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Items: 24


Dengue virus-elicited tryptase induces endothelial permeability and shock.

Rathore AP, Mantri CK, Aman SA, Syenina A, Ooi J, Jagaraj CJ, Goh CC, Tissera H, Wilder-Smith A, Ng LG, Gubler DJ, St John AL.

J Clin Invest. 2019 Jul 2;130:4180-4193. doi: 10.1172/JCI128426.


Maternal immunity and antibodies to dengue virus promote infection and Zika virus-induced microcephaly in fetuses.

Rathore APS, Saron WAA, Lim T, Jahan N, St John AL.

Sci Adv. 2019 Feb 27;5(2):eaav3208. doi: 10.1126/sciadv.aav3208. eCollection 2019 Feb.


Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT2 receptors.

Masri MFB, Mantri CK, Rathore APS, John ALS.

Blood. 2019 May 23;133(21):2325-2337. doi: 10.1182/blood-2018-08-869156. Epub 2019 Feb 12.


Japanese encephalitis virus neuropenetrance is driven by mast cell chymase.

Hsieh JT, Rathore APS, Soundarajan G, St John AL.

Nat Commun. 2019 Feb 11;10(1):706. doi: 10.1038/s41467-019-08641-z.


Adaptive immune responses to primary and secondary dengue virus infections.

St John AL, Rathore APS.

Nat Rev Immunol. 2019 Apr;19(4):218-230. doi: 10.1038/s41577-019-0123-x. Review.


Immune responses to dengue virus in the skin.

Rathore APS, St John AL.

Open Biol. 2018 Aug;8(8). pii: 180087. doi: 10.1098/rsob.180087. Review.


Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells.

Saron WAA, Rathore APS, Ting L, Ooi EE, Low J, Abraham SN, St John AL.

Sci Adv. 2018 Jul 4;4(7):eaar4297. doi: 10.1126/sciadv.aar4297. eCollection 2018 Jul.


Reprograming immunity to food allergens.

St John AL, Ang WXG, Rathore APS, Abraham SN.

J Allergy Clin Immunol. 2018 May;141(5):1936-1939.e2. doi: 10.1016/j.jaci.2018.01.020. Epub 2018 Feb 5. No abstract available.


Seasonal variation in natural abundance of δ13C and 15N in Salicornia brachiata Roxb. populations from a coastal area of India.

Chaudhary DR, Seo J, Kang H, Rathore AP, Jha B.

Isotopes Environ Health Stud. 2018 May;54(2):209-224. doi: 10.1080/10256016.2017.1391807. Epub 2017 Nov 5.


Chymase Level Is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients.

Tissera H, Rathore APS, Leong WY, Pike BL, Warkentien TE, Farouk FS, Syenina A, Eong Ooi E, Gubler DJ, Wilder-Smith A, St John AL.

J Infect Dis. 2017 Nov 27;216(9):1112-1121. doi: 10.1093/infdis/jix447.


Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model.

Morrison J, Rathore APS, Mantri CK, Aman SAB, Nishida A, St John AL.

J Virol. 2017 Aug 24;91(18). pii: e00617-17. doi: 10.1128/JVI.00617-17. Print 2017 Sep 15.


Spatial and halophyte-associated microbial communities in intertidal coastal region of India.

Chaudhary DR, Rathore AP, Kumar R, Jha B.

Int J Phytoremediation. 2017 May 4;19(5):478-489. doi: 10.1080/15226514.2016.1244168.


Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients.

Sung C, Wei Y, Watanabe S, Lee HS, Khoo YM, Fan L, Rathore AP, Chan KW, Choy MM, Kamaraj US, Sessions OM, Aw P, de Sessions PF, Lee B, Connolly JE, Hibberd ML, Vijaykrishna D, Wijaya L, Ooi EE, Low JG, Vasudevan SG.

PLoS Negl Trop Dis. 2016 Aug 10;10(8):e0004851. doi: 10.1371/journal.pntd.0004851. eCollection 2016 Aug.


Biomass production, nutrient cycling, and carbon fixation by Salicornia brachiata Roxb.: A promising halophyte for coastal saline soil rehabilitation.

Rathore AP, Chaudhary DR, Jha B.

Int J Phytoremediation. 2016 Aug 2;18(8):801-11. doi: 10.1080/15226514.2016.1146228.


Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial.

Low JG, Sung C, Wijaya L, Wei Y, Rathore APS, Watanabe S, Tan BH, Toh L, Chua LT, Hou Y, Chow A, Howe S, Chan WK, Tan KH, Chung JS, Cherng BP, Lye DC, Tambayah PA, Ng LC, Connolly J, Hibberd ML, Leo YS, Cheung YB, Ooi EE, Vasudevan SG.

Lancet Infect Dis. 2014 Aug;14(8):706-715. doi: 10.1016/S1473-3099(14)70730-3. Epub 2014 May 28.


Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo.

Rathore AP, Haystead T, Das PK, Merits A, Ng ML, Vasudevan SG.

Antiviral Res. 2014 Mar;103:7-16. doi: 10.1016/j.antiviral.2013.12.010. Epub 2013 Dec 31.


Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

Tay MY, Fraser JE, Chan WK, Moreland NJ, Rathore AP, Wang C, Vasudevan SG, Jans DA.

Antiviral Res. 2013 Sep;99(3):301-6. doi: 10.1016/j.antiviral.2013.06.002. Epub 2013 Jun 14.


Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.

St John AL, Rathore AP, Raghavan B, Ng ML, Abraham SN.

Elife. 2013 Apr 30;2:e00481. doi: 10.7554/eLife.00481.


Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial.

Watanabe S, Rathore AP, Sung C, Lu F, Khoo YM, Connolly J, Low J, Ooi EE, Lee HS, Vasudevan SG.

Antiviral Res. 2012 Oct;96(1):32-5. doi: 10.1016/j.antiviral.2012.07.008. Epub 2012 Jul 31.


The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model.

Watanabe S, Tan KH, Rathore AP, Rozen-Gagnon K, Shuai W, Ruedl C, Vasudevan SG.

J Virol. 2012 May;86(10):5508-14. doi: 10.1128/JVI.07081-11. Epub 2012 Mar 14.


Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex.

Moreland NJ, Tay MY, Lim E, Rathore AP, Lim AP, Hanson BJ, Vasudevan SG.

J Virol Methods. 2012 Jan;179(1):97-103. doi: 10.1016/j.jviromet.2011.10.006. Epub 2011 Oct 20.


Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model.

Rathore AP, Paradkar PN, Watanabe S, Tan KH, Sung C, Connolly JE, Low J, Ooi EE, Vasudevan SG.

Antiviral Res. 2011 Dec;92(3):453-60. doi: 10.1016/j.antiviral.2011.10.002. Epub 2011 Oct 12.


Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance.

St John AL, Rathore AP, Yap H, Ng ML, Metcalfe DD, Vasudevan SG, Abraham SN.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):9190-5. doi: 10.1073/pnas.1105079108. Epub 2011 May 16.

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