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Items: 1 to 50 of 57

1.

The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria.

Martorano L, Peron M, Laquatra C, Lidron E, Facchinello N, Meneghetti G, Tiso N, Rasola A, Ghezzi D, Argenton F.

Dis Model Mech. 2019 Mar 14;12(3). pii: dmm037226. doi: 10.1242/dmm.037226.

2.

Editorial: Redox and Metabolic Circuits in Cancer.

Rizza S, Rasola A, Townsend DM, Filomeni G.

Front Oncol. 2018 Sep 26;8:403. doi: 10.3389/fonc.2018.00403. eCollection 2018. No abstract available.

3.

Metabolic Plasticity of Tumor Cell Mitochondria.

Cannino G, Ciscato F, Masgras I, Sánchez-Martín C, Rasola A.

Front Oncol. 2018 Aug 24;8:333. doi: 10.3389/fonc.2018.00333. eCollection 2018. Review.

4.

Publisher Correction: Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.

Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, Pasquini E, Alajati A, Pinton S, Losa M, Civenni G, Catapano CV, Sgrignani J, Cavalli A, D'Antuono R, Asara JM, Morandi A, Chiarugi P, Crotti S, Agostini M, Montopoli M, Masgras I, Rasola A, Garcia-Escudero R, Delaleu N, Rinaldi A, Bertoni F, de Bono J, Carracedo A, Alimonti A.

Nat Genet. 2018 Sep;50(9):1343. doi: 10.1038/s41588-018-0181-1.

PMID:
30089860
5.

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.

Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, Pasquini E, Alajati A, Pinton S, Losa M, Civenni G, Catapano CV, Sgrignani J, Cavalli A, D'Antuono R, Asara JM, Morandi A, Chiarugi P, Crotti S, Agostini M, Montopoli M, Masgras I, Rasola A, Garcia-Escudero R, Delaleu N, Rinaldi A, Bertoni F, Bono J, Carracedo A, Alimonti A.

Nat Genet. 2018 Feb;50(2):219-228. doi: 10.1038/s41588-017-0026-3. Epub 2018 Jan 15. Erratum in: Nat Genet. 2018 Sep;50(9):1343.

6.

HSP90 proteins in the scenario of tumor complexity.

Rasola A.

Oncotarget. 2017 Mar 28;8(13):20521-20522. doi: 10.18632/oncotarget.16266. No abstract available.

7.

The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells.

Masgras I, Sanchez-Martin C, Colombo G, Rasola A.

Front Oncol. 2017 Mar 29;7:58. doi: 10.3389/fonc.2017.00058. eCollection 2017. Review.

8.

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.

D'Annessa I, Sattin S, Tao J, Pennati M, Sànchez-Martìn C, Moroni E, Rasola A, Zaffaroni N, Agard DA, Bernardi A, Colombo G.

Chemistry. 2017 Apr 19;23(22):5188-5192. doi: 10.1002/chem.201700169. Epub 2017 Mar 22.

9.

Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.

Masgras I, Ciscato F, Brunati AM, Tibaldi E, Indraccolo S, Curtarello M, Chiara F, Cannino G, Papaleo E, Lambrughi M, Guzzo G, Gambalunga A, Pizzi M, Guzzardo V, Rugge M, Vuljan SE, Calabrese F, Bernardi P, Rasola A.

Cell Rep. 2017 Jan 17;18(3):659-672. doi: 10.1016/j.celrep.2016.12.056.

10.

S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.

Rizza S, Montagna C, Cardaci S, Maiani E, Di Giacomo G, Sanchez-Quiles V, Blagoev B, Rasola A, De Zio D, Stamler JS, Cecconi F, Filomeni G.

Cancer Res. 2016 Jul 15;76(14):4170-82. doi: 10.1158/0008-5472.CAN-15-2637. Epub 2016 May 23.

11.

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis.

Kowalik MA, Guzzo G, Morandi A, Perra A, Menegon S, Masgras I, Trevisan E, Angioni MM, Fornari F, Quagliata L, Ledda-Columbano GM, Gramantieri L, Terracciano L, Giordano S, Chiarugi P, Rasola A, Columbano A.

Oncotarget. 2016 May 31;7(22):32375-93. doi: 10.18632/oncotarget.8632.

12.

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death.

Catanzaro D, Gaude E, Orso G, Giordano C, Guzzo G, Rasola A, Ragazzi E, Caparrotta L, Frezza C, Montopoli M.

Oncotarget. 2015 Oct 6;6(30):30102-14. doi: 10.18632/oncotarget.4945.

13.

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.

Giacco F, Du X, Carratú A, Gerfen GJ, D'Apolito M, Giardino I, Rasola A, Marin O, Divakaruni AS, Murphy AN, Shah MS, Brownlee M.

Diabetes. 2015 Sep;64(9):3273-84. doi: 10.2337/db15-0084.

14.

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.

Bernardi P, Rasola A, Forte M, Lippe G.

