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Items: 1 to 50 of 62

1.

Transactivation Assays that Identify Indirect and Direct Activators of Human Pregnane X Receptor (PXR, NR1I2) and Constitutive Androstane Receptor (CAR, NR1I3).

Pinne M, Ponce E, Raucy JL.

Drug Metab Lett. 2017;11(2):128-137. doi: 10.2174/1872312812666171207113639.

PMID:
29219065
2.

Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation.

Pinne M, Ponce E, Raucy JL.

PLoS One. 2016 Oct 12;11(10):e0164642. doi: 10.1371/journal.pone.0164642. eCollection 2016.

3.

Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery.

Pinne M, Raucy JL.

Expert Opin Drug Discov. 2014 Jun;9(6):669-86. doi: 10.1517/17460441.2014.913019. Epub 2014 May 12. Review.

PMID:
24819724
4.

Cell-based systems to assess nuclear receptor activation and their use in drug development.

Raucy JL, Lasker JM.

Drug Metab Rev. 2013 Feb;45(1):101-9. doi: 10.3109/03602532.2012.737333. Review.

PMID:
23330544
5.

Utility of DPX2 cells for predicting CYP3A induction-mediated drug-drug interactions and associated structure-activity relationships.

Fahmi OA, Raucy JL, Ponce E, Hassanali S, Lasker JM.

Drug Metab Dispos. 2012 Nov;40(11):2204-11. doi: 10.1124/dmd.112.047456. Epub 2012 Aug 21.

PMID:
22912432
6.

Current in vitro high throughput screening approaches to assess nuclear receptor activation.

Raucy JL, Lasker JM.

Curr Drug Metab. 2010 Nov;11(9):806-14. Review.

PMID:
21189134
7.

Nanosilver particle effects on drug metabolism in vitro.

Lamb JG, Hathaway LB, Munger MA, Raucy JL, Franklin MR.

Drug Metab Dispos. 2010 Dec;38(12):2246-51. doi: 10.1124/dmd.110.035238. Epub 2010 Sep 22.

PMID:
20861156
8.

The utility of stable cell lines to assess species differences in PXR transactivation.

Sinz MW, Pray D, Raucy J.

Drug Metab Lett. 2007 Apr;1(2):147-52.

PMID:
19356035
9.

A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.

Trubetskoy O, Marks B, Zielinski T, Yueh MF, Raucy J.

AAPS J. 2005 Mar 4;7(1):E6-13.

10.

Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.

Yueh MF, Kawahara M, Raucy J.

Toxicol In Vitro. 2005 Mar;19(2):275-87.

PMID:
15649641
11.

High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line.

Yueh MF, Kawahara M, Raucy J.

Drug Metab Dispos. 2005 Jan;33(1):38-48. Epub 2004 Oct 1.

PMID:
15466163
12.

Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19.

Hirani VN, Raucy JL, Lasker JM.

Drug Metab Dispos. 2004 Dec;32(12):1462-7. Epub 2004 Sep 24.

PMID:
15448116
13.

Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent.

Krueger SK, Siddens LK, Martin SR, Yu Z, Pereira CB, Cabacungan ET, Hines RN, Ardlie KG, Raucy JL, Williams DE.

Drug Metab Dispos. 2004 Dec;32(12):1337-40. Epub 2004 Sep 8.

PMID:
15355885
14.

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

Burk O, Koch I, Raucy J, Hustert E, Eichelbaum M, Brockmöller J, Zanger UM, Wojnowski L.

J Biol Chem. 2004 Sep 10;279(37):38379-85. Epub 2004 Jul 12.

15.

Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes.

Raucy JL, Lasker J, Ozaki K, Zoleta V.

Toxicol Sci. 2004 Jun;79(2):233-41. Epub 2004 Mar 31.

PMID:
15056802
16.
17.

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system.

Raucy J, Warfe L, Yueh MF, Allen SW.

J Pharmacol Exp Ther. 2002 Oct;303(1):412-23.

PMID:
12235278
18.

Genetic polymorphisms of flavin-containing monooxygenase (FMO).

Krueger SK, Williams DE, Yueh MF, Martin SR, Hines RN, Raucy JL, Dolphin CT, Shephard EA, Phillips IR.

Drug Metab Rev. 2002 Aug;34(3):523-32. Review.

PMID:
12214664
19.

Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes.

Raucy JL, Mueller L, Duan K, Allen SW, Strom S, Lasker JM.

J Pharmacol Exp Ther. 2002 Aug;302(2):475-82.

PMID:
12130704
20.

Recent advances in P450 research.

Raucy JL, Allen SW.

Pharmacogenomics J. 2001;1(3):178-86. Review.

21.

The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression.

Allen SW, Mueller L, Williams SN, Quattrochi LC, Raucy J.

Drug Metab Dispos. 2001 Aug;29(8):1074-9.

PMID:
11454723
22.

CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes.

Wester MR, Lasker JM, Johnson EF, Raucy JL.

Drug Metab Dispos. 2000 Mar;28(3):354-9.

PMID:
10681382
23.

CYP2E1 expression in human lymphocytes from various ethnic populations.

Raucy JL, Schultz ED, Kearins MC, Arora S, Johnston DE, Omdahl JL, Eckmann L, Carpenter SP.

Alcohol Clin Exp Res. 1999 Dec;23(12):1868-74.

PMID:
10630604
24.

Drug metabolizing enzymes in lymphocytes.

Raucy JL, Ingelman-Sundberg M, Carpenter S, Rannug A, Rane A, Franklin M, Romkes M.

J Biochem Mol Toxicol. 1999;13(3-4):223-6. Review. No abstract available.

PMID:
10098909
25.

Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4.

Jin R, Koop DR, Raucy JL, Lasker JM.

