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Items: 34

1.

Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis.

Nare B, Wring S, Bacchi C, Beaudet B, Bowling T, Brun R, Chen D, Ding C, Freund Y, Gaukel E, Hussain A, Jarnagin K, Jenks M, Kaiser M, Mercer L, Mejia E, Noe A, Orr M, Parham R, Plattner J, Randolph R, Rattendi D, Rewerts C, Sligar J, Yarlett N, Don R, Jacobs R.

Antimicrob Agents Chemother. 2010 Oct;54(10):4379-88. doi: 10.1128/AAC.00498-10. Epub 2010 Jul 26.

PMID:
20660666
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2.

Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.

Huang TL, Vanden Eynde JJ, Mayence A, Collins MS, Cushion MT, Rattendi D, Londono I, Mazumder L, Bacchi CJ, Yarlett N.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5884-6. doi: 10.1016/j.bmcl.2009.08.073. Epub 2009 Aug 23.

PMID:
19736009
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3.

Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Barker RH Jr, Rodriguez A, Hirth B, Rattendi D, Yarlett N, Hendrick CL, Sybertz E.

Antimicrob Agents Chemother. 2009 Aug;53(8):3269-72. doi: 10.1128/AAC.00076-09. Epub 2009 May 18.

PMID:
19451291
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4.

Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi.

Bacchi CJ, Yarlett N, Faciane E, Bi X, Rattendi D, Weiss LM, Woster PM.

Antimicrob Agents Chemother. 2009 Jun;53(6):2599-604. doi: 10.1128/AAC.00267-08. Epub 2009 Feb 17.

PMID:
19223636
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5.

Novel trypanocidal analogs of 5'-(methylthio)-adenosine.

Sufrin JR, Spiess AJ, Marasco CJ Jr, Rattendi D, Bacchi CJ.

Antimicrob Agents Chemother. 2008 Jan;52(1):211-9. Epub 2007 Oct 22.

PMID:
17954686
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6.

Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.

Huang TL, Bacchi CJ, Kode NR, Zhang Q, Wang G, Yartlet N, Rattendi D, Londono I, Mazumder L, Vanden Eynde JJ, Mayence A, Donkor IO.

Int J Antimicrob Agents. 2007 Dec;30(6):555-61. Epub 2007 Oct 24.

PMID:
17920820

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7.

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity.

Bi X, Lopez C, Bacchi CJ, Rattendi D, Woster PM.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3229-32. Epub 2006 Apr 17.

PMID:
16616495

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8.

Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues.

Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M.

Microbiology. 2004 May;150(Pt 5):1215-24.

PMID:
15133083
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9.

Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against kinetoplastid parasites.

Werbovetz KA, Sackett DL, Delfín D, Bhattacharya G, Salem M, Obrzut T, Rattendi D, Bacchi C.

Mol Pharmacol. 2003 Dec;64(6):1325-33.

PMID:
14645662

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10.

Trypanocidal diarylheptanoids from Aframomum letestuianum.

Kamnaing P, Tsopmo A, Tanifum EA, Tchuendem MH, Tane P, Ayafor JF, Sterner O, Rattendi D, Iwu MM, Schuster B, Bacchi C.

J Nat Prod. 2003 Mar;66(3):364-7.

PMID:
12662093

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11.

Trypanocidal activity of conformationally restricted pentamidine congeners.

Donkor IO, Huang TL, Tao B, Rattendi D, Lane S, Vargas M, Goldberg B, Bacchi C.

J Med Chem. 2003 Mar 13;46(6):1041-8.

PMID:
12620080

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12.

Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity.

Marasco CJ Jr, Kramer DL, Miller J, Porter CW, Bacchi CJ, Rattendi D, Kucera L, Iyer N, Bernacki R, Pera P, Sufrin JR.

J Med Chem. 2002 Nov 7;45(23):5112-22.

PMID:
12408722

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13.

Stage-specific polyamine metabolism in Trypanosoma cruzi.

Bacchi CJ, Braunstein VL, Rattendi D, Yarlett N, Wittner M, Tanowitz HB.

J Eukaryot Microbiol. 2001;Suppl:201S-202S. No abstract available.

PMID:
11906064

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14.

Trypanocidal activity of dicationic compounds related to pentamidine.

Donkor IO, Assefa H, Rattendi D, Lane S, Vargas M, Goldberg B, Bacchi C.

Eur J Med Chem. 2001 Jun;36(6):531-8.

PMID:
11525843

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15.

Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity.

Zou Y, Wu Z, Sirisoma N, Woster PM, Casero RA Jr, Weiss LM, Rattendi D, Lane S, Bacchi CJ.

Bioorg Med Chem Lett. 2001 Jun 18;11(12):1613-7.

PMID:
11412992
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16.

In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.

Goldberg B, Rattendi D, Lloyd D, Sufrin JR, Bacchi CJ.

Biochem Pharmacol. 2001 Feb 15;61(4):449-57.

PMID:
11226379

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17.

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.

Li Z, Fennie MW, Ganem B, Hancock MT, Kobaslija M, Rattendi D, Bacchi CJ, O'Sullivan MC.

Bioorg Med Chem Lett. 2001 Jan 22;11(2):251-4.

