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Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2-neo mouse rescued by L-type calcium channel blockers.

Calorio C, Gavello D, Guarina L, Salio C, Sassoè-Pognetto M, Riganti C, Bianchi FT, Hofer NT, Tuluc P, Obermair GJ, Defilippi P, Balzac F, Turco E, Bett GC, Rasmusson RL, Carbone E.

J Physiol. 2019 Mar;597(6):1705-1733. doi: 10.1113/JP277487. Epub 2019 Jan 28.


Enhanced oligodendrocyte maturation and myelination in a mouse model of Timothy syndrome.

Cheli VT, Santiago González DA, Zamora NN, Lama TN, Spreuer V, Rasmusson RL, Bett GC, Panagiotakos G, Paez PM.

Glia. 2018 Nov;66(11):2324-2339. doi: 10.1002/glia.23468. Epub 2018 Aug 26.


Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient.

Ma D, Liu Z, Loh LJ, Zhao Y, Li G, Liew R, Islam O, Wu J, Chung YY, Teo WS, Ching CK, Tan BY, Chong D, Ho KL, Lim P, Yong RYY, Panama BK, Kaplan AD, Bett GCL, Ware J, Bezzina CR, Verkerk AO, Cook SA, Rasmusson RL, Wei H.

Sci Rep. 2018 Jul 26;8(1):11246. doi: 10.1038/s41598-018-29574-5.


Depletion of Stercobilin in Fecal Matter from a Mouse Model of Autism Spectrum Disorders.

Sekera ER, Rudolph HL, Carro SD, Morales MJ, Bett GCL, Rasmusson RL, Wood TD.

Metabolomics. 2017 Nov;13(11). pii: 132. doi: 10.1007/s11306-017-1277-9. Epub 2017 Oct 3.


Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women.

Papp R, Bett GCL, Lis A, Rasmusson RL, Baczkó I, Varró A, Salama G.

Biol Sex Differ. 2017 Aug 14;8(1):26. doi: 10.1186/s13293-017-0148-4.


Action Potential Shape Is a Crucial Measure of Cell Type of Stem Cell-Derived Cardiocytes.

Bett GC, Kaplan AD, Rasmusson RL.

Biophys J. 2016 Jan 5;110(1):284-6. doi: 10.1016/j.bpj.2015.11.026. No abstract available.


The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole.

Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP.

Cell Host Microbe. 2015 May 13;17(5):642-52. doi: 10.1016/j.chom.2015.04.003.


Regional variation of the inwardly rectifying potassium current in the canine heart and the contributions to differences in action potential repolarization.

Cordeiro JM, Zeina T, Goodrow R, Kaplan AD, Thomas LM, Nesterenko VV, Treat JA, Hawel L 3rd, Byus C, Bett GC, Rasmusson RL, Panama BK.

J Mol Cell Cardiol. 2015 Jul;84:52-60. doi: 10.1016/j.yjmcc.2015.04.010. Epub 2015 Apr 15.


Activation of HERG channels: opening new applications for the biophysics of antiarrhythmic therapy.

Rasmusson RL, Anumonwo JM.

Biophys J. 2015 Mar 24;108(6):1309-1311. doi: 10.1016/j.bpj.2015.01.011. No abstract available.


Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy.

Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L.

Dis Model Mech. 2015 May;8(5):457-66. doi: 10.1242/dmm.019505. Epub 2015 Mar 19.


Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.


Reconciling computer models and stem cell models of human cardiac repolarization: reply.

Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L.

Cardiovasc Res. 2015 Apr 1;106(1):6-7. doi: 10.1093/cvr/cvv039. Epub 2015 Feb 17. No abstract available.


Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells.

Kim JJ, Yang L, Lin B, Zhu X, Sun B, Kaplan AD, Bett GC, Rasmusson RL, London B, Salama G.

J Mol Cell Cardiol. 2015 Apr;81:81-93. doi: 10.1016/j.yjmcc.2015.01.013. Epub 2015 Jan 30.


Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells.

Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L.

Cardiovasc Res. 2014 Nov 1;104(2):258-69. doi: 10.1093/cvr/cvu205. Epub 2014 Sep 10.


Autism and induced labor: is calcium a potential mechanistic link?

Barnabei VM, Rasmusson RL, Bett GC.

