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Items: 1 to 50 of 102

1.

Long non-coding RNA repertoire and open chromatin regions constitute midbrain dopaminergic neuron - specific molecular signatures.

Gendron J, Colace-Sauty C, Beaume N, Cartonnet H, Guegan J, Ulveling D, Pardanaud-Glavieux C, Moszer I, Cheval H, Ravassard P.

Sci Rep. 2019 Feb 5;9(1):1409. doi: 10.1038/s41598-018-37872-1.

2.

Inhibition of Eph/ephrin interaction with the small molecule UniPR500 improves glucose tolerance in healthy and insulin-resistant mice.

Giorgio C, Incerti M, Pala D, Russo S, Chiodelli P, Rusnati M, Cantoni AM, Di Lecce R, Barocelli E, Bertoni S, Ravassard P, Manenti F, Piemonti L, Ferlenghi F, Lodola A, Tognolini M.

Pharmacol Res. 2019 Mar;141:319-330. doi: 10.1016/j.phrs.2019.01.011. Epub 2019 Jan 6.

PMID:
30625359
3.

Lentiviral Mediated Production of Transgenic Mice: A Simple and Highly Efficient Method for Direct Study of Founders.

Dussaud S, Pardanaud-Glavieux C, Sauty-Colace C, Ravassard P.

J Vis Exp. 2018 Oct 7;(140). doi: 10.3791/57609.

PMID:
30346378
4.

Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line.

Pellegrini S, Manenti F, Chimienti R, Nano R, Ottoboni L, Ruffini F, Martino G, Ravassard P, Piemonti L, Sordi V.

Cell Transplant. 2018 Oct;27(10):1548-1560. doi: 10.1177/0963689718798564. Epub 2018 Sep 25.

5.

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.

Marie C, Clavairoly A, Frah M, Hmidan H, Yan J, Zhao C, Van Steenwinckel J, Daveau R, Zalc B, Hassan B, Thomas JL, Gressens P, Ravassard P, Moszer I, Martin DM, Lu QR, Parras C.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8246-E8255. doi: 10.1073/pnas.1802620115. Epub 2018 Aug 14.

6.

The Wnt/β-catenin pathway determines the predisposition and efficiency of liver-to-pancreas reprogramming.

Cohen H, Barash H, Meivar-Levy I, Molakandov K, Ben-Shimon M, Gurevich M, Zoabi F, Har-Zahav A, Gebhardt R, Gaunitz F, Gurevich M, Mor E, Ravassard P, Greenberger S, Ferber S.

Hepatology. 2018 Oct;68(4):1589-1603. doi: 10.1002/hep.29827. Epub 2018 May 24.

PMID:
29394503
7.

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T.

Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19.

8.

miR-204 is associated with an endocrine phenotype in human pancreatic islets but does not regulate the insulin mRNA through MAFA.

Marzinotto I, Pellegrini S, Brigatti C, Nano R, Melzi R, Mercalli A, Liberati D, Sordi V, Ferrari M, Falconi M, Doglioni C, Ravassard P, Piemonti L, Lampasona V.

Sci Rep. 2017 Oct 25;7(1):14051. doi: 10.1038/s41598-017-13622-7.

9.

Insular and Ventrolateral Orbitofrontal Cortices Differentially Contribute to Goal-Directed Behavior in Rodents.

Parkes SL, Ravassard PM, Cerpa JC, Wolff M, Ferreira G, Coutureau E.

Cereb Cortex. 2018 Jul 1;28(7):2313-2325. doi: 10.1093/cercor/bhx132.

PMID:
28541407
10.

Development of the Endocrine Pancreas in the Beagle Dog: From Fetal to Adult Life.

Bricout-Neveu E, Pechberty S, Reynaud K, Maenhoudt C, José Lecomte M, Ravassard P, Czernichow P.

Anat Rec (Hoboken). 2017 Aug;300(8):1429-1438. doi: 10.1002/ar.23595. Epub 2017 Mar 27.

11.

Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats.

Moore JJ, Ravassard PM, Ho D, Acharya L, Kees AL, Vuong C, Mehta MR.

Science. 2017 Mar 24;355(6331). pii: eaaj1497. doi: 10.1126/science.aaj1497. Epub 2017 Mar 9.

PMID:
28280248
12.

[Tuning transgene expression with an artificial diet: a compelling resource in gene therapy].

Bruhat A, Chaveroux C, Carraro V, Jousse C, Averous J, Maurin AC, Parry L, Mesclon F, Muranishi Y, Baril P, Do Thi A, Ravassard P, Mallet J, Fafournoux P.

