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Mycoplasma genitalium, Chlamydia trachomatis, and Neisseria gonorrhoeae Detected With Aptima Assays Performed on Self-Obtained Vaginal Swabs and Urine Collected at Home and in a Clinic.

Chernesky M, Jang D, Martin I, Arias M, Shah A, Smieja M, Ratnam S, Getman D, Schachter J.

Sex Transm Dis. 2019 Sep;46(9):e87-e89. doi: 10.1097/OLQ.0000000000001004.


Treatment of first-void urine with Aptima Transfer Solution increases detection of high-risk HPV E6/E7 mRNA.

Arias M, Jang D, Dockter J, Ratnam S, Shah A, Elit L, Smieja M, Lytwyn A, Getman D, Weinbaum B, Chernesky M.

J Virol Methods. 2019 May;267:48-52. doi: 10.1016/j.jviromet.2019.02.007. Epub 2019 Feb 21.


Assessing the time dependence of prognostic values of cytology and human papillomavirus testing in cervical cancer screening.

Isidean SD, Wang Y, Mayrand MH, Ratnam S, Coutlée F, Franco EL, Abrahamowicz M; CCCaST Study Group.

Int J Cancer. 2019 May 15;144(10):2408-2418. doi: 10.1002/ijc.31970. Epub 2019 Jan 21.


Detection of cervical precancerous lesions with Aptima HPV assays using SurePath preservative fluid specimens.

Chernesky M, Jang D, Escott N, Gilchrist J, Li J, Elit L, Lytwyn A, Smieja M, Ratnam S, Arias M, Getman D, Weinbaum B, Kirkconnell B, Dockter J.

Papillomavirus Res. 2017 Jun;3:155-159. doi: 10.1016/j.pvr.2017.04.005. Epub 2017 Apr 28.


Mycoplasma genitalium Antibiotic Resistance-Mediating Mutations in Canadian Women With or Without Chlamydia Trachomatis Infection.

Chernesky MA, Jang D, Martin I, Hoang LMN, Naidu P, Levett PN, Wylie J, Rebbapragada A, Ratnam S, Smieja M, Weinbaum B, Getman D; Canadian MG Study Group.

Sex Transm Dis. 2017 Jul;44(7):433-435. doi: 10.1097/OLQ.0000000000000617.


Phylogenetic analysis of emergent Streptococcus pneumoniae serotype 22F causing invasive pneumococcal disease using whole genome sequencing.

Demczuk WHB, Martin I, Hoang L, Van Caeseele P, Lefebvre B, Horsman G, Haldane D, Gubbay J, Ratnam S, German G, Daley Bernier J, Strudwick L, McGeer A, Zhanel GG, Van Domselaar G, Graham M, Mulvey MR.

PLoS One. 2017 May 22;12(5):e0178040. doi: 10.1371/journal.pone.0178040. eCollection 2017.


Ssm1b expression and function in germ cells of adult mice and in early embryos.

Ratnam S, Bozek G, Martin T, Gallagher SJ, Payne CJ, Storb U.

Mol Reprod Dev. 2017 Jul;84(7):596-613. doi: 10.1002/mrd.22826. Epub 2017 Jun 5.


Introduction of molecular HPV testing as the primary technology in cervical cancer screening: Acting on evidence to change the current paradigm.

Tota JE, Bentley J, Blake J, Coutlée F, Duggan MA, Ferenczy A, Franco EL, Fung-Kee-Fung M, Gotlieb W, Mayrand MH, McLachlin M, Murphy J, Ogilvie G, Ratnam S.

Prev Med. 2017 May;98:5-14. doi: 10.1016/j.ypmed.2016.11.029. Epub 2017 Feb 6.


Approaches for triaging women who test positive for human papillomavirus in cervical cancer screening.

Tota JE, Bentley J, Blake J, Coutlée F, Duggan MA, Ferenczy A, Franco EL, Fung-Kee-Fung M, Gotlieb W, Mayrand MH, McLachlin M, Murphy J, Ogilvie G, Ratnam S.

