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Items: 4

1.

Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats.

Rautiola D, Maglalang PD, Cheryala N, Nelson KM, Georg GI, Fine JM, Svitak AL, Faltesek KA, Hanson LR, Mishra U, Coles LD, Cloyd JC, Siegel RA.

J Pharmacol Exp Ther. 2019 Sep;370(3):796-805. doi: 10.1124/jpet.118.255943. Epub 2019 Mar 5.

PMID:
30837282
2.

Conversion of a soluble diazepam prodrug to supersaturated diazepam for rapid intranasal delivery: Kinetics and stability.

Rautiola D, Cloyd JC, Siegel RA.

J Control Release. 2018 Nov 10;289:1-9. doi: 10.1016/j.jconrel.2018.09.013. Epub 2018 Sep 15.

PMID:
30227158
3.

Rescue therapies for seizure emergencies: New modes of administration.

Maglalang PD, Rautiola D, Siegel RA, Fine JM, Hanson LR, Coles LD, Cloyd JC.

Epilepsia. 2018 Oct;59 Suppl 2:207-215. doi: 10.1111/epi.14479. Epub 2018 Aug 29.

4.

Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines.

Kapoor M, Cheryala N, Rautiola D, Georg GI, Cloyd JC, Siegel RA.

J Pharm Sci. 2016 Aug;105(8):2365-71. doi: 10.1016/j.xphs.2016.05.011. Epub 2016 Jun 22.

PMID:
27342435

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