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Items: 46

1.

Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: A comparison of free non-protein-bound concentrations.

Patsalos PN, Zugman M, Lake C, James A, Ratnaraj N, Sander JW.

Epilepsia. 2017 Jul;58(7):1234-1243. doi: 10.1111/epi.13802. Epub 2017 May 24.

2.

Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.

Markoula S, Teotonio R, Ratnaraj N, Duncan JS, Sander JW, Patsalos PN.

Ther Drug Monit. 2014 Aug;36(4):494-8. doi: 10.1097/FTD.0000000000000051.

PMID:
24562047
3.

Saliva and serum lacosamide concentrations in patients with epilepsy.

Greenaway C, Ratnaraj N, Sander JW, Patsalos PN.

Epilepsia. 2011 Feb;52(2):258-63. doi: 10.1111/j.1528-1167.2010.02751.x. Epub 2010 Oct 13.

4.

Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model.

Luszczki JJ, Trojnar MK, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Epilepsy Res. 2010 Aug;90(3):188-98. doi: 10.1016/j.eplepsyres.2010.04.006. Epub 2010 May 20.

PMID:
20493662
5.

A high-performance liquid chromatography assay to monitor the new antiepileptic drug lacosamide in patients with epilepsy.

Greenaway C, Ratnaraj N, Sander JW, Patsalos PN.

Ther Drug Monit. 2010 Aug;32(4):448-52. doi: 10.1097/FTD.0b013e3181dcc5fb.

PMID:
20386357
6.

Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures.

Chrościńska-Krawczyk M, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Pharmacol Rep. 2009 Sep-Oct;61(5):819-26.

7.

Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.

Dudra-Jastrzebska M, Andres-Mach MM, Ratnaraj N, Patsalos PN, Czuczwar SJ, Luszczki JJ.

Seizure. 2009 Nov;18(9):607-14. doi: 10.1016/j.seizure.2009.06.009. Epub 2009 Jul 23.

8.

Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.

Dudra-Jastrzebska M, Andres-Mach MM, Sielski M, Ratnaraj N, Patsalos PN, Czuczwar SJ, Luszczki JJ.

Eur J Pharmacol. 2009 Mar 1;605(1-3):87-94. doi: 10.1016/j.ejphar.2008.12.046. Epub 2009 Jan 11.

PMID:
19168049
9.

Vigabatrin extracellular pharmacokinetics and concurrent gamma-aminobutyric acid neurotransmitter effects in rat frontal cortex and hippocampus using microdialysis.

Tong X, Ratnaraj N, Patsalos PN.

Epilepsia. 2009 Feb;50(2):174-83. doi: 10.1111/j.1528-1167.2008.01863.x. Epub 2008 Nov 12.

10.

Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy.

Luszczki JJ, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Eur J Pharmacol. 2008 Oct 24;595(1-3):13-21. doi: 10.1016/j.ejphar.2008.07.051. Epub 2008 Jul 31.

PMID:
18708046
11.

Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.

Borowicz KK, Malek R, Luszczki JJ, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Epilepsy Behav. 2007 Aug;11(1):6-12. Epub 2007 Jun 29.

PMID:
17602881
12.

Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock model.

Luszczki JJ, Andres-Mach MM, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Epilepsia. 2007 Apr;48(4):806-15. Epub 2007 Feb 5.

13.

Free phenytoin concentration measurement in brain extracellular fluid: a pilot study.

Tisdall M, Russo S, Sen J, Belli A, Ratnaraj N, Patsalos P, Petzold A, Kitchen N, Smith M.

Br J Neurosurg. 2006 Oct;20(5):285-9.

PMID:
17129875
14.

The pharmacokinetics of vigabatrin in rat blood and cerebrospinal fluid.

Tong X, Ratnaraj N, Patsalos PN.

Seizure. 2007 Jan;16(1):43-9. Epub 2006 Nov 22.

16.

In situ metabolism of levetiracetam in blood of patients with epilepsy.

Patsalos PN, Ghattaura S, Ratnaraj N, Sander JW.

Epilepsia. 2006 Nov;47(11):1818-21.

17.

Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model.

Borowicz KK, Luszczki JJ, Sobieszek G, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Eur Neuropsychopharmacol. 2007 Mar;17(4):265-72. Epub 2006 Jul 28.

PMID:
16876388
18.

Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model.

