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Items: 38

1.

A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-γ signals.

Nakagawa MM, Rathinam CV.

Sci Rep. 2019 Sep 2;9(1):12658. doi: 10.1038/s41598-019-49038-8.

2.
3.

A20 deficiency in multipotent progenitors perturbs quiescence of hematopoietic stem cells.

Nakagawa MM, Davis H, Rathinam CV.

Stem Cell Res. 2018 Dec;33:199-205. doi: 10.1016/j.scr.2018.10.020. Epub 2018 Oct 31.

4.

Constitutive Activation of NF-κB Pathway in Hematopoietic Stem Cells Causes Loss of Quiescence and Deregulated Transcription Factor Networks.

Nakagawa MM, Chen H, Rathinam CV.

Front Cell Dev Biol. 2018 Oct 30;6:143. doi: 10.3389/fcell.2018.00143. eCollection 2018.

5.

Effectiveness of virtual reality in the treatment of hand function in children with cerebral palsy: A systematic review.

Rathinam C, Mohan V, Peirson J, Skinner J, Nethaji KS, Kuhn I.

J Hand Ther. 2018 Jul 13. pii: S0894-1130(17)30107-2. doi: 10.1016/j.jht.2018.01.006. [Epub ahead of print]

PMID:
30017414
6.

Slicer Endonuclease Argonaute 2 Is a Negative Regulator of Hematopoietic Stem Cell Quiescence.

Lu K, Nakagawa MM, Thummar K, Rathinam CV.

Stem Cells. 2016 May;34(5):1343-53. doi: 10.1002/stem.2302. Epub 2016 Mar 28.

7.

The 'inflammatory' control of hematopoietic stem cells.

Rathinam C.

Oncotarget. 2015 Aug 21;6(24):19938-9. No abstract available.

8.

FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice.

Kode A, Mosialou I, Manavalan SJ, Rathinam CV, Friedman RA, Teruya-Feldstein J, Bhagat G, Berman E, Kousteni S.

Leukemia. 2016 Jan;30(1):1-13. doi: 10.1038/leu.2015.161. Epub 2015 Jun 25.

9.

Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence.

Nakagawa MM, Thummar K, Mandelbaum J, Pasqualucci L, Rathinam CV.

J Exp Med. 2015 Feb 9;212(2):203-16. doi: 10.1084/jem.20132544. Epub 2015 Jan 26.

10.

The deubiquitinase activity of A20 is dispensable for NF-κB signaling.

De A, Dainichi T, Rathinam CV, Ghosh S.

EMBO Rep. 2014 Jul;15(7):775-83. doi: 10.15252/embr.201338305. Epub 2014 May 30.

11.

Observational gait assessment tools in paediatrics--a systematic review.

Rathinam C, Bateman A, Peirson J, Skinner J.

Gait Posture. 2014 Jun;40(2):279-85. doi: 10.1016/j.gaitpost.2014.04.187. Epub 2014 Apr 18. Review.

PMID:
24798609
12.

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.

Kode A, Manavalan JS, Mosialou I, Bhagat G, Rathinam CV, Luo N, Khiabanian H, Lee A, Murty VV, Friedman R, Brum A, Park D, Galili N, Mukherjee S, Teruya-Feldstein J, Raza A, Rabadan R, Berman E, Kousteni S.

Nature. 2014 Feb 13;506(7487):240-4. doi: 10.1038/nature12883. Epub 2014 Jan 15.

13.

Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes.

Baldzizhar R, Fedorchuk C, Jha M, Rathinam C, Henegariu O, Czyzyk J.

J Biol Chem. 2013 Jan 18;288(3):1612-9. doi: 10.1074/jbc.M112.409664. Epub 2012 Nov 29. Erratum in: J Biol Chem. 2013 Apr 19;288(16):11506.

14.

Retraction: Transcription factor Gfi1 restricts B cell-mediated autoimmunity.

Rathinam C, Lassmann H, Mengel M, Klein C.

J Immunol. 2012 Oct 1;189(7):3777. No abstract available.

15.

Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells.

Kriegel MA, Rathinam C, Flavell RA.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3457-62. doi: 10.1073/pnas.1115308109. Epub 2012 Feb 10.

16.

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

Ahmed N, Zeng M, Sinha I, Polin L, Wei WZ, Rathinam C, Flavell R, Massoumi R, Venuprasad K.

Nat Immunol. 2011 Nov 6;12(12):1176-83. doi: 10.1038/ni.2157.

17.

Efficient differentiation and function of human macrophages in humanized CSF-1 mice.

Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA.