Am J Obstet Gynecol. 2014 May;210(5):494-5. doi: 10.1016/j.ajog.2014.01.020. Epub 2014 Jan 16. No abstract available.


Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells.

Bett GC, Kaplan AD, Lis A, Cimato TR, Tzanakakis ES, Zhou Q, Morales MJ, Rasmusson RL.

Heart Rhythm. 2013 Dec;10(12):1903-10. doi: 10.1016/j.hrthm.2013.09.061. Epub 2013 Sep 19.


Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts.

Parikh A, Patel D, McTiernan CF, Xiang W, Haney J, Yang L, Lin B, Kaplan AD, Bett GC, Rasmusson RL, Shroff SG, Schwartzman D, Salama G.

Circ Res. 2013 Jul 19;113(3):313-21. doi: 10.1161/CIRCRESAHA.113.301646. Epub 2013 Jun 7.


Interaction of the S6 proline hinge with N-type and C-type inactivation in Kv1.4 channels.

Bett GC, Lis A, Guo H, Liu M, Zhou Q, Rasmusson RL.

Biophys J. 2012 Oct 3;103(7):1440-50. doi: 10.1016/j.bpj.2012.08.036. Epub 2012 Oct 2.


Markov models of use-dependence and reverse use-dependence during the mouse cardiac action potential.

Zhou Q, Bett GC, Rasmusson RL.

PLoS One. 2012;7(8):e42295. doi: 10.1371/journal.pone.0042295. Epub 2012 Aug 6.


A Mouse Model of Timothy Syndrome: a Complex Autistic Disorder Resulting from a Point Mutation in Cav1.2.

Bett GC, Lis A, Wersinger SR, Baizer JS, Duffey ME, Rasmusson RL.

N Am J Med Sci (Boston). 2012 Jul 25;5(3):135-140.


Mathematical modeling mechanisms of arrhythmias in transgenic mouse heart overexpressing TNF-α.

Petkova-Kirova PS, London B, Salama G, Rasmusson RL, Bondarenko VE.

Am J Physiol Heart Circ Physiol. 2012 Feb 15;302(4):H934-52. doi: 10.1152/ajpheart.00493.2011. Epub 2011 Nov 11.


Mouse model of Timothy syndrome recapitulates triad of autistic traits.

Bader PL, Faizi M, Kim LH, Owen SF, Tadross MR, Alfa RW, Bett GC, Tsien RW, Rasmusson RL, Shamloo M.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15432-7. doi: 10.1073/pnas.1112667108. Epub 2011 Aug 30.


Models of HERG gating.

Bett GC, Zhou Q, Rasmusson RL.

Biophys J. 2011 Aug 3;101(3):631-42. doi: 10.1016/j.bpj.2011.06.050.


A model of the interaction between N-type and C-type inactivation in Kv1.4 channels.

Bett GC, Dinga-Madou I, Zhou Q, Bondarenko VE, Rasmusson RL.

Biophys J. 2011 Jan 5;100(1):11-21. doi: 10.1016/j.bpj.2010.11.011.


Transmural heterogeneity of repolarization and Ca2+ handling in a model of mouse ventricular tissue.

Bondarenko VE, Rasmusson RL.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H454-69. doi: 10.1152/ajpheart.00907.2009. Epub 2010 Jun 4.


Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.

Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA.

Circulation. 2008 Sep 9;118(11):1202-11. doi: 10.1161/CIRCULATIONAHA.108.772715.


Effect of amiodarone on Kv1.4 channel C-type inactivation: comparison of its effects with those induced by propafenone and verapamil.

Xu L, Huang C, Chen J, Jiang X, Li X, Bett GC, Rasmusson RL, Wang S.

Pharmazie. 2008 Jun;63(6):475-9.


Modification of K+ channel-drug interactions by ancillary subunits.

Bett GC, Rasmusson RL.

J Physiol. 2008 Feb 15;586(4):929-50. Epub 2007 Dec 20. Review.


Simulations of propagated mouse ventricular action potentials: effects of molecular heterogeneity.

Bondarenko VE, Rasmusson RL.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1816-32. Epub 2007 Jun 22.


Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel.

Bett GC, Morales MJ, Beahm DL, Duffey ME, Rasmusson RL.

