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Effects of rigosertib on the osteo-hematopoietic niche in myelodysplastic syndromes.

Balaian E, Weidner H, Wobus M, Baschant U, Jacobi A, Mies A, Bornhäuser M, Guck J, Hofbauer LC, Rauner M, Platzbecker U.

Ann Hematol. 2019 Jul 16. doi: 10.1007/s00277-019-03756-1. [Epub ahead of print]


Regulation of sclerostin in glucocorticoid-induced osteoporosis (GIO) in mice and humans.

Thiele S, Hannemann A, Winzer M, Baschant U, Weidner H, Nauck M, Thakker R, Bornhäuser M, Hofbauer L, Rauner M.

Endocr Connect. 2019 Jun 1. pii: EC-19-0104.R2. doi: 10.1530/EC-19-0104. [Epub ahead of print]


Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients.

Göbel A, Kuhlmann JD, Link T, Wimberger P, Link-Rachner C, Thiele S, Dell'Endice S, Furesi G, Breining D, Rauner M, Hofbauer LC, Rachner TD.

J Bone Oncol. 2019 Apr 4;16:100237. doi: 10.1016/j.jbo.2019.100237. eCollection 2019 Jun.


[Diagnosis and management of patients with diabetes and co-existing osteoporosis (Update 2019) : Common guideline of the Autrian Society for Bone and Mineral Research and the Austrian Diabetes Society].

Muschitz C, Kautzky-Willer A, Rauner M, Winhöfer-Stöckl Y, Haschka J.

Wien Klin Wochenschr. 2019 May;131(Suppl 1):174-185. doi: 10.1007/s00508-019-1462-0. German.


Developmental origin, functional maintenance and genetic rescue of osteoclasts.

Jacome-Galarza CE, Percin GI, Muller JT, Mass E, Lazarov T, Eitler J, Rauner M, Yadav VK, Crozet L, Bohm M, Loyher PL, Karsenty G, Waskow C, Geissmann F.

Nature. 2019 Apr;568(7753):541-545. doi: 10.1038/s41586-019-1105-7. Epub 2019 Apr 10.


Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling.

Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Colucci S, Muckenthaler MU, Schett G, Komla Ebri D, Bassett JHD, Williams GR, Platzbecker U, Hofbauer LC.

Nat Metab. 2019 Jan;1(1):111-124. doi: 10.1038/s42255-018-0005-8. Epub 2019 Jan 7.


Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation.

Kresinsky A, Schnöder TM, Jacobsen ID, Rauner M, Hofbauer LC, Ast V, König R, Hoffmann B, Svensson CM, Figge MT, Hilger I, Heidel FH, Böhmer FD, Müller JP.

Oncogene. 2019 Jun;38(24):4773-4787. doi: 10.1038/s41388-019-0757-y. Epub 2019 Feb 28.


Osteogenic Dkk1 Mediates Glucocorticoid-Induced but Not Arthritis-Induced Bone Loss.

Colditz J, Thiele S, Baschant U, Garbe AI, Niehrs C, Hofbauer LC, Rauner M.

J Bone Miner Res. 2019 Feb 19. doi: 10.1002/jbmr.3702. [Epub ahead of print]


Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties.

Picke AK, Campbell G, Napoli N, Hofbauer LC, Rauner M.

Endocr Connect. 2019 Mar 1;8(3):R55-R70. doi: 10.1530/EC-18-0456. Review.


Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells.

Göbel A, Breining D, Rauner M, Hofbauer LC, Rachner TD.

Cell Death Dis. 2019 Jan 28;10(2):91. doi: 10.1038/s41419-019-1322-x.


The Role of Dickkopf-1 in Thyroid Hormone-Induced Changes of Bone Remodeling in Male Mice.

Tsourdi E, Colditz J, Lademann F, Rijntjes E, Köhrle J, Niehrs C, Hofbauer LC, Rauner M.

Endocrinology. 2019 Mar 1;160(3):664-674. doi: 10.1210/en.2018-00998.


Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast Cancer.

Rachner TD, Kasimir-Bauer S, Göbel A, Erdmann K, Hoffmann O, Browne A, Wimberger P, Rauner M, Hofbauer LC, Kimmig R, Bittner AK.

Clin Cancer Res. 2019 Feb 15;25(4):1369-1378. doi: 10.1158/1078-0432.CCR-18-2482. Epub 2018 Nov 13.


Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption.

Picke AK, Campbell GM, Schmidt FN, Busse B, Rauner M, Simon JC, Anderegg U, Hofbauer LC, Saalbach A.

