Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 129

1.

Speech of Patients With Unilateral Complete Cleft Lip and Palate: Comparison of Three Different Surgical Protocols for Primary Repair.

Ahti V, Alaluusua S, Rautio J, Leikola J, Hukki J, Saarikko A.

J Craniofac Surg. 2020 Feb 14. doi: 10.1097/SCS.0000000000006242. [Epub ahead of print]

PMID:
32068730
2.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

Vanden Eynde JJ, Mangoni AA, Rautio J, Leprince J, Azuma YT, García-Sosa AT, Hulme C, Jampilek J, Karaman R, Li W, Gomes PAC, Hadjipavlou-Litina D, Capasso R, Geronikaki A, Cerchia L, Sabatier JM, Ragno R, Tuccinardi T, Trabocchi A, Winum JY, Luque FJ, Prokai-Tatrai K, Spetea M, Gütschow M, Kosalec I, Guillou C, Vasconcelos MH, Kokotos G, Rastelli G, de Sousa ME, Manera C, Gemma S, Mangani S, Siciliano C, Galdiero S, Liu H, Scott PJH, de Los Ríos C, Agrofoglio LA, Collina S, Guedes RC, Muñoz-Torrero D.

Molecules. 2019 Dec 28;25(1). pii: E119. doi: 10.3390/molecules25010119.

3.

Scandcleft Project Trial 2-Comparison of Speech Outcome in 1- and 2-Stage Palatal Closure in 5-Year-Olds With UCLP.

Hammarström IL, Nyberg J, Alaluusua S, Rautio J, Neovius E, Berggren A, Persson C, Willadsen E, Lohmander A.

Cleft Palate Craniofac J. 2019 Nov 20:1055665619888316. doi: 10.1177/1055665619888316. [Epub ahead of print]

PMID:
31746642
4.

Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells.

Srisongkram T, Weerapreeyakul N, Kärkkäinen J, Rautio J.

Molecules. 2019 Oct 27;24(21). pii: E3869. doi: 10.3390/molecules24213869.

5.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.

Mangoni AA, Eynde JJV, Jampilek J, Hadjipavlou-Litina D, Liu H, Reynisson J, Sousa ME, Gomes PAC, Prokai-Tatrai K, Tuccinardi T, Sabatier JM, Luque FJ, Rautio J, Karaman R, Vasconcelos MH, Gemma S, Galdiero S, Hulme C, Collina S, Gütschow M, Kokotos G, Siciliano C, Capasso R, Agrofoglio LA, Ragno R, Muñoz-Torrero D.

Molecules. 2019 Jun 30;24(13). pii: E2415. doi: 10.3390/molecules24132415.

6.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4.

Mangoni AA, Guillou C, Vanden Eynde JJ, Hulme C, Jampilek J, Li W, Prokai-Tatrai K, Rautio J, Collina S, Tuccinardi T, Sousa ME, Sabatier JM, Galdiero S, Karaman R, Kokotos G, Torri G, Luque FJ, Vasconcelos MH, Hadjipavlou-Litina D, Siciliano C, Gütschow M, Ragno R, Gomes PAC, Agrofoglio LA, Muñoz-Torrero D.

Molecules. 2018 Dec 31;24(1). pii: E130. doi: 10.3390/molecules24010130.

7.

Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase.

Lukin A, Kramer J, Hartmann M, Weizel L, Hernandez-Olmos V, Falahati K, Burghardt I, Kalinchenkova N, Bagnyukova D, Zhurilo N, Rautio J, Forsberg M, Ihalainen J, Auriola S, Leppänen J, Konstantinov I, Pogoryelov D, Proschak E, Dar'in D, Krasavin M.

Bioorg Chem. 2018 Oct;80:655-667. doi: 10.1016/j.bioorg.2018.07.014. Epub 2018 Jul 17.

PMID:
30059891
8.

Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug.