Med Sci (Paris). 2017 Feb;33(2):136-139. doi: 10.1051/medsci/20173302007. Epub 2017 Feb 27. French. No abstract available.

13.

A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element.

van Arensbergen J, Dussaud S, Pardanaud-Glavieux C, García-Hurtado J, Sauty C, Guerci A, Ferrer J, Ravassard P.

PLoS One. 2017 Feb 22;12(2):e0171508. doi: 10.1371/journal.pone.0171508. eCollection 2017.

14.

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks.

Akerman I, Tu Z, Beucher A, Rolando DMY, Sauty-Colace C, Benazra M, Nakic N, Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco R, Stewart AF, Bonner C, Piemonti L, Berney T, Groop L, Kerr-Conte J, Pattou F, Argmann C, Schadt E, Ravassard P, Ferrer J.

Cell Metab. 2017 Feb 7;25(2):400-411. doi: 10.1016/j.cmet.2016.11.016. Epub 2016 Dec 29.

15.

Aggregation of Engineered Human β-Cells Into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu.

Lecomte MJ, Pechberty S, Machado C, Da Barroca S, Ravassard P, Scharfmann R, Czernichow P, Duvillié B.

Cell Med. 2016 Aug 12;8(3):99-112. doi: 10.3727/215517916X692843. eCollection 2016 Dec 3.

16.

Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids.

Chaveroux C, Bruhat A, Carraro V, Jousse C, Averous J, Maurin AC, Parry L, Mesclon F, Muranishi Y, Cordelier P, Meulle A, Baril P, Do Thi A, Ravassard P, Mallet J, Fafournoux P.

Nat Biotechnol. 2016 Jul;34(7):746-51. doi: 10.1038/nbt.3582. Epub 2016 Jun 6.

PMID:
27272383
17.

A human beta cell line with drug inducible excision of immortalizing transgenes.

Benazra M, Lecomte MJ, Colace C, Müller A, Machado C, Pechberty S, Bricout-Neveu E, Grenier-Godard M, Solimena M, Scharfmann R, Czernichow P, Ravassard P.

Mol Metab. 2015 Oct 20;4(12):916-25. doi: 10.1016/j.molmet.2015.09.008. eCollection 2015 Dec.

18.

Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

Kirkegaard JS, Ravassard P, Ingvarsen S, Diedisheim M, Bricout-Neveu E, Grønborg M, Frogne T, Scharfmann R, Madsen OD, Rescan C, Albagli O.

J Clin Invest. 2016 Mar 1;126(3):1109-13. doi: 10.1172/JCI83573. Epub 2016 Feb 22.

19.

The supramammillary nucleus and the claustrum activate the cortex during REM sleep.

Renouard L, Billwiller F, Ogawa K, Clément O, Camargo N, Abdelkarim M, Gay N, Scoté-Blachon C, Touré R, Libourel PA, Ravassard P, Salvert D, Peyron C, Claustrat B, Léger L, Salin P, Malleret G, Fort P, Luppi PH.

Sci Adv. 2015 Apr 3;1(3):e1400177. doi: 10.1126/sciadv.1400177. eCollection 2015 Apr.

20.

Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.

Prel A, Caval V, Gayon R, Ravassard P, Duthoit C, Payen E, Maouche-Chretien L, Creneguy A, Nguyen TH, Martin N, Piver E, Sevrain R, Lamouroux L, Leboulch P, Deschaseaux F, Bouillé P, Sensébé L, Pagès JC.

Mol Ther Methods Clin Dev. 2015 Oct 21;2:15039. doi: 10.1038/mtm.2015.39. eCollection 2015.

21.

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy.

van der Torren CR, Zaldumbide A, Roelen DL, Duinkerken G, Brand-Schaaf SH, Peakman M, Czernichow P, Ravassard P, Scharfmann R, Roep BO.

Diabetologia. 2016 Jan;59(1):170-175. doi: 10.1007/s00125-015-3779-1.

22.

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death.

Fred RG, Kappe C, Ameur A, Cen J, Bergsten P, Ravassard P, Scharfmann R, Welsh N.

Mol Cell Endocrinol. 2015 Oct 15;414:53-63. doi: 10.1016/j.mce.2015.07.015. Epub 2015 Jul 26.

PMID:
26213325
23.

In vivo imaging of the spatiotemporal activity of the eIF2α-ATF4 signaling pathway: Insights into stress and related disorders.

Chaveroux C, Carraro V, Canaple L, Averous J, Maurin AC, Jousse C, Muranishi Y, Parry L, Mesclon F, Gatti E, Mallet J, Ravassard P, Pierre P, Fafournoux P, Bruhat A.

