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Structural Effects and Functional Implications of Phalloidin and Jasplakinolide Binding to Actin Filaments.

Pospich S, Merino F, Raunser S.

Structure. 2020 Feb 12. pii: S0969-2126(20)30041-1. doi: 10.1016/j.str.2020.01.014. [Epub ahead of print]


The evolution of SPHIRE-crYOLO particle picking and its application in automated cryo-EM processing workflows.

Wagner T, Raunser S.

Commun Biol. 2020 Feb 11;3(1):61. doi: 10.1038/s42003-020-0790-y. No abstract available.


Structure of the human BBSome core complex.

Klink BU, Gatsogiannis C, Hofnagel O, Wittinghofer A, Raunser S.

Elife. 2020 Jan 17;9. pii: e53910. doi: 10.7554/eLife.53910.


Towards a structural understanding of the remodeling of the actin cytoskeleton.

Merino F, Pospich S, Raunser S.

Semin Cell Dev Biol. 2019 Dec 10. pii: S1084-9521(19)30190-9. doi: 10.1016/j.semcdb.2019.11.018. [Epub ahead of print] Review.


Towards the application of Tc toxins as a universal protein translocation system.

Roderer D, Schubert E, Sitsel O, Raunser S.

Nat Commun. 2019 Nov 20;10(1):5263. doi: 10.1038/s41467-019-13253-8.


Structure of a Tc holotoxin pore provides insights into the translocation mechanism.

Roderer D, Hofnagel O, Benz R, Raunser S.

Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23083-23090. doi: 10.1073/pnas.1909821116. Epub 2019 Oct 30.


Common architecture of Tc toxins from human and insect pathogenic bacteria.

Leidreiter F, Roderer D, Meusch D, Gatsogiannis C, Benz R, Raunser S.

Sci Adv. 2019 Oct 16;5(10):eaax6497. doi: 10.1126/sciadv.aax6497. eCollection 2019 Oct.


Profilin and formin constitute a pacemaker system for robust actin filament growth.

Funk J, Merino F, Venkova L, Heydenreich L, Kierfeld J, Vargas P, Raunser S, Piel M, Bieling P.

Elife. 2019 Oct 24;8. pii: e50963. doi: 10.7554/eLife.50963.


Cryo-EM structure of the ClpXP protein degradation machinery.

Gatsogiannis C, Balogh D, Merino F, Sieber SA, Raunser S.

Nat Struct Mol Biol. 2019 Oct;26(10):946-954. doi: 10.1038/s41594-019-0304-0. Epub 2019 Oct 3.


Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.

Raisch T, Chang CT, Levdansky Y, Muthukumar S, Raunser S, Valkov E.

Nat Commun. 2019 Jul 18;10(1):3173. doi: 10.1038/s41467-019-11094-z.


Micellar Brønsted Acid Mediated Synthesis of DNA-Tagged Heterocycles.

Škopić MK, Götte K, Gramse C, Dieter M, Pospich S, Raunser S, Weberskirch R, Brunschweiger A.

J Am Chem Soc. 2019 Jul 3;141(26):10546-10555. doi: 10.1021/jacs.9b05696. Epub 2019 Jun 21.


SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM.

Wagner T, Merino F, Stabrin M, Moriya T, Antoni C, Apelbaum A, Hagel P, Sitsel O, Raisch T, Prumbaum D, Quentin D, Roderer D, Tacke S, Siebolds B, Schubert E, Shaikh TR, Lill P, Gatsogiannis C, Raunser S.

Commun Biol. 2019 Jun 19;2:218. doi: 10.1038/s42003-019-0437-z. eCollection 2019.


Tc Toxin Complexes: Assembly, Membrane Permeation, and Protein Translocation.

Roderer D, Raunser S.

Annu Rev Microbiol. 2019 Sep 8;73:247-265. doi: 10.1146/annurev-micro-102215-095531. Epub 2019 May 29.


Cryo-EM reveals the asymmetric assembly of squid hemocyanin.

Tanaka Y, Kato S, Stabrin M, Raunser S, Matsui T, Gatsogiannis C.

IUCrJ. 2019 Apr 5;6(Pt 3):426-437. doi: 10.1107/S205225251900321X. eCollection 2019 May 1.


Big insights from tiny crystals.

Sitsel O, Raunser S.

Nat Chem. 2019 Feb;11(2):106-108. doi: 10.1038/s41557-019-0211-3. No abstract available.


Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales.

Ludwig AK, De Miroschedji K, Doeppner TR, Börger V, Ruesing J, Rebmann V, Durst S, Jansen S, Bremer M, Behrmann E, Singer BB, Jastrow H, Kuhlmann JD, El Magraoui F, Meyer HE, Hermann DM, Opalka B, Raunser S, Epple M, Horn PA, Giebel B.

