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Items: 7


Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis.

Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW.

Sci Immunol. 2018 Aug 24;3(26). pii: eaat2738. doi: 10.1126/sciimmunol.aat2738.


Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity.

Chirieleison SM, Rathkey JK, Abbott DW.

Sci Signal. 2018 Jul 17;11(539). pii: eaao3964. doi: 10.1126/scisignal.aao3964.


Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.

Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797. doi: 10.1073/pnas.1800562115. Epub 2018 Jun 11.


Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.

Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS.

Structure. 2018 May 1;26(5):778-784.e3. doi: 10.1016/j.str.2018.03.002. Epub 2018 Mar 22.


Live-cell visualization of gasdermin D-driven pyroptotic cell death.

Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW.

J Biol Chem. 2017 Sep 1;292(35):14649-14658. doi: 10.1074/jbc.M117.797217. Epub 2017 Jul 18.


Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease.

Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW.

J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12.


People choose to run at their optimal speed.

Rathkey JK, Wall-Scheffler CM.

Am J Phys Anthropol. 2017 May;163(1):85-93. doi: 10.1002/ajpa.23187. Epub 2017 Feb 14.


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