Front Cell Dev Biol. 2018 Oct 2;6:127. doi: 10.3389/fcell.2018.00127. eCollection 2018.


Denosumab effects on bone density and turnover in postmenopausal women with low bone mass with or without previous treatment.

Tsourdi E, Makras P, Rachner TD, Polyzos S, Rauner M, Mandanas S, Hofbauer LC, Anastasilakis AD.

Bone. 2019 Mar;120:44-49. doi: 10.1016/j.bone.2018.10.001. Epub 2018 Oct 4.


Physiological and pathological osteocytic osteolysis.

Tsourdi E, Jähn K, Rauner M, Busse B, Bonewald LF.

J Musculoskelet Neuronal Interact. 2018 Sep 1;18(3):292-303.


Thy-1 (CD90) promotes bone formation and protects against obesity.

Picke AK, Campbell GM, Blüher M, Krügel U, Schmidt FN, Tsourdi E, Winzer M, Rauner M, Vukicevic V, Busse B, Salbach-Hirsch J, Tuckermann JP, Simon JC, Anderegg U, Hofbauer LC, Saalbach A.

Sci Transl Med. 2018 Aug 8;10(453). pii: eaao6806. doi: 10.1126/scitranslmed.aao6806.


Differential effects of high-fat diet and exercise training on bone and energy metabolism.

Picke AK, Sylow L, Møller LLV, Kjøbsted R, Schmidt FN, Steejn MW, Salbach-Hirsch J, Hofbauer C, Blüher M, Saalbach A, Busse B, Rauner M, Hofbauer LC.

Bone. 2018 Nov;116:120-134. doi: 10.1016/j.bone.2018.07.015. Epub 2018 Jul 20.


Immune Profiling of Polysaccharide Submicron Vesicles.

Toma CC, Aloisi A, Bordoni V, Di Corato R, Rauner M, Cuniberti G, Delogu LG, Rinaldi R.

Biomacromolecules. 2018 Aug 13;19(8):3560-3571. doi: 10.1021/acs.biomac.8b00832. Epub 2018 Jul 27.


Role of WNT5A receptors FZD5 and RYK in prostate cancer cells.

Thiele S, Zimmer A, Göbel A, Rachner TD, Rother S, Fuessel S, Froehner M, Wirth MP, Muders MH, Baretton GB, Jakob F, Rauner M, Hofbauer LC.

Oncotarget. 2018 Jun 5;9(43):27293-27304. doi: 10.18632/oncotarget.25551. eCollection 2018 Jun 5.


Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo.

Hildebrandt S, Baschant U, Thiele S, Tuckermann J, Hofbauer LC, Rauner M.

Sci Rep. 2018 Jun 7;8(1):8711. doi: 10.1038/s41598-018-26300-z.


Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression.

Colditz J, Thiele S, Baschant U, Niehrs C, Bonewald LF, Hofbauer LC, Rauner M.

J Bone Miner Res. 2018 Sep;33(9):1698-1707. doi: 10.1002/jbmr.3463. Epub 2018 Jun 12.


[Osteoimmunology-IMMUNOBONE : Regulation of bone by inflammation].

Rauner M, Buttgereit F, Distler J, Garbe AI, Herrmann M, Hofbauer L, Hoffmann M, Jessberger R, Kornak U, Krönke G, Mundlos S, Spies C, Tuckermann J, Zwerina J.

Z Rheumatol. 2018 May;77(Suppl 1):12-15. doi: 10.1007/s00393-018-0455-0. Review. German. No abstract available.


Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway.

Balaian E, Wobus M, Weidner H, Baschant U, Stiehler M, Ehninger G, Bornhäuser M, Hofbauer LC, Rauner M, Platzbecker U.

Haematologica. 2018 Jan;103(1):61-68. doi: 10.3324/haematol.2017.172726. Epub 2017 Oct 27.


Sclerostin Blockade and Zoledronic Acid Improve Bone Mass and Strength in Male Mice With Exogenous Hyperthyroidism.

Tsourdi E, Lademann F, Ominsky MS, Rijntjes E, Köhrle J, Misof BM, Roschger P, Klaushofer K, Hofbauer LC, Rauner M.

Endocrinology. 2017 Nov 1;158(11):3765-3777. doi: 10.1210/en.2017-00247.


Concurrent antitumor and bone-protective effects of everolimus in osteotropic breast cancer.

Browne AJ, Kubasch ML, Göbel A, Hadji P, Chen D, Rauner M, Stölzel F, Hofbauer LC, Rachner TD.

Breast Cancer Res. 2017 Aug 9;19(1):92. doi: 10.1186/s13058-017-0885-7.


