Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 286


Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control.

Cheng X, Prange-Barczynska M, Fielding JW, Zhang M, Burrell AL, Lima JD, Eckardt L, Argles I, Pugh CW, Buckler KJ, Robbins PA, Hodson EJ, Bruick RK, Collinson LM, Rastinejad F, Bishop T, Ratcliffe PJ.

J Clin Invest. 2020 Jan 30. pii: 133194. doi: 10.1172/JCI133194. [Epub ahead of print]


Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4.

Bishop T, Ratcliffe PJ.

Sci Signal. 2020 Jan 21;13(615). pii: eaba1302. doi: 10.1126/scisignal.aba1302. Review.


Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer.

Schmid V, Lafleur VN, Lombardi O, Li R, Salama R, Colli L, Choudhry H, Chanock S, Ratcliffe PJ, Mole DR.

Sci Rep. 2019 Dec 10;9(1):18768. doi: 10.1038/s41598-019-55098-7.


Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.

Holt-Martyn JP, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans CT, Langley GW, Figg W Jr, McDonough MA, Pugh CW, Ratcliffe PJ, Schofield CJ.

ChemMedChem. 2020 Feb 5;15(3):270-273. doi: 10.1002/cmdc.201900557. Epub 2019 Dec 3.


Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI.

Lauer V, Grampp S, Platt J, Lafleur V, Lombardi O, Choudhry H, Kranz F, Hartmann A, Wullich B, Yamamoto A, Coleman ML, Ratcliffe PJ, Mole DR, Schödel J.

J Biol Chem. 2019 Nov 5. pii: jbc.RA119.009827. doi: 10.1074/jbc.RA119.009827. [Epub ahead of print]


Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.

Cockman ME, Lippl K, Tian YM, Pegg HB, Figg WD Jnr, Abboud MI, Heilig R, Fischer R, Myllyharju J, Schofield CJ, Ratcliffe PJ.

Elife. 2019 Sep 10;8. pii: e46490. doi: 10.7554/eLife.46490.


Mechanisms of hypoxia signalling: new implications for nephrology.

Schödel J, Ratcliffe PJ.

Nat Rev Nephrol. 2019 Oct;15(10):641-659. doi: 10.1038/s41581-019-0182-z. Epub 2019 Sep 5. Review.


Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.

Masson N, Keeley TP, Giuntoli B, White MD, Puerta ML, Perata P, Hopkinson RJ, Flashman E, Licausi F, Ratcliffe PJ.

Science. 2019 Jul 5;365(6448):65-69. doi: 10.1126/science.aaw0112.


Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.

Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW.

J Clin Invest. 2019 Jun 4;129(9):3640-3656. doi: 10.1172/JCI124099.


Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin.

Smythies JA, Sun M, Masson N, Salama R, Simpson PD, Murray E, Neumann V, Cockman ME, Choudhry H, Ratcliffe PJ, Mole DR.

EMBO Rep. 2019 Jan;20(1). pii: e46401. doi: 10.15252/embr.201846401. Epub 2018 Nov 14.


Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively.

Wang Y, Zhong S, Schofield CJ, Ratcliffe PJ, Lu X.

J Cell Sci. 2018 Nov 19;131(22). pii: jcs219782. doi: 10.1242/jcs.219782.


Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ.

Nat Chem Biol. 2018 Oct;14(10):988. doi: 10.1038/s41589-018-0104-6.


PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies.

Fielding JW, Hodson EJ, Cheng X, Ferguson DJP, Eckardt L, Adam J, Lip P, Maton-Howarth M, Ratnayaka I, Pugh CW, Buckler KJ, Ratcliffe PJ, Bishop T.

J Physiol. 2018 Jun 19. doi: 10.1113/JP275996. [Epub ahead of print]


The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ.

Nat Chem Biol. 2018 Jul;14(7):688-695. doi: 10.1038/s41589-018-0071-y. Epub 2018 Jun 18. Erratum in: Nat Chem Biol. 2018 Jun 27;:.


Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.

Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, Flashman E, Lu X, Ratcliffe PJ, Chowdhury R, Pugh CW, Schofield CJ.

Chem Sci. 2017 Nov 1;8(11):7651-7668. doi: 10.1039/c7sc02103h. Epub 2017 Sep 11.


Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.


Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

Grampp S, Schmid V, Salama R, Lauer V, Kranz F, Platt JL, Smythies J, Choudhry H, Goppelt-Struebe M, Ratcliffe PJ, Mole DR, Schödel J.

PLoS Genet. 2017 Jul 17;13(7):e1006872. doi: 10.1371/journal.pgen.1006872. eCollection 2017 Jul.


