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Items: 1 to 50 of 102

1.

Decreased In Vitro Artemisinin Sensitivity of Plasmodium falciparum across India.

Chakrabarti R, White J, Babar PH, Kumar S, Mudeppa DG, Mascarenhas A, Pereira L, Dash R, Maki JN, Sharma A, Gogoi K, Sarma DK, Pal Bhowmick I, Manoharan SK, Gomes E, Mahanta J, Mohapatra PK, Chery L, Rathod PK.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00101-19. doi: 10.1128/AAC.00101-19. Print 2019 Oct.

2.

Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults.

Duffy F, Bernabeu M, Babar PH, Kessler A, Wang CW, Vaz M, Chery L, Mandala WL, Rogerson SJ, Taylor TE, Seydel KB, Lavstsen T, Gomes E, Kim K, Lusingu J, Rathod PK, Aitchison JD, Smith JD.

MBio. 2019 Apr 30;10(2). pii: e00217-19. doi: 10.1128/mBio.00217-19.

3.

Hospital-derived antibody profiles of malaria patients in Southwest India.

Venkatesh A, Jain A, Davies H, Periera L, Maki JN, Gomes E, Felgner PL, Srivastava S, Patankar S, Rathod PK.

Malar J. 2019 Apr 17;18(1):138. doi: 10.1186/s12936-019-2771-5.

4.

Heterologous expression in Toxoplasma gondii reveals a topogenic signal anchor in a Plasmodium apicoplast protein.

Narayan A, Mastud P, Thakur V, Rathod PK, Mohmmed A, Patankar S.

FEBS Open Bio. 2018 Oct 22;8(11):1746-1762. doi: 10.1002/2211-5463.12527. eCollection 2018 Nov.

5.

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.

White J, Dhingra SK, Deng X, El Mazouni F, Lee MCS, Afanador GA, Lawong A, Tomchick DR, Ng CL, Bath J, Rathod PK, Fidock DA, Phillips MA.

ACS Infect Dis. 2019 Jan 11;5(1):90-101. doi: 10.1021/acsinfecdis.8b00211. Epub 2018 Nov 13.

PMID:
30375858
6.

A call to arms: Unifying the fight against resistance.

Kaushansky A, Hedstrom L, Goldman A, Singh J, Yang PL, Rathod PK, Cynamon M, Wodarz D, Mahadevan D, Tomaras A, Navia MA, Schiffer CA.

Sci Signal. 2018 Oct 23;11(553). pii: eaav0442. doi: 10.1126/scisignal.aav0442.

PMID:
30352947
7.

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.

Kokkonda S, El Mazouni F, White KL, White J, Shackleford DM, Lafuente-Monasterio MJ, Rowland P, Manjalanagara K, Joseph JT, Garcia-Pérez A, Fernandez J, Gamo FJ, Waterson D, Burrows JN, Palmer MJ, Charman SA, Rathod PK, Phillips MA.

ACS Omega. 2018 Aug 31;3(8):9227-9240. doi: 10.1021/acsomega.8b01573. Epub 2018 Aug 15.

8.

Susceptibility of wild and colonized Anopheles stephensi to Plasmodium vivax infection.

Mohanty AK, Nina PB, Ballav S, Vernekar S, Parkar S, D'souza M, Zuo W, Gomes E, Chery L, Tuljapurkar S, Valecha N, Rathod PK, Kumar A.

Malar J. 2018 Jun 5;17(1):225. doi: 10.1186/s12936-018-2343-0.

9.

Indispensable malaria genes.

White J, Rathod PK.

Science. 2018 May 4;360(6388):490-491. doi: 10.1126/science.aat5092. No abstract available.

10.

Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays.

Rangel GW, Clark MA, Kanjee U, Lim C, Shaw-Saliba K, Menezes MJ, Mascarenhas A, Chery L, Gomes E, Rathod PK, Ferreira MU, Duraisingh MT.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02519-17. doi: 10.1128/AAC.02519-17. Print 2018 Apr.

11.

Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax.

Patankar S, Sharma S, Rathod PK, Duraisingh MT.

Proteomics Clin Appl. 2018 Jul;12(4):e1700024. doi: 10.1002/prca.201700024. Epub 2018 Jan 11. Review.

12.