J Extracell Vesicles. 2018 Oct 17;7(1):1528109. doi: 10.1080/20013078.2018.1528109. eCollection 2018.


Tc toxin activation requires unfolding and refolding of a β-propeller.

Gatsogiannis C, Merino F, Roderer D, Balchin D, Schubert E, Kuhlee A, Hayer-Hartl M, Raunser S.

Nature. 2018 Nov;563(7730):209-213. doi: 10.1038/s41586-018-0556-6. Epub 2018 Sep 19.


Mechanism of loading and translocation of type VI secretion system effector Tse6.

Quentin D, Ahmad S, Shanthamoorthy P, Mougous JD, Whitney JC, Raunser S.

Nat Microbiol. 2018 Oct;3(10):1142-1152. doi: 10.1038/s41564-018-0238-z. Epub 2018 Sep 3.


Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.

Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A.

Mol Cell. 2018 Sep 20;71(6):923-939.e10. doi: 10.1016/j.molcel.2018.07.038. Epub 2018 Aug 30.


Single particle cryo-EM-an optimal tool to study cytoskeletal proteins.

Pospich S, Raunser S.

Curr Opin Struct Biol. 2018 Oct;52:16-24. doi: 10.1016/ Epub 2018 Jul 26. Review.


Membrane insertion of α-xenorhabdolysin in near-atomic detail.

Schubert E, Vetter IR, Prumbaum D, Penczek PA, Raunser S.

Elife. 2018 Jul 16;7. pii: e38017. doi: 10.7554/eLife.38017.


Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM.

Merino F, Pospich S, Funk J, Wagner T, Küllmer F, Arndt HD, Bieling P, Raunser S.

Nat Struct Mol Biol. 2018 Jun;25(6):528-537. doi: 10.1038/s41594-018-0074-0. Epub 2018 Jun 4.


Electron cryomicroscopy as a powerful tool in biomedical research.

Quentin D, Raunser S.

J Mol Med (Berl). 2018 Jun;96(6):483-493. doi: 10.1007/s00109-018-1640-y. Epub 2018 May 5. Review.


Electron cryo-microscopy structure of the canonical TRPC4 ion channel.

Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S.

Elife. 2018 May 2;7. pii: e36615. doi: 10.7554/eLife.36615.


Arrest of trans-SNARE zippering uncovers loosely and tightly docked intermediates in membrane fusion.

Yavuz H, Kattan I, Hernandez JM, Hofnagel O, Witkowska A, Raunser S, Walla PJ, Jahn R.

J Biol Chem. 2018 Jun 1;293(22):8645-8655. doi: 10.1074/jbc.RA118.003313. Epub 2018 Apr 17.


The complex simplicity of the bacterial cytoskeleton.

Merino F, Raunser S.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3205-3206. doi: 10.1073/pnas.1801783115. Epub 2018 Mar 16. No abstract available.


Cryo-EM Revolutionizes the Structure Determination of Biomolecules.

Raunser S.

Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16450-16452. doi: 10.1002/anie.201710679. Epub 2017 Dec 7.


A recombinant BBSome core complex and how it interacts with ciliary cargo.

Klink BU, Zent E, Juneja P, Kuhlee A, Raunser S, Wittinghofer A.

Elife. 2017 Nov 15;6. pii: e27434. doi: 10.7554/eLife.27434.


Structural basis for tRNA-dependent cysteine biosynthesis.

Chen M, Kato K, Kubo Y, Tanaka Y, Liu Y, Long F, Whitman WB, Lill P, Gatsogiannis C, Raunser S, Shimizu N, Shinoda A, Nakamura A, Tanaka I, Yao M.

Nat Commun. 2017 Nov 15;8(1):1521. doi: 10.1038/s41467-017-01543-y.


The molecular basis of Alzheimer's plaques.

Pospich S, Raunser S.

Science. 2017 Oct 6;358(6359):45-46. doi: 10.1126/science.aap8002. No abstract available.


Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability.

Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I, Raunser S.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10636-10641. doi: 10.1073/pnas.1707506114. Epub 2017 Sep 18.


Lipid Nanodiscs as a Tool for High-Resolution Structure Determination of Membrane Proteins by Single-Particle Cryo-EM.

Efremov RG, Gatsogiannis C, Raunser S.

Methods Enzymol. 2017;594:1-30. doi: 10.1016/bs.mie.2017.05.007. Epub 2017 Jul 19.


High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE.

Moriya T, Saur M, Stabrin M, Merino F, Voicu H, Huang Z, Penczek PA, Raunser S, Gatsogiannis C.