Arch Biochem Biophys. 1998 Nov 1;359(1):89-98.

PMID:
9799565
26.

Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations.

Lasker JM, Wester MR, Aramsombatdee E, Raucy JL.

Arch Biochem Biophys. 1998 May 1;353(1):16-28.

PMID:
9578596
27.

Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity.

Raucy JL, Schultz ED, Wester MR, Arora S, Johnston DE, Omdahl JL, Carpenter SP.

Drug Metab Dispos. 1997 Dec;25(12):1429-35.

PMID:
9394034
28.

Peroxisome proliferator activated receptor-alpha expression in human liver.

Palmer CN, Hsu MH, Griffin KJ, Raucy JL, Johnson EF.

Mol Pharmacol. 1998 Jan;53(1):14-22.

PMID:
9443928
29.

Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion.

Rowell DL, Eckmann L, Dwinell MB, Carpenter SP, Raucy JL, Yang SK, Kagnoff MF.

Am J Physiol. 1997 Aug;273(2 Pt 1):G322-32.

PMID:
9277410
30.

Ethanol-mediated transplacental induction of CYP2E1 in fetal rat liver.

Carpenter SP, Savage DD, Schultz ED, Raucy JL.

J Pharmacol Exp Ther. 1997 Aug;282(2):1028-36.

PMID:
9262372
31.

Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51.

Richardson TH, Griffin KJ, Jung F, Raucy JL, Johnson EF.

Arch Biochem Biophys. 1997 Feb 15;338(2):157-64.

PMID:
9028867
32.

Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases.

Jung F, Richardson TH, Raucy JL, Johnson EF.

Drug Metab Dispos. 1997 Feb;25(2):133-9.

PMID:
9029042
33.

Drug metabolic enzymes in developmental toxicology.

Miller MS, Juchau MR, Guengerich FP, Nebert DW, Raucy JL.

Fundam Appl Toxicol. 1996 Dec;34(2):165-75. Review.

PMID:
8954747
34.
35.
36.

Use of lymphocytes for assessing ethanol-mediated alterations in the expression of hepatic cytochrome P4502E1.

Raucy JL, Curley G, Carpenter SP.

Alcohol Clin Exp Res. 1995 Dec;19(6):1369-75.

PMID:
8749797
37.

A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli.

Richardson TH, Jung F, Griffin KJ, Wester M, Raucy JL, Kemper B, Bornheim LM, Hassett C, Omiecinski CJ, Johnson EF.

Arch Biochem Biophys. 1995 Oct 20;323(1):87-96.

PMID:
7487078
38.

Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.

Daikh BE, Lasker JM, Raucy JL, Koop DR.

J Pharmacol Exp Ther. 1994 Dec;271(3):1427-33.

PMID:
7996455
39.

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.

Goldstein JA, Faletto MB, Romkes-Sparks M, Sullivan T, Kitareewan S, Raucy JL, Lasker JM, Ghanayem BI.

Biochemistry. 1994 Feb 22;33(7):1743-52.

PMID:
8110777
40.

The expression of xenobiotic-metabolizing cytochromes P450 in fetal tissues.

Raucy JL, Carpenter SJ.

J Pharmacol Toxicol Methods. 1993 Jun;29(3):121-8. Review. No abstract available.

PMID:
8364226
41.

Induction of P4502E1 by acetone in isolated rabbit hepatocytes. Role of increased protein and mRNA synthesis.

Kraner JC, Lasker JM, Corcoran GB, Ray SD, Raucy JL.

Biochem Pharmacol. 1993 Apr 6;45(7):1483-92.

PMID:
8471070
42.

Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily.

Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA.

Biochemistry. 1993 Feb 9;32(5):1390. No abstract available.

PMID:
8095407
43.

Bioactivation of halogenated hydrocarbons by cytochrome P4502E1.

Raucy JL, Kraner JC, Lasker JM.

Crit Rev Toxicol. 1993;23(1):1-20. Review.

PMID:
8471158
44.

Expression of cytochrome P450 3A in amphibian, rat, and human kidney.

Schuetz EG, Schuetz JD, Grogan WM, Naray-Fejes-Toth A, Fejes-Toth G, Raucy J, Guzelian P, Gionela K, Watlington CO.

Arch Biochem Biophys. 1992 Apr;294(1):206-14.

PMID:
1550347
45.

Human hepatic microsomal metabolism of delta 1-tetrahydrocannabinol.

Bornheim LM, Lasker JM, Raucy JL.

Drug Metab Dispos. 1992 Mar-Apr;20(2):241-6.

PMID:
1352216
46.

Identification of lanosterol 14 alpha-methyl demethylase in human tissues.

Raucy JL, Carpenter SJ, Trzaskos JM.

Biochem Biophys Res Commun. 1991 May 31;177(1):497-503.

PMID:
2043135
47.

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA.

Biochemistry. 1991 Apr 2;30(13):3247-55. Erratum in: Biochemistry. 1993 Feb 9;32(5):1390.

PMID:
2009263
48.

Induction of cytochrome P450IIE1 in the obese overfed rat.

Raucy JL, Lasker JM, Kraner JC, Salazar DE, Lieber CS, Corcoran GB.

Mol Pharmacol. 1991 Mar;39(3):275-80.

PMID:
2005876
49.

Extensive alteration of genomic DNA and rise in nuclear Ca2+ in vivo early after hepatotoxic acetaminophen overdose in mice.

Ray SD, Sorge CL, Tavacoli A, Raucy JL, Corcoran GB.

Adv Exp Med Biol. 1991;283:699-705.

PMID:
2069042
50.

Isolation of P450 enzymes from human liver.

Raucy JL, Lasker JM.

Methods Enzymol. 1991;206:577-87. No abstract available.

PMID:
1664480

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