Thiele NA, Kärkkäinen J, Sloan KB, Rautio J, Huttunen KM.

Bioorg Med Chem Lett. 2018 Sep 15;28(17):2856-2860. doi: 10.1016/j.bmcl.2018.07.030. Epub 2018 Jul 18.

PMID:
30055889
9.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3.

Mangoni AA, Tuccinardi T, Collina S, Vanden Eynde JJ, Muñoz-Torrero D, Karaman R, Siciliano C, de Sousa ME, Prokai-Tatrai K, Rautio J, Guillou C, Gütschow M, Galdiero S, Liu H, Agrofoglio LA, Sabatier JM, Hulme C, Kokotos G, You Q, Gomes PAC.

Molecules. 2018 Jun 30;23(7). pii: E1596. doi: 10.3390/molecules23071596. No abstract available.

10.

The expanding role of prodrugs in contemporary drug design and development.

Rautio J, Meanwell NA, Di L, Hageman MJ.

Nat Rev Drug Discov. 2018 Aug;17(8):559-587. doi: 10.1038/nrd.2018.46. Epub 2018 Apr 27. Review.

PMID:
29700501
11.

Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake.

Kärkkäinen J, Gynther M, Kokkola T, Petsalo A, Auriola S, Lahtela-Kakkonen M, Laine K, Rautio J, Huttunen KM.

Int J Pharm. 2018 Jun 10;544(1):91-99. doi: 10.1016/j.ijpharm.2018.04.025. Epub 2018 Apr 15.

PMID:
29669256
12.

Incidence of Speech-Correcting Surgery in Children With Isolated Cleft Palate.

Gustafsson C, Heliövaara A, Leikola J, Rautio J.

Cleft Palate Craniofac J. 2018 Jan 1:1055665618760889. doi: 10.1177/1055665618760889. [Epub ahead of print]

PMID:
29537881
13.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

Muñoz-Torrero D, Mangoni AA, Liu H, Hulme C, Rautio J, Karaman R, de Sousa ME, Prokai-Tatrai K, Sabatier JM, Siciliano C, Luque FJ, Kokotos G, Ragno R, Collina S, Guillou C, Gütschow M, Agrofoglio LA.

Molecules. 2017 Dec 28;23(1). pii: E65. doi: 10.3390/molecules23010065.

14.

Prodrugs - Recent approvals and a glimpse of the pipeline.

Rautio J, Kärkkäinen J, Sloan KB.

Eur J Pharm Sci. 2017 Nov 15;109:146-161. doi: 10.1016/j.ejps.2017.08.002. Epub 2017 Aug 4. Review.

PMID:
28782609
15.

Prodrugs in medicinal chemistry and enzyme prodrug therapies.

Walther R, Rautio J, Zelikin AN.

Adv Drug Deliv Rev. 2017 Sep 1;118:65-77. doi: 10.1016/j.addr.2017.06.013. Epub 2017 Jul 1. Review.

PMID:
28676386
16.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes.

Muñoz-Torrero D, Mangoni AA, Guillou C, Collina S, Vanden Eynde JJ, Rautio J, Keserű GM, Hulme C, Chibale K, Luque FJ, Karaman R, Gütschow M, Liu H, Ragno R.

Molecules. 2017 May 5;22(5). pii: E743. doi: 10.3390/molecules22050743.

17.

A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.

