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Items: 25

1.

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis.

Mostafavi M, Wang L, Xie L, Takeoka KT, Richie DL, Casey F, Ruzin A, Sawyer WS, Rath CM, Wei JR, Dean CR.

mSphere. 2018 Oct 31;3(5). pii: e00508-18. doi: 10.1128/mSphere.00508-18.

2.

Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity.

Skepper CK, Moreau RJ, Appleton BA, Benton BM, Drumm JE 3rd, Feng BY, Geng M, Hu C, Li C, Lingel A, Lu Y, Mamo M, Mergo W, Mostafavi M, Rath CM, Steffek M, Takeoka KT, Uehara K, Wang L, Wei JR, Xie L, Xu W, Zhang Q, de Vicente J.

J Med Chem. 2018 Apr 26;61(8):3325-3349. doi: 10.1021/acs.jmedchem.7b01861. Epub 2018 Apr 13.

PMID:
29551072
3.

Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics.

Rath CM, Benton BM, de Vicente J, Drumm JE, Geng M, Li C, Moreau RJ, Shen X, Skepper CK, Steffek M, Takeoka K, Wang L, Wei JR, Xu W, Zhang Q, Feng BY.

ACS Infect Dis. 2018 Mar 9;4(3):391-402. doi: 10.1021/acsinfecdis.7b00214. Epub 2017 Dec 22.

PMID:
29243909
4.

LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates.

Wei JR, Richie DL, Mostafavi M, Metzger LE 4th, Rath CM, Sawyer WS, Takeoka KT, Dean CR.

mSphere. 2017 Jul 26;2(4). pii: e00199-17. doi: 10.1128/mSphere.00199-17. eCollection 2017 Jul-Aug.

5.

Assessing Antibiotic Permeability of Gram-Negative Bacteria via Nanofluidics.

Hong S, Moritz TJ, Rath CM, Tamrakar P, Lee P, Krucker T, Lee LP.

ACS Nano. 2017 Jul 25;11(7):6959-6967. doi: 10.1021/acsnano.7b02267. Epub 2017 Jun 16.

PMID:
28605582
6.

Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.

Dovala D, Rath CM, Hu Q, Sawyer WS, Shia S, Elling RA, Knapp MS, Metzger LE 4th.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6064-E6071. Epub 2016 Sep 28.

7.

Toxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606.

Richie DL, Takeoka KT, Bojkovic J, Metzger LE 4th, Rath CM, Sawyer WS, Wei JR, Dean CR.

PLoS One. 2016 Aug 15;11(8):e0160918. doi: 10.1371/journal.pone.0160918. eCollection 2016.

8.

Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.

Bojkovic J, Richie DL, Six DA, Rath CM, Sawyer WS, Hu Q, Dean CR.

J Bacteriol. 2015 Dec 14;198(4):731-41. doi: 10.1128/JB.00639-15.

9.

Rapid analysis of protein expression and solubility with the SpyTag-SpyCatcher system.

Dovala D, Sawyer WS, Rath CM, Metzger LE 4th.

Protein Expr Purif. 2016 Jan;117:44-51. doi: 10.1016/j.pep.2015.09.021. Epub 2015 Sep 21.

10.

Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate.

Rateb ME, Zhai Y, Ehrner E, Rath CM, Wang X, Tabudravu J, Ebel R, Bibb M, Kyeremeh K, Dorrestein PC, Hong K, Jaspars M, Deng H.

Org Biomol Chem. 2015 Oct 7;13(37):9585-92. doi: 10.1039/c5ob01269d.

PMID:
26256511
11.

Molecular cartography of the human skin surface in 3D.

Bouslimani A, Porto C, Rath CM, Wang M, Guo Y, Gonzalez A, Berg-Lyon D, Ackermann G, Moeller Christensen GJ, Nakatsuji T, Zhang L, Borkowski AW, Meehan MJ, Dorrestein K, Gallo RL, Bandeira N, Knight R, Alexandrov T, Dorrestein PC.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2120-9. doi: 10.1073/pnas.1424409112. Epub 2015 Mar 30.