Dynamics of Plasmodium vivax sporogony in wild Anopheles stephensi in a malaria-endemic region of Western India.

Balabaskaran Nina P, Mohanty AK, Ballav S, Vernekar S, Bhinge S, D'souza M, Walke J, Manoharan SK, Mascarenhas A, Gomes E, Chery L, Valecha N, Kumar A, Rathod PK.

Malar J. 2017 Jul 11;16(1):284. doi: 10.1186/s12936-017-1931-8.

13.

Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India.

Chery L, Maki JN, Mascarenhas A, Walke JT, Gawas P, Almeida A, Fernandes M, Vaz M, Ramanan R, Shirodkar D, Bernabeu M, Manoharan SK, Pereira L, Dash R, Sharma A, Shaik RB, Chakrabarti R, Babar P, White J 3rd, Mudeppa DG, Kumar S, Zuo W, Skillman KM, Kanjee U, Lim C, Shaw-Saliba K, Kumar A, Valecha N, Jindal VN, Khandeparkar A, Naik P, Amonkar S, Duraisingh MT, Tuljapurkar S, Smith JD, Dubhashi N, Pinto RG, Silveria M, Gomes E, Rathod PK.

Malar J. 2016 Nov 25;15(1):569.

14.

Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications.

Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, Rayner JC.

PLoS Negl Trop Dis. 2016 Oct 31;10(10):e0005091. doi: 10.1371/journal.pntd.0005091. eCollection 2016 Oct.

15.

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.

Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh K, Tomchick DR, Manjalanagara K, Rudra KR, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Shackleford DM, Chiu FC, Campbell M, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Martinez MS, Lafuente-Monasterio M, Kaminsky W, Silue K, Zeeman AM, Kocken C, Leroy D, Blasco B, Rossignol E, Rueckle T, Matthews D, Burrows JN, Waterson D, Palmer MJ, Rathod PK, Charman SA.

ACS Infect Dis. 2016 Dec 9;2(12):945-957. Epub 2016 Oct 4.

16.

Distinct genomic architecture of Plasmodium falciparum populations from South Asia.

Kumar S, Mudeppa DG, Sharma A, Mascarenhas A, Dash R, Pereira L, Shaik RB, Maki JN, White J 3rd, Zuo W, Tuljapurkar S, Duraisingh MT, Gomes E, Chery L, Rathod PK.

Mol Biochem Parasitol. 2016 Nov - Dec;210(1-2):1-4. doi: 10.1016/j.molbiopara.2016.07.005. Epub 2016 Jul 22.

17.

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT.

Int J Parasitol. 2016 Oct;46(11):679-83. doi: 10.1016/j.ijpara.2016.06.003. Epub 2016 Jul 25.

18.

Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates.

Lim C, Pereira L, Saliba KS, Mascarenhas A, Maki JN, Chery L, Gomes E, Rathod PK, Duraisingh MT.

J Infect Dis. 2016 Oct 1;214(7):1081-4. doi: 10.1093/infdis/jiw303. Epub 2016 Jul 17.

19.

Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass.

Bernabeu M, Danziger SA, Avril M, Vaz M, Babar PH, Brazier AJ, Herricks T, Maki JN, Pereira L, Mascarenhas A, Gomes E, Chery L, Aitchison JD, Rathod PK, Smith JD.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3270-9. doi: 10.1073/pnas.1524294113. Epub 2016 May 16.

20.

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.

Kokkonda S, Deng X, White KL, Coteron JM, Marco M, de Las Heras L, White J, El Mazouni F, Tomchick DR, Manjalanagara K, Rudra KR, Chen G, Morizzi J, Ryan E, Kaminsky W, Leroy D, Martínez-Martínez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Waterson D, Burrows JN, Matthews D, Charman SA, Phillips MA, Rathod PK.

J Med Chem. 2016 Jun 9;59(11):5416-31. doi: 10.1021/acs.jmedchem.6b00275. Epub 2016 May 21.

21.

Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia.

Lim C, Pereira L, Shardul P, Mascarenhas A, Maki J, Rixon J, Shaw-Saliba K, White J, Silveira M, Gomes E, Chery L, Rathod PK, Duraisingh MT.

Am J Hematol. 2016 Aug;91(8):852-5. doi: 10.1002/ajh.24383. Epub 2016 May 24.

22.