Prev Med. 2017 May;98:15-20. doi: 10.1016/j.ypmed.2016.11.030. Epub 2017 Feb 6.


Comparison of cobas 4800, m2000, Viper XTR, and Infinity 80 Automated Instruments When Processing Urine Specimens for the Diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae.

Chernesky MA, Jang D, Gilchrist J, Smieja M, Arias M, Hatchette T, Poirier A, Mayne D, Ratnam S.

Sex Transm Dis. 2017 Mar;44(3):161-165. doi: 10.1097/OLQ.0000000000000570.


Comparison of Triage Strategies for HPV-Positive Women: Canadian Cervical Cancer Screening Trial Results.

Isidean SD, Mayrand MH, Ramanakumar AV, Rodrigues I, Ferenczy A, Ratnam S, Coutlée F, Franco EL; CCCaST Study Group.

Cancer Epidemiol Biomarkers Prev. 2017 Jun;26(6):923-929. doi: 10.1158/1055-9965.EPI-16-0705. Epub 2017 Jan 17.


Human papillomavirus testing versus cytology in primary cervical cancer screening: End-of-study and extended follow-up results from the Canadian cervical cancer screening trial.

Isidean SD, Mayrand MH, Ramanakumar AV, Gilbert L, Reid SL, Rodrigues I, Ferenczy A, Ratnam S, Coutlée F, Franco EL; CCCaST Study Group.

Int J Cancer. 2016 Dec 1;139(11):2456-66. doi: 10.1002/ijc.30385. Epub 2016 Aug 30.


Phenotypic H-Antigen Typing by Mass Spectrometry Combined with Genetic Typing of H Antigens, O Antigens, and Toxins by Whole-Genome Sequencing Enhances Identification of Escherichia coli Isolates.

Cheng K, Chui H, Domish L, Sloan A, Hernandez D, McCorrister S, Robinson A, Walker M, Peterson LA, Majcher M, Ratnam S, Haldane DJ, Bekal S, Wylie J, Chui L, Tyler S, Xu B, Reimer A, Nadon C, Knox JD, Wang G.

J Clin Microbiol. 2016 Aug;54(8):2162-8. doi: 10.1128/JCM.00422-16. Epub 2016 Jun 15.


Comparison of Workflow, Maintenance, and Consumables in the GeneXpert Infinity 80 and Panther Instruments While Testing for Chlamydia trachomatis and Neisseria gonorrhoeae.

Jang D, Ratnam S, Gilchrist J, Arias M, Smieja M, Mayne D, Chernesky MA.

Sex Transm Dis. 2016 Jun;43(6):377-81. doi: 10.1097/OLQ.0000000000000444.


Sensitivity of APTIMA HPV E6/E7 mRNA test in comparison with hybrid capture 2 HPV DNA test for detection of high risk oncogenic human papillomavirus in 396 biopsy confirmed cervical cancers.

Basu P, Banerjee D, Mittal S, Dutta S, Ghosh I, Chowdhury N, Abraham P, Chandna P, Ratnam S.

J Med Virol. 2016 Jul;88(7):1271-8. doi: 10.1002/jmv.24453. Epub 2016 Jan 6.


Decline in Decreased Cephalosporin Susceptibility and Increase in Azithromycin Resistance in Neisseria gonorrhoeae, Canada.

Martin I, Sawatzky P, Liu G, Allen V, Lefebvre B, Hoang L, Drews S, Horsman G, Wylie J, Haldane D, Garceau R, Ratnam S, Wong T, Archibald C, Mulvey MR.

Emerg Infect Dis. 2016 Jan;22(1):65-7. doi: 10.3201/eid2201.151247.


HPV DNA testing with cytology triage in cervical cancer screening: Influence of revealing HPV infection status.

Richardson LA, El-Zein M, Ramanakumar AV, Ratnam S, Sangwa-Lugoma G, Longatto-Filho A, Cardoso MA, Coutlée F, Franco EL; PEACHS (Pap Efficacy After Cervical HPV Status) Study Consortium.