Physiol Rev. 2015 Oct;95(4):1111-55. doi: 10.1152/physrev.00001.2015. Review.

15.

Gold(III)-pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents.

Nardon C, Chiara F, Brustolin L, Gambalunga A, Ciscato F, Rasola A, Trevisan A, Fregona D.

ChemistryOpen. 2015 Apr;4(2):183-91. doi: 10.1002/open.201402091. Epub 2015 Feb 19.

16.

Reprint of "The mitochondrial permeability transition pore and its adaptive responses in tumor cells".

Rasola A, Bernardi P.

Cell Calcium. 2015 Jul;58(1):18-26. doi: 10.1016/j.ceca.2015.03.004. Epub 2015 Mar 28. Review.

PMID:
25828565
17.
18.

The mitochondrial permeability transition pore and its adaptive responses in tumor cells.

Rasola A, Bernardi P.

Cell Calcium. 2014 Dec;56(6):437-45. doi: 10.1016/j.ceca.2014.10.003. Epub 2014 Oct 16. Review.

19.

VEGF-targeted therapy stably modulates the glycolytic phenotype of tumor cells.

Curtarello M, Zulato E, Nardo G, Valtorta S, Guzzo G, Rossi E, Esposito G, Msaki A, Pastò A, Rasola A, Persano L, Ciccarese F, Bertorelle R, Todde S, Plebani M, Schroer H, Walenta S, Mueller-Klieser W, Amadori A, Moresco RM, Indraccolo S.

Cancer Res. 2015 Jan 1;75(1):120-33. doi: 10.1158/0008-5472.CAN-13-2037. Epub 2014 Nov 7.

20.

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation.

Pastò A, Bellio C, Pilotto G, Ciminale V, Silic-Benussi M, Guzzo G, Rasola A, Frasson C, Nardo G, Zulato E, Nicoletto MO, Manicone M, Indraccolo S, Amadori A.

Oncotarget. 2014 Jun 30;5(12):4305-19.

21.

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I.

Ciscato F, Sciacovelli M, Villano G, Turato C, Bernardi P, Rasola A, Pontisso P.

Oncotarget. 2014 May 15;5(9):2418-27.

22.

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells.

Rasola A, Neckers L, Picard D.

Trends Cell Biol. 2014 Aug;24(8):455-63. doi: 10.1016/j.tcb.2014.03.005. Epub 2014 Apr 11. Review.

PMID:
24731398
23.

Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface.

Pantic B, Trevisan E, Citta A, Rigobello MP, Marin O, Bernardi P, Salvatori S, Rasola A.

Cell Death Dis. 2013 Oct 17;4:e858. doi: 10.1038/cddis.2013.385.

24.

The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase.

Sciacovelli M, Guzzo G, Morello V, Frezza C, Zheng L, Nannini N, Calabrese F, Laudiero G, Esposito F, Landriscina M, Defilippi P, Bernardi P, Rasola A.

Cell Metab. 2013 Jun 4;17(6):988-99. doi: 10.1016/j.cmet.2013.04.019.

25.

GSK-3 and mitochondria in cancer cells.

Chiara F, Rasola A.

Front Oncol. 2013 Feb 5;3:16. doi: 10.3389/fonc.2013.00016. eCollection 2013.

26.

Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death.

Chiara F, Gambalunga A, Sciacovelli M, Nicolli A, Ronconi L, Fregona D, Bernardi P, Rasola A, Trevisan A.

Cell Death Dis. 2012 Dec 13;3:e444. doi: 10.1038/cddis.2012.184.

27.

Induction of the permeability transition pore in cells depleted of mitochondrial DNA.

Masgras I, Rasola A, Bernardi P.

Biochim Biophys Acta. 2012 Oct;1817(10):1860-6. doi: 10.1016/j.bbabio.2012.02.022. Epub 2012 Feb 28.

28.

A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure.

Jambekar AA, Palma E, Nicolosi L, Rasola A, Petronilli V, Chiara F, Bernardi P, Needleman R, Brusilow WS.

Liver Int. 2011 Sep;31(8):1209-21. doi: 10.1111/j.1478-3231.2011.02553.x. Epub 2011 May 31.

PMID:
21745296
29.

Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis.

Rasola A, Bernardi P.

Cell Calcium. 2011 Sep;50(3):222-33. doi: 10.1016/j.ceca.2011.04.007. Epub 2011 May 23. Review.

PMID:
21601280
30.

Gadd45α activity is the principal effector of Shigella mitochondria-dependent epithelial cell death in vitro and ex vivo.

Lembo-Fazio L, Nigro G, Noël G, Rossi G, Chiara F, Tsilingiri K, Rescigno M, Rasola A, Bernardini ML.

Cell Death Dis. 2011 Feb 24;2:e122. doi: 10.1038/cddis.2011.4.

31.

Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore.

Azzolin L, Antolini N, Calderan A, Ruzza P, Sciacovelli M, Marin O, Mammi S, Bernardi P, Rasola A.

