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Items: 1 to 50 of 72

1.

Bidirectional modulation of HIF-2 activity through chemical ligands.

Wu D, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim Y, Khorasanizadeh S, Rastinejad F.

Nat Chem Biol. 2019 Apr;15(4):367-376. doi: 10.1038/s41589-019-0234-5. Epub 2019 Feb 25.

2.

The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.

Daniel B, Nagy G, Czimmerer Z, Horvath A, Hammers DW, Cuaranta-Monroy I, Poliska S, Tzerpos P, Kolostyak Z, Hays TT, Patsalos A, Houtman R, Sauer S, Francois-Deleuze J, Rastinejad F, Balint BL, Sweeney HL, Nagy L.

Immunity. 2018 Oct 16;49(4):615-626.e6. doi: 10.1016/j.immuni.2018.09.005.

3.

A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis.

Parafati M, Kirby RJ, Khorasanizadeh S, Rastinejad F, Malany S.

Dis Model Mech. 2018 Sep 25;11(9). pii: dmm033530. doi: 10.1242/dmm.033530.

4.

Retraction Note: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.

Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR.

Nature. 2018 Oct;562(7725):150. doi: 10.1038/s41586-018-0311-z.

5.

The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission.

Chandra V, Wu D, Li S, Potluri N, Kim Y, Rastinejad F.

Nat Commun. 2017 Oct 11;8(1):868. doi: 10.1038/s41467-017-00981-y.

6.

Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans.

Smith SH, Jayawickreme C, Rickard DJ, Nicodeme E, Bui T, Simmons C, Coquery CM, Neil J, Pryor WM, Mayhew D, Rajpal DK, Creech K, Furst S, Lee J, Wu D, Rastinejad F, Willson TM, Viviani F, Morris DC, Moore JT, Cote-Sierra J.

J Invest Dermatol. 2017 Oct;137(10):2110-2119. doi: 10.1016/j.jid.2017.05.004. Epub 2017 Jun 6.

7.

Visualizing the Architectures and Interactions of Nuclear Receptors.

Khorasanizadeh S, Rastinejad F.

Endocrinology. 2016 Nov;157(11):4212-4221. Epub 2016 Oct 5. Review.

8.

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.

Wu D, Su X, Potluri N, Kim Y, Rastinejad F.

Elife. 2016 Oct 26;5. pii: e18790. doi: 10.7554/eLife.18790.

9.

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors.

Singh A, Venkannagari S, Oh KH, Zhang YQ, Rohde JM, Liu L, Nimmagadda S, Sudini K, Brimacombe KR, Gajghate S, Ma J, Wang A, Xu X, Shahane SA, Xia M, Woo J, Mensah GA, Wang Z, Ferrer M, Gabrielson E, Li Z, Rastinejad F, Shen M, Boxer MB, Biswal S.

ACS Chem Biol. 2016 Nov 18;11(11):3214-3225. Epub 2016 Oct 17.

10.

Structural characterization of mammalian bHLH-PAS transcription factors.

Wu D, Rastinejad F.

Curr Opin Struct Biol. 2017 Apr;43:1-9. doi: 10.1016/j.sbi.2016.09.011. Epub 2016 Oct 6. Review.

11.

Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.

Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR.

Nature. 2016 May 5;533(7601):130. doi: 10.1038/nature16968. Epub 2016 Jan 20. No abstract available.

PMID:
26789242
12.

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.

Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR.

Nature. 2015 Dec 24;528(7583):517-22. doi: 10.1038/nature16193. Epub 2015 Dec 16. Erratum in: Nature. 2016 May 5;533(7601):130. Rigo, Frank W [Corrected to Rigo, Frank].. Retraction in: Nature. 2018 Oct;562(7725):150.

13.

Structural integration in hypoxia-inducible factors.

Wu D, Potluri N, Lu J, Kim Y, Rastinejad F.

Nature. 2015 Aug 20;524(7565):303-8. doi: 10.1038/nature14883. Epub 2015 Aug 5.

PMID:
26245371
14.

Response to Moras et al.

Rastinejad F, Ollendorff V, Polikarpov I.

Trends Biochem Sci. 2015 Jun;40(6):290-2. doi: 10.1016/j.tibs.2015.03.008. Epub 2015 Apr 15.

PMID:
25890866
15.

