvin S, Ravizza T, Aronica E.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

32.

Astrocyte immune responses in epilepsy.

Aronica E, Ravizza T, Zurolo E, Vezzani A.

Glia. 2012 Aug;60(8):1258-68. doi: 10.1002/glia.22312. Epub 2012 Feb 13. Review.

PMID:
22331574
33.

Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1.

Maroso M, Balosso S, Ravizza T, Liu J, Bianchi ME, Vezzani A.

J Intern Med. 2011 Oct;270(4):319-26. doi: 10.1111/j.1365-2796.2011.02431.x.

34.

IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence.

Akin D, Ravizza T, Maroso M, Carcak N, Eryigit T, Vanzulli I, Aker RG, Vezzani A, Onat FY.

Neurobiol Dis. 2011 Dec;44(3):259-69. doi: 10.1016/j.nbd.2011.05.015. Epub 2011 May 30.

PMID:
21645619
35.

Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice.

Maroso M, Balosso S, Ravizza T, Iori V, Wright CI, French J, Vezzani A.

Neurotherapeutics. 2011 Apr;8(2):304-15. doi: 10.1007/s13311-011-0039-z.

36.

Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development.

Zurolo E, Iyer A, Maroso M, Carbonell C, Anink JJ, Ravizza T, Fluiter K, Spliet WG, van Rijen PC, Vezzani A, Aronica E.

Brain. 2011 Apr;134(Pt 4):1015-32. doi: 10.1093/brain/awr032. Epub 2011 Mar 16.

PMID:
21414994
37.

Inflammation and prevention of epileptogenesis.

Ravizza T, Balosso S, Vezzani A.

Neurosci Lett. 2011 Jun 27;497(3):223-30. doi: 10.1016/j.neulet.2011.02.040. Epub 2011 Feb 26. Review.

PMID:
21362451
38.

Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers.

Dubé CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, Andres AL, Nalcioglu O, Obenaus A, Vezzani A, Baram TZ.

J Neurosci. 2010 Jun 2;30(22):7484-94. doi: 10.1523/JNEUROSCI.0551-10.2010.

39.

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.

Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, Rossetti C, Molteni M, Casalgrandi M, Manfredi AA, Bianchi ME, Vezzani A.

Nat Med. 2010 Apr;16(4):413-9. doi: 10.1038/nm.2127. Epub 2010 Mar 28.

PMID:
20348922
40.

ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy.

Vezzani A, Balosso S, Maroso M, Zardoni D, Noé F, Ravizza T.

Curr Opin Investig Drugs. 2010 Jan;11(1):43-50. Review.

PMID:
20047158
41.

Basic mechanisms of status epilepticus due to infection and inflammation.

Vezzani A, Balosso S, Aronica E, Ravizza T.

Epilepsia. 2009 Dec;50 Suppl 12:56-7. doi: 10.1111/j.1528-1167.2009.02370.x. No abstract available.

42.

Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis.

Marcon J, Gagliardi B, Balosso S, Maroso M, Noé F, Morin M, Lerner-Natoli M, Vezzani A, Ravizza T.

Neurobiol Dis. 2009 Apr;34(1):121-32.

PMID:
19320047
43.

Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocampus: implications for seizure susceptibility.

Balosso S, Ravizza T, Pierucci M, Calcagno E, Invernizzi R, Di Giovanni G, Esposito E, Vezzani A.

Neuroscience. 2009 Jun 16;161(1):293-300. doi: 10.1016/j.neuroscience.2009.03.005. Epub 2009 Mar 11.

PMID:
19285115
44.

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta.

Balosso S, Maroso M, Sanchez-Alavez M, Ravizza T, Frasca A, Bartfai T, Vezzani A.

Brain. 2008 Dec;131(Pt 12):3256-65. doi: 10.1093/brain/awn271. Epub 2008 Oct 24.

45.

Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production.

Ravizza T, Noé F, Zardoni D, Vaghi V, Sifringer M, Vezzani A.

Neurobiol Dis. 2008 Sep;31(3):327-33. doi: 10.1016/j.nbd.2008.05.007. Epub 2008 May 29.

PMID:
18632279
46.

The role of cytokines in the pathophysiology of epilepsy.

Vezzani A, Balosso S, Ravizza T.

Brain Behav Immun. 2008 Aug;22(6):797-803. doi: 10.1016/j.bbi.2008.03.009. Epub 2008 May 20. Review.

PMID:
18495419
47.

Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release.

Bernardino L, Balosso S, Ravizza T, Marchi N, Ku G, Randle JC, Malva JO, Vezzani A.

J Neurochem. 2008 Jul;106(1):271-80. doi: 10.1111/j.1471-4159.2008.05387.x. Epub 2008 Jul 1.

48.

Glia as a source of cytokines: implications for neuronal excitability and survival.

Vezzani A, Ravizza T, Balosso S, Aronica E.

Epilepsia. 2008;49 Suppl 2:24-32. doi: 10.1111/j.1528-1167.2008.01490.x. Review.

49.

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy.

Ravizza T, Gagliardi B, Noé F, Boer K, Aronica E, Vezzani A.

Neurobiol Dis. 2008 Jan;29(1):142-60. Epub 2007 Aug 31.

PMID:
17931873
50.

Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development.

Marchi N, Guiso G, Caccia S, Rizzi M, Gagliardi B, Noé F, Ravizza T, Bassanini S, Chimenti S, Battaglia G, Vezzani A.

Neurobiol Dis. 2006 Dec;24(3):429-42. Epub 2006 Oct 5.

PMID:
17027274

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