Immune Suppressive and Bone Inhibitory Effects of Prednisolone in Growing and Regenerating Zebrafish Tissues.

Geurtzen K, Vernet A, Freidin A, Rauner M, Hofbauer LC, Schneider JE, Brand M, Knopf F.

J Bone Miner Res. 2017 Dec;32(12):2476-2488. doi: 10.1002/jbmr.3231. Epub 2017 Sep 13.


Adjuvant tamoxifen but not aromatase inhibitor therapy decreases serum levels of the Wnt inhibitor dickkopf-1 while not affecting sclerostin in breast cancer patients.

Göbel A, Kuhlmann JD, Link T, Wimberger P, Browne AJ, Rauner M, Hofbauer LC, Rachner TD.

Breast Cancer Res Treat. 2017 Aug;164(3):737-743. doi: 10.1007/s10549-017-4296-3. Epub 2017 May 19.


Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis.

Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Wittig R, Rauner M, David JP, Bertolino P, Zhang CX, Tuckermann JP.

Cell Death Differ. 2017 Apr;24(4):672-682. doi: 10.1038/cdd.2016.165. Epub 2017 Jan 20.


Myelodysplastic syndromes and bone loss in mice and men.

Weidner H, Rauner M, Trautmann F, Schmitt J, Balaian E, Mies A, Helas S, Baschant U, Khandanpour C, Bornhäuser M, Hofbauer LC, Platzbecker U.

Leukemia. 2017 Apr;31(4):1003-1007. doi: 10.1038/leu.2017.7. Epub 2017 Jan 11. No abstract available.


Bone Formation and the Wnt Signaling Pathway.

Rauner M, Rachner TD, Hofbauer LC.

N Engl J Med. 2016 Nov 10;375(19):1902. doi: 10.1056/NEJMc1609768. No abstract available.


Sclerostin Blockade-A Dual Mode of Action After All?

Baschant U, Henneicke H, Hofbauer LC, Rauner M.

J Bone Miner Res. 2016 Oct;31(10):1787-1790. doi: 10.1002/jbmr.2988. Epub 2016 Sep 14. No abstract available.


Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells.

Rauner M, Franke K, Murray M, Singh RP, Hiram-Bab S, Platzbecker U, Gassmann M, Socolovsky M, Neumann D, Gabet Y, Chavakis T, Hofbauer LC, Wielockx B.

J Bone Miner Res. 2016 Oct;31(10):1877-1887. doi: 10.1002/jbmr.2857. Epub 2016 May 13.


Role of milk fat globule-epidermal growth factor 8 in osteoimmunology.

Sinningen K, Thiele S, Hofbauer LC, Rauner M.

Bonekey Rep. 2016 Jul 20;5:820. doi: 10.1038/bonekey.2016.52. eCollection 2016. Review.


Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors.

Baschant U, Rauner M, Balaian E, Weidner H, Roetto A, Platzbecker U, Hofbauer LC.

Haematologica. 2016 Dec;101(12):1499-1507. Epub 2016 Aug 18.


Effects of insulin therapy on porosity, non-enzymatic glycation and mechanical competence in the bone of rats with type 2 diabetes mellitus.

Campbell GM, Tiwari S, Picke AK, Hofbauer C, Rauner M, Morlock MM, Hofbauer LC, Glüer CC.

Bone. 2016 Oct;91:186-93. doi: 10.1016/j.bone.2016.08.003. Epub 2016 Aug 4.


WNT5A and Its Receptors in the Bone-Cancer Dialogue.

Thiele S, Rachner TD, Rauner M, Hofbauer LC.

J Bone Miner Res. 2016 Aug;31(8):1488-96. doi: 10.1002/jbmr.2899. Review.


Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function.

Picke AK, Salbach-Hirsch J, Hintze V, Rother S, Rauner M, Kascholke C, Möller S, Bernhardt R, Rammelt S, Pisabarro MT, Ruiz-Gómez G, Schnabelrauch M, Schulz-Siegmund M, Hacker MC, Scharnweber D, Hofbauer C, Hofbauer LC.

Biomaterials. 2016 Jul;96:11-23. doi: 10.1016/j.biomaterials.2016.04.013. Epub 2016 Apr 21.


Combined inhibition of the mevalonate pathway with statins and zoledronic acid potentiates their anti-tumor effects in human breast cancer cells.

Göbel A, Thiele S, Browne AJ, Rauner M, Zinna VM, Hofbauer LC, Rachner TD.

Cancer Lett. 2016 May 28;375(1):162-171. doi: 10.1016/j.canlet.2016.03.004. Epub 2016 Mar 8.


p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells.

