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Items: 1 to 50 of 131

1.

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.

Manshouri R, Coyaud E, Kundu ST, Peng DH, Stratton SA, Alton K, Bajaj R, Fradette JJ, Minelli R, Peoples MD, Carugo A, Chen F, Bristow C, Kovacs JJ, Barton MC, Heffernan T, Creighton CJ, Raught B, Gibbons DL.

Nat Commun. 2019 Nov 12;10(1):5125. doi: 10.1038/s41467-019-12832-z.

2.

Multiple direct interactions of TBP with the MYC oncoprotein.

Wei Y, Resetca D, Li Z, Johansson-Åkhe I, Ahlner A, Helander S, Wallenhammar A, Morad V, Raught B, Wallner B, Kokubo T, Tong Y, Penn LZ, Sunnerhagen M.

Nat Struct Mol Biol. 2019 Nov;26(11):1035-1043. doi: 10.1038/s41594-019-0321-z. Epub 2019 Nov 4.

PMID:
31686052
3.

FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer.

Mangé A, Coyaud E, Desmetz C, Laurent E, Béganton B, Coopman P, Raught B, Solassol J.

Theranostics. 2019 Sep 21;9(23):7003-7015. doi: 10.7150/thno.35561. eCollection 2019.

4.

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.

Lu Y, Zheng Y, Coyaud É, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z, Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught B, Sun Q, Neculai D.

Science. 2019 Oct 25;366(6464):460-467. doi: 10.1126/science.aau6391. Epub 2019 Oct 24.

PMID:
31649195
5.

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

Botham A, Coyaud E, Nirmalanandhan VS, Gronda M, Hurren R, Maclean N, St-Germain J, Mirali S, Laurent E, Raught B, Schimmer A.

Proteomics. 2019 Oct 16:e1900139. doi: 10.1002/pmic.201900139. [Epub ahead of print]

PMID:
31617661
6.

BioID screen of Salmonella type 3 secreted effectors reveals host factors involved in vacuole positioning and stability during infection.

D'Costa VM, Coyaud E, Boddy KC, Laurent EMN, St-Germain J, Li T, Grinstein S, Raught B, Brumell JH.

Nat Microbiol. 2019 Dec;4(12):2511-2522. doi: 10.1038/s41564-019-0580-9. Epub 2019 Oct 14.

PMID:
31611645
7.

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

Chan CJ, Le R, Burns K, Ahmed K, Coyaud E, Laurent EMN, Raught B, Melançon P.

Mol Cell Proteomics. 2019 Nov;18(11):2285-2297. doi: 10.1074/mcp.RA119.001645. Epub 2019 Sep 13.

PMID:
31519766
8.

Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.

Frendo-Cumbo S, Jaldin-Fincati JR, Coyaud E, Laurent EMN, Townsend LK, Tan JMJ, Xavier RJ, Pillon NJ, Raught B, Wright DC, Brumell JH, Klip A.

J Biol Chem. 2019 Nov 1;294(44):16172-16185. doi: 10.1074/jbc.RA119.009110. Epub 2019 Sep 12.

PMID:
31515271
9.

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

Dho SE, Silva-Gagliardi N, Morgese F, Coyaud E, Lamoureux E, Berry DM, Raught B, McGlade CJ.

Sci Rep. 2019 Aug 28;9(1):12471. doi: 10.1038/s41598-019-48902-x.

10.

Spatial and proteomic profiling reveals centrosome-independent features of centriolar satellites.

Gheiratmand L, Coyaud E, Gupta GD, Laurent EM, Hasegan M, Prosser SL, Gonçalves J, Raught B, Pelletier L.

EMBO J. 2019 Jul 15;38(14):e101109. doi: 10.15252/embj.2018101109. Epub 2019 Jun 3.

11.

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1.

Demian WL, Persaud A, Jiang C, Coyaud É, Liu S, Kapus A, Kafri R, Raught B, Rotin D.

