Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 182


Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models.

Kukuyan AM, Sementino E, Kadariya Y, Menges CW, Cheung M, Tan Y, Cai KQ, Slifker MJ, Peri S, Klein-Szanto AJ, Rauscher FJ 3rd, Testa JR.

Cancer Res. 2019 Aug 15;79(16):4113-4123. doi: 10.1158/0008-5472.CAN-18-4093. Epub 2019 May 31.


Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas.

Sementino E, Menges CW, Kadariya Y, Peri S, Xu J, Liu Z, Wilkes RG, Cai KQ, Rauscher FJ 3rd, Klein-Szanto AJ, Testa JR.

J Cell Physiol. 2018 Nov;233(11):8952-8961. doi: 10.1002/jcp.26830. Epub 2018 Jun 15.


LIMD2 Is Overexpressed in BRAF V600E-Positive Papillary Thyroid Carcinomas and Matched Lymph Node Metastases.

Pinheiro Dos Santos MJC, Bastos AU, da Costa VR, Delcelo R, Lindsey SC, Colozza-Gama GA, Peng H, Rauscher FJ 3rd, Oler G, Cerutti JM.

Endocr Pathol. 2018 Sep;29(3):222-230. doi: 10.1007/s12022-018-9526-7.


Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.

Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J.

J Am Soc Nephrol. 2018 May;29(5):1525-1535. doi: 10.1681/ASN.2017080856. Epub 2018 Feb 23.


Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains.

Peng H, Prokop J, Karar J, Park K, Cao L, Harbour JW, Bowcock AM, Malkowicz SB, Cheung M, Testa JR, Rauscher FJ 3rd.

Cancer Res. 2018 Mar 1;78(5):1200-1213. doi: 10.1158/0008-5472.CAN-17-2876. Epub 2017 Dec 28.


MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression.

Heppt MV, Wang JX, Hristova DM, Wei Z, Li L, Evans B, Beqiri M, Zaman S, Zhang J, Irmler M, Berking C, Besch R, Beckers J, Rauscher FJ 3rd, Sturm RA, Fisher DE, Herlyn M, Fukunaga-Kalabis M.

J Invest Dermatol. 2018 Jan;138(1):141-149. doi: 10.1016/j.jid.2017.05.038. Epub 2017 Sep 18.


ARID1A-mutated ovarian cancers depend on HDAC6 activity.

Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher FJ III, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R.

Nat Cell Biol. 2017 Aug;19(8):962-973. doi: 10.1038/ncb3582. Epub 2017 Jul 24.


Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations.

Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR.

Cancer Res. 2016 May 1;76(9):2836-44. doi: 10.1158/0008-5472.CAN-15-3371. Epub 2016 Feb 19.


Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer.

Ohar JA, Cheung M, Talarchek J, Howard SE, Howard TD, Hesdorffer M, Peng H, Rauscher FJ, Testa JR.

Cancer Res. 2016 Jan 15;76(2):206-15. doi: 10.1158/0008-5472.CAN-15-0295. Epub 2015 Dec 30. Erratum in: Cancer Res. 2017 Jun 1;77(11):3124. Cancer Res. 2018 Jan 1;78(1):309.


The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction.

Li Q, Peng H, Fan H, Zou X, Liu Q, Zhang Y, Xu H, Chu Y, Wang C, Ayyanathan K, Rauscher FJ, Zhang K, Hou Z.

Cell Death Differ. 2016 Jan;23(1):158-68. doi: 10.1038/cdd.2015.83. Epub 2015 Jun 26.


An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors.

Chang AT, Liu Y, Ayyanathan K, Benner C, Jiang Y, Prokop JW, Paz H, Wang D, Li HR, Fu XD, Rauscher FJ 3rd, Yang J.

Genes Dev. 2015 Mar 15;29(6):603-16. doi: 10.1101/gad.242842.114. Epub 2015 Mar 11.


Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway.

Yao Q, Zhang L, Wan X, Chen J, Hu L, Ding X, Li L, Karar J, Peng H, Chen S, Huang N, Rauscher FJ 3rd, Shao F.

PLoS Pathog. 2014 Nov 20;10(11):e1004522. doi: 10.1371/journal.ppat.1004522. eCollection 2014 Nov.


Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.

Xu J, Kadariya Y, Cheung M, Pei J, Talarchek J, Sementino E, Tan Y, Menges CW, Cai KQ, Litwin S, Peng H, Karar J, Rauscher FJ, Testa JR.

Cancer Res. 2014 Aug 15;74(16):4388-97. doi: 10.1158/0008-5472.CAN-14-1328. Epub 2014 Jun 13.


Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells.

Chen J, Xu H, Zou X, Wang J, Zhu Y, Chen H, Shen B, Deng X, Zhou A, Chin YE, Rauscher FJ 3rd, Peng C, Hou Z.

Cancer Res. 2014 Aug 15;74(16):4353-63. doi: 10.1158/0008-5472.CAN-14-0181. Epub 2014 Jun 5.


LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.

Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KLB, Rauscher FJ 3rd.

Cancer Res. 2014 Mar 1;74(5):1390-1403. doi: 10.1158/0008-5472.CAN-13-1275.


MAS promoter regulation: a role for Sry and tyrosine nitration of the KRAB domain of ZNF274 as a feedback mechanism.

Prokop JW, Rauscher FJ 3rd, Peng H, Liu Y, Araujo FC, Watanabe I, Reis FM, Milsted A.

Clin Sci (Lond). 2014 May;126(10):727-38. doi: 10.1042/CS20130385.


Retraction: Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

Negorev DG, Vladimirova OV, Kossenkov AV, Demarest RM, Showe MK, Rauscher FJ 3rd, Showe LC, Nikonova EV, Capobianco AJ.

Cancer Res. 2013 Aug 1;73(15):4960-1. doi: 10.1158/0008-5472.CAN-13-1715. No abstract available.


Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma cells: altered metabolic phenotype associated with reactive oxygen species, nitric oxide and SXR target genes involved in cholesterol and lipid metabolism.

Fredericks WJ, Yin H, Lal P, Puthiyaveettil R, Malkowicz SB, Fredericks NJ, Tomaszewski J, Rauscher FJ 3rd, Malkowicz SB.

Int J Oncol. 2013 Aug;43(2):638-52. doi: 10.3892/ijo.2013.1985. Epub 2013 Jun 12.


A method for in silico identification of SNAIL/SLUG DNA binding potentials to the E-box sequence using molecular dynamics and evolutionary conserved amino acids.

Prokop JW, Liu Y, Milsted A, Peng H, Rauscher FJ 3rd.

J Mol Model. 2013 Sep;19(9):3463-9. doi: 10.1007/s00894-013-1876-y. Epub 2013 May 25.


The TERE1 protein interacts with mitochondrial TBL2: regulation of trans-membrane potential, ROS/RNS and SXR target genes.

Fredericks WJ, McGarvey T, Wang H, Zheng Y, Fredericks NJ, Yin H, Wang LP, Hsiao W, Lee R, Weiss JS, Nickerson ML, Kruth HS, Rauscher FJ 3rd, Malkowicz SB.

J Cell Biochem. 2013 Sep;114(9):2170-87. doi: 10.1002/jcb.24567.


Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature.

Wang T, Ge Y, Xiao M, Lopez-Coral A, Azuma R, Somasundaram R, Zhang G, Wei Z, Xu X, Rauscher FJ 3rd, Herlyn M, Kaufman RE.

Pigment Cell Melanoma Res. 2012 Jul;25(4):493-505. doi: 10.1111/j.1755-148X.2012.01005.x.


The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation.

White D, Rafalska-Metcalf IU, Ivanov AV, Corsinotti A, Peng H, Lee SC, Trono D, Janicki SM, Rauscher FJ 3rd.

Mol Cancer Res. 2012 Mar;10(3):401-14. doi: 10.1158/1541-7786.MCR-11-0134. Epub 2011 Dec 28.


Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.

Liang Q, Deng H, Li X, Wu X, Tang Q, Chang TH, Peng H, Rauscher FJ 3rd, Ozato K, Zhu F.

J Immunol. 2011 Nov 1;187(9):4754-63. doi: 10.4049/jimmunol.1101704. Epub 2011 Sep 21.


Functional analysis of KAP1 genomic recruitment.

Iyengar S, Ivanov AV, Jin VX, Rauscher FJ 3rd, Farnham PJ.

Mol Cell Biol. 2011 May;31(9):1833-47. doi: 10.1128/MCB.01331-10. Epub 2011 Feb 22.


Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis.

Mellert HS, Stanek TJ, Sykes SM, Rauscher FJ 3rd, Schultz DC, McMahon SB.

J Biol Chem. 2011 Feb 11;286(6):4264-70. doi: 10.1074/jbc.M110.184663. Epub 2010 Dec 9.


Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

Negorev DG, Vladimirova OV, Kossenkov AV, Nikonova EV, Demarest RM, Capobianco AJ, Showe MK, Rauscher FJ 3rd, Showe LC, Maul GG.

Cancer Res. 2010 Dec 1;70(23):9991-10001. doi: 10.1158/0008-5472.CAN-10-1483. Epub 2010 Nov 30. Retraction in: Negorev DG, Vladimirova OV, Kossenkov AV, Demarest RM, Showe MK, Rauscher FJ 3rd, Showe LC, Nikonova EV, Capobianco AJ. Cancer Res. 2013 Aug 1;73(15):4960-1.


The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.

Yu H, Mashtalir N, Daou S, Hammond-Martel I, Ross J, Sui G, Hart GW, Rauscher FJ 3rd, Drobetsky E, Milot E, Shi Y, Affar el B.

Mol Cell Biol. 2010 Nov;30(21):5071-85. doi: 10.1128/MCB.00396-10. Epub 2010 Aug 30.