Identification of natural RORγ ligands that regulate the development of lymphoid cells.

Santori FR, Huang P, van de Pavert SA, Douglass EF Jr, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, Nes WD, Littman DR.

Cell Metab. 2015 Feb 3;21(2):286-298. doi: 10.1016/j.cmet.2015.01.004.

16.

Nuclear receptor full-length architectures: confronting myth and illusion with high resolution.

Rastinejad F, Ollendorff V, Polikarpov I.

Trends Biochem Sci. 2015 Jan;40(1):16-24. doi: 10.1016/j.tibs.2014.10.011. Epub 2014 Nov 28.

17.

Retinoic acid actions through mammalian nuclear receptors.

Huang P, Chandra V, Rastinejad F.

Chem Rev. 2014 Jan 8;114(1):233-54. doi: 10.1021/cr400161b. Epub 2013 Dec 5. Review. No abstract available.

18.

Understanding nuclear receptor form and function using structural biology.

Rastinejad F, Huang P, Chandra V, Khorasanizadeh S.

J Mol Endocrinol. 2013 Nov 7;51(3):T1-T21. doi: 10.1530/JME-13-0173. Print 2013 Dec. Review.

19.

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.

Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR.

ACS Med Chem Lett. 2013 Jan 10;4(1):79-84.

20.

Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.

Wu D, Potluri N, Kim Y, Rastinejad F.

Mol Cell Biol. 2013 Nov;33(21):4346-56. doi: 10.1128/MCB.00698-13. Epub 2013 Sep 3.

21.

Multidomain integration in the structure of the HNF-4α nuclear receptor complex.

Chandra V, Huang P, Potluri N, Wu D, Kim Y, Rastinejad F.

Nature. 2013 Mar 21;495(7441):394-8. doi: 10.1038/nature11966. Epub 2013 Mar 13.

22.

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.

Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR.

Nature. 2011 Apr 28;472(7344):486-90. doi: 10.1038/nature09978. Epub 2011 Mar 27.

23.

Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.

Kim D, Blus BJ, Chandra V, Huang P, Rastinejad F, Khorasanizadeh S.

Nat Struct Mol Biol. 2010 Aug;17(8):1027-9. doi: 10.1038/nsmb.1856. Epub 2010 Jul 25.

24.

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.

Huang P, Chandra V, Rastinejad F.

Annu Rev Physiol. 2010;72:247-72. doi: 10.1146/annurev-physiol-021909-135917. Review.

25.

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.

Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP, Rastinejad F.

Nature. 2008 Nov 20;456(7220):350-6. doi: 10.1038/nature07413.

26.

Structural and functional basis for therapeutic modulation of p53 signaling.

Bassett EA, Wang W, Rastinejad F, El-Deiry WS.

Clin Cancer Res. 2008 Oct 15;14(20):6376-86. doi: 10.1158/1078-0432.CCR-08-1526. Review.

27.

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.

Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizadeh S, Burris TP, Rastinejad F.

Nat Struct Mol Biol. 2007 Dec;14(12):1207-13. Epub 2007 Nov 25.

28.

Molecular implications of evolutionary differences in CHD double chromodomains.

Flanagan JF, Blus BJ, Kim D, Clines KL, Rastinejad F, Khorasanizadeh S.

J Mol Biol. 2007 Jun 1;369(2):334-42. Epub 2007 Mar 19.

29.

The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits.

DePuy SD, Yao J, Hu C, McIntire W, Bidaud I, Lory P, Rastinejad F, Gonzalez C, Garrison JC, Barrett PQ.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14590-5. Epub 2006 Sep 14.

30.

Double chromodomains cooperate to recognize the methylated histone H3 tail.

Flanagan JF, Mi LZ, Chruszcz M, Cymborowski M, Clines KL, Kim Y, Minor W, Rastinejad F, Khorasanizadeh S.

Nature. 2005 Dec 22;438(7071):1181-5.

PMID:
16372014
31.

Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity.

Wright CS, Mi LZ, Lee S, Rastinejad F.

Biochemistry. 2005 Oct 18;44(41):13510-21.

PMID:
16216074
32.
33.

The emerging structural understanding of transglutaminase 3.

Ahvazi B, Boeshans KM, Rastinejad F.

J Struct Biol. 2004 Aug;147(2):200-7. Review.