Cell Rep. 2019 May 7;27(6):1886-1896.e6. doi: 10.1016/j.celrep.2019.04.034.

12.

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

Ceccarelli DF, Ivantsiv S, Mullin AA, Coyaud E, Manczyk N, Maisonneuve P, Kurinov I, Zhao L, Go C, Gingras AC, Raught B, Cordes S, Sicheri F.

Structure. 2019 Jun 4;27(6):1000-1012.e6. doi: 10.1016/j.str.2019.03.022. Epub 2019 May 2.

PMID:
31056421
13.

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.

Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M.

Cancer Cell. 2019 May 13;35(5):721-737.e9. doi: 10.1016/j.ccell.2019.03.014. Epub 2019 May 2.

PMID:
31056398
14.

LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer.

Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK.

Nature. 2019 May;569(7755):275-279. doi: 10.1038/s41586-019-1126-2. Epub 2019 Apr 17.

PMID:
30996345
15.

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

Georges A, Coyaud E, Marcon E, Greenblatt J, Raught B, Frappier L.

Sci Rep. 2019 Feb 25;9(1):2724. doi: 10.1038/s41598-019-39368-y.

16.

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

Kano Y, Gebregiworgis T, Marshall CB, Radulovich N, Poon BPK, St-Germain J, Cook JD, Valencia-Sama I, Grant BMM, Herrera SG, Miao J, Raught B, Irwin MS, Lee JE, Yeh JJ, Zhang ZY, Tsao MS, Ikura M, Ohh M.

Nat Commun. 2019 Jan 15;10(1):224. doi: 10.1038/s41467-018-08115-8.

17.

An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.

Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH.

Nat Microbiol. 2018 Dec;3(12):1472-1485. doi: 10.1038/s41564-018-0293-5. Epub 2018 Nov 26.

PMID:
30478389
18.

Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles.

Gingras AC, Abe KT, Raught B.

Curr Opin Chem Biol. 2019 Feb;48:44-54. doi: 10.1016/j.cbpa.2018.10.017. Epub 2018 Nov 17. Review.

PMID:
30458335
19.

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

Kalkat M, Resetca D, Lourenco C, Chan PK, Wei Y, Shiah YJ, Vitkin N, Tong Y, Sunnerhagen M, Done SJ, Boutros PC, Raught B, Penn LZ.

Mol Cell. 2018 Dec 6;72(5):836-848.e7. doi: 10.1016/j.molcel.2018.09.031. Epub 2018 Nov 8.

PMID:
30415952
20.

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.

Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ.

Cancer Cell. 2018 Oct 8;34(4):579-595.e8. doi: 10.1016/j.ccell.2018.09.001.

21.

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.

Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R.

J Clin Invest. 2018 Oct 1;128(10):4525-4542. doi: 10.1172/JCI120401. Epub 2018 Aug 2.

22.

PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN.

Sydor AM, Coyaud E, Rovelli C, Laurent E, Liu H, Raught B, Mennella V.

Elife. 2018 Aug 31;7. pii: e37846. doi: 10.7554/eLife.37846.

23.

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability.

Dingar D, Tu WB, Resetca D, Lourenco C, Tamachi A, De Melo J, Houlahan KE, Kalkat M, Chan PK, Boutros PC, Raught B, Penn LZ.

Nat Commun. 2018 Aug 29;9(1):3502. doi: 10.1038/s41467-018-05660-0.

24.

Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus.

Coyaud E, Ranadheera C, Cheng D, Gonçalves J, Dyakov BJA, Laurent EMN, St-Germain J, Pelletier L, Gingras AC, Brumell JH, Kim PK, Safronetz D, Raught B.

Mol Cell Proteomics. 2018 Nov;17(11):2242-2255. doi: 10.1074/mcp.TIR118.000800. Epub 2018 Jul 23.

25.

Salmonella exploits host Rho GTPase signalling pathways through the phosphatase activity of SopB.