PMID:
11206471

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18.

Kinetics of methionine transport and metabolism by Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.

Goldberg B, Rattendi D, Lloyd D, Yarlett N, Bacchi CJ.

Arch Biochem Biophys. 2000 May 1;377(1):49-57.

PMID:
10775440

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19.

Kinetics of S-adenosylmethionine cellular transport and protein methylation in Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.

Goldberg B, Rattendi D, Lloyd D, Yarlett N, Bacchi CJ.

Arch Biochem Biophys. 1999 Apr 1;364(1):13-8.

PMID:
10087160

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20.

Metabolic effects of a methylthioadenosine phosphorylase substrate analog on African trypanosomes.

Bacchi CJ, Goldberg B, Rattendi D, Gorrell TE, Spiess AJ, Sufrin JR.

Biochem Pharmacol. 1999 Jan 1;57(1):89-96.

PMID:
9920289

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21.

Antitrypanosomal activity of a new triazine derivative, SIPI 1029, In vitro and in model infections.

Bacchi CJ, Vargas M, Rattendi D, Goldberg B, Zhou W.

Antimicrob Agents Chemother. 1998 Oct;42(10):2718-21.

PMID:
9756783
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22.

Effects of intermediates of methionine metabolism and nucleoside analogs on S-adenosylmethionine transport by Trypanosoma brucei brucei and a drug-resistant Trypanosoma brucei rhodesiense.

Goldberg B, Rattendi D, Lloyd D, Sufrin JR, Bacchi CJ.

Biochem Pharmacol. 1998 Jul 1;56(1):95-103.

PMID:
9698093

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23.

The importance of the 4'-hydroxyl hydrogen for the anti-trypanosomal and antiviral properties of (+)-5'-noraristeromycin and two 7-deaza analogues.

Seley KL, Schneller SW, De Clercq E, Rattendi D, Lane S, Bacchi CJ, Korba B.

Bioorg Med Chem. 1998 Jun;6(6):797-801.

PMID:
9681145

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24.

Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities.

O'Sullivan MC, Zhou Q, Li Z, Durham TB, Rattendi D, Lane S, Bacchi CJ.

Bioorg Med Chem. 1997 Dec;5(12):2145-55.

PMID:
9459012

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25.

Synthesis and antitrypanosomal activities of a series of 7-deaza-5'-noraristeromycin derivatives with variations in the cyclopentyl ring substituents.

Seley KL, Schneller SW, Rattendi D, Lane S, Bacchi CJ.

Antimicrob Agents Chemother. 1997 Aug;41(8):1658-61.

PMID:
9257736
Free PMC Article

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26.

Effects of carboxylmethylation and polyamine synthesis inhibitors on methylation of Trypanosoma brucei cellular proteins and lipids.

Goldberg B, Rattendi D, Yarlett N, Lloyd D, Bacchi CJ.

J Eukaryot Microbiol. 1997 Jul-Aug;44(4):352-8.

PMID:
9225449

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27.

Rapid methylation of cell proteins and lipids in Trypanosoma brucei.

Goldberg B, Yarlett N, Rattendi D, Lloyd D, Bacchi CJ.

J Eukaryot Microbiol. 1997 Jul-Aug;44(4):345-51.

PMID:
9225448

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28.

Synthesis and anti-trypanosomal activity of various 8-aza-7-deaza-5'noraristeromycin derivatives.

Seley KL, Schneller SW, Rattendi D, Lane S, Bacchi CJ.

J Med Chem. 1997 Feb 14;40(4):625-9.

PMID:
9046354

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29.

(+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent.

Seley KL, Schneller SW, Rattendi D, Bacchi CJ.

J Med Chem. 1997 Feb 14;40(4):622-4.

PMID:
9046353

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30.

Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives.

Sufrin JR, Rattendi D, Spiess AJ, Lane S, Marasco CJ Jr, Bacchi CJ.

Antimicrob Agents Chemother. 1996 Nov;40(11):2567-72.

PMID:
8913466
Free PMC Article

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31.

In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

Brun R, Bühler Y, Sandmeier U, Kaminsky R, Bacchi CJ, Rattendi D, Lane S, Croft SL, Snowdon D, Yardley V, Caravatti G, Frei J, Stanek J, Mett H.

Antimicrob Agents Chemother. 1996 Jun;40(6):1442-7.

PMID:
8726017
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32.

Fate of soluble methionine in African trypanosomes: effects of metabolic inhibitors.

Bacchi CJ, Goldberg B, Garofalo-Hannan J, Rattendi D, Lyte P, Yarlett N.

Biochem J. 1995 Aug 1;309 ( Pt 3):737-43.

PMID:
7639687
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33.

S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): an irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity.

Guo J, Wu YQ, Rattendi D, Bacchi CJ, Woster PM.

J Med Chem. 1995 May 12;38(10):1770-7.

PMID:
7752200

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34.

Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine.

Bacchi CJ, Garofalo J, Ciminelli M, Rattendi D, Goldberg B, McCann PP, Yarlett N.

Biochem Pharmacol. 1993 Aug 3;46(3):471-81.

PMID:
8347171

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