Sci Signal. 2015 Apr 28;8(374):rs5. doi: 10.1126/scisignal.aaa0549.

PMID:
25921292
24.

Inducible VEGF expression by human embryonic stem cell-derived mesenchymal stromal cells reduces the minimal islet mass required to reverse diabetes.

Hajizadeh-Saffar E, Tahamtani Y, Aghdami N, Azadmanesh K, Habibi-Anbouhi M, Heremans Y, De Leu N, Heimberg H, Ravassard P, Shokrgozar MA, Baharvand H.

Sci Rep. 2015 Mar 30;5:9322. doi: 10.1038/srep09322.

25.

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

Andersson LE, Valtat B, Bagge A, Sharoyko VV, Nicholls DG, Ravassard P, Scharfmann R, Spégel P, Mulder H.

PLoS One. 2015 Mar 24;10(3):e0120879. doi: 10.1371/journal.pone.0120879. eCollection 2015.

26.

REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP.

Ravassard P, Hamieh AM, Joseph MA, Fraize N, Libourel PA, Lebarillier L, Arthaud S, Meissirel C, Touret M, Malleret G, Salin PA.

Cereb Cortex. 2016 Apr;26(4):1488-1500. doi: 10.1093/cercor/bhu310. Epub 2015 Jan 13.

PMID:
25585510
27.

Human Bone Marrow Subpopulations Sustain Human Islet Function and Viability In vitro.

Luo LG, Xiong F, Ravassard P, Luo JZ.

Br J Med Med Res. 2015;8(7):576-587. Epub 2015 May 18.

28.

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant.

Qamar Saeed M, Dufour N, Bartholmae C, Sieranska U, Knopf M, Thierry E, Thierry S, Delelis O, Grandchamp N, Pilet H, Ravassard P, Massonneau J, Pflumio F, von Kalle C, Lachapelle F, Bemelmans AP, Schmidt M, Serguera C.

Mol Ther Nucleic Acids. 2014 Dec 2;3:e213. doi: 10.1038/mtna.2014.65.

29.

Paradoxical sleep: A vigilance state to gate long-term brain plasticity?

Ravassard P, Hamieh AM, Malleret G, Salin PA.

Neurobiol Learn Mem. 2015 Jul;122:4-10. doi: 10.1016/j.nlm.2014.11.013. Epub 2014 Nov 28.

PMID:
25448317
30.

Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord.

Francius C, Ravassard P, Hidalgo-Figueroa M, Mallet J, Clotman F, Nardelli J.

Dev Neurobiol. 2015 Jul;75(7):721-37. doi: 10.1002/dneu.22244. Epub 2014 Nov 15.

31.

Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.

Ingallinesi M, Le Bouil L, Biguet NF, Thi AD, Mannoury la Cour C, Millan MJ, Ravassard P, Mallet J, Meloni R.

Mol Psychiatry. 2015 Aug;20(8):951-8. doi: 10.1038/mp.2014.92. Epub 2014 Aug 26.

PMID:
25155879
32.

Early netrin-1 expression impairs central nervous system remyelination.

Tepavčević V, Kerninon C, Aigrot MS, Meppiel E, Mozafari S, Arnould-Laurent R, Ravassard P, Kennedy TE, Nait-Oumesmar B, Lubetzki C.

Ann Neurol. 2014 Aug;76(2):252-68. doi: 10.1002/ana.24201. Epub 2014 Jul 15.

PMID:
24942777
33.

Tumor and endothelial cell hybrids participate in glioblastoma vasculature.

El Hallani S, Colin C, El Houfi Y, Idbaih A, Boisselier B, Marie Y, Ravassard P, Labussière M, Mokhtari K, Thomas JL, Delattre JY, Eichmann A, Sanson M.

Biomed Res Int. 2014;2014:827327. doi: 10.1155/2014/827327. Epub 2014 Apr 24.

34.

Development of a conditionally immortalized human pancreatic β cell line.

Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout-Neveu E, Grenier-Godard M, Guez F, Rachdi L, Lohmann M, Czernichow P, Ravassard P.

J Clin Invest. 2014 May;124(5):2087-98. doi: 10.1172/JCI72674. Epub 2014 Mar 25.

35.

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.

Pasquali L, Gaulton KJ, Rodríguez-Seguí SA, Mularoni L, Miguel-Escalada I, Akerman İ, Tena JJ, Morán I, Gómez-Marín C, van de Bunt M, Ponsa-Cobas J, Castro N, Nammo T, Cebola I, García-Hurtado J, Maestro MA, Pattou F, Piemonti L, Berney T, Gloyn AL, Ravassard P, Skarmeta JLG, Müller F, McCarthy MI, Ferrer J.