Cancer Cytopathol. 2015 Dec;123(12):745-54. doi: 10.1002/cncy.21596. Epub 2015 Jul 31.


Effect of vaginal self-sampling on cervical cancer screening rates: a community-based study in Newfoundland.

Duke P, Godwin M, Ratnam S, Dawson L, Fontaine D, Lear A, Traverso-Yepez M, Graham W, Ravalia M, Mugford G, Pike A, Fortier J, Peach M.

BMC Womens Health. 2015 Jun 10;15:47. doi: 10.1186/s12905-015-0206-1.


Rapid, Sensitive, and Specific Escherichia coli H Antigen Typing by Matrix-Assisted Laser Desorption Ionization-Time of Flight-Based Peptide Mass Fingerprinting.

Chui H, Chan M, Hernandez D, Chong P, McCorrister S, Robinson A, Walker M, Peterson LA, Ratnam S, Haldane DJ, Bekal S, Wylie J, Chui L, Westmacott G, Xu B, Drebot M, Nadon C, Knox JD, Wang G, Cheng K.

J Clin Microbiol. 2015 Aug;53(8):2480-5. doi: 10.1128/JCM.00593-15. Epub 2015 May 27.


Select critically ill patients at risk of augmented renal clearance: experience in a Malaysian intensive care unit.

Adnan S, Ratnam S, Kumar S, Paterson D, Lipman J, Roberts J, Udy AA.

Anaesth Intensive Care. 2014 Nov;42(6):715-22.


Acyclovir-Induced Neurotoxicity: A Case Report and Review of Literature.

Chowdhury MA, Derar N, Hasan S, Hinch B, Ratnam S, Assaly R.

Am J Ther. 2016 May-Jun;23(3):e941-3. doi: 10.1097/MJT.0000000000000093. Review.


Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis.

Ratnam S, Engler P, Bozek G, Mao L, Podlutsky A, Austad S, Martin T, Storb U.

Development. 2014 May;141(10):2024-34. doi: 10.1242/dev.105726.


Workflow and maintenance characteristics of five automated laboratory instruments for the diagnosis of sexually transmitted infections.

Ratnam S, Jang D, Gilchrist J, Smieja M, Poirier A, Hatchette T, Flandin JF, Chernesky M.

J Clin Microbiol. 2014 Jul;52(7):2299-304. doi: 10.1128/JCM.03549-13. Epub 2014 Apr 16.


Head-to-head comparison of second-generation nucleic acid amplification tests for detection of Chlamydia trachomatis and Neisseria gonorrhoeae on urine samples from female subjects and self-collected vaginal swabs.

Chernesky M, Jang D, Gilchrist J, Hatchette T, Poirier A, Flandin JF, Smieja M, Ratnam S.

J Clin Microbiol. 2014 Jul;52(7):2305-10. doi: 10.1128/JCM.03552-13. Epub 2014 Apr 2.


Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.

Aboualaiwi WA, Muntean BS, Ratnam S, Joe B, Liu L, Booth RL, Rodriguez I, Herbert BS, Bacallao RL, Fruttiger M, Mak TW, Zhou J, Nauli SM.

Circulation. 2014 Feb 11;129(6):660-72. doi: 10.1161/CIRCULATIONAHA.113.005746. Epub 2013 Nov 14.


Antimicrobial susceptibilities and distribution of sequence types of Neisseria gonorrhoeae isolates in Canada: 2010.

Martin I, Sawatzky P, Liu G, Allen V, Lefebvre B, Hoang L, Lovgren M, Haldane D, Caeseele PV, Horsman G, Garceau R, Ratnam S, Wong T, Gilmour M.

Can J Microbiol. 2013 Oct;59(10):671-8. doi: 10.1139/cjm-2013-0357. Epub 2013 Aug 27.