Truong D, Boddy KC, Canadien V, Brabant D, Fairn GD, D'Costa VM, Coyaud E, Raught B, Pérez-Sala D, Park WS, Heo WD, Grinstein S, Brumell JH.

Cell Microbiol. 2018 Oct;20(10):e12938. doi: 10.1111/cmi.12938. Epub 2018 Aug 3.

PMID:
30010242
26.

The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-terminal amphipathic α-helix.

Odeh HM, Coyaud E, Raught B, Matunis MJ.

Mol Biol Cell. 2018 Aug 1;29(15):1878-1890. doi: 10.1091/mbc.E17-07-0445. Epub 2018 Jun 6.

27.

Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages.

Chen J, Castelvecchi GD, Li-Villarreal N, Raught B, Krezel AM, McNeill H, Solnica-Krezel L.

Dev Cell. 2018 May 7;45(3):376-391.e5. doi: 10.1016/j.devcel.2018.04.009.

28.

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.

Liu Y, Gupta GD, Barnabas DD, Agircan FG, Mehmood S, Wu D, Coyaud E, Johnson CM, McLaughlin SH, Andreeva A, Freund SMV, Robinson CV, Cheung SWT, Raught B, Pelletier L, van Breugel M.

Nat Commun. 2018 Apr 30;9(1):1731. doi: 10.1038/s41467-018-04122-x.

29.

Spatiotemporal distribution of small ubiquitin-like modifiers during human placental development and in response to oxidative and inflammatory stress.

Baczyk D, Audette MC, Coyaud E, Raught B, Kingdom JC.

J Physiol. 2018 May 1;596(9):1587-1600. doi: 10.1113/JP275288. Epub 2018 Apr 6.

30.

EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.

Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH.

Nat Cell Biol. 2018 Feb;20(2):162-174. doi: 10.1038/s41556-017-0016-9. Epub 2018 Jan 15.

31.

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, Rottapel R.

Sci Signal. 2017 Oct 31;10(503). pii: eaan3286. doi: 10.1126/scisignal.aan3286.

32.

A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome.

Bertomeu T, Coulombe-Huntington J, Chatr-Aryamontri A, Bourdages KG, Coyaud E, Raught B, Xia Y, Tyers M.

Mol Cell Biol. 2017 Dec 13;38(1). pii: e00302-17. doi: 10.1128/MCB.00302-17. Print 2018 Jan 1.

33.

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

Kim BR, Coyaud E, Laurent EMN, St-Germain J, Van de Laar E, Tsao MS, Raught B, Moghal N.

Mol Cell Proteomics. 2017 Oct;16(10):1864-1888. doi: 10.1074/mcp.M116.064451. Epub 2017 Aug 9.

34.

Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.

Segura-Bayona S, Knobel PA, González-Burón H, Youssef SA, Peña-Blanco A, Coyaud É, López-Rovira T, Rein K, Palenzuela L, Colombelli J, Forrow S, Raught B, Groth A, de Bruin A, Stracker TH.

Cell Death Differ. 2017 Nov;24(11):1872-1885. doi: 10.1038/cdd.2017.108. Epub 2017 Jul 14.

35.

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

Swayampakula M, McDonald PC, Vallejo M, Coyaud E, Chafe SC, Westerback A, Venkateswaran G, Shankar J, Gao G, Laurent EMN, Lou Y, Bennewith KL, Supuran CT, Nabi IR, Raught B, Dedhar S.

Oncogene. 2017 Nov 9;36(45):6244-6261. doi: 10.1038/onc.2017.219. Epub 2017 Jul 10.

36.

ProHits-viz: a suite of web tools for visualizing interaction proteomics data.

Knight JDR, Choi H, Gupta GD, Pelletier L, Raught B, Nesvizhskii AI, Gingras AC.

Nat Methods. 2017 Jun 29;14(7):645-646. doi: 10.1038/nmeth.4330. No abstract available.

37.

The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.

Doiron K, Goyon V, Coyaud E, Rajapakse S, Raught B, McBride HM.