Semb G, Enemark H, Friede H, Paulin G, Lilja J, Rautio J, Andersen M, Åbyholm F, Lohmander A, Shaw W, Mølsted K, Heliövaara A, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Whitby D, Leonard A, Neovius E, Elander A, Willadsen E, Bannister RP, Bradbury E, Henningsson G, Persson C, Eyres P, Emborg B, Kisling-Møller M, Küseler A, Granhof Black B, Schöps A, Bau A, Boers M, Andersen HS, Jeppesen K, Marxen D, Paaso M, Hölttä E, Alaluusua S, Turunen L, Humerinta K, Elfving-Little U, Tørdal IB, Kjøll L, Aukner R, Hide Ø, Feragen KB, Rønning E, Skaare P, Brinck E, Semmingsen AM, Lindberg N, Bowden M, Davies J, Mooney J, Bellardie H, Schofield N, Nyberg J, Lundberg M, Karsten AL, Larson M, Holmefjord A, Reisæter S, Pedersen NH, Rasmussen T, Tindlund R, Sæle P, Blomhoff R, Jacobsen G, Havstam C, Rizell S, Enocson L, Hagberg C, Najar Chalien M, Paganini A, Lundeborg I, Marcusson A, Mjönes AB, Gustavsson A, Hayden C, McAleer E, Slevan E, Gregg T, Worthington H.

J Plast Surg Hand Surg. 2017 Feb;51(1):2-13. doi: 10.1080/2000656X.2016.1263202. Review. Erratum in: J Plast Surg Hand Surg. 2017 Apr;51(2):158.

PMID:
28218559
18.

Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 2. Surgical results.

Rautio J, Andersen M, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Åbyholm F, Whitby D, Leonard A, Lilja J, Neovius E, Elander A, Heliövaara A, Eyres P, Semb G.

J Plast Surg Hand Surg. 2017 Feb;51(1):14-20. doi: 10.1080/2000656X.2016.1254646. Review.

PMID:
28218552
19.

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

Krasavin M, Lukin A, Bagnyukova D, Zhurilo N, Zahanich I, Zozulya S, Ihalainen J, Forsberg MM, Lehtonen M, Rautio J, Moore D, Tikhonova IG.

Bioorg Med Chem. 2016 Nov 1;24(21):5481-5494. doi: 10.1016/j.bmc.2016.09.004. Epub 2016 Sep 3.

PMID:
27647366
20.

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure.

Gynther M, Peura L, Vernerová M, Leppänen J, Kärkkäinen J, Lehtonen M, Rautio J, Huttunen KM.

Neurochem Res. 2016 Oct;41(10):2797-2809. Epub 2016 Jul 14.

PMID:
27412117
21.

Craniofacial morphology in children with van der Woude syndrome and isolated cleft palate.

Heliövaara A, Karhulahti R, Rautio J.

J Plast Surg Hand Surg. 2015;49(4):209-13. doi: 10.3109/2000656X.2014.992904. Epub 2014 Dec 17.

PMID:
25516228
22.

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

Ramirez YP, Mladek AC, Phillips RM, Gynther M, Rautio J, Ross AH, Wheelhouse RT, Sakaria JN.

Mol Cancer Ther. 2015 Jan;14(1):111-9. doi: 10.1158/1535-7163.MCT-14-0113. Epub 2014 Oct 28.

23.

Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.

Gynther M, Kääriäinen TM, Hakkarainen JJ, Jalkanen AJ, Petsalo A, Lehtonen M, Peura L, Kurkipuro J, Samaranayake H, Ylä-Herttuala S, Rautio J, Forsberg MM.

Drug Metab Dispos. 2015 Jan;43(1):140-6. doi: 10.1124/dmd.114.059840. Epub 2014 Oct 27.

PMID:
25349125
24.

Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).

Rautio J, Kärkkäinen J, Huttunen KM, Gynther M.

Eur J Pharm Sci. 2015 Jan 23;66:36-40. doi: 10.1016/j.ejps.2014.09.025. Epub 2014 Oct 8.

PMID:
25305508
25.

Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug.

Rautio J, Vernerová M, Aufderhaar I, Huttunen KM.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5034-6. doi: 10.1016/j.bmcl.2014.09.019. Epub 2014 Sep 16.

PMID:
25248681
26.

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).

Ylikangas H, Malmioja K, Peura L, Gynther M, Nwachukwu EO, Leppänen J, Laine K, Rautio J, Lahtela-Kakkonen M, Huttunen KM, Poso A.