Stability of cervical specimens in SurePath medium for human papillomavirus testing with the Roche cobas 4800 assay.

Gilbert L, Oates E, Ratnam S.

J Clin Microbiol. 2013 Oct;51(10):3412-4. doi: 10.1128/JCM.01391-13. Epub 2013 Jul 31.


The prevalence of human papillomavirus and its impact on cervical dysplasia in Northern Canada.

Jiang Y, Brassard P, Severini A, Mao Y, Li YA, Laroche J, Chatwood S, Corriveau A, Kandola K, Hanley B, Sobol I, Ar-Rushdi M, Johnson G, Lo J, Ratnam S, Wong T, Demers A, Jayaraman G, Totten S, Morrison H.

Infect Agent Cancer. 2013 Jul 1;8(1):25. doi: 10.1186/1750-9378-8-25.


Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.

Kodgire P, Mukkawar P, Ratnam S, Martin TE, Storb U.

J Exp Med. 2013 Jul 1;210(7):1481-92. doi: 10.1084/jem.20121523. Epub 2013 Jun 10.


Type-specific prevalence of human papillomavirus in women screened for cervical cancer in Labrador, Canada.

Severini A, Jiang Y, Brassard P, Morrison H, Demers AA, Oguntuase E, Al-Rushdi M, Preston F, Ratnam S, Mao Y.

Int J Circumpolar Health. 2013;72. doi: 10.3402/ijch.v72i0.19743. Epub 2013 Feb 21.


Performance of ProEx C and PreTect HPV-Proofer E6/E7 mRNA tests in comparison with the hybrid capture 2 HPV DNA test for triaging ASCUS and LSIL cytology.

Alaghehbandan R, Fontaine D, Bentley J, Escott N, Ghatage P, Lear A, Coutlee F, Ratnam S.

Diagn Cytopathol. 2013 Sep;41(9):767-75. doi: 10.1002/dc.22944. Epub 2013 Jan 22.


Results of continuous monitoring of the performance of rubella virus IgG and hepatitis B virus surface antibody assays using trueness controls in a multicenter trial.

Kruk T, Ratnam S, Preiksaitis J, Lau A, Hatchette T, Horsman G, Van Caeseele P, Timmons B, Tipples G.

Clin Vaccine Immunol. 2012 Oct;19(10):1624-32. Epub 2012 Aug 15.


The APTIMA HPV assay versus the Hybrid Capture 2 test in triage of women with ASC-US or LSIL cervical cytology: a meta-analysis of the diagnostic accuracy.

Arbyn M, Roelens J, Cuschieri K, Cuzick J, Szarewski A, Ratnam S, Reuschenbach M, Belinson S, Belinson JL, Monsonego J.

Int J Cancer. 2013 Jan 1;132(1):101-8. doi: 10.1002/ijc.27636. Epub 2012 Jun 13. Review.


Conservative management of post-transplant central nervous system lymphoma.

Valavoor SH, Ashraf Z, Narwal R, Ratnam S.

Int Urol Nephrol. 2013 Aug;45(4):1219-22. doi: 10.1007/s11255-012-0146-8. Epub 2012 Apr 3. Review.


Radiation exposure in whole body CT screening.

Suresh P, Ratnam SV, Rao KV.

J Indian Med Assoc. 2011 Apr;109(4):267-9, 271.


Novel microsphere-based method for detection and typing of 46 mucosal human papillomavirus types.

Zubach V, Smart G, Ratnam S, Severini A.

J Clin Microbiol. 2012 Feb;50(2):460-4. doi: 10.1128/JCM.06090-11. Epub 2011 Nov 23.


Decisions to operate: the ASA grade 5 dilemma.

Horwood J, Ratnam S, Maw A.

Ann R Coll Surg Engl. 2011 Jul;93(5):365-9. doi: 10.1308/003588411X581367.


The impact of anogenital warts on health-related quality of life: a 6-month prospective study.

Drolet M, Brisson M, Maunsell E, Franco EL, Coutlée F, Ferenczy A, Ratnam S, Fisher W, Mansi JA.