Sci Rep. 2017 Mar 7;7(1):107. doi: 10.1038/s41598-017-00151-6.

38.

Parallel Exploration of Interaction Space by BioID and Affinity Purification Coupled to Mass Spectrometry.

Hesketh GG, Youn JY, Samavarchi-Tehrani P, Raught B, Gingras AC.

Methods Mol Biol. 2017;1550:115-136. doi: 10.1007/978-1-4939-6747-6_10.

PMID:
28188527
39.

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis.

Hua R, Cheng D, Coyaud É, Freeman S, Di Pietro E, Wang Y, Vissa A, Yip CM, Fairn GD, Braverman N, Brumell JH, Trimble WS, Raught B, Kim PK.

J Cell Biol. 2017 Feb;216(2):367-377. doi: 10.1083/jcb.201608128. Epub 2017 Jan 20.

40.

UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.

Wheaton K, Sarkari F, Stanly Johns B, Davarinejad H, Egorova O, Kaustov L, Raught B, Saridakis V, Sheng Y.

J Biol Chem. 2017 Feb 17;292(7):2893-2902. doi: 10.1074/jbc.M116.749564. Epub 2017 Jan 10.

41.

Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria.

Liyanage SU, Coyaud E, Laurent EM, Hurren R, Maclean N, Wood SR, Kazak L, Shamas-Din A, Holt I, Raught B, Schimmer A.

Mitochondrion. 2017 Jan;32:31-35. doi: 10.1016/j.mito.2016.11.001. Epub 2016 Nov 11.

PMID:
27845271
42.

Data Independent Acquisition analysis in ProHits 4.0.

Liu G, Knight JD, Zhang JP, Tsou CC, Wang J, Lambert JP, Larsen B, Tyers M, Raught B, Bandeira N, Nesvizhskii AI, Choi H, Gingras AC.

J Proteomics. 2016 Oct 21;149:64-68. doi: 10.1016/j.jprot.2016.04.042. Epub 2016 Apr 29.

43.

A global genetic interaction network maps a wiring diagram of cellular function.

Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B, Boone C.

Science. 2016 Sep 23;353(6306). pii: aaf1420.

44.

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.

Guturi KKN, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R.

Nat Commun. 2016 Aug 25;7:12638. doi: 10.1038/ncomms12638.

45.

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation.

Stojanova A, Tu WB, Ponzielli R, Kotlyar M, Chan PK, Boutros PC, Khosravi F, Jurisica I, Raught B, Penn LZ.

Cell Cycle. 2016 Jul 2;15(13):1693-705. doi: 10.1080/15384101.2016.1146836. Epub 2016 Jun 7.

46.

ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data.

Lundberg SM, Tu WB, Raught B, Penn LZ, Hoffman MM, Lee SI.

Genome Biol. 2016 Apr 30;17:82. doi: 10.1186/s13059-016-0925-0.

47.

Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling.

Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon BP, Lee JE, Raught B, Ohh M.

J Biol Chem. 2016 Apr 1;291(14):7357-72. doi: 10.1074/jbc.M115.694562. Epub 2016 Feb 4.

48.

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.

Gupta GD, Coyaud É, Gonçalves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, Hildebrandt F, Moffat J, Gingras AC, Raught B, Pelletier L.

Cell. 2015 Dec 3;163(6):1484-99. doi: 10.1016/j.cell.2015.10.065.

49.

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis.

Bunda S, Burrell K, Heir P, Zeng L, Alamsahebpour A, Kano Y, Raught B, Zhang ZY, Zadeh G, Ohh M.

Nat Commun. 2015 Nov 30;6:8859. doi: 10.1038/ncomms9859.

50.

The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

Yeh C, Coyaud É, Bashkurov M, van der Lelij P, Cheung SW, Peters JM, Raught B, Pelletier L.

Curr Biol. 2015 Aug 31;25(17):2290-9. doi: 10.1016/j.cub.2015.07.025. Epub 2015 Aug 20.

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