New horizons in hypoxia signaling pathways.

Pugh CW, Ratcliffe PJ.

Exp Cell Res. 2017 Jul 15;356(2):116-121. doi: 10.1016/j.yexcr.2017.03.008. Epub 2017 Mar 15. Review.


A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism.

Paolini NA, Attwood M, Sondalle SB, Vieira CMDS, van Adrichem AM, di Summa FM, O'Donohue MF, Gleizes PE, Rachuri S, Briggs JW, Fischer R, Ratcliffe PJ, Wlodarski MW, Houtkooper RH, von Lindern M, Kuijpers TW, Dinman JD, Baserga SJ, Cockman ME, MacInnes AW.

Am J Hum Genet. 2017 Mar 2;100(3):506-522. doi: 10.1016/j.ajhg.2017.01.034.


Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations.

Camps C, Petousi N, Bento C, Cario H, Copley RR, McMullin MF, van Wijk R, Ratcliffe PJ, Robbins PA, Taylor JC; WGS500 Consortium.

Haematologica. 2016 Nov;101(11):1306-1318. Epub 2016 Sep 20.


Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.

Grampp S, Platt JL, Lauer V, Salama R, Kranz F, Neumann VK, Wach S, Stöhr C, Hartmann A, Eckardt KU, Ratcliffe PJ, Mole DR, Schödel J.

Nat Commun. 2016 Oct 24;7:13183. doi: 10.1038/ncomms13183.


Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.

Bardella C, Al-Dalahmah O, Krell D, Brazauskas P, Al-Qahtani K, Tomkova M, Adam J, Serres S, Lockstone H, Freeman-Mills L, Pfeffer I, Sibson N, Goldin R, Schuster-Böeckler B, Pollard PJ, Soga T, McCullagh JS, Schofield CJ, Mulholland P, Ansorge O, Kriaucionis S, Ratcliffe PJ, Szele FG, Tomlinson I.

Cancer Cell. 2016 Oct 10;30(4):578-594. doi: 10.1016/j.ccell.2016.08.017. Epub 2016 Sep 29.


Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award.

Kaelin WG Jr, Ratcliffe PJ, Semenza GL.

JAMA. 2016 Sep 27;316(12):1252-3. doi: 10.1001/jama.2016.12386. No abstract available.


Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ.

Nat Commun. 2016 Aug 26;7:12673. doi: 10.1038/ncomms12673.


Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.

Platt JL, Salama R, Smythies J, Choudhry H, Davies JO, Hughes JR, Ratcliffe PJ, Mole DR.

EMBO Rep. 2016 Oct;17(10):1410-1421. Epub 2016 Aug 8.


Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.

Chan MC, Ilott NE, Schödel J, Sims D, Tumber A, Lippl K, Mole DR, Pugh CW, Ratcliffe PJ, Ponting CP, Schofield CJ.

J Biol Chem. 2016 Sep 23;291(39):20661-73. doi: 10.1074/jbc.M116.749291. Epub 2016 Aug 8.


Clinical iron deficiency disturbs normal human responses to hypoxia.

Frise MC, Cheng HY, Nickol AH, Curtis MK, Pollard KA, Roberts DJ, Ratcliffe PJ, Dorrington KL, Robbins PA.

J Clin Invest. 2016 Jun 1;126(6):2139-50. doi: 10.1172/JCI85715. Epub 2016 May 3.


On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC, Aksentijević D, Gildea OS, Stuckey DJ, Yeoh KK, Carr CA, Evans RD, Aasum E, Schofield CJ, Ratcliffe PJ, Neubauer S, Robbins PA, Clarke K.

FASEB J. 2016 Aug;30(8):2684-97. doi: 10.1096/fj.201500094R. Epub 2016 Apr 21.


Adult hematopoietic stem cells lacking Hif-1α self-renew normally.

Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J, Lawson H, Villacreces A, Armesilla-Diaz A, Gezer D, Holyoake TL, Ratcliffe PJ, Kranc KR.

Blood. 2016 Jun 9;127(23):2841-6. doi: 10.1182/blood-2015-10-677138. Epub 2016 Apr 8.


Pharmacological targeting of the HIF hydroxylases--A new field in medicine development.

Chan MC, Holt-Martyn JP, Schofield CJ, Ratcliffe PJ.

Mol Aspects Med. 2016 Feb-Mar;47-48:54-75. doi: 10.1016/j.mam.2016.01.001. Epub 2016 Jan 11. Review.


Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.

Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J, Iglesias JM, Allen L, Glykofrydis F, Subramani C, Armesilla-Diaz A, Post AE, Schaak K, Gezer D, So CW, Holyoake TL, Wood A, O'Carroll D, Ratcliffe PJ, Kranc KR.

J Exp Med. 2015 Dec 14;212(13):2223-34. doi: 10.1084/jem.20150452. Epub 2015 Dec 7.


Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.

Thinnes CC, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan MC, Tran TA, Hsu K, Tarhonskaya H, Walport LJ, Wilkins SE, Martinez ED, Müller S, Pugh CW, Ratcliffe PJ, Brennan PE, Kawamura A, Schofield CJ.

Chem Commun (Camb). 2015 Oct 28;51(84):15458-61. doi: 10.1039/c5cc06095h.


Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway.

Hodson EJ, Nicholls LG, Turner PJ, Llyr R, Fielding JW, Douglas G, Ratnayaka I, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ, Bishop T.

J Physiol. 2016 Mar 1;594(5):1179-95. doi: 10.1113/JP271050. Epub 2015 Oct 6.


Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.

Schödel J, Grampp S, Maher ER, Moch H, Ratcliffe PJ, Russo P, Mole DR.

Eur Urol. 2016 Apr;69(4):646-657. doi: 10.1016/j.eururo.2015.08.007. Epub 2015 Aug 19. Review.


Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells.

Simpson PD, Eipper BA, Katz MJ, Gandara L, Wappner P, Fischer R, Hodson EJ, Ratcliffe PJ, Masson N.

J Biol Chem. 2015 Oct 9;290(41):24891-901. doi: 10.1074/jbc.M115.667246. Epub 2015 Aug 19.


Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.

Salama R, Masson N, Simpson P, Sciesielski LK, Sun M, Tian YM, Ratcliffe PJ, Mole DR.

PLoS One. 2015 Aug 11;10(8):e0134645. doi: 10.1371/journal.pone.0134645. eCollection 2015.


A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA.

BMJ Open. 2015 Jul 6;5(7):e007911. doi: 10.1136/bmjopen-2015-007911.


Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.

Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, Ratcliffe PJ, Schofield CJ.

PLoS One. 2015 Jul 6;10(7):e0132004. doi: 10.1371/journal.pone.0132004. eCollection 2015.


HIF hydroxylase pathways in cardiovascular physiology and medicine.

Bishop T, Ratcliffe PJ.

Circ Res. 2015 Jun 19;117(1):65-79. doi: 10.1161/CIRCRESAHA.117.305109. Review.


Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G.

Nat Genet. 2015 Jul;47(7):717-726. doi: 10.1038/ng.3304. Epub 2015 May 18.


Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives.

Bishop T, Ratcliffe PJ.

Hypoxia (Auckl). 2014 Dec 5;2:197-213. eCollection 2014. Review.


Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.

Michailidou Z, Morton NM, Moreno Navarrete JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR, Ratcliffe PJ.

Diabetes. 2015 Mar;64(3):733-45. doi: 10.2337/db14-0233. Epub 2014 Nov 5.


Erythrocytosis associated with a novel missense mutation in the BPGM gene.

Petousi N, Copley RR, Lappin TR, Haggan SE, Bento CM, Cario H, Percy MJ; WGS Consortium, Ratcliffe PJ, Robbins PA, McMullin MF.

Haematologica. 2014 Oct;99(10):e201-4. doi: 10.3324/haematol.2014.109306. Epub 2014 Jul 11. No abstract available.


Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth.

Katz MJ, Acevedo JM, Loenarz C, Galagovsky D, Liu-Yi P, Pérez-Pepe M, Thalhammer A, Sekirnik R, Ge W, Melani M, Thomas MG, Simonetta S, Boccaccio GL, Schofield CJ, Cockman ME, Ratcliffe PJ, Wappner P.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4025-30. doi: 10.1073/pnas.1314485111. Epub 2014 Feb 18.


Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.

Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4019-24. doi: 10.1073/pnas.1311750111. Epub 2014 Feb 18.


OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.

Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, Wappner P, Schofield CJ, Ratcliffe PJ, Cockman ME.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4031-6. doi: 10.1073/pnas.1314482111. Epub 2014 Feb 18.


Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, Kessler BM, Gilbert RJ, Frolova LY, Alkalaeva E, Ratcliffe PJ, Schofield CJ, Coleman ML.

Mol Cell. 2014 Feb 20;53(4):645-54. doi: 10.1016/j.molcel.2013.12.028. Epub 2014 Jan 30.

Supplemental Content

Loading ...
Support Center