PLoS One. 2011 Jan 28;6(1):e16280. doi: 10.1371/journal.pone.0016280.

32.

Signal transduction to the permeability transition pore.

Rasola A, Sciacovelli M, Pantic B, Bernardi P.

FEBS Lett. 2010 May 17;584(10):1989-96. doi: 10.1016/j.febslet.2010.02.022. Epub 2010 Feb 11. Review.

33.

Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition.

Rasola A, Sciacovelli M, Chiara F, Pantic B, Brusilow WS, Bernardi P.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):726-31. doi: 10.1073/pnas.0912742107. Epub 2009 Dec 22.

34.

Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons.

Martin MG, Trovò L, Perga S, Sadowska A, Rasola A, Chiara F, Dotti CG.

Neurobiol Aging. 2011 May;32(5):933-43. doi: 10.1016/j.neurobiolaging.2009.04.022. Epub 2009 Jun 3.

PMID:
19497639
35.

Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury.

Wang X, Carlsson Y, Basso E, Zhu C, Rousset CI, Rasola A, Johansson BR, Blomgren K, Mallard C, Bernardi P, Forte MA, Hagberg H.

J Neurosci. 2009 Feb 25;29(8):2588-96. doi: 10.1523/JNEUROSCI.5832-08.2009.

36.

Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores.

Rigoni M, Paoli M, Milanesi E, Caccin P, Rasola A, Bernardi P, Montecucco C.

J Biol Chem. 2008 Dec 5;283(49):34013-20. doi: 10.1074/jbc.M803243200. Epub 2008 Sep 22.

37.

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels.

Chiara F, Castellaro D, Marin O, Petronilli V, Brusilow WS, Juhaszova M, Sollott SJ, Forte M, Bernardi P, Rasola A.

PLoS One. 2008 Mar 19;3(3):e1852. doi: 10.1371/journal.pone.0001852.

38.

Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro.

Martin MG, Perga S, Trovò L, Rasola A, Holm P, Rantamäki T, Harkany T, Castrén E, Chiara F, Dotti CG.

Mol Biol Cell. 2008 May;19(5):2101-12. doi: 10.1091/mbc.E07-09-0897. Epub 2008 Feb 20.

39.

Calcium and cell death: the mitochondrial connection.

Bernardi P, Rasola A.

Subcell Biochem. 2007;45:481-506. Review.

PMID:
18193649
40.
41.

A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth.

Rasola A, Fassetta M, De Bacco F, D'Alessandro L, Gramaglia D, Di Renzo MF, Comoglio PM.

Oncogene. 2007 Feb 15;26(7):1078-87. Epub 2006 Sep 4.

PMID:
16953230
42.

Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin.

Olivero M, Ruggiero T, Saviozzi S, Rasola A, Coltella N, Crispi S, Di Cunto F, Calogero R, Di Renzo MF.

Mol Cancer Ther. 2006 May;5(5):1126-35.

43.

Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosis.

Fassetta M, D'Alessandro L, Coltella N, Di Renzo MF, Rasola A.

Cell Signal. 2006 Nov;18(11):1967-76. Epub 2006 May 3.

PMID:
16677802
44.

p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis.

Coltella N, Rasola A, Nano E, Bardella C, Fassetta M, Filigheddu N, Graziani A, Comoglio PM, Di Renzo MF.

Int J Cancer. 2006 Jun 15;118(12):2981-90.

45.

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.

Chiara F, Goumans MJ, Forsberg H, Ahgrén A, Rasola A, Aspenström P, Wernstedt C, Hellberg C, Heldin CH, Heuchel R.

J Biol Chem. 2004 Oct 8;279(41):42516-27. Epub 2004 Jul 28.

46.

Hepatocyte growth factor sensitizes human ovarian carcinoma cell lines to paclitaxel and cisplatin.

Rasola A, Anguissola S, Ferrero N, Gramaglia D, Maffe A, Maggiora P, Comoglio PM, Di Renzo MF.

Cancer Res. 2004 Mar 1;64(5):1744-50.

47.

Apoptosis to necrosis switching downstream of apoptosome formation requires inhibition of both glycolysis and oxidative phosphorylation in a BCL-X(L)- and PKB/AKT-independent fashion.

Gramaglia D, Gentile A, Battaglia M, Ranzato L, Petronilli V, Fassetta M, Bernardi P, Rasola A.

Cell Death Differ. 2004 Mar;11(3):342-53.

48.
49.

Apoptosis enhancement by the HIV-1 Nef protein.

Rasola A, Gramaglia D, Boccaccio C, Comoglio PM.

J Immunol. 2001 Jan 1;166(1):81-8.

50.

Lack of internucleosomal DNA fragmentation is related to Cl(-) efflux impairment in hematopoietic cell apoptosis.

Rasola A, Farahi Far D, Hofman P, Rossi B.

FASEB J. 1999 Oct;13(13):1711-23.

PMID:
10506574

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