ChemMedChem. 2014 Dec;9(12):2699-707. doi: 10.1002/cmdc.201402281. Epub 2014 Sep 9.

PMID:
25205473
27.
28.

Variation in α-acetolactate production within the hybrid lager yeast group Saccharomyces pastorianus and affirmation of the central role of the ILV6 gene.

Gibson B, Krogerus K, Ekberg J, Monroux A, Mattinen L, Rautio J, Vidgren V.

Yeast. 2015 Jan;32(1):301-16. doi: 10.1002/yea.3026. Epub 2014 Aug 6.

29.

Direct and rapid transcript analysis assay for CYP mRNA expression and inducibility in human primary hepatocytes.

Mattinen L, Kublbeck J, Rechardt O, Honkakoski P, Rautio J.

Drug Metab Lett. 2014;8(2):77-87.

PMID:
24910238
30.

Cone beam computed tomography in the assessment of alveolar bone grafting in children with unilateral cleft lip and palate.

Suomalainen A, Åberg T, Rautio J, Hurmerinta K.

Eur J Orthod. 2014 Oct;36(5):603-11. doi: 10.1093/ejo/cjt105. Epub 2014 Feb 7.

PMID:
24509615
31.

Cleft Lip and/or Palate and Auricular Malformations.

Suutarla S, Rautio J, Klockars T.

Cleft Palate Craniofac J. 2015 Jan;52(1):62-5. doi: 10.1597/13-069.

PMID:
24437583
32.

Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development.

Peyrard-Janvid M, Leslie EJ, Kousa YA, Smith TL, Dunnwald M, Magnusson M, Lentz BA, Unneberg P, Fransson I, Koillinen HK, Rautio J, Pegelow M, Karsten A, Basel-Vanagaite L, Gordon W, Andersen B, Svensson T, Murray JC, Cornell RA, Kere J, Schutte BC.

Am J Hum Genet. 2014 Jan 2;94(1):23-32. doi: 10.1016/j.ajhg.2013.11.009. Epub 2013 Dec 19.

33.

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.

Peura L, Malmioja K, Huttunen K, Leppänen J, Hämäläinen M, Forsberg MM, Gynther M, Rautio J, Laine K.

Pharm Res. 2013 Oct;30(10):2523-37. Erratum in: Pharm Res. 2013 Jun;30(6):1714. Gynther, Mikko [added].

PMID:
24137801
34.

Anterior crossbite, dental arch dimensions, and later need for orthognathic surgery in 6-year-old children with unilateral cleft lip and palate.

Heliövaara A, Leikola J, Rautio J.

Cleft Palate Craniofac J. 2014 Sep;51(5):579-84. doi: 10.1597/12-198. Epub 2013 Sep 4.

PMID:
24003835
35.

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin.

Huttunen KM, Leppänen J, Laine K, Vepsäläinen J, Rautio J.

Eur J Pharm Sci. 2013 Jul 16;49(4):624-8. doi: 10.1016/j.ejps.2013.05.023. Epub 2013 Jun 1.

PMID:
23732628
36.

LAT1-mediated prodrug uptake: a way to breach the blood-brain barrier?

Rautio J, Gynther M, Laine K.

Ther Deliv. 2013 Mar;4(3):281-4. doi: 10.4155/tde.12.165. No abstract available.

37.

Adaptive evolution of the lager brewing yeast Saccharomyces pastorianus for improved growth under hyperosmotic conditions and its influence on fermentation performance.

Ekberg J, Rautio J, Mattinen L, Vidgren V, Londesborough J, Gibson BR.

FEMS Yeast Res. 2013 May;13(3):335-49. doi: 10.1111/1567-1364.12038. Epub 2013 Mar 7.

38.

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion.

Ylikangas H, Peura L, Malmioja K, Leppänen J, Laine K, Poso A, Lahtela-Kakkonen M, Rautio J.