Glycemic Status in Organophosphorus Poisoning.

Panda S, Nanda R, Mangaraj M, Rathod PK, Mishra PK.

J Nepal Health Res Counc. 2015 Sep-Dec;13(31):214-9.

PMID:
27005715
23.

Anopheles subpictus carry human malaria parasites in an urban area of Western India and may facilitate perennial malaria transmission.

Kumar A, Hosmani R, Jadhav S, de Sousa T, Mohanty A, Naik M, Shettigar A, Kale S, Valecha N, Chery L, Rathod PK.

Malar J. 2016 Feb 27;15:124. doi: 10.1186/s12936-016-1177-x.

24.

In vitro adaptation of Plasmodium falciparum reveal variations in cultivability.

White J 3rd, Mascarenhas A, Pereira L, Dash R, Walke JT, Gawas P, Sharma A, Manoharan SK, Guler JL, Maki JN, Kumar A, Mahanta J, Valecha N, Dubhashi N, Vaz M, Gomes E, Chery L, Rathod PK.

Malar J. 2016 Jan 22;15:33. doi: 10.1186/s12936-015-1053-0.

25.

Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis.

Mullowney MW, Hwang CH, Newsome AG, Wei X, Tanouye U, Wan B, Carlson S, Barranis NJ, hAinmhire E, Chen WL, Krishnamoorthy K, White J, Blair R, Lee H, Burdette JE, Rathod PK, Parish T, Cho S, Franzblau SG, Murphy BT.

ACS Infect Dis. 2015 Apr 10;1(4):168-174. Epub 2015 Mar 11.

26.

Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network.

Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ.

Am J Trop Med Hyg. 2015 Sep;93(3 Suppl):57-68. doi: 10.4269/ajtmh.15-0007. Epub 2015 Aug 10. Review.

27.

Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach.

Wassmer SC, Taylor TE, Rathod PK, Mishra SK, Mohanty S, Arevalo-Herrera M, Duraisingh MT, Smith JD.

Am J Trop Med Hyg. 2015 Sep;93(3 Suppl):42-56. doi: 10.4269/ajtmh.14-0841. Epub 2015 Aug 10. Review.

28.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA.

Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645.

29.

Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION.

Mudeppa DG, Kumar S, Kokkonda S, White J, Rathod PK.

J Biol Chem. 2015 Aug 14;290(33):20313-24. doi: 10.1074/jbc.M115.639039. Epub 2015 Jun 8.

30.

Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions.

Kumar S, Krishnamoorthy K, Mudeppa DG, Rathod PK.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):600-8. doi: 10.1107/S2053230X1500549X. Epub 2015 Apr 21.

31.

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.

Deng X, Matthews D, Rathod PK, Phillips MA.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):553-9. doi: 10.1107/S2053230X15000989. Epub 2015 Apr 21.

32.

Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor.

Guler JL, White J 3rd, Phillips MA, Rathod PK.

Antimicrob Agents Chemother. 2015 Jan;59(1):686-9. doi: 10.1128/AAC.02347-14. Epub 2014 Oct 20.

33.

Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.

Deng X, Kokkonda S, El Mazouni F, White J, Burrows JN, Kaminsky W, Charman SA, Matthews D, Rathod PK, Phillips MA.

J Med Chem. 2014 Jun 26;57(12):5381-94. doi: 10.1021/jm500481t. Epub 2014 Jun 13.

34.

Expression of functional Plasmodium falciparum enzymes using a wheat germ cell-free system.

Mudeppa DG, Rathod PK.

Eukaryot Cell. 2013 Dec;12(12):1653-63. doi: 10.1128/EC.00222-13. Epub 2013 Oct 11.

35.

A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway.

Mailu BM, Ramasamay G, Mudeppa DG, Li L, Lindner SE, Peterson MJ, DeRocher AE, Kappe SH, Rathod PK, Gardner MJ.

J Biol Chem. 2013 Nov 8;288(45):32539-52. doi: 10.1074/jbc.M113.507467. Epub 2013 Sep 26.

36.

Clonal variants of Plasmodium falciparum exhibit a narrow range of rolling velocities to host receptor CD36 under dynamic flow conditions.

Herricks T, Avril M, Janes J, Smith JD, Rathod PK.

Eukaryot Cell. 2013 Nov;12(11):1490-8. doi: 10.1128/EC.00148-13. Epub 2013 Sep 6.