J Physiol. 2006 Nov 1;576(Pt 3):755-67. Epub 2006 Aug 3.


Hyperpolarization-activated cation channels are expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons.

Arroyo A, Kim B, Rasmusson RL, Bett G, Yeh J.

J Soc Gynecol Investig. 2006 Sep;13(6):442-50. Epub 2006 Jul 31.


KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine.

Bett GC, Morales MJ, Strauss HC, Rasmusson RL.

Biochem Biophys Res Commun. 2006 Feb 24;340(4):1167-77. Epub 2006 Jan 4.


Time- and voltage-dependent components of Kv4.3 inactivation.

Wang S, Bondarenko VE, Qu YJ, Bett GC, Morales MJ, Rasmusson RL, Strauss HC.

Biophys J. 2005 Nov;89(5):3026-41. Epub 2005 Aug 12.


Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents.

Wang X, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ.

Biophys J. 2005 Sep;89(3):1731-43. Epub 2005 Jun 24.


Computer model of action potential of mouse ventricular myocytes.

Bondarenko VE, Szigeti GP, Bett GC, Kim SJ, Rasmusson RL.

Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1378-403. Epub 2004 May 13.


Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence.

Wang S, Bondarenko VE, Qu Y, Morales MJ, Rasmusson RL, Strauss HC.

J Physiol. 2004 Jun 15;557(Pt 3):705-17. Epub 2004 Mar 5.


Functionally-distinct proton-binding in HERG suggests the presence of two binding sites.

Bett GC, Rasmusson RL.

Cell Biochem Biophys. 2003;39(3):183-93.


A model of graded calcium release and L-type Ca2+ channel inactivation in cardiac muscle.

Bondarenko VE, Bett GC, Rasmusson RL.

Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1154-69. Epub 2003 Nov 20.


C-type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 K+ channels expressed in Xenopus oocytes.

Jiang X, Bett GC, Li X, Bondarenko VE, Rasmusson RL.

J Physiol. 2003 Jun 15;549(Pt 3):683-95. Epub 2003 May 2.


Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect.

Wang S, Morales MJ, Qu YJ, Bett GC, Strauss HC, Rasmusson RL.

J Physiol. 2003 Jan 15;546(Pt 2):387-401.


Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication.

Li X, Bett GC, Jiang X, Bondarenko VE, Morales MJ, Rasmusson RL.

Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H71-80. Epub 2002 Aug 29.


Restitution, ventricular fibrillation, and drugs: where are we now?

Strauss HC, Rasmusson RL.

J Cardiovasc Electrophysiol. 2002 Sep;13(9):915-7. No abstract available.


A novel mechanism for myocardial stunning involving impaired Ca(2+) handling.

Kim SJ, Kudej RK, Yatani A, Kim YK, Takagi G, Honda R, Colantonio DA, Van Eyk JE, Vatner DE, Rasmusson RL, Vatner SF.

Circ Res. 2001 Oct 26;89(9):831-7.


Distinct transient outward potassium current (Ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes.

Brahmajothi MV, Campbell DL, Rasmusson RL, Morales MJ, Trimmer JS, Nerbonne JM, Strauss HC.

J Gen Physiol. 1999 Apr;113(4):581-600.


Inactivation of voltage-gated cardiac K+ channels.

Rasmusson RL, Morales MJ, Wang S, Liu S, Campbell DL, Brahmajothi MV, Strauss HC.

Circ Res. 1998 Apr 20;82(7):739-50. Review.


Voltage-dependent, open channel blockade of the cardiac sarcoplasmic reticulum potassium channel by 4-aminopyridine.

Liu QY, Rasmusson RL, Liu QX, Strauss HC.

Can J Cardiol. 1998 Feb;14(2):275-80. Review.


Models of potassium channel inactivation: implications for open channel block.

Liu S, Rasmusson RL.

Can J Cardiol. 1998 Jan;14(1):101-7.


Modulation of HERG affinity for E-4031 by [K+]o and C-type inactivation.

Wang S, Morales MJ, Liu S, Strauss HC, Rasmusson RL.

FEBS Lett. 1997 Nov 3;417(1):43-7.


A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes.

Wang S, Liu S, Morales MJ, Strauss HC, Rasmusson RL.

J Physiol. 1997 Jul 1;502 ( Pt 1):45-60.

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