J Vis Exp. 2017 May 16;(123). doi: 10.3791/55448.


Sensory Rhodopsin I and Sensory Rhodopsin II Form Trimers of Dimers in Complex with their Cognate Transducers.

Orekhov P, Bothe A, Steinhoff HJ, Shaitan KV, Raunser S, Fotiadis D, Schlesinger R, Klare JP, Engelhard M.

Photochem Photobiol. 2017 May;93(3):796-804. doi: 10.1111/php.12763.


Structure of the RZZ complex and molecular basis of its interaction with Spindly.

Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S, Musacchio A.

J Cell Biol. 2017 Apr 3;216(4):961-981. doi: 10.1083/jcb.201611060. Epub 2017 Mar 20.


Retromer-driven membrane tubulation separates endosomal recycling from Rab7/Ypt7-dependent fusion.

Purushothaman LK, Arlt H, Kuhlee A, Raunser S, Ungermann C.

Mol Biol Cell. 2017 Mar 15;28(6):783-791. doi: 10.1091/mbc.E16-08-0582. Epub 2017 Jan 18.


Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.

Kiontke S, Langemeyer L, Kuhlee A, Schuback S, Raunser S, Ungermann C, Kümmel D.

Nat Commun. 2017 Jan 4;8:14034. doi: 10.1038/ncomms14034.


The mother of all actins?

Merino F, Raunser S.

Elife. 2016 Dec 20;5. pii: e23354. doi: 10.7554/eLife.23354.


Electron Cryo-microscopy as a Tool for Structure-Based Drug Development.

Merino F, Raunser S.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2846-2860. doi: 10.1002/anie.201608432. Epub 2017 Feb 6. Review.


Multivalent Rab interactions determine tether-mediated membrane fusion.

Lürick A, Gao J, Kuhlee A, Yavavli E, Langemeyer L, Perz A, Raunser S, Ungermann C.

Mol Biol Cell. 2017 Jan 15;28(2):322-332. doi: 10.1091/mbc.E16-11-0764. Epub 2016 Nov 16.



Andersen CBF, Stødkilde K, Sæderup KL, Kuhlee A, Raunser S, Graversen JH, Moestrup SK.

Antioxid Redox Signal. 2017 May 10;26(14):814-831. doi: 10.1089/ars.2016.6793. Epub 2016 Nov 8. Review.


Membrane insertion of a Tc toxin in near-atomic detail.

Gatsogiannis C, Merino F, Prumbaum D, Roderer D, Leidreiter F, Meusch D, Raunser S.

Nat Struct Mol Biol. 2016 Oct;23(10):884-890. doi: 10.1038/nsmb.3281. Epub 2016 Aug 29.


Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution.

von der Ecken J, Heissler SM, Pathan-Chhatbar S, Manstein DJ, Raunser S.

Nature. 2016 Jun 30;534(7609):724-8. Epub 2016 Jun 20.


Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin.

Friese A, Faesen AC, Huis in 't Veld PJ, Fischböck J, Prumbaum D, Petrovic A, Raunser S, Herzog F, Musacchio A.

Nat Commun. 2016 Apr 20;7:11407. doi: 10.1038/ncomms11407.


Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster.

Liu Y, Petrovic A, Rombaut P, Mosalaganti S, Keller J, Raunser S, Herzog F, Musacchio A.

Open Biol. 2016 Feb;6(2):150236. doi: 10.1098/rsob.150236.


An interbacterial NAD(P)(+) glycohydrolase toxin requires elongation factor Tu for delivery to target cells.

Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD.

Cell. 2015 Oct 22;163(3):607-19. doi: 10.1016/j.cell.2015.09.027. Epub 2015 Oct 8.


Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M.

Nat Chem Biol. 2015 Nov;11(11):862-9. doi: 10.1038/nchembio.1931. Epub 2015 Oct 5.


The role of Bni5 in the regulation of septin higher-order structure formation.

Patasi C, Godočíková J, Michlíková S, Nie Y, Káčeriková R, Kválová K, Raunser S, Farkašovský M.

Biol Chem. 2015 Dec;396(12):1325-37. doi: 10.1515/hsz-2015-0165.


Condensation agents determine the temperature-pressure stability of F-actin bundles.

Gao M, Berghaus M, von der Ecken J, Raunser S, Winter R.

Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11088-92. doi: 10.1002/anie.201504247. Epub 2015 Aug 5.


Functional homologies in vesicle tethering.

Kuhlee A, Raunser S, Ungermann C.

FEBS Lett. 2015 Sep 14;589(19 Pt A):2487-97. doi: 10.1016/j.febslet.2015.06.001. Epub 2015 Jun 10. Review.

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