Sex Transm Dis. 2011 Oct;38(10):949-56. doi: 10.1097/OLQ.0b013e3182215512.


MassARRAY spectrometry is more sensitive than PreTect HPV-Proofer and consensus PCR for type-specific detection of high-risk oncogenic human papillomavirus genotypes in cervical cancer.

Basu P, Chandna P, Bamezai RN, Siddiqi M, Saranath D, Lear A, Ratnam S.

J Clin Microbiol. 2011 Oct;49(10):3537-44. doi: 10.1128/JCM.00354-11. Epub 2011 Aug 3.


Distribution of human papillomavirus genotypes in cervical intraepithelial neoplasia and invasive cervical cancer in Canada.

Coutlée F, Ratnam S, Ramanakumar AV, Insinga RR, Bentley J, Escott N, Ghatage P, Koushik A, Ferenczy A, Franco EL.

J Med Virol. 2011 Jun;83(6):1034-41. doi: 10.1002/jmv.22081.


Successful preemptive renal retransplantation in a patient with previous acute graft loss secondary to HIT type II: a case report and review of literature.

Muzaffar M, Li X, Ratnam S.

Int Urol Nephrol. 2012 Jun;44(3):991-4. doi: 10.1007/s11255-011-9935-8. Epub 2011 Mar 20. Review.


Loss of quality of life associated with genital warts: baseline analyses from a prospective study.

Sénécal M, Brisson M, Maunsell E, Ferenczy A, Franco EL, Ratnam S, Coutlée F, Palefsky JM, Mansi JA.

Sex Transm Infect. 2011 Apr;87(3):209-15. doi: 10.1136/sti.2009.039982. Epub 2011 Feb 18.


Aptima HPV E6/E7 mRNA test is as sensitive as Hybrid Capture 2 Assay but more specific at detecting cervical precancer and cancer.

Ratnam S, Coutlee F, Fontaine D, Bentley J, Escott N, Ghatage P, Gadag V, Holloway G, Bartellas E, Kum N, Giede C, Lear A.

J Clin Microbiol. 2011 Feb;49(2):557-64. doi: 10.1128/JCM.02147-10. Epub 2010 Dec 8.


Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation.

AbouAlaiwi WA, Ratnam S, Booth RL, Shah JV, Nauli SM.

Hum Mol Genet. 2011 Jan 15;20(2):354-67. doi: 10.1093/hmg/ddq470. Epub 2010 Nov 1.


The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.

Ratnam S, Bozek G, Nicolae D, Storb U.

Mol Immunol. 2010 Oct;47(16):2611-8. doi: 10.1016/j.molimm.2010.05.291. Epub 2010 Aug 5.


Clinical performance of the PreTect HPV-Proofer E6/E7 mRNA assay in comparison with that of the Hybrid Capture 2 test for identification of women at risk of cervical cancer.

Ratnam S, Coutlee F, Fontaine D, Bentley J, Escott N, Ghatage P, Gadag V, Holloway G, Bartellas E, Kum N, Giede C, Lear A.

J Clin Microbiol. 2010 Aug;48(8):2779-85. doi: 10.1128/JCM.00382-10. Epub 2010 Jun 23.


Attracting AID to targets of somatic hypermutation.

Tanaka A, Shen HM, Ratnam S, Kodgire P, Storb U.

J Exp Med. 2010 Feb 15;207(2):405-15. doi: 10.1084/jem.20090821. Epub 2010 Jan 25.


Characterization of leptospira borgpetersenii isolates from field rats (rattus norvegicus) by 16s rrna and lipl32 gene sequencing.

Vedhagiri K, Natarajaseenivasan K, Prabhakaran SG, Selvin J, Narayanan R, Shouche YS, Vijayachari P, Ratnam S.

Braz J Microbiol. 2010 Jan;41(1):150-7. doi: 10.1590/S1517-838220100001000022. Epub 2010 Mar 1.

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