Browne AJ, Göbel A, Thiele S, Hofbauer LC, Rauner M, Rachner TD.

Cell Death Dis. 2016 Feb 25;7:e2119. doi: 10.1038/cddis.2016.32.


RANKL/OPG in Breast Cancer - Extending Its Territory to BRCA Mutation Carriers.

Rachner TD, Rauner M.

EBioMedicine. 2015 Sep 24;2(10):1270-1. doi: 10.1016/j.ebiom.2015.09.035. eCollection 2015 Oct. No abstract available.


Potentiated suppression of Dickkopf-1 in breast cancer by combined administration of the mevalonate pathway inhibitors zoledronic acid and statins.

Göbel A, Browne AJ, Thiele S, Rauner M, Hofbauer LC, Rachner TD.

Breast Cancer Res Treat. 2015 Dec;154(3):623-31. doi: 10.1007/s10549-015-3624-8. Epub 2015 Oct 29.


P38 regulates the Wnt inhibitor Dickkopf-1 in breast cancer.

Rachner TD, Göbel A, Browne A, Hötzel J, Rauner M, Hofbauer LC.

Biochem Biophys Res Commun. 2015 Oct 30;466(4):728-32. doi: 10.1016/j.bbrc.2015.09.101. Epub 2015 Sep 25.


Milk Fat Globule-Epidermal Growth Factor 8 (MFG-E8) Is a Novel Anti-inflammatory Factor in Rheumatoid Arthritis in Mice and Humans.

Albus E, Sinningen K, Winzer M, Thiele S, Baschant U, Hannemann A, Fantana J, Tausche AK, Wallaschofski H, Nauck M, Völzke H, Grossklaus S, Chavakis T, Udey MC, Hofbauer LC, Rauner M.

J Bone Miner Res. 2016 Mar;31(3):596-605. doi: 10.1002/jbmr.2721. Epub 2015 Nov 9.


[Prevention of Occupational Injuries Related to Hands: Calculation of Subsequent Injury Costs for the Austrian Social Occupational Insurance Institution (AUVA)].

Rauner MS, Mayer B, Schaffhauser-Linzatti MM.

Handchir Mikrochir Plast Chir. 2015 Aug;47(4):228-34. doi: 10.1055/s-0035-1550044. Epub 2015 Aug 19. German.


Thyrotropin serum levels are differentially associated with biochemical markers of bone turnover and stiffness in women and men: results from the SHIP cohorts.

Tsourdi E, Wallaschofski H, Rauner M, Nauck M, Pietzner M, Rettig R, Ittermann T, Völzke H, Völker U, Hofbauer LC, Hannemann A.

Osteoporos Int. 2016 Feb;27(2):719-27. doi: 10.1007/s00198-015-3276-x. Epub 2015 Aug 12.


Structural and functional insights into sclerostin-glycosaminoglycan interactions in bone.

Salbach-Hirsch J, Samsonov SA, Hintze V, Hofbauer C, Picke AK, Rauner M, Gehrcke JP, Moeller S, Schnabelrauch M, Scharnweber D, Pisabarro MT, Hofbauer LC.

Biomaterials. 2015 Oct;67:335-45. doi: 10.1016/j.biomaterials.2015.07.021. Epub 2015 Jul 15.


Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1.

Tsourdi E, Rijntjes E, Köhrle J, Hofbauer LC, Rauner M.

Endocrinology. 2015 Oct;156(10):3517-27. doi: 10.1210/en.2015-1073. Epub 2015 Jul 28.


Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells.

Ebert R, Benisch P, Krug M, Zeck S, Meißner-Weigl J, Steinert A, Rauner M, Hofbauer L, Jakob F.

Stem Cell Res. 2015 Jul;15(1):231-9. doi: 10.1016/j.scr.2015.06.008. Epub 2015 Jun 23.


Serum fetuin-A levels and abdominal aortic calcification in healthy men - The STRAMBO study.

Schoppet M, Rauner M, Benner J, Chapurlat R, Hofbauer LC, Szulc P.

Bone. 2015 Oct;79:196-202. doi: 10.1016/j.bone.2015.06.004. Epub 2015 Jun 12.


Bone defect regeneration and cortical bone parameters of type 2 diabetic rats are improved by insulin therapy.

Picke AK, Gordaliza Alaguero I, Campbell GM, Glüer CC, Salbach-Hirsch J, Rauner M, Hofbauer LC, Hofbauer C.

Bone. 2016 Jan;82:108-15. doi: 10.1016/j.bone.2015.06.001. Epub 2015 Jun 6.


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