14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiation.

Hou Z, Peng H, White DE, Wang P, Lieberman PM, Halazonetis T, Rauscher FJ 3rd.

Cancer Res. 2010 Jun 1;70(11):4385-93. doi: 10.1158/0008-5472.CAN-10-0070. Epub 2010 May 25. Erratum in: Cancer Res. 2010 Sep 1;70(17):7012-3.


LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.

Hou Z, Peng H, White DE, Negorev DG, Maul GG, Feng Y, Longmore GD, Waxman S, Zelent A, Rauscher FJ 3rd.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2938-43. doi: 10.1073/pnas.0908656107. Epub 2010 Jan 26.


Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ 3rd.

J Biol Chem. 2009 Dec 18;284(51):35670-80. doi: 10.1074/jbc.M109.032086.


The year ahead.

Rauscher FJ 3rd.

Cancer Res. 2009 Jan 1;69(1):1. doi: 10.1158/0008-5472.CAN-69-1-ED. No abstract available.


Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing.

Zeng L, Yap KL, Ivanov AV, Wang X, Mujtaba S, Plotnikova O, Rauscher FJ 3rd, Zhou MM.

Nat Struct Mol Biol. 2008 Jun;15(6):626-33. doi: 10.1038/nsmb.1416. Epub 2008 May 18.


The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression.

Hou Z, Peng H, Ayyanathan K, Yan KP, Langer EM, Longmore GD, Rauscher FJ 3rd.

Mol Cell Biol. 2008 May;28(10):3198-207. doi: 10.1128/MCB.01435-07. Epub 2008 Mar 17.


Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

Langer EM, Feng Y, Zhaoyuan H, Rauscher FJ 3rd, Kroll KL, Longmore GD.

Dev Cell. 2008 Mar;14(3):424-36. doi: 10.1016/j.devcel.2008.01.005.


PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.

Ivanov AV, Peng H, Yurchenko V, Yap KL, Negorev DG, Schultz DC, Psulkowski E, Fredericks WJ, White DE, Maul GG, Sadofsky MJ, Zhou MM, Rauscher FJ 3rd.

Mol Cell. 2007 Dec 14;28(5):823-37.


The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling.

Ayyanathan K, Peng H, Hou Z, Fredericks WJ, Goyal RK, Langer EM, Longmore GD, Rauscher FJ 3rd.

Cancer Res. 2007 Oct 1;67(19):9097-106.


Regulation of E2F1 function by the nuclear corepressor KAP1.

Wang C, Rauscher FJ 3rd, Cress WD, Chen J.

J Biol Chem. 2007 Oct 12;282(41):29902-9. Epub 2007 Aug 17.


The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain.

Peng H, Gibson LC, Capili AD, Borden KL, Osborne MJ, Harper SL, Speicher DW, Zhao K, Marmorstein R, Rock TA, Rauscher FJ 3rd.

J Mol Biol. 2007 Jul 6;370(2):269-89. Epub 2007 Mar 24.


Drosophila SETDB1 is required for chromosome 4 silencing.

Seum C, Reo E, Peng H, Rauscher FJ 3rd, Spierer P, Bontron S.

PLoS Genet. 2007 May 11;3(5):e76.


A proximal activator of transcription in epithelial-mesenchymal transition.

Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, Nagai K, Xu C, Dimitrova YN, Rauscher FJ, Neilson EG.

J Clin Invest. 2007 Feb;117(2):482-91.


KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions.

White DE, Negorev D, Peng H, Ivanov AV, Maul GG, Rauscher FJ 3rd.

Cancer Res. 2006 Dec 15;66(24):11594-9.


It is time for a Human Epigenome Project.

Rauscher FJ 3rd.

Cancer Res. 2005 Dec 15;65(24):11229. No abstract available.


MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, Rauscher FJ 3rd, Chen J.

EMBO J. 2005 Sep 21;24(18):3279-90. Epub 2005 Aug 18.


The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.

Lechner MS, Schultz DC, Negorev D, Maul GG, Rauscher FJ 3rd.

Biochem Biophys Res Commun. 2005 Jun 17;331(4):929-37.


Novel consensus DNA-binding sequence for BRCA1 protein complexes.

Cable PL, Wilson CA, Calzone FJ, Rauscher FJ 3rd, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA.

Mol Carcinog. 2003 Oct;38(2):85-96.


Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation.

Ayyanathan K, Lechner MS, Bell P, Maul GG, Schultz DC, Yamada Y, Tanaka K, Torigoe K, Rauscher FJ 3rd.

Genes Dev. 2003 Aug 1;17(15):1855-69. Epub 2003 Jul 17.


A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1.

Peng H, Zheng L, Lee WH, Rux JJ, Rauscher FJ 3rd.

Cancer Res. 2002 Jul 1;62(13):3773-81.

Supplemental Content

Loading ...
Support Center