Eur J Pharm Sci. 2013 Feb 14;48(3):523-31. doi: 10.1016/j.ejps.2012.11.014. Epub 2012 Dec 8.

PMID:
23228412
39.

Amino acids as promoieties in prodrug design and development.

Vig BS, Huttunen KM, Laine K, Rautio J.

Adv Drug Deliv Rev. 2013 Oct;65(10):1370-85. doi: 10.1016/j.addr.2012.10.001. Epub 2012 Oct 22. Review.

PMID:
23099277
40.

Inhibitors of LRRK2 kinase activity to probe the treatment option in Parkinson's disease.

Rautio J.

J Med Chem. 2012 Nov 26;55(22):9414-5. doi: 10.1021/jm301460x. Epub 2012 Oct 18. No abstract available.

PMID:
23078245
41.

Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome p450-activated prodrugs.

Huttunen KM, Tani N, Juvonen RO, Raunio H, Rautio J.

Mol Pharm. 2013 Feb 4;10(2):532-7. doi: 10.1021/mp300330v. Epub 2012 Aug 31.

PMID:
22937971
42.

Amino acid prodrugs for oral delivery: challenges and opportunities.

Vig B, Rautio J.

Ther Deliv. 2011 Aug;2(8):959-62. No abstract available.

43.

Early placement of ventilation tubes in cleft lip and palate patients: does palatal closure affect tube occlusion and short-term outcome?

Klockars T, Rautio J.

Int J Pediatr Otorhinolaryngol. 2012 Oct;76(10):1481-4. doi: 10.1016/j.ijporl.2012.06.028. Epub 2012 Jul 15.

PMID:
22796197
44.

Aesthetics of the auricle and its implications for otoplasty and auricular reconstruction.

Klockars T, Mäkitie A, Rautio J.

Int J Pediatr Otorhinolaryngol. 2012 Sep;76(9):1347-50. doi: 10.1016/j.ijporl.2012.06.004. Epub 2012 Jul 3.

PMID:
22763209
45.

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.

Huttunen KM, Leppänen J, Vepsäläinen J, Sirviö J, Laine K, Rautio J.

J Pharm Sci. 2012 Aug;101(8):2854-60. doi: 10.1002/jps.23221. Epub 2012 May 30.

PMID:
22648910
46.

Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression.

Forbes-Lorman RM, Rautio JJ, Kurian JR, Auger AP, Auger CJ.

Epigenetics. 2012 Mar;7(3):230-8. doi: 10.4161/epi.7.3.19265.

47.

Correlation of gene expression and protein production rate - a system wide study.

Arvas M, Pakula T, Smit B, Rautio J, Koivistoinen H, Jouhten P, Lindfors E, Wiebe M, Penttilä M, Saloheimo M.

BMC Genomics. 2011 Dec 20;12:616. doi: 10.1186/1471-2164-12-616.

48.

The effect of temperature and pH gradients on Lactobacillus rhamnosus gene expression of stress-related genes.

Wallenius J, Uuksulainen T, Salonen K, Rautio J, Eerikäinen T.

Bioprocess Biosyst Eng. 2011 Nov;34(9):1169-76. doi: 10.1007/s00449-011-0568-1. Epub 2011 Jul 21.

PMID:
21779891
49.

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.

Peura L, Malmioja K, Laine K, Leppänen J, Gynther M, Isotalo A, Rautio J.

Mol Pharm. 2011 Oct 3;8(5):1857-66. doi: 10.1021/mp2001878. Epub 2011 Aug 9.

PMID:
21770378
50.

Prodrugs--from serendipity to rational design.

Huttunen KM, Raunio H, Rautio J.

Pharmacol Rev. 2011 Sep;63(3):750-71. doi: 10.1124/pr.110.003459. Epub 2011 Jul 7. Review.

PMID:
21737530

Supplemental Content

Loading ...
Support Center