12.

Molecular networking as a dereplication strategy.

Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, Dorrestein PC.

J Nat Prod. 2013 Sep 27;76(9):1686-99. doi: 10.1021/np400413s. Epub 2013 Sep 11.

13.

Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin.

Hansen DA, Rath CM, Eisman EB, Narayan AR, Kittendorf JD, Mortison JD, Yoon YJ, Sherman DH.

J Am Chem Soc. 2013 Jul 31;135(30):11232-8. doi: 10.1021/ja404134f. Epub 2013 Jul 18.

14.

Data-independent microbial metabolomics with ambient ionization mass spectrometry.

Rath CM, Yang JY, Alexandrov T, Dorrestein PC.

J Am Soc Mass Spectrom. 2013 Aug;24(8):1167-76. doi: 10.1007/s13361-013-0608-y. Epub 2013 Apr 9.

15.

Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations.

Rath CM, Alexandrov T, Higginbottom SK, Song J, Milla ME, Fischbach MA, Sonnenburg JL, Dorrestein PC.

Anal Chem. 2012 Nov 6;84(21):9259-67. doi: 10.1021/ac302039u. Epub 2012 Oct 10.

16.

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.

Chemler JA, Buchholz TJ, Geders TW, Akey DL, Rath CM, Chlipala GE, Smith JL, Sherman DH.

J Am Chem Soc. 2012 May 2;134(17):7359-66. doi: 10.1021/ja2112228. Epub 2012 Apr 23.

17.

The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes.

Rath CM, Dorrestein PC.

Curr Opin Microbiol. 2012 Apr;15(2):147-54. doi: 10.1016/j.mib.2011.12.009. Epub 2011 Dec 30. Review.

18.

Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.

Bonnett SA, Rath CM, Shareef AR, Joels JR, Chemler JA, Håkansson K, Reynolds K, Sherman DH.

Chem Biol. 2011 Sep 23;18(9):1075-81. doi: 10.1016/j.chembiol.2011.07.016.

19.

Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.

Rath CM, Janto B, Earl J, Ahmed A, Hu FZ, Hiller L, Dahlgren M, Kreft R, Yu F, Wolff JJ, Kweon HK, Christiansen MA, Håkansson K, Williams RM, Ehrlich GD, Sherman DH.

ACS Chem Biol. 2011 Nov 18;6(11):1244-56. doi: 10.1021/cb200244t. Epub 2011 Sep 20.

20.

Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module.

Ding Y, Rath CM, Bolduc KL, Håkansson K, Sherman DH.

J Am Chem Soc. 2011 Sep 21;133(37):14492-5. doi: 10.1021/ja204716f. Epub 2011 Aug 25.

21.

Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.

Buchholz TJ, Rath CM, Lopanik NB, Gardner NP, Håkansson K, Sherman DH.

Chem Biol. 2010 Oct 29;17(10):1092-100. doi: 10.1016/j.chembiol.2010.08.008.

22.

Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.

Scaglione JB, Akey DL, Sullivan R, Kittendorf JD, Rath CM, Kim ES, Smith JL, Sherman DH.

Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5726-30. doi: 10.1002/anie.201000032. No abstract available.

23.

Predictors of emotional distress reported by soldiers in the combat zone.

Ferrier-Auerbach AG, Erbes CR, Polusny MA, Rath CM, Sponheim SR.

J Psychiatr Res. 2010 May;44(7):470-6. doi: 10.1016/j.jpsychires.2009.10.010. Epub 2009 Nov 25.

PMID:
19939409
24.

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

Lopanik NB, Shields JA, Buchholz TJ, Rath CM, Hothersall J, Haygood MG, Håkansson K, Thomas CM, Sherman DH.

Chem Biol. 2008 Nov 24;15(11):1175-86. doi: 10.1016/j.chembiol.2008.09.013.

25.

Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.

Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17133-8. doi: 10.1073/pnas.0808118105. Epub 2008 Oct 27.

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