Luszczki JJ, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Naunyn Schmiedebergs Arch Pharmacol. 2006 May;373(2):169-81. Epub 2006 Apr 8.

PMID:
16604339
19.

Isobolographic analysis of interactions between losigamone and conventional antiepileptic drugs in the mouse maximal electroshock model.

Borowicz KK, Kimber-Trojnar Z, Ratnaraj N, Patsalos PN, Luszczki JJ, Czuczwar SJ.

Eur Neuropsychopharmacol. 2007 Jan 15;17(2):94-101. Epub 2006 Mar 6.

PMID:
16600575
20.
22.

Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in mice.

Luszczki JJ, Andres MM, Czuczwar P, Cioczek-Czuczwar A, Wojcik-Cwikla J, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Eur Neuropsychopharmacol. 2005 Dec;15(6):609-16.

PMID:
15922567
24.

Caffeine has no effect on measures of cortical excitability.

Orth M, Amann B, Ratnaraj N, Patsalos PN, Rothwell JC.

Clin Neurophysiol. 2005 Feb;116(2):308-14.

PMID:
15661109
25.

Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study.

Katzenschlager R, Evans A, Manson A, Patsalos PN, Ratnaraj N, Watt H, Timmermann L, Van der Giessen R, Lees AJ.

J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1672-7.

27.

Effect of felbamate and its combinations with conventional antiepileptics in amygdala-kindled rats.

Borowicz KK, Ratnaraj N, Patsalos PN, Czuczwar SJ.

Pharmacol Biochem Behav. 2004 May;78(1):103-10.

PMID:
15159139
28.
29.

Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS).

Sen S, Ratnaraj N, Davies NA, Mookerjee RP, Cooper CE, Patsalos PN, Williams R, Jalan R.

Epilepsia. 2003 Feb;44(2):265-7.

30.

Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.

Sills GJ, Patsalos PN, Butler E, Forrest G, Ratnaraj N, Brodie MJ.

Neurology. 2001 Jul 24;57(2):196-200.

PMID:
11468302
31.

Intravenous apomorphine therapy in Parkinson's disease: clinical and pharmacokinetic observations.

Manson AJ, Hanagasi H, Turner K, Patsalos PN, Carey P, Ratnaraj N, Lees AJ.

Brain. 2001 Feb;124(Pt 2):331-40.

PMID:
11157560
32.
33.

Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat.

Doheny HC, Ratnaraj N, Whittington MA, Jefferys JG, Patsalos PN.

Epilepsy Res. 1999 Apr;34(2-3):161-8.

PMID:
10210031
34.
36.

A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring.

O'Connell MT, Ratnaraj N, Elyas AA, Doheny MH, Darsot S, Patsalos PN.

Ther Drug Monit. 1995 Oct;17(5):549-55.

PMID:
8585122
37.
38.
40.

Temperature effects on the estimation of free levels of phenytoin carbamazepine and phenobarbitone.

Ratnaraj N, Goldberg VD, Hjelm M.

Ther Drug Monit. 1990 Sep;12(5):465-72.

PMID:
2293409
41.

A micromethod for the estimation of free levels of anticonvulsant drugs in serum.

Ratnaraj N, Goldberg VD, Hjelm M.

Clin Biochem. 1989 Dec;22(6):443-50.

PMID:
2692873
42.

Correlation between fluorescent polarisation immunoassay and enzyme immunoassay of anticonvulsant drugs, and stability of calibration graphs.

Ratnaraj N, Goldberg VD, Lascelles PT.

Analyst. 1986 May;111(5):517-23. No abstract available.

PMID:
3526974
43.

Determination of clobazam and desmethylclobazam in serum using high-performance liquid chromatography.

Ratnaraj N, Goldberg V, Lascelles PT.

Analyst. 1984 Jul;109(7):813-5. No abstract available.

PMID:
6486453
44.
45.

Determination of diazepam and its major metabolites using high-performance liquid chromatography.

Ratnaraj N, Goldberg VD, Elyas A, Lascelles PT.

Analyst. 1981 Sep;106(1266):1001-4. No abstract available.

PMID:
7294362
46.

Valproic acid estimation by enzyme immunoassay.

Elyas AA, Goldberg VD, Ratnaraj N, Lascelles PT.

Ann Clin Biochem. 1980 Nov;17(6):307-10.

PMID:
6782934

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