PMID:
15193648
34.

Plasticity of the ecdysone receptor DNA binding domain.

Orlowski M, Szyszka M, Kowalska A, Grad I, Zoglowek A, Rymarczyk G, Dobryszycki P, Krowarsch D, Rastinejad F, Kochman M, Ozyhar A.

Mol Endocrinol. 2004 Sep;18(9):2166-84. Epub 2004 Jun 10.

PMID:
15192079
35.

Structural basis for the coordinated regulation of transglutaminase 3 by guanine nucleotides and calcium/magnesium.

Ahvazi B, Boeshans KM, Idler W, Baxa U, Steinert PM, Rastinejad F.

J Biol Chem. 2004 Feb 20;279(8):7180-92. Epub 2003 Nov 28. Erratum in: J Biol Chem. 2007 Apr 27;282(17):13139.

36.

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.

Wischhusen J, Naumann U, Ohgaki H, Rastinejad F, Weller M.

Oncogene. 2003 Nov 13;22(51):8233-45.

PMID:
14614447
37.

Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy.

Beebe JS, Jani JP, Knauth E, Goodwin P, Higdon C, Rossi AM, Emerson E, Finkelstein M, Floyd E, Harriman S, Atherton J, Hillerman S, Soderstrom C, Kou K, Gant T, Noe MC, Foster B, Rastinejad F, Marx MA, Schaeffer T, Whalen PM, Roberts WG.

Cancer Res. 2003 Nov 1;63(21):7301-9.

38.

Structure of the heterodimeric ecdysone receptor DNA-binding complex.

Devarakonda S, Harp JM, Kim Y, Ozyhar A, Rastinejad F.

EMBO J. 2003 Nov 3;22(21):5827-40.

39.

Insights into catalysis by a knotted TrmD tRNA methyltransferase.

Elkins PA, Watts JM, Zalacain M, van Thiel A, Vitazka PR, Redlak M, Andraos-Selim C, Rastinejad F, Holmes WM.

J Mol Biol. 2003 Nov 7;333(5):931-49.

PMID:
14583191
40.

Restoring p53-dependent tumor suppression.

Wang W, Rastinejad F, El-Deiry WS.

Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S55-63. Review.

PMID:
14508081
41.

Structural analysis of lipid complexes of GM2-activator protein.

Wright CS, Zhao Q, Rastinejad F.

J Mol Biol. 2003 Aug 22;331(4):951-64.

PMID:
12909021
42.

Structural basis for bile acid binding and activation of the nuclear receptor FXR.

Mi LZ, Devarakonda S, Harp JM, Han Q, Pellicciari R, Willson TM, Khorasanizadeh S, Rastinejad F.

Mol Cell. 2003 Apr;11(4):1093-100.

43.
44.

The active site of the SET domain is constructed on a knot.

Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S.

Nat Struct Biol. 2002 Nov;9(11):833-8. Erratum in: Nat Struct Biol. 2003 Jun;10(7):578.

PMID:
12389038
45.

The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein.

Takimoto R, Wang W, Dicker DT, Rastinejad F, Lyssikatos J, el-Deiry WS.

Cancer Biol Ther. 2002 Jan-Feb;1(1):47-55.

PMID:
12174820
46.

Ca2+-dependent nuclear export mediated by calreticulin.

Holaska JM, Black BE, Rastinejad F, Paschal BM.

Mol Cell Biol. 2002 Sep;22(17):6286-97.

47.

DNA binding domains in diverse nuclear receptors function as nuclear export signals.

Black BE, Holaska JM, Rastinejad F, Paschal BM.

Curr Biol. 2001 Nov 13;11(22):1749-58.

48.

DNA deformability as a recognition feature in the reverb response element.

Sierk ML, Zhao Q, Rastinejad F.

Biochemistry. 2001 Oct 30;40(43):12833-43.

PMID:
11669620
49.

Physical structure of nuclear receptor-DNA complexes.

Chasse SA, Rastinejad F.

Methods Mol Biol. 2001;176:91-103. Review. No abstract available.

PMID:
11554341
50.

Large scale production of nuclear receptor ligand-binding domains.

Mi LZ, Rastinejad F.

Methods Mol Biol. 2001;176:81-90. Review. No abstract available.

PMID:
11554340

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