Nat Genet. 2014 Feb;46(2):136-143. doi: 10.1038/ng.2870. Epub 2014 Jan 12.

36.

Multisensory control of multimodal behavior: do the legs know what the tongue is doing?

Cushman JD, Aharoni DB, Willers B, Ravassard P, Kees A, Vuong C, Popeney B, Arisaka K, Mehta MR.

PLoS One. 2013 Nov 4;8(11):e80465. doi: 10.1371/journal.pone.0080465. eCollection 2013.

37.

The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.

Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, Burel-Vandenbos F, Ambrosetti D, Hecksher-Sorensen J, Ravassard P, Heimberg H, Mansouri A, Collombat P.

PLoS Genet. 2013 Oct;9(10):e1003934. doi: 10.1371/journal.pgen.1003934. Epub 2013 Oct 31.

38.

Mouse muscle as an ectopic permissive site for human pancreatic development.

Capito C, Simon MT, Aiello V, Clark A, Aigrain Y, Ravassard P, Scharfmann R.

Diabetes. 2013 Oct;62(10):3479-87. doi: 10.2337/db13-0554. Epub 2013 Jul 8.

39.

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.

Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P.

Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27.

40.

Multisensory control of hippocampal spatiotemporal selectivity.

Ravassard P, Kees A, Willers B, Ho D, Aharoni DA, Cushman J, Aghajan ZM, Mehta MR.

Science. 2013 Jun 14;340(6138):1342-1346. doi: 10.1126/science.1232655. Epub 2013 May 2.

41.

Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells.

Lima MJ, Muir KR, Docherty HM, Drummond R, McGowan NW, Forbes S, Heremans Y, Houbracken I, Ross JA, Forbes SJ, Ravassard P, Heimberg H, Casey J, Docherty K.

Diabetes. 2013 Aug;62(8):2821-33. doi: 10.2337/db12-1256. Epub 2013 Apr 22.

42.

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl.

Mokhtari D, Al-Amin A, Turpaev K, Li T, Idevall-Hagren O, Li J, Wuttke A, Fred RG, Ravassard P, Scharfmann R, Tengholm A, Welsh N.

Diabetologia. 2013 Jun;56(6):1327-38. doi: 10.1007/s00125-013-2868-2. Epub 2013 Mar 5.

PMID:
23462796
43.

Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors.

Delaspre F, Massumi M, Salido M, Soria B, Ravassard P, Savatier P, Skoudy A.

PLoS One. 2013;8(1):e54243. doi: 10.1371/journal.pone.0054243. Epub 2013 Jan 17.

44.

Concise review: in search of unlimited sources of functional human pancreatic beta cells.

Scharfmann R, Rachdi L, Ravassard P.

Stem Cells Transl Med. 2013 Jan;2(1):61-7. doi: 10.5966/sctm.2012-0120. Epub 2012 Dec 19. Review.

45.

Gene delivery to pancreatic exocrine cells in vivo and in vitro.

Houbracken I, Baeyens L, Ravassard P, Heimberg H, Bouwens L.

BMC Biotechnol. 2012 Oct 22;12:74. doi: 10.1186/1472-6750-12-74.

46.

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.

Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakić N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J.

Cell Metab. 2012 Oct 3;16(4):435-48. doi: 10.1016/j.cmet.2012.08.010.

47.

Activation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cell differentiation in rats.

Soggia A, Flosseau K, Ravassard P, Szinnai G, Scharfmann R, Guillemain G.

Diabetologia. 2012 Oct;55(10):2713-2722. doi: 10.1007/s00125-012-2623-0. Epub 2012 Jul 5.

48.

Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.

Swales N, Martens GA, Bonné S, Heremans Y, Borup R, Van de Casteele M, Ling Z, Pipeleers D, Ravassard P, Nielsen F, Ferrer J, Heimberg H.

PLoS One. 2012;7(5):e37055. doi: 10.1371/journal.pone.0037055. Epub 2012 May 14.

49.

[First immortalised cell lines phenotypically and functionally equivalent to human insulin-secreting pancreatic beta cells].

Ravassard P, Czernichow P, Scharfmann R.

Med Sci (Paris). 2012 Feb;28(2):149-51. doi: 10.1051/medsci/2012282011. Epub 2012 Feb 27. French. No abstract available.

50.

Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fate.

Mauda-Havakuk M, Litichever N, Chernichovski E, Nakar O, Winkler E, Mazkereth R, Orenstein A, Bar-Meir E, Ravassard P, Meivar-Levy I, Ferber S.

PLoS One. 2011;6(10):e26298. doi: 10.1371/journal.pone.0026298. Epub 2011 Oct 18.

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