Blood. 2011 Sep 15;118(11):3119-28. doi: 10.1182/blood-2010-12-326926. Epub 2011 Jul 25.

18.

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13218-23. doi: 10.1073/pnas.1109769108. Epub 2011 Jul 25.

19.

Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.

Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W Jr, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA.

J Exp Med. 2011 May 9;208(5):1027-40. doi: 10.1084/jem.20102149. Epub 2011 Apr 25.

20.

The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells.

Rathinam C, Matesic LE, Flavell RA.

Nat Immunol. 2011 May;12(5):399-407. doi: 10.1038/ni.2021. Epub 2011 Apr 10.

PMID:
21478879
21.

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.

Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2378-83. doi: 10.1073/pnas.1019524108. Epub 2011 Jan 24.

22.

Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.

Rathinam C, Thien CB, Flavell RA, Langdon WY.

Cancer Cell. 2010 Oct 19;18(4):341-52. doi: 10.1016/j.ccr.2010.09.008.

23.

c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner.

Rathinam C, Flavell RA.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8316-21. doi: 10.1073/pnas.0914496107. Epub 2010 Apr 19.

24.

E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance.

Kriegel MA, Rathinam C, Flavell RA.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16770-5. doi: 10.1073/pnas.0908957106. Epub 2009 Sep 17.

25.

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P.

Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006. Review.

26.

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.

Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki H, Kotlyarov A, Klein C, Gaestel M.

EMBO J. 2009 May 20;28(10):1392-406. doi: 10.1038/emboj.2009.100. Epub 2009 Apr 16.

27.

The hematopoiesis paradigm: clarity or ambiguity?

Rathinam C, Flavell RA.

Blood. 2008 Nov 1;112(9):3534-5. doi: 10.1182/blood-2008-07-167759. No abstract available.

28.
29.

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.

Rathinam C, Thien CB, Langdon WY, Gu H, Flavell RA.

Genes Dev. 2008 Apr 15;22(8):992-7. doi: 10.1101/gad.1651408. Erratum in: Genes Dev. 2009 Sep 1;23(17):2116.

30.

Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of beta-catenin.

Templin C, Kotlarz D, Rathinam C, Rudolph C, Schätzlein S, Ramireddy K, Rudolph KL, Schlegelberger B, Klein C, Drexler H.

Exp Hematol. 2008 Feb;36(2):204-15. doi: 10.1016/j.exphem.2007.10.005.

PMID:
18206728
31.

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.

Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, Trumpp A, Rudolph KL.

Nat Med. 2007 Jun;13(6):742-7. Epub 2007 May 7.

PMID:
17486088
33.

A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.

Bohn G, Allroth A, Brandes G, Thiel J, Glocker E, Schäffer AA, Rathinam C, Taub N, Teis D, Zeidler C, Dewey RA, Geffers R, Buer J, Huber LA, Welte K, Grimbacher B, Klein C.

Nat Med. 2007 Jan;13(1):38-45. Epub 2006 Dec 31.

PMID:
17195838
34.

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease).

Klein C, Grudzien M, Appaswamy G, Germeshausen M, Sandrock I, Schäffer AA, Rathinam C, Boztug K, Schwinzer B, Rezaei N, Bohn G, Melin M, Carlsson G, Fadeel B, Dahl N, Palmblad J, Henter JI, Zeidler C, Grimbacher B, Welte K.

Nat Genet. 2007 Jan;39(1):86-92. Epub 2006 Dec 24.

PMID:
17187068
35.

Self-reported motorcycle riding behaviour among school children in India.

Rathinam C, Nair N, Gupta A, Joshi S, Bansal S.

Accid Anal Prev. 2007 Mar;39(2):334-9. Epub 2006 Oct 17.

PMID:
17049470
36.

Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2.

Jung J, Bohn G, Allroth A, Boztug K, Brandes G, Sandrock I, Schäffer AA, Rathinam C, Köllner I, Beger C, Schilke R, Welte K, Grimbacher B, Klein C.

Blood. 2006 Jul 1;108(1):362-9. Epub 2006 Mar 14.

37.

Generation and characterization of a novel hematopoietic progenitor cell line with DC differentiation potential.

Rathinam C, Sauer M, Ghosh A, Rudolph C, Hegazy A, Schlegelberger B, Welte K, Klein C.

Leukemia. 2006 May;20(5):870-6. Erratum in: Leukemia. 2012 Oct;26(10):2302.

PMID:
16511513
38.

The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function.

Rathinam C, Geffers R, Yücel R, Buer J, Welte K, Möröy T, Klein C.

Immunity. 2005 Jun;22(6):717-28.

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