Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 26

1.

IID572, A New Potentially Best-In-Class β-Lactamase Inhibitor.

Reck F, Bermingham A, Blais J, Casarez A, Colvin R, Dean CR, Furegati M, Gamboa L, Growcott E, Li C, Lopez S, Metzger LE, Nocito S, Ossola F, Phizackerley K, Rasper D, Shaul J, Shen X, Simmons R, Tang D, Tashiro K, Yue Q.

ACS Infect Dis. 2019 Mar 12. doi: 10.1021/acsinfecdis.9b00031. [Epub ahead of print]

PMID:
30861342
2.

Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.

Dean CR, Barkan DT, Bermingham A, Blais J, Casey F, Casarez A, Colvin R, Fuller J, Jones AK, Li C, Lopez S, Metzger LE 4th, Mostafavi M, Prathapam R, Rasper D, Reck F, Ruzin A, Shaul J, Shen X, Simmons RL, Skewes-Cox P, Takeoka KT, Tamrakar P, Uehara T, Wei JR.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01200-18. doi: 10.1128/AAC.01200-18. Print 2018 Oct.

3.

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.

Reck F, Bermingham A, Blais J, Capka V, Cariaga T, Casarez A, Colvin R, Dean CR, Fekete A, Gong W, Growcott E, Guo H, Jones AK, Li C, Li F, Lin X, Lindvall M, Lopez S, McKenney D, Metzger L, Moser HE, Prathapam R, Rasper D, Rudewicz P, Sethuraman V, Shen X, Shaul J, Simmons RL, Tashiro K, Tang D, Tjandra M, Turner N, Uehara T, Vitt C, Whitebread S, Yifru A, Zang X, Zhu Q.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):748-755. doi: 10.1016/j.bmcl.2018.01.006. Epub 2018 Jan 4.

PMID:
29336873
4.

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Isabel E, Aspiotis R, Black WC, Colucci J, Fortin R, Giroux A, Grimm EL, Han Y, Mellon C, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Tawa P, Vaillancourt JP, Xanthoudakis S, Zamboni RJ.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1671-4. Epub 2007 Jan 11.

PMID:
17251019
5.

Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.

Mellon C, Aspiotis R, Black CW, Bayly CI, Grimm EL, Giroux A, Han Y, Isabel E, McKay DJ, Nicholson DW, Rasper DM, Roy S, Tam J, Thornberry NA, Vaillancourt JP, Xanthoudakis S, Zamboni R.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3886-90.

PMID:
16023344
6.

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.

Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J, Tawa P, Nicholson DW, Zamboni RJ.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80.

PMID:
15686936
7.

Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.

Houde C, Banks KG, Coulombe N, Rasper D, Grimm E, Roy S, Simpson EM, Nicholson DW.

J Neurosci. 2004 Nov 3;24(44):9977-84.

8.

Solid phase synthesis of selective caspase-3 peptide inhibitors.

Grimm EL, Roy B, Aspiotis R, Bayly CI, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Tawa P, Vaillancourt JP, Xanthoudakis S, Zamboni RJ.

Bioorg Med Chem. 2004 Mar 1;12(5):845-51.

PMID:
14980595
9.

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.

Han Y, Giroux A, Grimm EL, Aspiotis R, Francoeur S, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt JP, Rasper DM, Tam J, Tawa P, Thornberry NA, Paterson EP, Garcia-Calvo M, Becker JW, Rotonda J, Nicholson DW, Zamboni RJ.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):805-8.

PMID:
14741294
10.

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics.

Méthot N, Huang J, Coulombe N, Vaillancourt JP, Rasper D, Tam J, Han Y, Colucci J, Zamboni R, Xanthoudakis S, Toulmond S, Nicholson DW, Roy S.

J Exp Med. 2004 Jan 19;199(2):199-207. Epub 2004 Jan 12.

11.

Nicotinyl aspartyl ketones as inhibitors of caspase-3.

Isabel E, Black WC, Bayly CI, Grimm EL, Janes MK, McKay DJ, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Thornberry NA, Vaillancourt JP, Xanthoudakis S, Zamboni R.

Bioorg Med Chem Lett. 2003 Jul 7;13(13):2137-40.

PMID:
12798321
12.

The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.

Maier JK, Lahoua Z, Gendron NH, Fetni R, Johnston A, Davoodi J, Rasper D, Roy S, Slack RS, Nicholson DW, MacKenzie AE.

J Neurosci. 2002 Mar 15;22(6):2035-43.

13.

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW.

Nat Cell Biol. 2002 Feb;4(2):95-105.

PMID:
11788820
14.

HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.

Chopra VS, Metzler M, Rasper DM, Engqvist-Goldstein AE, Singaraja R, Gan L, Fichter KM, McCutcheon K, Drubin D, Nicholson DW, Hayden MR.

Mamm Genome. 2000 Nov;11(11):1006-15.

PMID:
11063258
15.

Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3.

Hadano S, Nasir J, Nichol K, Rasper DM, Vaillancourt JP, Sherer SW, Beatty BG, Ikeda JE, Nicholson DW, Hayden MR.

Mamm Genome. 1999 Jul;10(7):757-60. No abstract available.

PMID:
10384055
16.

Purification and catalytic properties of human caspase family members.

Garcia-Calvo M, Peterson EP, Rasper DM, Vaillancourt JP, Zamboni R, Nicholson DW, Thornberry NA.

Cell Death Differ. 1999 Apr;6(4):362-9.

17.

Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis.

Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, Tawa P, Ruel R, Rosen A, Nicholson DW.

EMBO J. 1999 Apr 15;18(8):2049-56.

18.

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

Rasper DM, Vaillancourt JP, Hadano S, Houtzager VM, Seiden I, Keen SL, Tawa P, Xanthoudakis S, Nasir J, Martindale D, Koop BF, Peterson EP, Thornberry NA, Huang J, MacPherson DP, Black SC, Hornung F, Lenardo MJ, Hayden MR, Roy S, Nicholson DW.

Cell Death Differ. 1998 Apr;5(4):271-88.

19.

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.

Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR.

J Biol Chem. 1998 Apr 10;273(15):9158-67.

20.

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.

Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW.

J Biol Chem. 1997 Jul 18;272(29):17907-11.

21.

Localization of the cell death genes CPP32 and Mch-2 to human chromosome 4q.

Nasir J, Theilmann JL, Chopra V, Jones AM, Walker D, Rasper DM, Vaillancourt JP, Hewitt JE, Nicholson DW, Hayden MR.

Mamm Genome. 1997 Jan;8(1):56-9. No abstract available.

PMID:
9021152
22.

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.

Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK, Bromm M, Kazemi-Esfarjani P, Thornberry NA, Vaillancourt JP, Hayden MR.

Nat Genet. 1996 Aug;13(4):442-9.

PMID:
8696339
23.

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.

Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA, Becker JW.

Nat Struct Biol. 1996 Jul;3(7):619-25.

PMID:
8673606
24.
25.

Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells.

Nicholson DW, Klemba MW, Rasper DM, Metters KM, Zamboni RJ, Ford-Hutchinson AW.

Eur J Biochem. 1992 Oct 15;209(2):725-34.

26.

Characterization of an inducible aryl hydrocarbon receptor-like protein in rat liver.

Landers JP, Winhall MJ, McCready TL, Sanders DA, Rasper D, Nakai JS, Bunce NJ.

J Biol Chem. 1991 May 25;266(15):9471-80.

Supplemental Content

Loading ...
Support Center