37.

Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications.

Guler JL, Freeman DL, Ahyong V, Patrapuvich R, White J, Gujjar R, Phillips MA, DeRisi J, Rathod PK.

PLoS Pathog. 2013;9(5):e1003375. doi: 10.1371/journal.ppat.1003375. Epub 2013 May 23.

38.

Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients.

Herricks T, Seydel KB, Molyneux M, Taylor T, Rathod PK.

Cell Microbiol. 2012 Dec;14(12):1880-91. doi: 10.1111/cmi.12007. Epub 2012 Sep 4.

39.

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.

Marwaha A, White J, El Mazouni F, Creason SA, Kokkonda S, Buckner FS, Charman SA, Phillips MA, Rathod PK.

J Med Chem. 2012 Sep 13;55(17):7425-36. doi: 10.1021/jm300351w. Epub 2012 Aug 21.

40.

Malaria evolution in South Asia: knowledge for control and elimination.

Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowble J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, Shastri J, Smith J, Valecha N, White J, Rathod PK.

Acta Trop. 2012 Mar;121(3):256-66. doi: 10.1016/j.actatropica.2012.01.008. Epub 2012 Jan 14. Review.

41.

Malaria in South Asia: prevalence and control.

Kumar A, Chery L, Biswas C, Dubhashi N, Dutta P, Dua VK, Kacchap M, Kakati S, Khandeparkar A, Kour D, Mahajan SN, Maji A, Majumder P, Mohanta J, Mohapatra PK, Narayanasamy K, Roy K, Shastri J, Valecha N, Vikash R, Wani R, White J, Rathod PK.

Acta Trop. 2012 Mar;121(3):246-55. doi: 10.1016/j.actatropica.2012.01.004. Epub 2012 Jan 8. Review.

42.

A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells.

Herricks T, Seydel KB, Turner G, Molyneux M, Heyderman R, Taylor T, Rathod PK.

Lab Chip. 2011 Sep 7;11(17):2994-3000. doi: 10.1039/c1lc20131j. Epub 2011 Jul 11.

43.

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.

Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford DM, Angulo-Barturen I, Ferrer SB, Jiménez-Díaz MB, Gamo FJ, Goldsmith EJ, Charman WN, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA.

J Med Chem. 2011 Aug 11;54(15):5540-61. doi: 10.1021/jm200592f. Epub 2011 Jul 14.

44.

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

Gujjar R, El Mazouni F, White KL, White J, Creason S, Shackleford DM, Deng X, Charman WN, Bathurst I, Burrows J, Floyd DM, Matthews D, Buckner FS, Charman SA, Phillips MA, Rathod PK.

J Med Chem. 2011 Jun 9;54(11):3935-49. doi: 10.1021/jm200265b. Epub 2011 May 12.

45.

Malaria-attributed death rates in India.

Kumar A, Dua VK, Rathod PK.

Lancet. 2011 Mar 19;377(9770):991-2; author reply 994-5. doi: 10.1016/S0140-6736(11)60379-6. No abstract available.

46.

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Ganesan SM, Morrisey JM, Ke H, Painter HJ, Laroiya K, Phillips MA, Rathod PK, Mather MW, Vaidya AB.

Mol Biochem Parasitol. 2011 May;177(1):29-34. doi: 10.1016/j.molbiopara.2011.01.004. Epub 2011 Jan 18.

47.

Chemical genetics of Plasmodium falciparum.

Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK.

Nature. 2010 May 20;465(7296):311-5. doi: 10.1038/nature09099.

48.

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.

Phillips MA, Rathod PK.

Infect Disord Drug Targets. 2010 Jun;10(3):226-39. Review.

49.

Prodrug activation by Cryptosporidium thymidine kinase.

Sun XE, Sharling L, Muthalagi M, Mudeppa DG, Pankiewicz KW, Felczak K, Rathod PK, Mead J, Striepen B, Hedstrom L.

J Biol Chem. 2010 May 21;285(21):15916-22. doi: 10.1074/jbc.M110.101543. Epub 2010 Mar 15.

50.

The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.

Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA.

J Mol Biol. 2010 Mar 12;396(5):1244-59. doi: 10.1016/j.jmb.2010.01.013. Epub 2010 Jan 11.

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