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Items: 25

1.

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions.

Lin Y, McCarty J, Rauch JN, Delaney KT, Kosik KS, Fredrickson GH, Shea JE, Han S.

Elife. 2019 Apr 5;8. pii: e42571. doi: 10.7554/eLife.42571.

2.

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaat3005. doi: 10.1126/scitranslmed.aat3005.

PMID:
30918111
3.

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.

Meister-Broekema M, Freilich R, Jagadeesan C, Rauch JN, Bengoechea R, Motley WW, Kuiper EFE, Minoia M, Furtado GV, van Waarde MAWH, Bird SJ, Rebelo A, Zuchner S, Pytel P, Scherer SS, Morelli FF, Carra S, Weihl CC, Bergink S, Gestwicki JE, Kampinga HH.

Nat Commun. 2018 Dec 17;9(1):5342. doi: 10.1038/s41467-018-07718-5.

4.

Cofactors are essential constituents of stable and seeding-active tau fibrils.

Fichou Y, Lin Y, Rauch JN, Vigers M, Zeng Z, Srivastava M, Keller TJ, Freed JH, Kosik KS, Han S.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13234-13239. doi: 10.1073/pnas.1810058115. Epub 2018 Dec 11.

PMID:
30538196
5.

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.

Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30.

6.

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS.

Sci Rep. 2018 Apr 23;8(1):6382. doi: 10.1038/s41598-018-24904-z.

7.

High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex.

Taylor IR, Dunyak BM, Komiyama T, Shao H, Ran X, Assimon VA, Kalyanaraman C, Rauch JN, Jacobson MP, Zuiderweg ERP, Gestwicki JE.

J Biol Chem. 2018 Mar 16;293(11):4014-4025. doi: 10.1074/jbc.RA117.001575. Epub 2018 Feb 2.

8.

RNA stores tau reversibly in complex coacervates.

Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S.

PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul.

9.

Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.

Rauch JN, Olson SH, Gestwicki JE.

Cold Spring Harb Perspect Med. 2017 Jul 5;7(7). pii: a024034. doi: 10.1101/cshperspect.a024034. Review.

10.

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE.

J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21.

11.

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.

Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE.

Cell Chem Biol. 2016 Aug 18;23(8):992-1001. doi: 10.1016/j.chembiol.2016.04.014. Epub 2016 Aug 4.

12.

Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release.

Rauch JN, Zuiderweg ER, Gestwicki JE.

J Biol Chem. 2016 Sep 16;291(38):19848-57. doi: 10.1074/jbc.M116.742502. Epub 2016 Jul 29.

13.

Protein Cross-Linking Capillary Electrophoresis for Protein-Protein Interaction Analysis.

Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues B, Dickey CA, Gestwicki JE, Kennedy RT.

Anal Chem. 2016 Aug 16;88(16):8272-8. doi: 10.1021/acs.analchem.6b02126. Epub 2016 Jul 28.

14.

Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy.

Morozova K, Clement CC, Kaushik S, Stiller B, Arias E, Ahmad A, Rauch JN, Chatterjee V, Melis C, Scharf B, Gestwicki JE, Cuervo AM, Zuiderweg ER, Santambrogio L.

J Biol Chem. 2016 Aug 26;291(35):18096-106. doi: 10.1074/jbc.M116.736744. Epub 2016 Jul 12.

15.

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.

Taguwa S, Maringer K, Li X, Bernal-Rubio D, Rauch JN, Gestwicki JE, Andino R, Fernandez-Sesma A, Frydman J.

Cell. 2015 Nov 19;163(5):1108-1123. doi: 10.1016/j.cell.2015.10.046. Epub 2015 Nov 12.

16.

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA.

J Biol Chem. 2015 May 22;290(21):13115-27. doi: 10.1074/jbc.M115.637595. Epub 2015 Apr 11.

17.

Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.

Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE.

Mol Cancer Ther. 2015 Mar;14(3):642-8. doi: 10.1158/1535-7163.MCT-14-0650. Epub 2015 Jan 6.

18.

Rehabilitating mutant GCase.

Rauch JN, Gestwicki JE.

Chem Biol. 2014 Aug 14;21(8):919-20. doi: 10.1016/j.chembiol.2014.07.010.

19.

Hsp70-Bag3 interactions regulate cancer-related signaling networks.

Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY.

Cancer Res. 2014 Sep 1;74(17):4731-40. doi: 10.1158/0008-5472.CAN-14-0747. Epub 2014 Jul 3.

20.

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

Rauch JN, Gestwicki JE.

J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 10.1074/jbc.M113.521997. Epub 2013 Dec 5.

21.

Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions.

Rauch JN, Nie J, Buchholz TJ, Gestwicki JE, Kennedy RT.

Anal Chem. 2013 Oct 15;85(20):9824-31. doi: 10.1021/ac4023082. Epub 2013 Sep 23.

22.

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70.

Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE.

Chem Biol. 2012 Nov 21;19(11):1391-9. doi: 10.1016/j.chembiol.2012.07.026.

23.

Hsp70 protein complexes as drug targets.

Assimon VA, Gillies AT, Rauch JN, Gestwicki JE.

Curr Pharm Des. 2013;19(3):404-17. Review.

24.

Global spatial indexing of the human impact on Al, Cu, Fe, and Zn mobilization.

Rauch JN.

Environ Sci Technol. 2010 Aug 1;44(15):5728-34. doi: 10.1021/es100813y.

PMID:
20666554
25.

Global mapping of Al, Cu, Fe, and Zn in-use stocks and in-ground resources.

Rauch JN.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18920-5. doi: 10.1073/pnas.0900658106. Epub 2009 Oct 26.

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